NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	8022-00-2
Chemical Name	Demeton-methyl
Substance ID	m-nite-8022-00-2_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Flammable liquids	Classification not possible	- -	-	-	Classification not possible due to lack of data, though it is flammable (ICSC, 2001)	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Self-reactive substances and mixtures	Classification not possible	- -	-	-	Classification not possible due to lack of data, though the substance contains P-O bonds as chemical groups with self-reactive properties present.	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Pyrophoric liquids	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	Since aqueous solubility measurements is performed, it judges to be stable in the water (ICSC (2001) etc.).	FY2006	GHS Classification Manual （10 Feb, 2006）
13	Oxidizing liquids	Classification not possible	- -	-	-	Classification not possible due to lack of data, though organic compounds containing oxygen chemically bonded to phosphorus.	FY2006	GHS Classification Manual （10 Feb, 2006）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no -0-0- structure	FY2006	GHS Classification Manual （10 Feb, 2006）
16	Corrosive to metals	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 2	Danger	H300	P301+P310 P264 P270 P321 P330 P405 P501	O-object: It was set as Category 2 based on rat LD50= 30mg/kg obtained from the calculation using eight data (ACGIH (2001), JMPR 264 (1973), JMPR 790 (1989)). S-object: It was set as Category 2 based on rat LD50= 47g/kg obtained from the calculation using six data (ACGIH (2001), PATTY (5th, 2001), JMPR 264 (1973)).	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Dermal)	Category 1	Danger	H310	P302+P352 P361+P364 P262 P264 P270 P280 P310 P321 P405 P501	O-object: It was set as Category 2 based on LD50 = 100mg/kg calculated from four data (JMPR 264 (1973), JMPR 790 (1989)) of rat LD50 value. S-object: It was set as Category 1 based on LD50 = 45g/kg calculated from four data (PATTY (5th, 2001), JMPR 264 (1973)) of rat LD50 value.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Dusts and mists)	Category 2	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	The saturated vapor pressures concentrations pressure of this product is 0.396ppm (0.00373mg/L), and it is thought that the inhalation study was done in mist. It was set as Category 2 based on LC50 = 0.427mg/L calculated from three data (JMPR 790 (1989)) of O-body: rat LC50 value. It was set as Category 2 based on LC50=0.21mg/L calculated from four data (PATTY (5th, 2001)) of S-body: rat LC50 value.	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Skin corrosion/irritation	Category 3	- Warning	-	-	O-body: Based on the description that although erythema was seen on rabbits, it recovered 72 hours afterward to indicate mild skin irritation (JMPR 790 (1989)), it was classified as Category 3. S-body: Based on descriptions that although slight erythema and edema were observed on rabbits, it disappeared three days afterward (PATTY (5th, 2001) vol.7) and that it has mild irritation on humans (HSDB (2005)), it was classified as Category 3.	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Serious eye damage/eye irritation	Category 2A	Warning	H319	P305+P351+P338 P337+P313 P264 P280	O-body: In the rabbit, although corneal cloudings, conjunctival redness, and gum of eyelid were seen, it recovered 21 days afterward altogether, and it is thought that it is a stimulant of primaries to eye (JMPR 790 (1989)). Based on above statement it was set as Category 2A-2B. S-body : although tearing and miosis were seen with the rabbit and the slight corneal cloudings, discontinuous redness, and a conjunctiva dropsy were seen, and it disappeared seven days afterward (PATTY(5th, 2001) vol.7, JMPR 264 (1973)), and it had mild irritation in humans (HSDB (2005)). So it was set as Category 2B.	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	O-object: Based on the statement (JMPR 790 (1989)) that it showed skin sensitivity by the maximization test, the Klecak test, and the patch test with guinea pigs,.it was referred to as Category 1. S-object : Baded on the statement (PATTY(5th, 2001) vol.7, JMPR 790 (1989)) that although the maximization test indicated skin sensitization in guinea pigs, the skin patch tests did not show the sensitization, it was referred to as Category 1.	