NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	8032-32-4
Chemical Name	Ligroine; Low boiling point naphtha
Substance ID	m-nite-8032-32-4_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	Due to dissociation of nitrogen and oxygen from hydrocarbon through the formation of ammonia and water, the saturation of unsaturated bonds and the deposition and separation of its metal components by the catalysts during the hydrorefining process, the substance does not contain chemical groups associated with explosive properties.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (room temperature)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (room temperature)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (room temperature)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Flammable liquids	Category 2	Danger	H225	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	Since its flash point is >= -17.8degC (Chemical Substances Safety Data Book, 1997), and its initial boiling point is between 40 and 120degC (Merck 14th, 2006; Sax 11th, 2004; Chemical Substances Safety Data Book, 1997), the substance was classified into Category 2.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (room temperature)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	Due to dissociation of nitrogen and oxygen from hydrocarbon through the formation of ammonia and water, the saturation of unsaturated bonds and the deposition and separation of its metal components by the catalysts during the hydrorefining process, the substance does not contain chemical groups associated with explosive or self-reactive properties.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Pyrophoric liquids	Not classified	- -	-	-	Its autoignition point is 550degF (unit-conversion value: 288degC) (Sax 11th, 2004) and 288degC (Chemical Substances Safety Data Book, 1997). According to classification guidelines, a substance with its autoignition point >= 70 falls under "Not classified" category.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (room temperature)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Due to deposition and separation of its metal components by the catalysts during the hydrorefining process, the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, and At).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Due to dissociation of oxygen from hydrocarbon through water formation, and the deposition and separation of its metal components by the catalysts during the hydrorefining process, the substance does not contain oxygen or halogen.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (room temperature)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Due to dissociation of oxygen from hydrocarbon through water formation during the hydrorefining process, the substance is considered as an organic compound containing no bivalent -O-O- structure.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	Based on rat LD50 value documented: > 25.0 ml/kg (conversion value: > 15875 mg/kg bw, based on its specific gravity of 0.635 (Sax 11th, 2004) ) (EHC 20, 1982), the substance was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Based on rabbit LD50 value (4h) documented: > 5.0 ml/kg (conversion value: > 3175 mg/kg bw, based on its specific gravity of 0.635 (Sax 11th, 2004) (EHC 20, 1982), the substance was classified into "Not classified". It is uncertain if the substance is to be rated as Category 5 in the United Nations classification.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (room temperature)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Vapours)	Category 4	Warning	H332	P304+P340 P261 P271 P312	Its rat LC50 value (4h) of 14000-16000 ppm (EHC 20, 1982) is documented. Its saturated vapour pressure concentration (calculated based on the vapour pressure of 40 mmHg at 20degC (HSDB, 2005)) is approximately 52632 ppm. Since the documented LC50 value is <=90% of the saturated vapour pressure concentration, classification was conducted using ppmV concentration criteria for vapour with almost no included mists. Thus, based on the LC50 value (4h) of 14000-16000 ppm, the substance was classified into Category 4.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Its rat LC50 value (4h) of 73680 ppm (EHC 20, 1982) is documented. Its saturated vapour pressure concentration (calculated based on the vapour pressure of 40 mmHg at 20degC (HSDB, 2005)) is approximately 52632 ppm. Since the documented LC50 value is >= saturated vapour pressure concentration, classification was conducted for mist. However, since its molecular weight cannot be identified, the unit cannot be converted from ppm to mg/L. As such, the substance was classified into "Classification not possible".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	There is a description that the application of this substance on the skin of forearms of three men for 10-30 minutes caused serious irritation (EHC 20, 1982; HSDB, 2005). It is also documented on the toxicity of this substance that is known to be the cause of erythema, edema, disruption of the horny layer, and peeling (Patty 5th, 2001). There are two rabbits tests (EHC 20, 1982), one resulted Draize score of 1.92 (equivalent to Category 3 in the United Nations classifications) and other resulted Draize score of 1.13 which is equivalent to "Not classified" category. However, weighing the effects on humans over those results on rabbits, the substance was classified into Category 2.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Serious eye damage/eye irritation	Category 2	Warning	H319	P305+P351+P338 P337+P313 P264 P280	In two rabbit tests (EHC 20, 1982), the substance was documented to be minimally irritating. In addition, it is reported that the substance irritates the eyes and skin by contact (HSFS, 2007). Based on these reports, the substance was classified into Category 2. With lack of information on recoverability of the eyes, refined categorization was not conducted.