NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	7783-70-2
Chemical Name	Antimony(V) fluoride
Substance ID	m-nite-7783-70-2_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Not classified	- -	-	-	It is not combustible (GESTIS (Access on July 2015)).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified	- -	-	-	It is not combustible (GESTIS (Access on July 2015)).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Not classified	- -	-	-	It is not combustible (GESTIS (Access on July 2015)).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	It contains metalloids (Sb) and reacts with water (NITE Chemical Risk Information Platform (NITE-CHRIP) (Access on July 2015)), however, gas produced is hydrogen fluoride, which is not combustible.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Classification not possible	- -	-	-	It is an inorganic compound containing fluorine (but not oxygen), but the classification is not possible due to no data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	It is an inorganic compound.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	It is described that it attacks many metals (ICSC (2011)), but the classification is not possible due to no data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, the estimated lethal doses of 5-50 mg/kg as antimony salt for humans were reported (Sittig's (5th, 2008)), but they were not adopted for classification because of unreliable information.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	Classification not possible due to lack of data. The LC50 value of 152 mg Sb/kg (2hours) (SbF5 converted value: 270 mg/kg) for mice was reported (DFGOT vol. 23 (2007)), but it was not adopted for classification because adequate unit was not used. Moreover, the LC50 value of 270 mg/m3 (30.5 ppm) for mice was reported (RTECS (Access on August 2015)), but it was not adopted for classification because exposure time is unknown. The reference values in the unit of ppm was applied as vapour without mist because the LC50 values are lower than the saturated vapor pressure concentration (12,833 ppm). The classification was revised by taking into account the exposure times.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	There is a description that this substance is severely irritating to the skin to the skin (HSDB (Access on August 2015)), and that it causes skin burns (HSDB (Access on August 2015)). The classification was changed to Category 2 due to no description of the recovery.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Category 2A	Warning	H319	P305+P351+P338 P337+P313 P264 P280	Although there is no detailed information, it is described that this substance is severely irritating to the eye (HSDB (Access on August 2015)). The classification was changed to Category 2A due to no description of the recovery.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Classification not possible	- -	-	-	There is no information regarding carcinogenicity of this substance for either humans or experimental animals. Among antimony compounds, as for antimony trioxide, it was reported that many deaths due to lung cancer occurred among factory workers in the Great Britain who were mainly exposed to dust of antimony trioxide in the antimony manufacturing process for not less than 8 years. After that, in the expanded investigation, the expected rate of deaths from lung cancer (5.7) was slightly higher than the expected rate of deaths from lung cancer of the same age (4.5). However, this excess risk of carcinogenicity was not necessarily of consequence statistically because of the relatively small numbers involved, and it was concluded as an "equivocal result" (ACGIH (7th, 2001)). Additionally, it is described that as for the workers exposed to antimony and arsenic in the antimony ore smelting factory in the United States, the lung cancer by exposing to antimony trioxide dust was concerned about, but there was no record of death due to lung cancer, etc., therefore, it could not be analyzed due to lack of information (ACGIH (7th, 2001)). In the inhalation test in which rats were exposed to antimony trioxide dust (45mg/m3) or antimony ore concentrate (40mg/m3) for 1 year, lung tumors were found at the incidence of 32% in both exposed groups, and it was revealed that tumor types included squamous cell carcinomas, bronchoalveolar adenomas, bronchoalveolar carcinomas, and scirrhous carcinomas (ACGIH (7th, 2001)). Based on these findings in the experimental animals in addition to the limited epidemiological findings in humans, "production of antimony trioxide" was given an A2 designation by ACGIH, but antimony and its compounds were not classified for the carcinogenicity (ACGIH (7th, 2001)). As for the carcinogenicity of antimony compounds, the Japan Society for Occupational Health classified only antimony trioxide in Group 2B (OEL Documentations (Japan Society For Occupational Health (JSOH), 2013)). From the above, as for carcinogenicity, it was considered antimony trioxide was equivalent to Category 2 or Category 1B, but no other data were available for other antimony compounds. Therefore, this substance was also classified as "Classification not possible" due to lack of data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Category 1 (respiratory organs, cardiovascular system, liver, kidney)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	This substance is irritating to the respiratory tract (DFGOT vol. 23 (2007), HSDB (Access on August 2015)). Although the details of the data are unknown, it is described that the acute effects of this substance due to human poisoning are cough, wheezing, dyspnea, chest tightness and pulmonary edema by inhalation and dermal exposure; severe burns of oral cavity and throat, nausea, vomiting, abdominal cramp, and bloody diarrhea by oral ingestion; and bradycardia, hypotension, coma, seizures, cardiac arrest, jaundice, glomerular nephritis, albuminuria, severe hypocalcemia, hyperkalemia and hypomagnesemia which are lead to by systemic absorption via any route (HSDB (Access on August 2015)). As described above, this substance is irritating to the respiratory tract, and as for other target organs, effects on the respiratory organs, cardiovascular system, liver, and kidney were adopted based on the information source in List 2. Therefore, this substance was classified in Category 1 (respiratory organs, cardiovascular system, liver, kidney). Since new information was added, the previous classification was revised.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	There is no data available for this substance itself, therefore, classification was not possible due to lack of data. Besides, in ACGIH's "ANTIMONY and COMPOUNDS," it was described that pneumonia, cardiac and hematological disorders are predicted with acute and chronic exposure to high concentrations (ACGIH (7th, 2001)). Moreover, in ACGIH's "FLUORIDES," bone lesions related to fluorosis due to occupational exposure to inorganic fluorides was reported (ACGIH (7th, 2001)). In the previous classification, based mainly on a description in ACGIH, the effect on the bone as fluoride and effect on the lung, cardiovascular system and liver as antimony compound were used for classification, but these data were used only as references because these were not the data of this substance.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, based on the numeric in HSDB (Access on August 2015) (viscosity: 0.768 mPa*s (24.4 deg C), density (specific gravity): 3.097 (25.8 deg C)), kinematic viscosity was calculated to 0.248 mm2/sec (25/26 deg C).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	No data available.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data available.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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