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Germ cell mutagenicity	Category 2	Warning	H341	P308+P313 P201 P202 P280 P405 P501	O-body : The substance was regarded as outside the categories. Because there are no positive results in human multi-generation epidemiological tests, multi-generation mutagenicity tests and in vivo mutagenicity tests using germ cells and somatic cells, and there are records of negative results from the in vivo dominant lethal tests in mice (PATTY (5th, 2001) vol. 7, JMPR 697 (1984)). S-body: The substance was classified as Category 2. Because there are no positive test results from human multi-generation epidemiological tests, multi-generation mutagenicity tests and in vivo mutagenicity tests in germ cells, and there is a record of a negative test result from the in vivo chromosome aberration test using Syrian hamster bone-marrow cells (PATTY (5th, 2001) vol. 7).	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Carcinogenicity	Classification not possible	- -	-	-	O-: Classification not possible due to lack of data S-: Classification not possible due to lack of data	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	O-object : since there is the description that there were the significant reduction of the gravidity and of the litter count in rat, the reduction of oogenesis in third generation of 3/10 female, and there is the vacuolating of the epididymis epithelium of parent occurs in dose dependence at the dose no descriptioin about general toxicity to parent (JMPR 790(1988)), and there is the description that there is the reduction of conception rate and survival rate of neonatal in the dose causing reduced weight gain in parent (JMPR 264 (1973)), it is classified into the Category 2. S-object : since there is the description that there is suppress of survival rate, nursing rate, weight gaining in rat, and there is the reduction of the average of weight of embryo in rabbit, with the dose no description about general toxicity to parent (PATTY(5th, 2001) vol.7, JMPR 697 (1984)), it is classified into the Category 2.	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Specific target organ toxicity - Single exposure	Category 1 (nervous system)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	Mixture : In humans, spasm, giddiness, stuffiness, nausea, constricted pupil, muscular spasticity, salivation, sweating, loss of consciousness, stomach cramps, diarrhea, vomiting etc. are observed, and the serum cholinesterase activity is decreased (ACGIH (2001), PATTY(5th, 2001) vol.7, ICSC (J) (2001), HSDB (2005)). So it was classified into Category 1(nerve systems). O-Body : In humans, miosis, muscle spasticity, salivation, sweating, nausea, dizziness, closeness, feeling of weariness, stomach cramp, vomiting, diarrhea, cramp, loss of consciousness, dysphoria, cough, and muscle fasciculation etc., are observed, and the serum cholinesterase activity is decreased (ACGIH (2001), PATTY (5th, 2001) vol. 7, ICSC (J) (2001), HSDB (2005)). So it was classified into Category 1. S-Body : In humans, based on the description that miosis, muscle spasticity, salivation, sweating, nausea, vomited, stomach cramps, diarrhea, dizziness, closeness, feeling of weariness, loss of consciousness, gastrointestinal disorder, fatigue, headach, sweating, lacrimation, tremor, ataxia, hiccup, muscular fasciculation, etc. are observed, and the serum cholinesterase activity is decreased (PATTY (5th, 2001) vol. 7, ICSC (J) (2001)). So it was classified into Category 1 (nerve systems).	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Specific target organ toxicity - Repeated exposure	Category 1 (nervous system)	Danger	H372	P260 P264 P270 P314 P501	O-object : It was classified to as Category 1 (nervous systems) since the toxic symptoms of cholinergics are looked, and inhibition of cholinesterase activity in brains, plasma and serum are indicated by the dosage of guidance value within the limits of Category 1in rats (JMPR 264 (1973), JMPR 790 (1989)), and cholinesterase inhibition is indicated in humans (JMPR 264 (1973)). S-object : It was referred to as Category 1 (nervous systems) since the toxic symptoms of the cholinergics (mild tremor and bundle twich) are seen, and inhibition of cholinesterase activity in brains, plasma and serum is indicated in rats and dogs, by the dosage of guidance value within the limits of Category 1(PATTY(5th, 2001) vol.7, JMPR 264 (1973), JMPR 790 (1989)).	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available (o-, S-)	FY2006	GHS Classification Manual （10 Feb, 2006）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	It was classified into Category 1 from 96-hour LC50=190microg/L of Crustacea (Amphipod) (AQUIRE, 2003).	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	Classified into Category 1, since acute toxicity was Category 1, supposed not rapidly degrading (BIOWIN), though supposed less bioaccumulative (log Kow=1.11(PHYSPROP Database, 2005)).	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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