NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	78587-05-0
Chemical Name	hexythiazox; trans-5-(4-chlorophenyl)-N-cyclohexyl-4-methyl-2-oxo-3-thiazolidine-carboxamide
Substance ID	m-nite-78587-05-0_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Flammable solids	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Pyrophoric solids	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to solid (melting point <= 140degC) substances are not available. (melting point: 105.5degC, Merck (14th, 2006))	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Organic compounds containing chlorine and oxygen (but not fluorine), which are chemically bonded only to carbon or hydrogen.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	Since its rat LD50 is > 5000 mg/kg bw (JMPR (1991)), the substance was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Since its rat LD50 is > 5000 mg/kg bw (JMPR (1991)), the substance was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Based on its rat LC50 of > 2.0 mg/kg bw/4h (JMPR (1991)), classification of the substance cannot be determined between Category 3 and "Not classified".; thus, the substance was classified into "Classification not possible". Since the test concentration was > 2.0 mg/L, which was higher than the saturated vapour concentration of the test substance (2.90E-004 mg/L), we determined that the test substance was in a dust state.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Skin corrosion/irritation	Not classified	- -	-	-	In the tests using rabbits that were treated with the substance for 4 hours, skin irritation was not observed 72 hours after the application (JMPR (1991)); thus, the substance was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	In rabbit tests, the application caused slight irritation, and signs of irritation were not observed 48 hours after application (JMPR (1991)). Based on these results, we determined that the effects are reversible and classified the substance into Category 2B.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Skin sensitization	Not classified	- -	-	-	Tests using guinea pigs (maximization tests) found that the substance is not sensitizing (JMPR (1991)), and other tests using guinea pigs found the same (Pesticide Safety Information (Japan Crop Protection Association) (AGCHEM AGE No.154, 1999)). Thus, the substance was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Germ cell mutagenicity	Not classified	- -	-	-	Based on negative results found in both micronucleus tests using bone marrow cells of mice that underwent oral administration, and chromosomal aberration tests using bone marrow cells of Chinese hamsters (both tests are in vivo mutagenicity tests using somatic cells) (JMPR (1991)), the substance was classified into "Not classified". With regard to in vitro mutagenicity tests, both Ames tests and chromosomal aberration tests using cultured CHO cells gave negative results (JMPR (1991); Pesticide Safety Information (Japan Crop Protection Association) FOOD SANITATION RESEARCH No.149, 1999))	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Carcinogenicity	Not classified	- -	-	-	In 104-week oral administration (mixed diet) tests using rats, incidences of tumorigenesis did not increase due to administration (JMPR (1991)). On the other hand, in 104-week oral administration (mixed diet) tests using mice, the incidence of hyperplastic nodes consisting of proliferating hepatocytes was increased in both sexes (rate of incidence: 52+104 weeks, 60 rats), and an increase in the incidence of hepatocellular adenomas or carcinomas was also observed at the end of the study (JMPR (1991)). Given these results, the US EPA has placed the substance in Category C. As such, we classified the substance into the "Not classified" category.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Reproductive toxicity	Not classified	- -	-	-	In oral administration tests conducted during the organogenetic period using either pregnant rats or pregnant rabbits, no changes due to administration were detected in terms of the total number of implantations, number of corpora lutea, number of surviving embryos and fetuses, and mortality or number of embryo resorption across maternal animals (Pesticide Safety Information (Japan Crop Protection Association) (AGCHEM AGE No.154, 1999)). Given these results, no changes by administration are detected on sex ratio, external abnormalities, skeletal abnormalities, or visceral abnormalities in embryos and fetuses (Pesticide Safety Information (Japan Crop Protection Association) (AGCHEM AGE No.154, 1999)). In addition, no signs of teratogenicity were detected in embryos and fetuses by administration of 2160 mg/kg/day to rats or administration of 1080 mg/kg/day to rabbits (JMPR (1991), Pesticide Safety Information (Japan Crop Protection Association) (AGCHEM AGE No.154, 1999)). Furthermore, in two-generation reproduction tests using rats that underwent oral administration, no effects of administration on reproduction of parental animals were detected in terms of mating rate, pregnancy rate, birthrate, or number of pups (Pesticide Safety Information (Japan Crop Protection Association) (AGCHEM AGE No.154, 1999)). Also, no effects of administration on offspring were detected in terms of survival rate of newborn offspring, or development and differentiation (Pesticide Safety Information (Japan Crop Protection Association) (AGCHEM AGE No.154, 1999)). It is concluded based on these results that no reproduction inhibitory effects or teratogenic effects are associated with this substance (JMPR (1991), Pesticide Safety Information (Japan Crop Protection Association) (AGCHEM AGE No.154, 1999)). Accordingly, the substance was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	In 13-week oral administration (mixed diet) tests using rats, changes in hematological parameters and biochemical values were detected in both sexes at >= 500 ppm (25 mg/kg), which falls under Category 2 guidance doses; swelling of hepatocytes in the central zone was observed in both sexes at 3500 ppm (175 mg/kg), which is above Category 2 guidance doses; and fatty degeneration of the zona fasciculata of the adrenal cortex was observed in both sexes at 500 ppm (25 mg/kg) (JMPR (1991), IRIS (2002), Pesticide Safety Information (Japan Crop Protection Association) (AGCHEM AGE No.154, 1999). In addition, a decrease in plasma cholinesterase was detected in female rats treated with 500 or 3500 ppm while no abnormalities were detected in the brain or with red blood cell cholinesterase (IRIS (2002), Pesticide Safety Information (Japan Crop Protection Association) (AGCHEM AGE No.154, 1999)). In 28-day oral administration (mixed diet) tests using mice, swollen liver cells were observed in male rats treated with >= 1800 ppm (90-day conversion: 90 mg/kg) and in female rats treated with 10800 ppm (90-day conversion: 540 mg/kg) (JMPR (1991), Pesticide Safety Information (Japan Crop Protection Association) (AGCHEM AGE No.154, 1999)). Overall, notable effects of administration were not identified other than hepatocyte hypertrophy in the liver and adipose degeneration of fascicular zone in the adrenal cortex. However, due to lack of additional information, the substance was classified into "Classification not possible" instead of "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	Since its 96-hour LC50 = 0.53 mg/L for fish (bluegills) (ECOTOX, 2008), the substance was classified into Category 1.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	Since its classification for acute toxicity is Category 1 and it is not rapidly degradable (SRC: BioWin V4.10), the substance was classified into Category 1.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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