NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	96-23-1
Chemical Name	1,3-Dichloro-2-propanol
Substance ID	m-nite-96-23-1_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Flammable liquids	Category 4	- Warning	H227	P370+P378 P210 P280 P403 P501	All flash points of 86 deg C [closed-cup] (MSDS (Sigma-Aldrich) (2011)), 74 deg C [open-cup] (NFPA (14th, 2010), CRC (91st, 2010), ICSC (2008), HSDB (2003)), and 88 deg C [unknown test method] (Ullmanns (E) (6th, 2003)) are > 60 deg C and <= 93 deg C. Therefore, it corresponds to Category 4.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Pyrophoric liquids	Classification not possible	- -	-	-	No data available.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	The substance is an organic compound containing chlorine and oxygen (but not fluorine) which are chemically bonded only to carbon or hydrogen.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 3	Danger	H301	P301+P310 P264 P270 P321 P330 P405 P501	Four LD50 values for rats (81 mg/kg (Environmental Risk Assessment for Chemical Substances vol. 4 (Ministry of the Environment, 2005)), 110 mg/kg (Environmental Risk Assessment for Chemical Substances vol. 2 (Ministry of the Environment, 2003)), 120 mg/kg (JECFA 1039 (2002)), 140 mg/kg (JECFA 1039 (2002))) were reported, and all correspond to Category 3.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Dermal)	Category 3	Danger	H311	P302+P352 P361+P364 P280 P312 P321 P405 P501	There are reports on three LD50 values for rabbits (590 mg/kg (Environmental Risk Assessment for Chemical Substances vol. 4 (Ministry of the Environment, 2005)), 800 mg/kg (JECFA 1039 (2002)), 0.8 mL/kg (= 1,081 mg/kg) (DFGMAK-Doc.1 (1991))), two correspond to Category 3, and one corresponds to Category 4. It was classified in Category 3, to which most corresponded.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Vapours)	Category 2	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	It was classified in Category 2 based on an LC50 value of 125 ppm/4 hours for rats (JECFA 1039 (2002)). Besides, because the LC50 value (125 ppm) was lower than 90% of the saturated vapour pressure concentration (987 ppm), the reference value of gases was applied as a vapour with little mist.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	It was classified in Category 2 because it was reported to be irritating in a test by 24-hour open application of 0.01 mL of undiluted this substance to rabbits (Initial Risk Assessment Report 201 (NITE, CERI, NEDO, 2008)). Besides, there are also reports that it was mildly irritating or slightly irritating (DFGMAK-Doc (1991), JECFA 1039 (2002)).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Serious eye damage/eye irritation	Category 2A	Warning	H319	P305+P351+P338 P337+P313 P264 P280	It was classified in Category 2A because it was assessed as severe irritation (Initial Risk Assessment Report 201 (NITE, CERI, NEDO, 2008)) or irritation and moderately severe damage (JECFA 1039 (2002)) in eye irritation tests with rabbits.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Skin sensitization	Classification not possible	- -	-	-	No data available.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Germ cell mutagenicity	Not classified	- -	-	-	It was classified as "Not classified" based on negative results in both a micronucleus test with bone marrow after oral administration to rats (OECD TG 474) and a micronucleus test with peripheral blood after oral administration to mice (both, in vivo somatic cell mutagenicity tests) (JECFA 1145 (2007), NTP DB G11538 (Access on Sep. 2011)). Besides, it was reported to be negative in an unscheduled DNA synthesis test with hepatocytes after oral administration to rats (in vivo somatic cell genotoxicity test; OECD TG 486), and as for in vitro tests, it was reported to be positive in an Ames test, gene mutation tests with lymphoma cells or prostate fibroblast of mice, and a chromosomal aberration test with CHO cells (NTP DB 843274 (1984), Initial Risk Assessment Report 201 (NITE, CERI, NEDO, 2008), Environmental Risk Assessment for Chemical Substances vol. 4 (Ministry of the Environment, 2005)).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Carcinogenicity	Category 2	Warning	H351	P308+P313 P201 P202 P280 P405 P501	It was classified in Category 2 because IARC classified it in Group 2B for carcinogenicity (IARC News: 101 (2011)). Besides, the EU classified it in Category 2 (R45) (EC-JRC (ESIS) (Access on Sep. 2011)). Also, it is reported that the results of a 104-week drinking water administration test with rats (OECD TG 453, GLP) strongly suggest carcinogenicity in the liver, kidney, tongue and oral cavity, and thyroid (Initial Risk Assessment Report 201 (NITE, CERI, NEDO, 2008)).