NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	78-00-2
Chemical Name	Lead, tetraethyl-
Substance ID	m-nite-78-00-2_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Flammable liquids	Category 4	- Warning	H227	P370+P378 P210 P280 P403 P501	Since its flash point is 93 degC (closed-cup) (ATSDR (2007)), the substance is classified into Category 4.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Pyrophoric liquids	Not classified	- -	-	-	Its autoignition temperature of 110 degC or more (ICSC (J) (2003)) was obtained and it is considered that the substance does not ignite at room temperature, therefore the substance is classified as "Not classified".	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	Although the substance contains a metal (Pb) in the molecule, the water solubility data 0.29 mg/L (HSDB (2005)) is obtained. Therefore it is considered that it does not react vigorously with water.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Organic compounds containing no oxygen, fluorine or chlorine in the molecule	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 2	Danger	H300	P301+P310 P264 P270 P321 P330 P405 P501	Three LD50 values of 35.0 mg/kg, 14 - 17 mg/kg (ACGIH (2001)) and 1.2 mg/kg (PIMs (1994)) for rats were reported. One of them corresponded to Category 1, and the other two corresponded to Category 2. The substance was classified as Category 2, since the majority of obtained data corresponded to it.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Dermal)	Category 3	Danger	H311	P302+P352 P361+P364 P280 P312 P321 P405 P501	Two LD50 values of 700 mg/kg (ACGIH (2001)) and 990 mg/kg (DFGMAK-Doc. 15 (2001)) for rabbits were reported. The substance was classified as Category 3, since all of them corresponded to the Category 3.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Vapours)	Category 1	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	Based on the rat LC50 value of 0.85 mg/L/1hｒ (= 64.26 ppmV/1hr = 32.13 ppmV/4hrs) (ACGIH (2001)), the substance was classified as Category 1. The LC50 value was lower than 90% of the saturated vapor pressure concentration (513 ppmV), it was judged as "vapor hardly coexisting mist" and the criterion values for gas were adopted.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Skin corrosion/irritation	Classification not possible	- -	-	-	No data were available. As relevant information, it is reported that the alkyl lead compounds are easily absorbed to skin and caused itch, burn and transient reddening (PIMs (1994)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Skin sensitization	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Germ cell mutagenicity	Not classified	- -	-	-	The substance was classified as "Not classified" based on the negative results in the dominant lethal test using mice orally and intraperitoneally administered (in vivo inheritable mutagenicity test in germ cells) (DFGMAK-Doc. 15 (2001)). As relevant information, as for in vitro study, negative results in the Ames test were reported (NTP DB (Access on Jun. 2009)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Carcinogenicity	Classification not possible	- -	-	-	It was classified as "Classification not possible" in accordance with the revision of the GHS guidance, based on the criteria of "Group 3" in the carcinogenicity assessment of the IARC (IARC suppl. 7 (1987)) and "A4" in the ACGIH (ACGIH (2001)). As relevant information, increase in the incidence of malignant lymphomas was found only in females surviving for 36 weeks after subcutaneous administration to mice through the lactation period from the birth (IARC 23 (1980)). In the human case-control study, a strong association between the occupational exposure and rectal cancer were found in workers involved in manufacturing this substance (PATTY, 5th (2001)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	In the gavage tests during the organogenetic period in rats or mice, increased resorption and decreased number of fetuses were observed in both species at the dose levels that general toxic effects such as decreased body weight gain, tremor, and convulsions were observed in dams. In the oral administration study in rats administered on day 9 - 11 of gestation, or day 12 - 14 of gestation, increased resorption was observed (DFGMAK-Doc.15 (2001)). Therefore, the substance was classified as Category 2.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Specific target organ toxicity - Single exposure	Category 1 (central nervous system)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	It was reported that when the substance was first introduced as a gasoline additive, more than 300 workers engaged in its production developed acute neurological symptoms and 5 died (PATTY, 5th (2001)). It was also reported that the brain was the critical organ for toxicity of the substance, and that early symptom following exposure such as nausea, vomiting and diarrhea were associated with nervous system complaints of irritability, headache, and restlessness, and might progress rapidly to severe signs of toxicity of the central nervous system containing convulsions and coma (PATTY, 5th (2001)). Based on the information, the substance was classified as Category 1 (central nervous system).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Specific target organ toxicity - Repeated exposure	Category 1 (nervous system, liver)	Danger	H372	P260 P264 P270 P314 P501	In the autopsy of the dead person who inhaled leaded gasoline, edema in the brain, necrosis of nerve cells in the hippocampus, loss of Purkinje's cells in the cerebellum and demyelination of the Varolius' pons were reported (DFGMAK-Doc.15 (2001)). Moreover, it was reported that chronic heavy abuse of sniffing of leaded gasoline might cause encephalopathy, cerebellar and corticospinal symptoms, signs of dementia, alterations in mental status, and persistent organic psychosis (PATTY, 5th (2001)). While in the 90-day oral dose study in rats, ultrastructural alterations in Schwann's cell and in unmyelinated axons were observed at the dose level of 0.2 mg/kg or more (ACGIH (2001)). In the 20-week oral (gavage) study in rats, swelling and cytoplasmic degeneration of the liver and neuronal damage were reported at the dose levels of 0.0017 - 0.17 mg/kg (IRIS (2002)). Further, in the 14-day oral dose study in mice, neurotoxic signs characterized by tremors and slight chronic hepatitis were reported at the dose level of 2.0 mg/kg (NTP Report No. IMM20009). As described above, since the effects on central nervous system and liver were evident and since the dose range were equivalent to Category 1 of the guidance values, the substance was classified as Category 1 (central nervous system, liver).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	Classified into Category 1 from its 96h-LC50 = 0.02 mg/L for fish (Lepomis macrochirus) (EHC85, 1989).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	Classified into Category 1 since its acute toxicity is Category 1 and the behavior in water and bioaccumulation potential are unknown from which it is a metal compound.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in Annexes to the Montreal Protocol.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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