NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	86-50-0
Chemical Name	O,O-Dimethyl S-[(4-oxo-1,2,3-benzotriazin-3(4H)-yl)methyl]phosphorodithioate, (Azinphos-methyl)
Substance ID	m-nite-86-50-0_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Classification not possible	- -	-	-	Classification is not possible since no data are available though the substance may be classified as "Explosives" from which it contains chemical groups associated with explosive properties present in the molecules and oxygen balance is -30.25 which is >-200.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Flammable solids	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Self-reactive substances and mixtures	Classification not possible	- -	-	-	Classification is not possible since no data are available though there are chemical groups associated with explosive properties present in the molecules (but not chemical groups associated with self-reactive properties).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Pyrophoric solids	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to solid (melting point <= 140 degC) substances are not available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	Not react with water (Weiss (2nd, 1985)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
14	Oxidizing solids	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 2	Danger	H300	P301+P310 P264 P270 P321 P330 P405 P501	LD50 values are 4.4, 4.6, 5.6, 7.4, 11, 12.2, 13 and 19.5 mg/kg (ACGIH (2002)), 4.4, 4.6, 6.4, 6.4, 6.7, 7.1, 9.1, 9.7, 9.7, 10, 11, 12.8, 15.6, 16, 16.75, 17.25, 19, 19, 24, 25, 25.4 and 26 mg/kg (JMPR 818 (1991)), 16 mg/kg (EHC 63 (1986)) for rats, and 4 of 31 values correspond to Category 1 and 27 of 31 values correspond to Category 2. The substance was classified into Category 2 since 27 values are in this category.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Dermal)	Category 2	Danger	H310	P302+P352 P361+P364 P262 P264 P270 P280 P310 P321 P405 P501	LD50 values are 155, 170, 220 and 220 mg/kg (ACGIH (2002)), 90, 225, 2500 and 5000 mg/kg (JMPR 818 (1991))) for rats, three values correspond to Category 2, three values correspond to Category 3 and two values correspond to "Not classified". The numbers of values corresponding to Category 2 and Category 3 are the same, the category with higher hazard was adopted and the substance was classified into Category 2.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Dusts and mists)	Category 2	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	Based on LC50 (4h) values of 0.107 mg/L, 0.155 mg/L (PATTY (5th, 2001)), 0.132 mg/L, 0.155 mg/L (JMPR 818 (1991)), 0.132 mg/L and 0.152 mg/L (ACGIH (2002)) for rats, the substance was classified into Category 2. The melting point of the substance is 72 - 73 degC (Merck (14th, 2006)). Since the substance was a solid at room temperature, the test was considered to be conducted for dusts.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Skin corrosion/irritation	Not classified	- -	-	-	Based on results of not irritating in two rabbit tests (ACGIH (2002), JMPR 818 (1991)), the substance was classified as "Not classified".	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	Based on reports of "Caused no significant reaction" (JMPR 818 (1991) and "slightly irritating" (IUCLID (2000)) in rabbit tests, the substance was classified into Category 2B.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	In 2 guinea pig skin sensitizing tests (maximization test and Buehler test), positive rates were 95% and approximately 50% (JMPR 818 (1991)), respectively. Based on positive results in both tests, the substance was classified into Category 1. As relevant information, the substance was classified into T; R43 in EU classification.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Germ cell mutagenicity	Not classified	- -	-	-	Based on negative results in mouse dominant lethal tests by intraperitoneal (JMPR 255 (1973)) or oral administration (JMPR 818 (1991)) (in vivo heritable germ cell mutagenicity test) and a mouse bone marrow micronucleus test by intraperitoneal administration (in vivo somatic cell mutagenicity test) (ACGIH (2002)), the substance was classified as "Not classified". As relevant information, from in vitro mutagenicity tests, there are reports of a negative Ames test (ACGIH (2002)), a positive CHO cell chromosomal aberration test (JMPR 818 (1991)) and a negative SCE assay (JMPR 818 (1991)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Carcinogenicity	Not classified	- -	-	-	Based on the classification of "A4" in ACGIH (ACGIH (2002)), the substance was classified as "Not classified". In carcinogenicity tests by oral administration to Osborne-Mendel rats and B6C3F1 mice for 80-weeks, neoplasms of the thyroid and pancreatic islets suggested, but did not provide sufficient evidence for carcinogenicity in male rats. No evidence for carcinogenicity was observed in female rats or in mice of either sex (NTP TR 69 (1978)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	In a developmental toxicity test in rabbits by oral administration during organogenesis period, a significant increase in pre-implantation loss, an increase in post implantation loss, and a significant decrease in live fetuses/doe were observed at doses in which tremors, ataxia and decreased cholinesterase activity were observed in maternal animals (ACGIH (2002)). Based on the data, the substance was classified into Category 2. In a two-generation reproduction test, a reduction in pup viability occurred at doses in which general toxicity such as increased dam mortality and decreased body weight was manifested (ACGIH (2002)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Specific target organ toxicity - Single exposure	Category 1 (nervous system)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	A case report reported symptoms of organophosphate poisoning in a human who spilled azinphos-methyl concentrate on his hands. He experienced visual disturbances, headache, tightness in the chest, and abdominal cramps (ACGIH (2002)). In a rat oral test, cholinesterase activity was inhibited and neurobehavioral effect was enhanced at dose levels of 3 - 6 mg/kg and higher. High mortality was noted at dose levels of 6 - 12 mg/kg (ACGIH (2002)). Based on the data, the substance was classified into Category 1 (nervous system).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Specific target organ toxicity - Repeated exposure	Category 1 (nervous system)	Danger	H372	P260 P264 P270 P314 P501	In rats exposed by gavage for 13 - 16 weeks, cholinergic reactions or symptoms including salivation, lacrimation, muscle tremor and fasciculationa, a clear inhibition of erythrocyte and brain cholinesterase activities. Deaths were observed at dose levels of 3 - 6 mg/kg/kg and higher (PATTY (5th, 2001), ACGIH (2002), JMPR 111 (1968)). Several tests have indicated that orchard sprayers using azinphos-methyl showed a reduction in blood cholinesterase activity due primarily to dermal exposure (ACGIH (2002)). Based on the results in the rat oral test that cholinergic symptoms and cholinesterase activity inhibition accompanied by deaths were observed at dose levels within the guidance value range for Category 1 and several reports of reduction in blood cholinesterase activity by exposure during work in orchards, the substance was classified into Category 1 (nervous system).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	Classified into Category 1 from its 96h-LC50 = 0.00029 mg/L for Crustacea (Mysid shrimp) (ECETOC TR91, 2003).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	Classified into Category 1 since its acute toxicity is Category 1 and it is not rapidly degradable (BIOWIN).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in Annexes to the Montreal Protocol.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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