NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	88-73-3
Chemical Name	o-Nitrochlorobenzene
Substance ID	m-nite-88-73-3_v2
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified	- -	-	-	Classified into Not classified since the substance is classified into Division 6.1 in UNRTDG (UN1578) and is not "Explosives" though it contains chemical groups (N-O) associated with explosive properties present in the molecules. The calculated oxygen balance is -121 (calculated value).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Flammable solids	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Self-reactive substances and mixtures	Classification not possible	- -	-	-	Classification is not possible since no data are available though there are chemical groups (nitro group) associated with explosive properties present in the molecules.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Pyrophoric solids	Not classified	- -	-	-	Auto-ignition point is 487 degC (ICSC (J) (2002)) and the substance does not spontaneously ignite on contact with room temperature air.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to solid (melting point <= 140 degC) substances are not available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	The substance contains chlorine which is chemically bonded only to carbon.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 3	Danger	H301	P301+P310 P264 P270 P321 P330 P405 P501	LD50 values are 144, 251, 263, 550 mg/kg bw (SIDS (2001)), 270, 510 mg/kg bw (DFGOT vol. 4 (1992)), 219 and 457 mg/kg bw (BUA Report No. 2 (1985)), and five values correspond to Category 3 and three values correspond to Category 4. The substance was classified into Category 3 since 5 of 8 LD50 values are in this category.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Dermal)	Category 3	Danger	H311	P302+P352 P361+P364 P280 P312 P321 P405 P501	LD50 values of 655 mg/kg bw and 1320 mg/kg bw for rats (SIDS (2001)) for rats correspond to Category 3 and 4, respectively. The category with higher hazard was adopted, the substance was classified into Category 3.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Vapours)	Category 3	Danger	H331	P304+P340 P403+P233 P261 P271 P311 P321 P405 P501	Based on a LC50 value (vapour/aerosol mixture) of 495 ppm (3.18 mg/L) for rats (SIDS (2001)), the substance was classified into Category 3. Although there is a report that a vapour/aerosol mixture was used in this inhalation test, it is considered that the test was conducted for vapour mixed with mist since the test concentration (495 ppm) is between saturated vapour pressure concentration of 526 ppm (calculated from the vapour pressure of 0.4 mmHg (25 degC) (NTP TOX No. 33 (1993))) and 90% of saturated vapour pressure concentration (473 ppm).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Skin corrosion/irritation	Classification not possible	- -	-	-	In rabbit skin irritation tests, although results of "mild irritation" (in one test) and "no irritation" (in two tests) are reported, the administration procedures employed in these tests were not standard. Review of the data indicated "the tests gave no evidence of a skin irritating potential" (SIDS (2001)). Classification was not possible due to lack of data.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	In a rabbit eye irritation test, 1-hour post application slight conjunctival injections (score 1-2/0-3) were noted in the eyes of 6/6 rabbits, and 24-hour post application no irritating effects were observed (SIDS (2001)). In another test, slight redness (score 1/3) was observed in the eye of 1/2 rabbits, which disappeared within 24-hour, and no signs of irritation were observed in cornea on the day of application or during the 7 day post exposure observation period (SIDS (2001)). Based on the reports, the substance was classified into Category 2B.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Respiratory sensitization	Classification not possible	- -	-	-	Although there is a report that rats exposed via inhalation for 5 months showed positive sensitization reactions (SIDS (2001)), the details are not clear. Classification was not possible due to lack of other data.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Skin sensitization	Classification not possible	- -	-	-	No data available. In regard to a positive result in a modified Freunds complete adjuvant test with guinea pigs (SIDS (2001)), there is a comment that "due to the limited and poor quality information available, it cannot be concluded whether or not the chemical has a sensitizing activity" (SIDS (2001)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data from in vivo mutagenicity tests. There is a report of a positive result in an in vivo genotoxicity test, intraperitoneal injection mouse DNA damage test (alkaline elution assay) (liver, kidney) (SIDS (2001)). From in vitro mutagenicity tests, there are reports of weakly positive (with S9) results in a chromosomal aberration test and a sister chromatid exchange test using Chinese hamster ovary cells (NTP TOX No. 33 (1993)), but negative (with and without S9) result in the other chromosomal aberration test using Chinese hamster ovary cells (SIDS (2001)). As relevant information, there are many reports of negative and positive Ames tests (IARC vol. 65 (1996). SIDS (2001) concluded that the substance is suspected of being genotoxic, at least a weak clastogen.