NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	96-34-4
Chemical Name	Methyl chloroacetate
Substance ID	m-nite-96-34-4_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Flammable liquids	Category 3	Warning	H226	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	Classified into Category 3 since flash point 52 degC (closed-cup) (IUCLID (2000)) is >=23 degC and <=60 deg.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Pyrophoric liquids	Not classified	- -	-	-	Auto-ignition point is 465 degC (Hommel (1996)) exceeding 70 degC.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	The substance is an organic compound containing chlorine and oxygen (but not fluorine) which are chemically bonded only to carbon or hydrogen.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 3	Danger	H301	P301+P310 P264 P270 P321 P330 P405 P501	Based on LD50 values of 107 mg/kg and 140 mg/kg for rats (DFGOT vol. 9 (1998)), the substance was classified into Category 3.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Dermal)	Category 2	Danger	H310	P302+P352 P361+P364 P262 P264 P270 P280 P310 P321 P405 P501	LD50 values of 137 mg/kg (DFGOT vol. 9 (1998)) and 470 mg/kg (DFGOT vol. 9 (1998)) for rats corresponds to Category 2 based on the lower value. A LD50 value of 318 mg/kg (DFGOT vol. 9 (1998)) for rabbits corresponds to Category 3. The rats data with higher hazard was adopted and the substance was classified into Category 2.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Vapours)	Category 2	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	Based on LC50 values of approximately 300 ppm (DFGOT vol. 9 (1998)) and 210 - 315 ppm (OECD TG403 (GLP), IUCLID (2000)) for rats, the substance was classified into Category 2. Since the LC50 values were lower than 90% of saturated vapour pressure concentration (10,039 ppm), the classification criteria for gas was adopted.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	In rabbits, following occlusive application of 0.5 mL (approximately 300 mg/kg), the skin was greatly swollen and corroded and all animals died after 2 to 8-hour (DFGOT vol. 9 (1998)). Occlusive application of 125 mg/kg to the skin for 24-hour led to severe skin damage and corrosion (DFGOT vol. 9 (1998)). Additionally, in another rabbit test (FDA guideline), it was reported that severe to very severe erythema and oedema, as well as necrosis, and the primary irritation value was between 6.6 and 6.8 (BUA 150 (1994)). Based on these data, the substance was classified into Category 1 since the irreversible damages were observed in one and more test.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	Based on a report that "severe irritation" and irreversible corneal damage (vascularization, detachment, scarring) and inflammation of the iris were observed after administration into the conjunctiva sac of the eye in a rabbit test (DFGOT vol. 9 (1998)) and results of severe mucous membrane irritant on the basis of the highest irritation index of 64 after 72-hour in another rabbit test (FDA guideline) (BUA 150 (1994)), the substance was classified into Category 1. As relevant information, in EU classification, the substance is classified into Xi; R41 (EU-Annex I (access on Aug. 2009)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	Based on a result of positive (positive ratio: 65% (13/20) vs. control positive ratio: 0% (0/10)) in a guinea pig maximization test (DFGOT vol. 9 (1998)), the substance was classified into Category 1. As relevant information, there is a human case report that a 28-year-old man showed strong positive reaction in patch test after accidental exposure to this substance (DFGOT vol. 9 (1998)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Germ cell mutagenicity	Not classified	- -	-	-	Based on a negative result in an oral mouse bone marrow micronucleus test (in vivo somatic cell mutagenicity tests) DFGOT vol. 9 (1998)), the substance was classified as "Not classified". As relevant information, from in vitro mutagenicity tests, there is a report of a negative Ames test (DFGOT vol. 9 (1998)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Carcinogenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. There is a report that there was no increased incidence of lung tumours in a test where mice received intraperitoneal injections for 8 weeks and follow-up for an additional 16 weeks (DFGOT vol. 9 (1998)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Reproductive toxicity	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Specific target organ toxicity - Single exposure	Category 2 (systemic), Category 3 (respiratory tract irritation)	- -	-	-	In rat oral acute toxicity tests, the animals showed clinical symptoms such as dyspnea, passivity, apathy, squatting position, abdominal position, disorders of balance, diarrhea, and ruffled fur. Autopsy of the animals which had died gave findings such as liver, spleen and kidneys coloured deep brown, dilatation of the heart, congestive hyperaemia, and bloody corrosive gastritis (BUA 150 (1994)). In rat inhalation acute toxicity tests, the animals showed intoxication symptoms such as impairment of the respiratory system and of coordinated movements and reflexes, an increased tendency to clean themselves, red incrusted noses and cyanosis, in addition to non-specific symptoms such as prone position and disorders of balance (DFGOT Vol. 9 (1998)). Autopsy of the animals which had died showed changes in the lungs and gastro-intestinal tract (BUA 150 (1994)). In dermal acute toxicity tests with rats and rabbits, the animals showed skin symptoms such as erythema and oedema, and autopsy of the animals which had died showed redness of the small intestine with injected blood vessels, as well as deep brown coloured livers (BUA 150 (1994)). Following oral and dermal application, autopsy of the surviving animals showed no abnormalities macroscopically, but following inhalation exposure, enlargement and coloured of the lungs was observed (BUA 150 (1994)). From the LD50 values (oral: 107 - 140 mg/kg, dermal: 136 - 318 mg/kg, inhalation: 0.945 - 1.418 mg/L), the toxic effects were observed at dose levels within the guidance value range for Category 1. However, the affected organ cannot be identified and the information are reported in a document in List 2, so the substance was classified into Category 2 (systemic toxicity). In addition, based on a report that concentrations of 210 ppm or more led to severe irritation of the respiratory tract (DFGOT vol. 9 (1998)), the substance was classified into Category 3 (respiratory tract irritation).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	In a inhalation test with rats exposed to vapour for 28 days, squatting position, irregular breathing, uncoordinated gait, impaired body weight gain, and increased relative lung weight were observed at the highest dose level of 100 mL/m3 (0.45 mg/L, 90-day equivalent: 0.14 mg/L) (DFGOT vol. 9 (1998)). However, since these effects showed some level of reversibility and no effects were noted in gross or histopathological examination (BUA 150 (1994)), the effects are not considered to be significant toxic effects. Since the dose levels were at the low end of the guidance value range, classification was not possible due to lack of other sufficient data.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 2	- -	H401	P273 P501	Classified into Category 2 from its 96h-LC50 = 1.13 mg/L for fish (Zebrafish) (IUCLID, 2000; BUA 150, 1994).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 2	-	H411	P273 P391 P501	Classified into Category 2 since its acute toxicity is Category 2 and it is not rapidly degradable (BOD degradation rate = 32, 29, 75% at 4 weeks) (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1989).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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