NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	95-14-7
Chemical Name	1,2,3-Benzotriazole
Substance ID	m-nite-95-14-7_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Classification not possible	- -	-	-	It contains chemical groups (adjacent nitrogen atoms) associated with explosive properties in the molecule. Since no test results are available, classification is not possible.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Flammable solids	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Self-reactive substances and mixtures	Classification not possible	- -	-	-	It contains chemical groups (adjacent nitrogen atoms) associated with explosive properties in the molecule. Since no test results are available, classification is not possible. In addition, it is reported that the substance may detonate at 220 degC or during vacuum distillation (Sax (11th, 2004)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Pyrophoric solids	Not classified	- -	-	-	Since its autoignition temperature is 210 degC (ICSC (1998)), it is considered that the substance does not ignite at room temperature.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to solid (melting point <= 140 degC) substances are not available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Organic compounds containing no oxygen, fluorine or chlorine.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	The three LD50 values for rats of 560, 600 and 965 mg/kg bw were reported (DFGMAK-Doc. Vol.2 (1991)), and all data correspond to Category 4. Thus the substance was classified into Category 4.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Based on the rat LD50 value of > 10000 mg/kg (HSDB (2003)), the substance was classified as "Not classified".	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Dusts and mists)	Category 4	Warning	H332	P304+P340 P261 P271 P312	Based on the rat LC50 value of 1.9 mg/L/3hrs (= 1.43 mg/L/4hrs) (PATTY, 5th (2001)), the substance was classified as Category 4. The acute toxicity value (1.9 mg/L) was higher than the saturated vapor pressure concentration (0.000158 mg/L) at room temperature, the criterion values for mist/dust were adopted.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Skin corrosion/irritation	Not classified	- -	-	-	No skin irritation was reported in rabbit test (DFGMAK-Doc. Vol.2 (1991)). In other rabbit test, irritation scores both of erythema and edema were 0 in all observation time (Keml-Riskline (2000)). Based on these documents, the substance was classified as "Not classified".	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Serious eye damage/eye irritation	Category 2	Warning	H319	P305+P351+P338 P337+P313 P264 P280	The substance was classified as Category 2 based on the rabbit test in which corneal opacity and redness of conjunctiva or iris were noted (DFGMAK-Doc. Vol.2 (1991)). As relevant notes, in another rabbit test, the irritation score was 81.0, and that after 26 days was 31.0. However, it was reported that these irritation scores were due to mechanical stimulus like the stimulation by sand (HSDB (2003)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Skin sensitization	Classification not possible	- -	-	-	In the maximization test using guinea pigs, weak positive effects (1/20) were reported (Keml-Riskline (2000)). On the other hand, in other maximization test using guinea pigs, the negative result was reported (DFGMAK-Doc. Vol.2 (1991)). Because these test results were contradictory, the substance was classified as "Classification not possible". As relevant notes, in the maximization test in guinea pigs using the technical product, it was reported that weak positive reaction in 3 of 20 animals was shown. Thus, it was suggested that sensitization by occupational exposure might occur (DFGMAK-Doc. Vol.2 (1991)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Germ cell mutagenicity	Not classified	- -	-	-	The classification was concluded as "Not classified" based on the negative results in the micronucleus test using bone marrow obtained from mice orally administered (in vivo mutagenicity test in somatic cells) (compliant to the OECD guidelines) (KemI-Riskline (2000)). As relevant information, as for in vitro studies, positive results were reported in the Ames test and the chromosome aberration test using CHO cells (NTP DB (Access on Sep. 2010)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Carcinogenicity	Classification not possible	- -	-	-	In the 104-week feeding study in mice, no tumors were observed in males. Vesiculobronchial carcinomas were observed in the low-dose group of females. But, because the incidences were not dose-dependent and were within the background data of the test facility, the effects were concluded to be no relation to the administration. In the 78-week feeding study in rats, neoplasms in nodules of the liver were significantly increased in high dose group of males, however, the effects were concluded to be no relation to the administration as compared to the background data of the test laboratory. In the same test, brain tumors were observed in all dose groups of males, however, it is insufficient to conclude that it was an evidence of carcinogenicity (NTP TR 88 (1978)). Endometrial stromal polyps without dose response seen in females were also concluded not treatment-related. (NTP TR 88 (1978), DFGMAK-Doc. Vol.2 (1991)). However, because the rat study was conducted during 78-week, the results could not adopt for the basis of classification. Therefore, totally, the classification was concluded as "Classification not possible" due to lack of data.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Reproductive toxicity	Classification not possible	- -	-	-	In the combined repeated oral dose toxicity study with the reproduction/developmental toxicity test in rats orally administered for 42 days for both sexes (OECD TG 422, GLP-compliant), no effects of the compound were observed on the copulation index, fertility index, number of corpora lutea of pregnancy, number of implantations, implantation index, number of pups born, number of live pups, delivery index, live birth index, and sex ratio. Thus, no adverse effects were observed on the sexual functions and fertility of parental animals (Safety Test Results (Ministry of Economy, Trade and Industry) (2007)). However, since data on development of the offspring were insufficient, the substance was classified as "Classification not possible".	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Specific target organ toxicity - Single exposure	Category 2 (respiratory organs), Category 3 (narcotic effects)	Warning	H371 H336	P308+P311 P260 P264 P270 P405 P501 P304+P340 P403+P233 P261 P271 P312	In the inhalation toxicity study in rats (LC50 value: 1.43 mg/L/4hrs), since clinical signs of deep abdominal breathing with open mouth gasping and severe hemorrhage in the lungs was observed at doses within Category 2 of the guidance values (HSDB (2003)), the substance was classified as Category 2 (respiratory organs). In the acute oral toxicity study in rats, depressed righting reflexes and analgesia were also observed. Based on the findings, Category 3 (narcotic effects) was added.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	In the 8-week feeding study with rats, the only effect seen in the dose outside the guidance value of Category 2 was reduction of body weight gain (DFGMAK-Doc, Vol.2 (1991)). In the 42-day oral dose toxicity study in rats, several abnormalities in the parameters for hematology and clinical chemistry were observed in the doses outside of Category 2, while no relevant abnormalities were not seen in histopathology (Safety Test Results (Ministry of Economy, Trade and Industry) (Access on 2007)). Based on the reports described above, the classification corresponded to "Not classified" category in oral route, but was concluded as "Classification not possible" due to no information available for the other routes.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in Annexes to the Montreal Protocol.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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