NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	85535-84-8
Chemical Name	Chloroalkane(C10-13)
Substance ID	m-nite-85535-84-8_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Flammable liquids	Not classified	- -	-	-	The flash point by IUCLID(2000), which has 49% or more of Cl content, is more than 166degC(closed type) it was classified into Not classified.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive or self-reactive properties present in the molecule.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Pyrophoric liquids	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	The test method suitable for liquid substances is not established.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Although it is an organic compound including chlorine, not fluorine and oxygen, this chlorine has not chemically bound to any elements other than carbon and hydrogen.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	The organic compound not including peroxy group in molecule.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
16	Corrosive to metals	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	In the oral administration test employing a rat, from the fact that there was no mortality at dose of 10,000 mg/kg (carbon number C10-13/chlorination rate (41- 50%, 51-60% or 61-70%)) and at dose of 13,600 mg/kg (carbon number C12/chlorination rate 60%) (EU-RAR (1999)), it was classified into "Not classified". In addition, EU-RAR (1999) indicates that the symptom and its extent are irrelevant to the chlorination rate.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	It was classified into "Not classified" from LD50 value 13,500 mg/kg (number of carbon: C12 / rate of chlorination: 59%) (EU-RAR (1999)) of the dermal administration test employing a rabbit.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Dusts and mists)	Not classified	- -	-	-	It is written that there is no mortality with 3.3 mg/L of 1-hour exposure amount in carbon number C12/ chloridization rate 59%, and there is no mortality with 48 mg/L of 1-hour exposure amount in carbon number C10-C13/ chloridization rate 50% in the inhalation exposure test (EU-RAR (1999)). Since saturated vapor pressure at 25degC is 0.000037-0.00014 mg/L (carbon number C10-C13/ chloridization rate 50%), the mist standard is applied. Since it was presumed that 4-hour equivalent LC50 values are >0.83 mg/L and >12 mg/L ,respectively, it was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Skin corrosion/irritation	Not classified	- -	-	-	There is an information that erythema and slight edema could be seen in rabbits but such symptoms disappeared (carbon number C10-13/chloridization rate 70%) within 7 days (EU-RAR (1999)). In this datum the score value for erythema of 2 out of 3 animals is 1 (maximum: 4) and the score value for edema of 2 out of 3 animals is 1 (maximum:4 until 24 hours after application). There is an information about humans beside them that although slight erythema and dry skin were observed, the effect (carbon number C10-12/ chloridization rate 5-% 63%) was corresponding to that of the control group or there was no symptom (carbon number C12/chloridization rate 59%), and there is an information about rabbits that there is no irritation (carbon number C10-13/chloridization rate 59%) (EU-RAR (1999)). It was classified into "Not classified" based on the above-mentioned.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	Since EU-RAR (1999) has summarized that it is a mild irritation from the data of slight redness (59% of carbon number C12-/chlorination rate) and redness and conjunctiva dropsy being produced and continuing for 24 hours (carbon number: C10-13/chlorination rate: 63%, including an additive or stabilizer), and mild hyperaemia/ redness of conjunctiva (carbon number: C10-13/chlorination rate: 40%, 52%, including an additive or stabilizer) in rabbits, etc., it was classified into Category 2B.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification is not possible since there is no data. It has been concluded that "although it has been widely used in industrially important substances despite no information on humans or animals, since there is no report indicating respiratory sensitization, it has no respiratory sensitization" in EU-RAR (1999).