NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	823-40-5
Chemical Name	2-methyl-m-phenylene diamine
Substance ID	m-nite-823-40-5_v2
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	-	- -	-	-	-	-	-
2	Flammable gases	-	- -	-	-	-	-	-
3	Aerosols	-	- -	-	-	-	-	-
4	Oxidizing gases	-	- -	-	-	-	-	-
5	Gases under pressure	-	- -	-	-	-	-	-
6	Flammable liquids	-	- -	-	-	-	-	-
7	Flammable solids	-	- -	-	-	-	-	-
8	Self-reactive substances and mixtures	-	- -	-	-	-	-	-
9	Pyrophoric liquids	-	- -	-	-	-	-	-
10	Pyrophoric solids	-	- -	-	-	-	-	-
11	Self-heating substances and mixtures	-	- -	-	-	-	-	-
12	Substances and mixtures which, in contact with water, emit flammable gases	-	- -	-	-	-	-	-
13	Oxidizing liquids	-	- -	-	-	-	-	-
14	Oxidizing solids	-	- -	-	-	-	-	-
15	Organic peroxides	-	- -	-	-	-	-	-
16	Corrosive to metals	-	- -	-	-	-	-	-
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Classification not possible	- -	-	-	Classification is not possible because there is no data. In addition, 2,5-TDA, and 2,4-TDA are equivalent to Category 3. [NOTE] See the classification results of 2,4-TDA (2,4-toluene diamine, ID167, CAS: 95-80-7), 2,5-TDA (paratoluylenediamime, ID1324, CAS: 95-70-5)), TDA (Toluylenediamine, ID1309, CAS: 25376-45-8) which is a collective term for TDA constitutional isomer. For this harmful effect for the health, the classification result of these isomers is indicated as needed.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification is not possible because there is no data. In addition, 2,5-TDA cannot be classified, and 2,4-TDA is Category 3.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Since it was a solid by the definition of GHS, it was classified into "Not applicable".	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	Although there is no skin irritation test data of this substance, it has been described that this substance has a "skin irritation" in ICSC (2001) or that "Diaminotoluene irritates skin" in EHC 74 (1987). It may be classified as Category 2 or Category 3 since it is likely to have an irritation despite its unknown degree. It is classified into Category 2 from a viewpoint of safety. In addition, 2,5-TDA and 2,4-TDA can be classified as Category 3.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
3	Serious eye damage/eye irritation	Category 2	Warning	H319	P305+P351+P338 P337+P313 P264 P280	Although there is no data of the eye irritation test of this substance, it has been described that the substance is "eye-irritative" in ICSC (2001), or that "Diaminotoluene irritates eyes" in EHC 74 (1987). Although the level is unknown, since it is considered to own irritation, it is classified into Category 2. In addition, 2,5-TDA is Category 2A-2B and 2,4-TDA are Category 2A.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification is not possible since there is no data.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
4	Skin sensitization	Classification not possible	- -	-	-	It can be classified as R43 in EU-Annex I which is the source of information of Priority2, and it has been described in ICSC (2001) which is the source of information of Priority2 in the same way that skin may be sensitized by the repeated or long-term contact." However, it was classified into "Classification not possible" because of no data of concrete epidemiologic survey, case report, and animal experiment. In addition, 2,5-TDA, 2,4-TDA, and TDA are Category 1.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
5	Germ cell mutagenicity	Not classified	- -	-	-	Although there are very weak positive findings (Carcinogenesis, 12, 2233-2237, 1991) in rat bone marrow micronucleus tests as a result of investigation not only on the information source of Priority 1, 2, it was defined as "Not classified" from the weight of the evidence based on two negative findings in the mutation assays employing transgenic mice (Environ Health Perspect, 104 (Suppl 3), 683-686, 1996; Mutat Res, 608,88-96, 2006) and the negative results in rat liver UDS tests (Carcinogenesis,12, 2233-2237,1991). Moreover, although 2,4-TDA is defined as "Not classified" as a result of the previous classification, a positive result has been obtained in the above mutation assays employing transgenic mice, and it is classified into Category 2.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
6	Carcinogenicity	Not classified	- -	-	-	There is no existing classification. On the other hand, EHC 74 (1987) cited the 103-week oral administration test employing rats and mice by NCI (1980). EHC is saying that "NCI (1980) concluded that 2,6-TDA does not show carcinogenicityity to F344 rat of male and female, and B6C3F1 mouse of male and female" based on various statistical evaluations, and the reliability of the data of NCI can be evaluated. Therefore, the conclusion of NCI was adopted and it was carries out "Not classified". In addition, in a three-ministry GHS classification, 2,5-TDA is "Not classified", 2,4-TDA and TDA are in Category 2.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	Since embryonic death has been identified at the dose level where decrease in the body weight of mother animals is identified in the oral administration study using rabbits in the description of EHC 74 (1987), it is classified in Category 2. In addition, since increase of imperfect spinal segments development in fetuses at the dose level where the body weight reduction of mother animals is not identified is identified in the oral administration study using rats published in EHC 74 (1987), which corresponds to a skeletal variant, GHS is considered to correspond to Category 2. Moreover, strenebrae deficiencies and imperfect closure of skulls have been observed at the dose level where the body weight reduction in mother animals is observed. 2.5-TDA, 2.4-TDA and TDA are all Category 2.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
8	Specific target organ toxicity - Single exposure	Category 2 (blood system), Category 3 (respiratory tract irritation, narcotic effects)	Warning	H371 H335 H336	P308+P311 P260 P264 P270 P405 P501 P304+P340 P403+P233 P261 P271 P312	About humans, ICSC (J) (2001) which is the information source of Priority2, have descriptions of "cough, dizziness, headache, shortness of breath, confusion, spasm, nausea, and deliquium animi" as acute symptoms by inhalation exposures, and that "airway is stimulated. Blood may be affected and a methemoglobin may be generated" as effects of short durations exposures. Therefore, it was considered to have Respiratory tract irritation and Narcotic effects, and its target organ was the blood systems. As mentioned above, the category was taken as Category 2 (blood system) and Category 3 (Respiratory tract irritation, Narcotic effects).	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	Classification is not possible because there is no data. In addition, 2,5-TDA cannot be classified, and 2,4-TDA is classified as Category 1 (liver, kidney), Category 2 (blood system, lien, testis). TDA is classified as Category 1 (liver).	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	No data available.	FY2021	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data available.	FY2021	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.	FY2021	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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