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Reproductive toxicity	Classification not possible	- -	-	-	Data are lacking. Besides, it is reported that as a result of 8-day gavage administration of 100 mg/kg/day to three male rats followed by mating and observation of implanted embryos on a gestational day 9 or 10, there was no copulation for one pair and no embryogenesis in another pair, and the other showed a normal number of implantations, but it was impossible to determine the effects of the test substance due to a small number of animals and limited test items (Initial Risk Assessment Report 201 (NITE, CERI, NEDO, 2008)).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Specific target organ toxicity - Single exposure	Category 1 (liver), Category 3 (respiratory tract irritation)	Danger Warning	H370 H335	P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312	As an accident case report in humans, six out of 12 men engaged in cleaning a saponification tower to synthesize epichlorohydrin developed acute hepatic disorders, and two of them died. Both the men complained of general malaise, nausea, and vomiting after work, and hepatomegaly, marked increases in AST and ALT, extended prothrombin time, etc. were observed, and they were diagnosed with fulminant hepatitis, and this substance was detected in the serum and plasma (Initial Risk Assessment Report 201 (NITE, CERI, NEDO, 2008)). Also, in animal tests, it is described that acute toxicity by subcutaneous or intraperitoneal administration is mainly liver defect, and severe vacuolar degeneration, fatty degeneration, focal necrosis, etc. of hepatocytes were observed, showing pathologic state for fulminant hepatitis (Initial Risk Assessment Report 201 (NITE, CERI, NEDO, 2008)). From the above, it was classified in Category 1 (liver). On the other hand, it was classified in Category 3 (respiratory tract irritation) because it is described that this substance is severely irritating to the mucous membranes, and inhalation causes cough, tachypnea, and wheezing (HSDB (2003)).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Specific target organ toxicity - Repeated exposure	Category 1 (liver, kidney, blood), Category 2 (nasal cavity)	Danger Warning	H372 H373	P260 P264 P270 P314 P501	It was classified in Category 1 (liver) because fatty degeneration of hepatocytes was observed at or above 80 ppm (6.3-9.6 mg/kg/day) in a 104-week repeated oral administration test with rats (OECD test guideline, GLP), and enlargement of nucleoli of hepatocytes was found at or above 10 mg/kg/day in a 13-week repeated oral administration test with rats (US EPA TSCA test guideline, GLP) (Initial Risk Assessment Report 201 (NITE, CERI, NEDO, 2008)). There was an increase in urine protein at or above 240 ppm (19.3-30 mg/kg/day) in a 104-week repeated oral administration test with rats, and multifocal degeneration of renal tubules was seen at or above 10 mg/kg/day, corresponding to the upper limit of the guidance values for Category 1, in the 13-week repeated oral administration test (Initial Risk Assessment Report 201 (NITE, CERI, NEDO, 2008)). Therefore, it was classified in Category 1 (kidney). Furthermore, it was classified in Category 1 (blood) because hemosiderin deposits in Kupffer cells and decreases in hemoglobin level and hematocrit value were observed at or above 80 ppm (6.3-9.6 mg/kg/day) in the 104-week repeated oral administration test. Moreover, in the 13-week repeated oral administration test, histopathological changes in the nasal cavity (nasoturbinate adhesion, degeneration of the olfactory mucosa, hyperplasia of the respiratory and olfactory mucosa, etc.) were reported at 100 mg/kg/day (Initial Risk Assessment Report 201 (NITE, CERI, NEDO, 2008)). Therefore, it was classified in Category 2 (nasal cavity).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Not classified	- -	-	-	It was classified as "Not classified" because data above 100 mg/L were obtained for fish, crustacea, and algae (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 1996); Environmental Risk Assessment for Chemical Substances Vol. 4 (Ministry of the Environment, 2005)).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Hazardous to the aquatic environment Long term (Chronic)	Not classified	- -	-	-	If chronic toxicity data are used, then it is classified as "Not classified" due to being rapidly degradable (BOD: 84, 86, 0%, TOC: 99, 96, 40%, GC: 100, 100, 51% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1986)), and 21-day NOEC = 6.25 mg/L for crustacea (Daphnia magna) (Initial Risk Assessment (NITE, CERI, NEDO, 2008)). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified as "Not classified" due to 96-hour LC50 > 100 mg/L for fish (Oryzias latipes), and being not water-insoluble (water solubility = 99,000 mg/L (PHYSPROP Database, 2009)). From the above results, it was classified as "Not classified."	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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