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Skin sensitization	Not classified	- -	-	-	A conclusion in humans cannot be drawn from information of no allergic reaction in the human skin application (carbon number C12/ chlorination rate 59%) and of no positive reaction in cut refrigerant production workers (unknown carbon number and chlorination rate) (EU-RAR (1999)). On the other hand, it was classified into "Not classified" since it has been concluded in EU-RAR (1999) that there is no potential to produce sensitization from data of no skin reaction (carbon number C10-13/ chlorination rate 50%, including stabilizer) and no sensitization (carbon number C10-13/ chlorination rate 56%, incuding stabilizer) in guinea pig. In addition, it has been concluded that "although it has been widely used in industrially important substances despite no information on humans or animals, since there is no report indicating respiratory sensitization, it has no respiratory sensitization" in EU-RAR (1999)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Germ cell mutagenicity	Not classified	- -	-	-	Since there was no change in lost number or position of live embryos, dead embryos, early absorbed embryos, and preimplantation embryos in a productive cell in vivo heritable mutagenicity test (dominant lethal tests employing a rat) (58% of carbon number C10-12/chlorination rate), and there was no increase in frequency of a chromosome aberration by the body cell in vivo mutagenicity test (chromosome aberration test employing rats bone marrow cell) (58% of carbon number C10-12/chlorination rate) (EU-RAR (1999), it was classified into "Not classified". It was negative in the reverse mutation test employing the bacterial (number of carbon: C12/chlorination rate: 57%, 60%, number of carbon: C10-13/chlorination rate: 50%) and in the gene mutation test employing Chinese hamster culture cells (number of carbon: C10-13/chlorination rate: 56%) (EU-RAR (1999)) in the in vitro.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Carcinogenicity	Category 2	Warning	H351	P308+P313 P201 P202 P280 P405 P501	Since it is classified in group 2B (IARC 48 (1990)) by IARC and in Cat. 3; R40 (EU-Annex I) by the European Union classification, it is taken as Category 2. In addition, although it does not match up with the CAS number (85535-84-8) of this article, "Chlorinated Paraffins (C12, 60% Chlorine)" (CAS 108171-26-2) is classifiied into R by NTP (NTP RoC 11th, 2005), and Chlorinated Paraffins is classified into 2B (Japan Society for Occupational Health society advice (2007)) in Japan Society for Occupational Health, which are all equivalent to Category 2 of GHS.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Reproductive toxicity	Not classified	- -	-	-	According to EU-RAR (1999), while weight reduction of ovaria can be observed with the dose amount of 3,000mg/kg/day in the 14 day repeated oral administration study with rats (carbon number C10-12/chloridization rate 58%), no effect has been observed on male and female fertile capacities with the dose amount of 5,000mg/kg/day in the 13 week oral administration study (carbon number C12/chloridization rate 60%). Moreover, in the developmental toxicity study (carbon number C10-13/chloridization rate 58%) via oral administration using 25 pregnant rats in one group published in EU-RAR (1999) increase in the number of lost embryos after implantation and reduction in the number of live fetuses per mother animal have been observed with 2,000mg/kg/day where death (8 out of 25 animals), weakening, salivation and reduced activities of pregnant rats can be observed. There is a description as follows in AIST's Risk Assessment Documents 5 (2005), " The recognized reproductive toxicity is considered to be the secondary effect of the maternal toxicity and no effect on the development has been observed with the dose amount of 500mg/kg/day. Therefore, it was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Specific target organ toxicity - Single exposure	Category 3 (Narcotic effects)	Warning	H336	P304+P340 P403+P233 P261 P271 P312 P405 P501	From a description that inactivity and locomotor ataxia are seen in the oral administration test employing rats (EU-RAR (1999)) (number of carbon: C12/chlorination rate: 60%), it was classified into Category 3 (Narcotic effects).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Specific target organ toxicity - Repeated exposure	Not classified	- -	-	-	According to EU-RAR (1999), in a 90-day oral administration study in rats, weight increases in the liver and kidney and mild nephritis (carbon number C10-12/chlorination ratio 58%) in males were observed at 100 mg/kg. However, it was reported in EU-RAR (1999) that "the increase in liver weight reflects peroxisome proliferation, to which humans are not highly susceptible, so this is not relevant for human health," "it is uncertain if the effects on the kidney are toxicologically significant," and "the dosage at which other effects manifest themselves in rats is greater than 100 mg/kg." Using the reports in EU-RAR (1999), which are based on expert opinion, it was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	It was classified into Category 1 from 24 hours EC50=0.3mg/L of the crustacea (Daphnia magna) (EU-RAR (2000)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	Since acute toxicity was Category 1 and there were no rapid degradability (EU-RAR (2000)), it was classified into Category 1.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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