NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	8052-41-3
Chemical Name	Stoddard solvent
Substance ID	m-nite-8052-41-3_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)
Sample SDS by MHLW (External link)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Flammable liquids	Classification not possible	- -	-	-	Since compositions and fraction ranges vary with origin of manufacture, the flash point cannot be determined. Moreover, also in the classification applied to this product, packing Division is in range 1-3 by domestic laws. Therefore, if flash point and initial boiling point (can be substituted with boiling point) are not measured with an actual sample, it cannot be judged. The acceptance criteria are as follows: Category 1: flash point <23 degC, boiling point (initial boiling point) <=35 degC; Category2: flash point <23-degC and boiling point (initial boiling point)> 35 degC; Category3: 23 degC<= flash point <=60 degC	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive or self-reactive properties present in the molecule.	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Pyrophoric liquids	Not classified	- -	-	-	Flash point: 230-240degC ((ICSC (J), 2004)	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) though the molecular structure is unknown.	FY2006	GHS Classification Manual （10 Feb, 2006）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Oxygen, fluorine or chlorine atoms is not included in the molecule. (Although molecular structures is not specified, the mentioned fact is obvious from various data)	FY2006	GHS Classification Manual （10 Feb, 2006）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Containing no -0-0- structure in molecules according to some reports, though the molecular structure is unknown.	FY2006	GHS Classification Manual （10 Feb, 2006）
16	Corrosive to metals	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	From description that mortality was not acknowledged at 5000mg/kg in the study using the rat (EHC 187 (1996)), it was considred out of category.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	There was the description that one case of four cases died at 2000mg/kg in the test using rabbits (EHC 187 (1996)). But other data cannot be found and Category could not be specified. So it cannot be classified due to insufficient data.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	Based on descriptions that 1 out of 15 rats died in 8-hour exposure of 8.2mg/L (4-hour equivalent: 11mg/L) (EHC 187 (1996), ACGIH (7th, 2001), ATSDR (1995)), and that death was not observed in rat 4-hour exposure of 5.5mg/L (EHC 187 (1996)), there was possibility of Category 3 or 4. However, it could not be specified, it cannot be classified due to data insufficiency.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	It was set as Category 2 from description that the moderate irritation and slight edemas were admitted in the test applied to the skin of the rabbit for 4 hours (EHC 187 (1996)).	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Serious eye damage/eye irritation	Not classified	- -	-	-	There is the description that the ocular reaction disappeared 24 hours after administration in the test applied to the eyes of the rabbit (EHC 187 (1996)), we judged that it was incompatible for the acceptance criteria of irritation. So we classified it as Out Of Category.	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Skin sensitization	Not classified	- -	-	-	Based on the description that in Buehler test using the guinea pigs in EHC 187 (1996) sensitizing property was not acknowledged, we classified it as Out Of Category.	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Germ cell mutagenicity	Not classified	- -	-	-	There is the negative result by the dominant lethal test using the rat and mouse which are the in vivo multigeneration mutagenicity test using a germ cell (EHC 187, 1996; ATSDR, 1995), and by micronucleus test using mouse erythrocyte which is the in vivo mutagenicity test using a somatic, and chromosomal aberration test using rat myeloid cell (EHC 187, 1996, ATSDR, 1995). So it carried out the outside of Category.	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Carcinogenicity	Classification not possible	- -	-	-	It was classified into the category 2 in EU. But based on the description that basis for judgment is unknown and the epidemiologic survey data in humans is all inadequate as an object of evaluation. And it cannot be classified due to insufficient data. In addition, there is description that some evidence of carcinogenic activity was observed in male rats, and equivocal evidence of carcinogenic activity is observed in the female mice in the carcinogenicity tests where carried out inhalation exposure of Stoddard solvent IIC of NTP to rats and mouse for two years (HSDB, 2005).	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Reproductive toxicity	Not classified	- -	-	-	It was considered as out of Category based on the description that clear reproductive toxicity was not observed at the dose in which general toxicity is observed in dam animals in an inhalation exposure test during the pregnancy rat (EHC 187 (1996)).	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Specific target organ toxicity - Single exposure	Category 3 (narcotic effects, respiratory tract irritation)	Warning	H336 H335	P304+P340 P403+P233 P261 P271 P312 P405 P501	Because of descriptions in ACGIH (7th, 2001) and EHC 187 (1996) referring to confirmation of symptoms indicating effects on transient nervous systems such as decreased activity, hypomotility of coordinated movement, ataxia, tremors, and spasms through inhalation exposure tests using rats and dogs, and of descriptions in ACGIH (7th, 2001), EHC 187 (1996), and ATSDR (1995) referring to that effects on nervous systems such as headache, nausea, and dizziness and stimuli, and nasal irritation were confirmed in human exposure cases. So it was judged as Category 3 (anesthesia action, respiratory irritation).	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Specific target organ toxicity - Repeated exposure	Category 2 (liver, testis)	Warning	H373	P260 P314 P501	Based on descriptions that the effects on the liver was observed with the concentration within the guidance value range for Category 2 in the inhalation exposure test on guinea pigs (EHC 187 (1996)) and that reduction of sperm motility was observed in the inhalation exposure test on rats (NTP TR519 (HSDB, 2005)), it was classified into Category 2 (liver, teste).	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Aspiration hazard	Category 1	Danger	H304	P301+P310 P331 P405 P501	Since it is a hydrocarbon, and the 25-degree C dynamic viscosity calculated from the viscosity of the white spirit is 0.87-1.94 mm2/s, and may be 20.5mm2/s or less at 40 degrees C, and there is the descriptions that the aspiration may occuree chemical pneumonia (PATTY (4th, 1994), EHC 187 (1996), and ATSDR (1995)), we classified it as Category 1.	FY2006	GHS Classification Manual （10 Feb, 2006）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	It was classified into Category 1 from 48-hour LC50=0.42-2.3mg/L of Crustacea (Daphnia magna) (EHC187, 1996).	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	Classified into Category 1, since acute toxicity is Category 1,not rapidly degrading (BOD: 12-13% (EHC187, 1996)), and bioaccumulation potential is unknown.	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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