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Skin sensitization	Classification not possible	- -	-	-	Although no data are available on this substance, its evaluation as a petroleum solvent indicated the possibility that repeated contact with the skin may rarely cause allergic contact dermatitis (EHC 20, 1982).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	No data on in vivo tests are available; and only negative results have been obtained from in vitro mutagenicity tests (Ames tests and chromosomal aberration tests using CHO cells) (IARC vol. 47, 1989). As such, the substance was classified into "Classification not possible".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Carcinogenicity	Not classified	- -	-	-	According to the IARC, the substance is categorized into Group 3 (equivalent to "Not classified" category) in an overall evaluation of petroleum solvents (IARC vol. 47, 1989). The substance's EU Risk Phrase is Category 2; R45 (equivalent to Category 1B), but only when it contains 0.1% or more of benzene (EU-Annex 1, accessed in September 2008; GESTIS, accessed in September 2008). Based on the report that the substance contains hardly any benzene today (IARC vol. 47, 1989), it was classified into "Not classified" in accordance with the IARC's evaluation. According to the case-control studies targeting at rubber manufacturing workers (6678 males) at five locations in the USA, exposure to this substance caused an increase in relative risk of prostatic cancer and lymphatic leukemia. However, the number of cases in each category is small, multiple exposures were evaluated independently of other exposures, and none of the associations is significant (IARC vol. 47, 1989). Regarding case-control studies conducted in Canada (IARC vol. 47, 1989), as the exposure material contained this substance as well as other substances, these studies were not taken into consideration for the classification of this substance.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Reproductive toxicity	Classification not possible	- -	-	-	In an inhalation test using rats, specific developmental abnormalities were observed in musculoskeletal system, showing effects on behavior of neonates (RTECS, 2007; original literature: GISAAA Gigiena I Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- 56(9), 35, 1991); however, no detailed information on this test and the test substance is not available, and no other tests are documented. Thus, the substance was classified into "Classification not possible" due to lack of data.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Specific target organ toxicity - Single exposure	Category 3 (respiratory tract irritation, narcotic effects)	Warning	H335 H336	P304+P340 P403+P233 P261 P271 P312 P405 P501	As general poisoning symptoms in humans, peripheral nerve disorders, CNS depression, and skin and respiratory irritation are documented (Patty 5th, 2001). As symptoms of overexposure or inhalation exposure, CNS depression and irritation of respiratory tracts are reported (HSDB, 2005). As acute neurotoxic effects, anesthesia, euphoria, vertigo, and limb numbness are recorded (HSDB, 2005). In addition, there is a description that the accidental use of the substance as an anesthetic drug may cause reversible cerebral edema (Patty 5th, 2001). In animal studies, though animal species used were unknown, narcotic effects and irritation to respiratory tracts were detected in inhalation tests (EHC 20, 1982). Based on these results, the substance was classified into Category 3 (respiratory tract irritation and narcotic effects).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Specific target organ toxicity - Repeated exposure	Category 1 (nervous system)	Danger	H372	P260 P264 P270 P314 P501	It is documented that factory workers exposed to this substance, with its air concentration between 2.25 and 5.625 mg/L, showed polyneuropathy, and the workers complained of insomnia, irritability, and other non-specific CNS symptoms (EHC 20, 1982). In addition, under the working environment in which the workers underwent a long-term inhalation exposure of the substance due to insufficient ventilation, they developed polyneuropathy, which includes symptoms such as loss of appetite, muscle weakness, impairment of motor action, and paresthesia (Patty 5th, 2001). Furthermore, as chronic neurotoxic effects, motor poluneuropathy is listed (HSDB, 2005). In 24-week inhalation exposure tests using rats, though exact exposure concentrations are unknown, a slight decrease in functions of the peripheral nervous system was observed (IARC vol. 47, 1989). Based on these results, the substance was classified into Category 1 (nervous system). In inhalation exposure tests using rats that lasted for 1 to 6 months, nerve-related effects (decrease in conduction-velocity, increase in refractory period, and decrease in excitability) were observed. However, because of the description that test methods were not sufficiently rigorous (EHC 20, 1982), this study was not taken into consideration for the classification of this substance.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Aspiration hazard	Category 1	Danger	H304	P301+P310 P331 P405 P501	In humans, this substance, which may be contained in furniture polish or lighter fluid, if ingested by children, is a cause of chemical pneumonia and pneumatoceles (Patty 5th, 2001). In addition, aspiration of liquid may induce chemical pneumonia (HSDB, 2005). And the substance's EU Risk Phrase is R65 (EU-Annex 1, accessed in September 2008). Based on this information, the substance was classified into Category 1.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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