NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	919-30-2
Chemical Name	3-aminopropyltriethoxysilane
Substance ID	m-nite-919-30-2_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Flammable liquids	Not classified	- -	-	-	Its flash point is 96degC (closed cup) (SIDS (accessed July 2008)), which is >= 93degC.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Pyrophoric liquids	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Its melting point is -70degC (SIDS, accessed in July 2008). Test methods applicable to liquid (melting point <= 140degC) substances are not available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	It contains metalloid silane and its water solubility is 7.6*10^5mg/L at 25degC (SIDS (accessed in July 2008)). Based on the information, the substance was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
13	Oxidizing liquids	Classification not possible	- -	-	-	The substance contains oxygen (but not fluorine or chlorine), with oxygen chemically bonded to Si. Although the substance is classifiable, classification is not possible due to insufficient data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
16	Corrosive to metals	Classification not possible	- -	-	-	Its boiling point is 217degC (Sax (11th, 2004), HSDB (2002)), which is >= 55degC. Classification is not possible due to insufficient data.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	The tests using rats resulted in the LD50 values of 1570mg/kg (females), 2830mg/kg (males), and 3.65ml/kg (both sexes) (SIDS, (accessed in July 2008)). Of these LD50 values documented, 1570mg/kg (females) was adopted for the basis to classify the substance into Category 4, because the value was obtained from a GLP test and was a conservative estimate. In addition, the substance is listed as R22: harmful if swallowed, in the EU Risk Phrases (EU-Annex 1, accessed in July 2008).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Based on the rabbit LD50 value of 4.29g/kg bw (SIDS, (accessed July 2008)), the substance was classified into "Not classified" using JIS classification criteria (Category 5 in the United Nations classification).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	Its rat LC50 is documented to be >= 16ppm (4-hour conversion: >= 19.6ppm) in an inhalation test using rats (SIDS, accessed July 2008). Since the data was insufficient, the substance was classified into "Classification not possible".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Dusts and mists)	Not classified	- -	-	-	Based on its LC50 of 7.35mg/L (unit conversion: 812ppm) obtained from a 4-hour inhalation test using rats (SIDS, accessed July 2008), the substance was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	In the rabbits tests, alopecia, ulceration, and necrosis were observed. In addition, ecchymosis and moderate to severe edemas, though these symptoms were reversible, were observed (SIDS, accessed in July 2008). Since these observations indicate serious skin corrosion, the substance was classified into Category 1. Since no Draize score is available, refined classification within Category 1 is not available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	The data was obtained from tests using rabbits (OECD405). Corneal necrosis was observed in both rabbits with eyes unwashed and rabbits with eyes washed after the application (SIDS, accessed July 2008). Based on these results, the substance was classified into Category 1.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	In the guinea pig tests, in which peanut oil was used as a medium (1997), the substance was found to be irritating, and thus it was classified into Category 1. In 2 other tests (1996, 1987), physiological saline and water were used as media, which hydrolyzed the substance (SIDS, accessed July 2008). Thereby, the data was not evaluated for the classification of the substance.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Germ cell mutagenicity	Not classified	- -	-	-	Based on the negative results obtained from micronucleus tests using the bone marrow cells of mice that underwent intraperitoneal administration (in vivo mutagenicity tests using somatic cells) (SIDS, accessed July 2008), the substance was classified into "Not classified". Also, in vitro mutagenicity tests (Ames tests and chromosomal aberration tests using CHL cells) yielded negative results (SIDS (accessed July 2008)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Carcinogenicity	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Reproductive toxicity	Classification not possible	- -	-	-	In developmental toxicity tests using rats that underwent oral administration during the organogenetic period (SIDS, accessed in July 2008), non-ossification of presacral vertebrae and sternebra unossified was detected in the offspring at doses that suppressed body weight gain of parental animals. However, these results were not interpreted as clear cases of developmental toxicity. Since the information on sexual functions and fertility of parental animals was insufficient, the substance was classified into the "Classification not possible" category.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Specific target organ toxicity - Single exposure	Category 3 (respiratory tract irritation, narcotic effects)	Warning	H335 H336	P304+P340 P403+P233 P261 P271 P312 P405 P501	In oral administration tests using rats (OECD TG 401), symptoms such as motor ataxia and lethargy were observed at lethal dose (5.0mL/kg). In addition, in inhalation tests using rats (OECD TG 403), slow righting reflex, labored breathing, hypoactivity, ataxia and discharge from the mouth, nose and eyes were observed at the administration dose of 7.35mg/L, and these symptoms disappeared in 3 days (SIDS, accessed in July 2008). Based on these results, the substance was classified into Category 3 (respiratory tract irritation and narcotic effects).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Specific target organ toxicity - Repeated exposure	Category 2 (respiratory organs)	Warning	H373	P260 P314 P501	In the aerosol inhalation tests using rats, symptoms such as irritation to the respiratory system, inflammation, and metaplasia occurred at the concentration of 150mg/m3/6h (4-week exposure) (SIDS, accessed July 2008). Based on these results, the substance was classified into Category 2 (respiratory system).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Not classified	- -	-	-	Based on its 96-hour LC50 of >= 934mg/L for fish (zebra fish), 48-hour EC50 of 331mg/L for crustaceans (Daphnia magna), and 72-hour EbC50 of 603mg/L for algae (Scenedesmus) (SIDS, 2005), the substance was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Hazardous to the aquatic environment Long term (Chronic)	Not classified	- -	-	-	Since it is water soluble (water solubility = 760000mg/L (SIDS, 2005)) and its classification for acute toxicity is "Not classified", the substance was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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