NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	97-86-9
Chemical Name	Isobutyl methacrylate
Substance ID	m-nite-97-86-9_v2
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Category 3	Warning	H226	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	Based on a flash point of 35 deg C (closed cup) (HSDB (Access on August 2017)), it was classified in Category 3. Besides, stabilized one is classified in Class 3, PGIII in UNRTDG (UN 2283).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Type G	- -	-	-	There is a chemical group associated with self-reactive properties (ethylene group) in the molecule, but because stabilized one is classified in Class 3, PGIII in UNRTDG (UN 2283), it does not correspond to self-reactive substances and mixtures, hazard class with the highest precedence.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 385 deg C (GESTIS (Access on August 2017)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	Based on reports of LD50 values of 6,400-12,800 mg/kg (ECETOC JACC (1996)) and 9,590 mg/kg (SIDS (2009)) for rats, this substance was classified as "Not classified."	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Based on a report of an LD50 value of > 17,760 mg/kg (PATTY (6th, 2012), SIDS Dossier (2009), HSDB (Access on August 2017)) for guinea pigs, this substance was classified as "Not classified."	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	It is reported that an LC50 value in a 6-hour inhalation exposure test with rats was > 3,600 ppm (converted 4-hour equivalent value: > 4,409 ppm) (ECETOC JACC 36 (1996)), and it corresponds to Category 4 or "Not classified." However, it was classified as "Classification not possible" since it was not possible to identify the category from this value alone. Besides, since the exposure concentration was lower than 90% of the saturated vapor pressure concentration (4,791 ppm (27.84 mg/L)), a reference value in the unit of ppm was applied as vapour with little mist.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Not classified	- -	-	-	Based on a report that the LC50 value in a 290-min (4.83-hour) inhalation exposure test with mice is 5,026 ppm (29.74 mg/L) (converted 4-hour equivalent value: 5,523 ppm (32.68 mg/L)) (SIDS (2009), HSDB (Access on August 2017)), this substance was classified as "Not classified." Besides, the exposure concentration was higher than the saturated vapor pressure concentration (4,791 ppm (27.84 mg/L)), so the reference value in the unit of mg/L was applied as mist. The classification result was changed from the previous classification because the new information sources were used.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	There is a description that in a skin irritation test with rabbits, when this substance was applied for 2 hours, mild irritation was seen at a primary skin irritation index of 1.87 (SIDS (2009)). In addition, it was described that in two tests in which this substance was applied to rabbits for 24 hours, it was moderately irritating at a primary skin irritation index of 4.16, and it was slightly irritating at a primary skin irritation index of 1.83 (both ECETOC JACC (1996), SIDS (2009)). Since it was considered that this substance was irritating from these results, this substance was classified in Category 2. Besides, this substance was classified as "Skin Irrit. 2, H315" in the EU CLP classification (ECHA CL Inventory (Access on August 2017)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	There are descriptions that in an eye irritation test (OECD TG 405 compliant) with rabbits, one animal exhibited slight conjunctival redness, edema and discharge, but the redness resolved after 24 hours as did other irritation findings after 48 hours, and the remaining animals showed no irritation. Also, it is described that there was no primary irritation index (SIDS (2009)). In addition, there are reports that in other multiple eye irritation tests with rabbits, slight irritation was observed (ECETOC JACC (1996), SIDS (2009)). Based on these results, it was considered to have slight irritancy, and was classified in Category 2B. Besides, this substance was classified as "Eye Irrit. 2, H319" in the EU CLP classification (ECHA CL Inventory (Access on August 2017)). The classification was changed based on the information obtained in this research.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Category 1B	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	[Rationale for the Classification] Based on (1), it was classified in Category 1B. Based on the new findings, the classification result was changed. [Evidence Data] (1) It was reported that, in a Local Lymph Node Assay (LLNA) (OECD TG 429, GLP) with mice (n=5/group), the Stimulation Index (SI values) were 1.78 (25%), 3.64 (50%), and 5.13 (100%), and the EC3 value was calculated to be 41.4% (ECHA RAC Opinion (2016), CLH Report (2015), REACH registration dossier (Accessed Jan. 2022)). [Reference Data, etc.] (2) It was reported that, as a result of a maximization test with guinea pigs, it was not a skin sensitizing substance (ECETOC JACC (1996)). (3) In the ECHA, it was classified in Skin Sens. 1B (EU-CLP Classification Results (Accessed Jan. 2022)).	FY2021	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Since it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government, it was classified as "Classification not possible." As for in vivo, a micronucleus test with mouse bone marrow cells was negative (SIDS (2009)). As for in vitro, a bacterial reverse mutation test was negative (SIDS (2009), NTP DB (Access on August 2017)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Classification not possible	- -	-	-	As a result of intraperitoneal administration of this substance at doses of 10 to 33% of the LD50 value on Gestational Days 5, 10 and 15 in pregnant rats, fetal skeletal abnormality, fetal death, embryo/fetal absorption were observed. Regarding the above findings, it was pointed out that since the administration route was intraperitoneal, it had no indirect influence via the maternal body but it might have a direct action on the fetuses (PATTY (6th, 2012)), therefore, considering the administration route, it was not used for the classification. Because there is no other available data for the classification, this substance was classified as "Classification not possible" due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Category 3 (Respiratory tract irritation)	Warning	H335	P304+P340 P403+P233 P261 P271 P312 P405 P501	There is no single-exposure information on this substance in humans. As for experimental animals, in single inhalation exposure tests with rats and mice with this substance or n-butyl methacrylate (CAS RN 97-88-1), there is no detailed description of the dose where symptoms were observed, but there is a report that as a symptom common to both substances, lung noise, irregular respiration, and nasal discharge were observed, and it is described that it is thought to be due to exposure to substances irritant to the respiratory tract (ECETOC JACC (1996)). In the oral route, there is a report that in a single oral dose test with rats, hypoactivity, staggering gait, ataxia, decreased muscle tone of extremities and abdomen, diarrhea, piloerection, and decreased body temperature were observed (SIDS Dossier (2009)). However, it was not adopted as evidence of the classification since the minimal dose of the test was 8,880 mg/kg, above the Category 2 and there is no information on the dose below that. Therefore, this substance was classified in Category 3 (respiratory tract irritation). Besides, IUCLID (2000) used for the previous classification could not be confirmed because it was not available. The classification result was changed from the previous classification due to use of the new information sources.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 3	- -	H402	P273 P501	From 72-hour EC50 (rate method) = 16 mg/L for algae (Pseudokirchneriella subcapitata) (OECD SIDS: 2004), it was classified in Category 3.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Not classified	- -	-	-	Due to being rapidly degradable (readily biodegradable, judged by comparison with degradability of the related compounds (J-CHECK, 2012)), no bioaccumulation (LogKow: 2.66 (SRC PhysProp Database: 2017)), and 72-hour NOEC (rate method) = 5.8 mg/L for algae (Pseudokirchneriella subcapitata) (OECD SIDS: 2004), it was classified as "Not classified."	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

To GHS Information