Item | Information |
---|---|
CAS RN | 95-68-1 |
Chemical Name | 2,4-Dimethylaniline |
Substance ID | m-nite-95-68-1_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | To Workplace Safety Site (MHLW) |
Sample SDS by MHLW (External link) | To Workplace Safety Site (MHLW) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecules. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Liquid | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Liquid | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Liquid | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
6 | Flammable liquids | Category 4 |
Warning |
H227 | P370+P378 P210 P280 P403 P501 |
Since the flash point by ICSC(2007) is 90degC, it was classified into Category 4. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Liquid | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive or self-reactive properties present in the molecule. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
9 | Pyrophoric liquids | Not classified |
- |
- | - | Since it was classified into Class 6.1 and PG II in the United Nations Recommendations on the Transport of Dangerous Goods (UN No.1711 (ICSC, 2007)), it was classified into Not classified. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Liquid | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | The test method suitable for liquid substances is not established. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | It is an organic compound not containing oxygen, fluorine or chlorine. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Liquid | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | The organic compound not including peroxy group in molecule. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Classification not possible due to lack of data | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 | P301+P312 P264 P270 P330 P501 |
From a description of LD50 value of 470 mg/kg (DFGOT vol.19 (1998), ACGIH (7th, 2001)) in the oral administration test employing rats, it was classified into Category 4. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | There is description of LD50 value 3,300 mg/kg of the dermal administration test employing a rabbit (DFGOT vol.19 (1998)). Although LD50 value seemed to be equivalent to the U.N. GHS acute toxicity (dermal) Category 5, it fell under unadopted category in Japan and was classified into "Not classified". | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable". | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | Classification not possible due to lack of data | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Category 4 |
Warning |
H332 | P304+P340 P261 P271 P312 |
Saturated vapor pressure level of this substance (25degC)is 175 ppm (0.867 mg/L). Since LC50 value with 1.53 mg/L of the 4-hour inhalation exposure test employing rats (DFGOT vol.19 (1998)) was larger than saturated vapor pressure level, it was classified into Category 4 by applying the mist standard. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
2 | Skin corrosion/irritation | Not classified |
- |
- | - | It is described as "not irritating" (DFGOT Vol. 19 (1998)).for the skin irritation test comforming to OECD TG. Moreover, it is described as "skin: weak irritation" in BUA 161 (Summary, 1994). Although it seemed to correspond to UN GHS Skin irritation Category 3 based on the above-mentioned, it was classified into "Not classified", because Category 3 is not domestically adopted. In addition, there is a description, "It stimulates the skin.........causes reddening, when contacting the skin" in the section of Effects on Humans of the MOE Risk Assessment Vol 6 (2008). Moreover, there is a description "mildly irritating" in the section of EFFECTS OF SHORT-TERM EXPOSURE in the cited literature ICSC (2007). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
3 | Serious eye damage/eye irritation | Category 2 |
Warning |
H319 | P305+P351+P338 P337+P313 P264 P280 |
In the eye irritation examination in conformity to OECD TG, it has been described as "irritating" (DFGOT vol.19 (1998)). Moreover, it is described as "eye: irritant" in BUA 161 (Summary, 1994). As mentioned above, since the degree was unknown, it was not classified finely and was classified into "Category 2". In addition, the clause of influence in MOE Risk Assessment, Volume 6 (2008) describes as "It irritates the eye, and ... when it goes into the eye, redness and pain are caused." Moreover, it is described as "irritating" in the clause of EFFECTS OF SHORT-TERM EXPOSURE of ICSC (2007) which is a cited literature. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification is not possible since there is no data. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
4 | Skin sensitization | Classification not possible |
- |
- | - | Classification is not possible since there is no data. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Although there is a description of "positive" in the in vitro mutagenicity test (Ames test employing a Salmonella typhimurium) (NTP DB (Access on October 2008)), classification is not possible because there is no data of in vivo examination. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
6 | Carcinogenicity | Not classified |
- |
- | - | Since IARC has a description of group 3 (IARC Suppl.7 (1987)), it was classified into "Not classified" according to guidance. However, it is classified into the Category 2 (DFGOT vol.19 (1998)) in Germany DFG. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
8 | Specific target organ toxicity - Single exposure | Category 1 (blood system) |
Danger |
H370 | P308+P311 P260 P264 P270 P321 P405 P501 |
For animals, there is a description of "Hyperpnea was seen." in 4 hours inhalation exposure test employing rats (DFGOT vol.19 (1998)), and there is a description of "Methemoglobin was produced about 1 hour and a half after administration" in the oral administration test where the lethal dose in rats were calculated (DFGOT vol.19 (1998)). All these symptoms were seen within the range of the guidance value of Category 1. Although there is no data of this substance on the humans, the report that "2,6-xylidine, which is an isomer, caused methemoglobinemia on humans." is described in DFGOT vol.19 (1998). As mentioned above, it was classified into Category 1 (blood systems). In addition, in ICSC (2007), "The high concentration exposure may cause lowering of consciousness. The high concentration exposure may produce methemoglobin. These effects may occur backwardly. Although there is a description of "Medical follow up is needed, the details of doses are unknown. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (blood system, liver) |
Danger |
H372 | P260 P264 P270 P314 P501 |
Within the limits of the guidance value of Category 1, "an increase in relative and absolute liver weight, an increase in hyaline droplet on the epithelium of kidney tubules of kidney, a decrease in the amount of hemoglobin, an increase in the platelet count and an increase in activated partial thromboplastin time were observed in male rats, and an increase in the amount of total cholesterol was observed in female rats, as well as hypertrophy of hepatocytes at the center of the hepatic lobule was observed both in male and female rats."(MOE Risk Assessment vol. 6 (2008)) Within the limits of the guidance value of Category 2, "an increase in relative and absolute liver weight, an increase in relative kidney weight, a decrease in the amount of hemoglobin and a decrease in the prothrombin time were observed in female rats" (MOE Risk Assessment vol. 6 (2008)). About the effects on the liver, from description in ACGIH (7th, 2001) that "hepatocellular necrosis and bile duct hyperplasia were observed in male rats" within the limits of the guidance value of Category 2, they are adopted to categorize. Since an increase in hyaline droplet on the epithelium of kidney tubules of kidney was only observed in male rats, it is not adopted to categorize. Therefore, it is classified into Category 1 (blood systems, liver). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 2 |
- |
H401 | P273 P501 |
It was classified into Category 2 from 48 hours EC50=9.9mg/L of the crustacea (Daphnia magna) (AQUIRE (2008)). | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 2 |
- |
H411 | P273 P391 P501 |
Since acute toxicity was Category 2 and there were no rapid degradability (not readily degradable, the decomposition by BOD: 0% (Existing Chemical Safety Inspections Data (1978)), it was classified into Category 2. | FY2008 | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
12 | Hazardous to the ozone layer | - |
- |
- | - | - | - | - |
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