NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	868-85-9
Chemical Name	Dimethyl phosphite
Substance ID	m-nite-868-85-9_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Flammable liquids	Category 4	- Warning	H227	P370+P378 P210 P280 P403 P501	Since its flash point reported 64 degC (closed-cup) (Ullmanns (E) (2003)) is > 60 degC and <= 93 degC, the substance corresponds to Category 4.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Self-reactive substances and mixtures	Classification not possible	- -	-	-	Although there are chemical groups (P-O) present in the molecule associated with explosive or self-reactive properties, due to lack of additional data, classification is not possible.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Pyrophoric liquids	Not classified	- -	-	-	Since its auto ignition point is 237 degC (ICSC (2005)), it is considered that the substance does not ignite at room temperature.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	Although it contains a metalloid (P), its water solubility is > 10 g/100 mL (HSDB (2007)) and it is considered that the substance doesn't react strongly with water.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
13	Oxidizing liquids	Classification not possible	- -	-	-	Although this substance is an organic compound containing oxygen which is chemically bonded to P, other than carbon or hydrogen, due to lack of additional data, classification is not possible.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	Based on the rat LD50 values of 3040 (male) and 3283 (female) mg/kg (OECD TG401) (SIDS (2010)), the substance was classified as "Not classified" in the JIS classification (corresponding to Category 5 in the UN-GHS classification).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Dermal)	Category 3	Danger	H311	P302+P352 P361+P364 P280 P312 P321 P405 P501	The rabbit LD50 values of 681 mg/kg and 2400 mg/kg were documented (SIDS (2010)), and each of the data are equivalent to Category 3 and "Not classified" category in the JIS classification (corresponding to Category 5 in the UN-GHS classification) respectively. Selecting the greater hazard category, the substance was classified as Category 3.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	Although it was documented that the inhalation of 7.1 mg/L/6hrs (converted value as that of 4-hour exposure: 9 mg/L) for rats caused no mortality (SIDS (2010)), the datum did not provide a basis for the classification, the classification was not possible. For further information, the test concentration (7.1 mg/L) was higher than 90 % of the saturated vapor pressure concentration (26.8 mg/L), the criterion values for gas were adopted.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Skin corrosion/irritation	Not classified	- -	-	-	The substance was classified as "Not classified" in the JIS classification (corresponding to Category 3 in the UN-GHS classification) based on the documented case of "slightly irritating" (SIDS (2010)) resulted from the 4-hour rabbit test with 0.5 ml of the substance. As relevant notes, long term and repeated exposure of the substance caused moderate to severe irritation to the skin and mucous membrane of rabbit (SIDS (2010)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	In the rabbit test (equivalent to OECD TG405), mild to moderate edema were observed after 1 and 4 hours of applications and these symptoms recovered on day 5 - 7 (SIDS (2010)). Based on the document, the substance was classified as Category 2B.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Skin sensitization	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Germ cell mutagenicity	Category 2	Warning	H341	P308+P313 P201 P202 P280 P405 P501	The substance was classified as Category 2 based on the positive results in the micronucleus test and the chromosome aberration test using bone marrow cells of mice by intraperitoneal administration (in vivo mutagenicity test in somatic cells) (SIDS (2010)). As relevant information, as for in vitro mutagenicity studies, positive results in the Ames test at 5 - 10 mg, the mouse lymphoma assay and the chromosomal aberration test using CHO cells, were reported (SIDS (2010)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Carcinogenicity	Classification not possible	- -	-	-	The substance was classified as "Classification not possible" based on the criterion of "Group 3" by the IARC carcinogenicity assessment (IARC 71 (1999)). As relevant information, in the 2-year oral carcinogenicity studies of rats and mice, increased incidences of adenoma and carcinoma of alveolar/bronchi, squamous carcinoma of lung and tumors of forestomach were observed in both sexes of rats, however, the tumors were not observed in both sexes of mice (NTP TR287 (1985)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Reproductive toxicity	Classification not possible	- -	-	-	The classification was not possible due to lack of sufficient data. In the reproductive and developmental toxicity screening tests using rats (OECD TG 421), severe general toxic effects and effects on reproductive function and fertility were observed in both sexes. However, because the mortality of maternal animals increased and all female animals died (2/12 males died) (SIDS (2010)), this data was not used for evaluation.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Specific target organ toxicity - Single exposure	Category 2 (systemic)	Warning	H371	P308+P311 P260 P264 P270 P405 P501	In the acute dermal toxicity study with rabbits, decrease in locomotor activity, ptosis, dyspnea, ataxia and inanimation were noted at 1000 mg/kg, equivalent to Category 2 of guidance values (SIDS (2010)). It was difficult to identify the target organ(s) so that the substance was classified as Category 2 (systemic toxicity). As relevant information, in the acute inhalation study, no deaths occurred in both rats and mice, and labored respiration and ptosis were observed only in two of ten mice at concentration of 7 mg/L/6hrs (9 mg/L/4hrs) (SIDS (2010)). Furthermore, clinical signs such as inactivity, weakness, prostration and shallow breathing were observed at doses over the range of the guidance values in the acute oral toxicity studies in rats and mice (SIDS (2010)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Specific target organ toxicity - Repeated exposure	Category 1 (eye, skin)	Danger	H372	P260 P264 P270 P314 P501	In the 4-week inhalation study in rats (as vapor, 6 hours/day), deaths occurred at 0.483 mg/L or higher, irritation of superficial ocular structures, mucosal irritation and keratitis found at all concentrations, and these findings progressed to cataracts at concentrations more than 0.142 mg/L (converted dose level as that of 90-day study: 0.044 mg/L). Concurrently, skin irritation was also observed at 0.142 mg/L or higher, and these progressed to dermatitis at concentrations more than 0.483 mg/L (converted dose level as that of 90-day study: 0.149 mg/L). It was documented that the cause of death was attributed to necrosis and acute purulent inflammation of the skin (SIDS (2010)). In addition, repeated inhalation exposure produced cataracts and progression to necrosis and acute purulent inflammation of the skin that led to death at concentrations corresponding to Category 1. Thus, because it was considered that these severe symptoms were not caused by local effect only, the substance was, therefore, classified as Category 1 (eyes, skin). Besides, in the 13-week oral toxicity studies in both rats and mice, at high doses which exceeded the guidance values, eye changes (degeneration of the lens and keratitis) and lung lesions (inflammation, congestion and histiocytosis) were found in rats, while cardiac mineralization, hepatocellular vacuolization and congestion of the lung were observed in mice (SIDS (2010)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 3	- -	H402	P273 P501	Classified into Category 3 from its 48h-EC50 = 25 mg/L for crustacea (Daphnia magna) (SIDS, 2004).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 3	- -	H412	P273 P501	Classified into Category 3 since its acute toxicity is Category 3 and it is not rapidly degradable (28d-BOD degradation rate: 48% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1997)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in Annexes to the Montreal Protocol.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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