NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	80-15-9
Chemical Name	1-Methyl-1-phenylethyl hydroperoxide
Substance ID	m-nite-80-15-9_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified	- -	-	-	There is a chemical group associated with explosive properties (neighboring oxygen atoms) in the molecule, and the calculated oxygen balance of -231 is below the criteria, -200. Besides, it is estimated that one containing 90-98% does not correspond to explosives because it is classified in Organic peroxide type E in UNRTDG (UN 3107).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Category 4	- Warning	H227	P370+P378 P210 P280 P403 P501	Based on a flash point of 79 deg C (closed cup) (ICSC (J) (2005)), it was classified in Category 4.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	It is classified in Organic peroxide.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Classification not possible	- -	-	-	No data available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Classification not possible	- -	-	-	It is an organic compound which does not contain fluorine or chlorine but contains oxygen, and the oxygen is chemically bonded to the element other than carbon or hydrogen. However, the classification is not possible due to no data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Type E	Warning	H242	P370+P378 P210 P234 P235 P240 P280 P403 P410 P411 P420 P501	One containing 90-98% is classified in Division 5.2, type E in UNRTDG (UN 3107) (UNRTDG 2.5.3.2.4).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	No data available. Besides, there is the information it may decompose violently on contact with cobalt, copper or lead alloys and mineral acids (ICSC (J) (2005)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	Based on a report of an LD50 value of 382 mg/kg (DFGOT Vol. 3 (1992), PATTY (6th, 2012)) for rats, it was classified in Category 4.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Category 3	Danger	H311	P302+P352 P361+P364 P280 P312 P321 P405 P501	There are reports of LD50 values for rats of 0.5-1.0 mL/kg (530-1,060 mg/kg) and 1.13-1.43 mL/kg (1,198-1,516 mg/kg) (both in HSDB (Access on June 2017)). One case corresponds to Category 3 or Category 4, and the other case corresponds to Category 4. By adopting the category with higher hazard, it was classified in Category 3.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Category 4	Warning	H332	P304+P340 P261 P271 P312	Based on reports of LC50 values of 200 ppm (1.24 mg/L) (DFGOT Vol. 3 (1992)) and 220 ppm (1.36 mg/L) (PATTY (6th, 2012)) in 4-hour inhalation exposure tests with rats, it was classified in Category 4. Besides, because the LC50 values are higher than the saturated vapor pressure concentration (4.35 ppm), the reference value in the unit of mg/L as mist was applied.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	As for skin sensitization tests with rabbits, there is a report that severe irritation and damages were found (DFGOT Vol. 3 (1992)), and a description that severe irritation or corrosivity were observed (PATTY (6th, 2012)), therefore, it was classified in Category 1. Besides, this substance was classified as "Skin Corr. 1B" in EU CLP classification (ECHA CL Inventory (Access on June 2017)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	Since this substance was classified in Category 1 for skin corrosivity/irritation, it was classified in Category 1. Besides, as for eye irritation tests with rabbits, there is a report that severe irritation and damage were shown (DFGOT Vol. 3 (1992)), a description that it was irritating to the eyes (PATTY (6th, 2012)), and a report that redness and pains caused by severe deep burns occurred (HSDB (Access on June 2017)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, although there was a description that this substance was known as a skin sensitizer (HSDB (Access on June 2017)), it was not adopted because the details of the test method and so on were unknown.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	It was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, a dominant lethal test with mice and a micronucleus test with the peripheral blood of mice were negative (NTP DB (Access on July 2017), HSDB (Access on June 2017)). As for in vitro, bacterial reverse mutation tests were positive (SIAP (2008), NTP DB (Access on July 2017), HSDB (Access on June 2017)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Category 2 (respiratory organs)	Warning	H371	P308+P311 P260 P264 P270 P405 P501	There is no information on single exposure to this substance in humans. As for experimental animals, there is a report that in a 4-hour single inhalation exposure test with rats, at necropsy, severe inflammation of the trachea and lungs was observed (PATTY (6th, 2012)). Although there is no detailed description of the dose, since the LC50 value was reported as 220 ppm (1.36 mg/L) within the guidance value range of the mist for Category 2, it is thought that the effect was observed at the dose in the range for Category 2. Therefore, it was classified in Category 2 (respiratory organs).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Category 1 (respiratory organs, blood system)	Danger	H372	P260 P264 P270 P314 P501	No information on humans is available. As for experimental animals, in a 3-month inhalation toxicity test (6 hours/day, 5 days/week) with rats, deaths were observed at 124 mg/m3 (converted guidance value: 0.017 mg/L), which was within the guidance value range (mist) for Category 1, and surviving animals were urgently slaughtered on the 12th day of exposure. In the same group, symptoms of irritation of the eyes and nose, dyspnea, suppression of body weight gain, decreases in the erythrocyte count, hemoglobin level and leukocyte count, ulcers and inflammation of the cornea, nasal turbinate, and stomach, atrophy of the thymus, depletion of lymphatic system tissues of the germinal centers of the lymph nodules and spleen, and decreased lipid content of the liver were observed (Environmental Risk Assessment for Chemical Substances Vol.9, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2011)). From the above, effects on the haemal system in addition to irritation of the eyes, respiratory organs and gastrointestinal tract were observed. However, among these, the effect on the eyes corresponded to the hazard class for eye irritation, and the effect on the gastrointestinal tract was considered that to be due to ingestion or stress considered to be possibly due to ingestion or stress, thus, they were not included in the target organs. Therefore, it was classified in Category 1 (respiratory organs, haemal system). Besides, the classification was changed from the previous one since a new information source was adopted.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 2	- -	H401	P273 P501	From 72-hour EC50 (rate method) = 3.1 mg/L for algae (Pseudokirchneriella subcapitata) (OECD SIDS: 2008), it was classified in Category 2.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 2	-	H411	P273 P391 P501	If chronic toxicity data are used, then it is classified in Category 2 due to being not rapidly degradable (BioWin), and 72-hour NOEC (rate method) = 1.0 mg/L for algae (Pseudokirchneriella subcapitata) (OECD SIDS: 2008). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 2 due to being not rapidly degradable (BioWin), and 96-hour LC50 = 3.9 mg/L for fish (Oncorhynchus mykiss) (OECD SIDS: 2008). From the above results, it was classified in Category 2.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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