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Carcinogenicity	Category 1B	Danger	H350	P308+P313 P201 P202 P280 P405 P501	[Rationale for the Classification] Based on (1) and (2), clear evidence of carcinogenicity including malignant tumors was observed in two animal species, and based on (3), this substance is a target substance in the public announcement on guidelines in order to prevent the impairment of worker's health caused by the chemical substances decided by the Minister of Health, Labour and Welfare based on paragraph (3) of Article 28 of the Industrial Safety and Health Act, and emphasizing these, it was classified in Category 1B. [Evidence Data] (1) In a two-year carcinogenicity study with rats dosed by feeding, an increase in the incidence of liver tumors (hepatocellular adenoma and hepatocellular carcinoma) was observed both in males and females (Results from Carcinogenicity Studies (Ministry of Health, Labour and Welfare, 2006), IARC 123 (2020)). (2) In a two-year carcinogenicity study with mice dosed by feeding, an increase in the incidence of liver tumors (hepatocellular adenoma, hepatocellular carcinoma and hepatoblastoma) was observed both in males and females (Results from Carcinogenicity Studies (Ministry of Health, Labour and Welfare, 2006), IARC 123 (2020)). (3) This substance is a target substance in the public announcement on guidelines in order to prevent the impairment of worker's health caused by the chemical substances decided by the Minister of Health, Labour and Welfare based on paragraph (3) of Article 28 of the Industrial Safety and Health Act (guidelines in order to prevent the impairment of worker's health, announcement No. 27 on February 7, 2020). (4) As for the carcinogenicity classification results by domestic and international organizations, the IARC changed the category from the previous Group 3 (IARC 123 (2020)) to Group 2B based on the data in (2) and (3) (IARC 123 (2020)). The Japan Society For Occupational Health (JSOH) classified it in Group 2B (Recommendation of Occupational Exposure Limits (2020): Classification in 2019) and the DFG classified it in Category 3 (DFG MAK (2020)). [Reference Data, etc.] (5) In a 78-week feeding administration test with rats and mice, an increase in tumors in multiple organs in rats, and an increase in hepatocellular carcinoma in mice were suggested (SIDS (2004), IARC 65 (1996), Environmental Risk Assessment for Chemical Substances vol. 15 (Ministry of the Environment, 2017)).	FY2021	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
7	Reproductive toxicity	Classification not possible	- -	-	-	In a 13-week inhalation test in rats, decreases in the epididymal weight and spermatid count of males were observed at the high dose (18 ppm) without death. There were no significant changes in females (NTP TOX No. 33 (1993)). In a 13-week inhalation test in mice, sperm motility was significantly decreased in all dose groups (4.5, 9, 18 ppm) and the highest dose level (18 ppm) produced mortality (2/10). There were no significant changes in females (NTP TOX No. 33 (1993)). Based on the data, classification was not possible. In a continuous breeding test in mice (male and female mice received three dose levels by gavage for 7 days prior to cohabitation for 98 days for continuous breeding). Pup weight gain was lower but no effect on fertility was noted (NTP TOX No. 33 (1993)). In an oral test in pregnant rats by gavage, no differences in the number of the litters exhibiting malformations were evident in the treatment groups compared to the control group. Although there is no indication of developmental toxicity, it was reported in SIDS that there is a concern for a reproductive toxicity potential for the substance (SIDS (2001)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Specific target organ toxicity - Repeated exposure	Category 1 (blood, liver)	Danger	H372	P260 P264 P270 P314 P501	In a 13-week chronic inhalation (vapour) test in rats, methemoglobin concentrations were elevated at a dose level of 1.1 - 18 ppm (0.007 - 0.12 mg/L), which fall within the guidance value range for Category 1 (NTP TOX No. 33 (1993)). In a 13-week chronic inhalation (vapour) test in mice, liver lesions (hepatocellular necrosis, mineralization, chronic inflammation, hepatocytomegaly) and increased hematopoietic activity of the spleen were observed at 18 ppm (0.12 mg/L), which falls within the guidance value range for Category 1 (NTP TOX No. 33 (1993)). Based on the data, the substance was classified into Category 1 (blood system, liver).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 3	- -	H402	P273 P501	Classified into Category 3 from its 48h-EC50 = 21.3 mg/L for Crustacea (Daphnia magna) (SIDS, 2001).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 3	- -	H412	P273 P501	Classified into Category 3 since its acute toxicity is Category 3 and it is not rapidly degradable (BOD degradation rate: 0% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1977)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in Annexes to the Montreal Protocol.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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