Item | Information |
---|---|
CAS RN | 79-07-2 |
Chemical Name | Chloroacetamide |
Substance ID | m-nite-79-07-2_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
7 | Flammable solids | Classification not possible |
- |
- | - | No data available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
10 | Pyrophoric solids | Classification not possible |
- |
- | - | No data available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to solid (melting point <= 140 degC) substances are not available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | The substance is an organic compound containing oxygen and chlorine (but not fluorine) which are chemically bonded only to carbon or hydrogen. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 3 |
Danger |
H301 | P301+P310 P264 P270 P321 P330 P405 P501 |
Based on the rat LD50 value of 138 mg/kg (BUA Report 225 (2000)), the substance was classified into Category 3. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | No data available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | No data available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | No data available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
2 | Skin corrosion/irritation | Category 2 |
Warning |
H315 | P302+P352 P332+P313 P362+P364 P264 P280 P321 |
In the rabbit test (OECD TG 404), 4-hour application of 500 mg of the substance as paste form with saline solution to 3 rabbits caused mild erythema and edema in one animal, moderate erythema and edema in the second one, and severe erythema and edema in the third one 1 hour to 3 days after patch removal. All signs of irritation were reversible 7 days after removal of the patch, and authors evaluated the substance as slightly irritating (BUA Report 225 (2000)). The substance was classified as Category 2 based on the document that two of three animals exhibited more than moderate irritation 1 hour to 3 days after patch removal. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
3 | Serious eye damage/eye irritation | Category 2A |
Warning |
H319 | P305+P351+P338 P337+P313 P264 P280 |
In the rabbit eye irritation test (OECD TG 405), instillation of 100 mg of the substance to conjunctival sac caused severe reddening and swelling of conjunctiva and corneal opacity 1 to 7 hours after application. The disappearance of these effects were very slow but were reversible after 21 days, and authors evaluated the substance as irritating to eyes (BUA Report 225 (2000)). Based on the information, the substance was classified as Category 2A. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Skin sensitization | Category 1 |
Warning |
H317 | P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501 |
In humans, there were many case reports of occurrence of allergic contact dermatitis and positive results in the patch tests with both patient and healthy volunteers (BUA Report 225 (2000), HSDB (2006)). In the guinea pig maximization test, 60 - 80% of treated animals showed positive response after the initial challenge. At rechallenge, 80% of the animals showed positive reaction, and the authors concluded that the substance had strong sensitizing potential (BUA Report 225 (2000)). This substance is used as preservative in cutting oil, paints, adhesives and for leather. A contact dermatitis may be caused in hairdressers and shoes manufacturers, and the substance was listed as a skin sensitizer (Contact Dermatitis, Frosch, 4th (2006)). Based on these documents, the substance was classified as Category 1. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
5 | Germ cell mutagenicity | Not classified |
- |
- | - | The classification was concluded as "Not classified" based on the negative results in the dominant lethal test using mice intraperitoneally administered (in vivo inheritable mutagenicity test in germ cells), the chromosome aberration test using spermatogonia and bone marrow cells of Chinese hamster orally administered (in vivo mutagenicity test in germ cells), and the micronucleus test using bone marrow of mice orally administered (in vivo mutagenicity test in somatic cells) (BUA Report 225 (2000)). As relevant information, as for in vitro study, negative results were reported in the Ames test (BUA Report 225 (2000)). | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | No data available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
7 | Reproductive toxicity | Category 2 |
Warning |
H361 | P308+P313 P201 P202 P280 P405 P501 |
In the study that 50 mg/kg of the substance was subcutaneously administered to the rats of 2 strains (CD and BDIX) on days 13 or 14 of gestation, no developmental effects of prenatal fetus were observed, postnatal deaths were observed in about half of the pups in both strains (BUA Report 225 (2000)). In addition, the EU classification for the substance was "GHS Repro cat. 2". Therefore, the substance was classified as Category 2. As relevant information, in the study that 20 mg/kg of the substance was intraperitoneally administered to the rats on day 7 or 11 and 12 of gestation, no effects on the fetus were observed (BUA Report 225 (2000)). In addition, the substance was prohibited from using in Canada in 2009, the evaluation was necessary when placing it back on the market. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - | No data available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | In two 3-month feeding studies in rats, significant reduction in testicular weight and dysfunction of spermatogenesis was reported at the highest dose level of 50 mg/kg/day (BUA Report 225 (2000)). However, testicular effect was treated as adverse in the classification for reproductive toxicity, therefore it was not object of this hazard class. As for the other effects, there were no reports describing adverse effects. The effects at the upper limit of the guidance values (100 mg/kg/day) or higher were unknown. Furthermore, in the 30-day dermal application study in rabbits, fatty infiltration of the liver and heart, and deposition of hemosiderin in the spleen were reported at the dose level of 100 mg/kg/day (converted dose level as that of 90-day study: 33.3 mg/kg/day) or higher (BUA Report 225 (2000)). However, since no effects were seen in hematology and no details for the degree and toxicological significance of the histopathological changes were known, "Classification not possible" was concluded. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Classification not possible |
- |
- | - | No data available. | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Classification not possible |
- |
- | - | No data available. | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
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