NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	97-99-4
Chemical Name	tetrahydro-2-furylmethanol; tetrahydrofurfuryl alcohol
Substance ID	m-nite-97-99-4_v2
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Flammable liquids	Category 4	- Warning	H227	P370+P378 P210 P280 P403 P501	Its flash point is 84degC (Merck No. 9213), which is <= 93degC and >= 60degC.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Pyrophoric liquids	Not classified	- -	-	-	Its autoignition point is 282degC (HSDB (2003)), which is > 70degC.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	Since exposure to the substance at 2000mg/kg did not cause mortality in rats (OECD TG 423) (Toxicity Testing Reports of Environmental Chemicals (Chemicals Investigation Promoting Council) (2008)), the substance was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Insufficient data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Dusts and mists)	Not classified	- -	-	-	Since its rat LC50 (6hr) = 52.8mg/L (4-hour conversion: 79.2mg/L) (SIDS (2005)), the substance was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	Since the substance is documented as moderately irritating to guinea pigs and humans (SIDS (2005), PATTY (5th, 2001), it was classified into Category 2.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Serious eye damage/eye irritation	Category 2A	Warning	H319	P305+P351+P338 P337+P313 P264 P280	In several studies using rabbits, the substance was characterized as "not irritating," "irritant," and "moderate to severe irritation." While information regarding the effects of the substance on humans is scarce, one literature addressed the substance as a severe eye irritant (SIDS (2005)). Based on these results and information, the substance was classified into Category 2A.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	In vitro mutagenicity tests (Ames tests and chromosomal aberration tests) provided negative results only (SIDS (2005)). Since there were no in vivo data available, classification is not possible.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Carcinogenicity	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Reproductive toxicity	Category 1B	Danger	H360	P308+P313 P201 P202 P280 P405 P501	[Rationale for the Classification] Based on (1), at the dose at which general toxicity effects were observed in parental animals, adverse effects on fertility and reproductive function as well as embryotoxicity/fetotoxicity were observed. Based on (2), at the dose at which no maternal toxicity was observed, although not significant statistically, external malformation (filamentous tail) was observed. In addition, total early resorptions were observed at the dose one step higher than the dose at which no serious toxicity was observed in maternal body. Accordingly, since developmental effects were observed at the dose at which no maternal toxicity was observed, it was classified in Category 1B. Based on the new information source, the category was changed. [Evidence Data] (1) In a reproduction/developmental toxicity screening test with rats dosed by gavage (OECD TG 421, GLP, administration period: males: a total of 47 days beginning 14 days before mating, females: 42 to 52 days beginning 14 days before mating to day 4 of lactation), at the high dose (150 mg/kg/day) at which systemic toxicity effects (such as reduced body weight gain, decreased food consumption, increased/reduced locomotor activity, capsule inflammation in the spleen) were caused in parental animals, a trend towards prolonged estrous cycles, prolonged gestation length, and decreased delivery index were observed, and marked decreases in the number of pups born and live birth index (only 4 live pups per litter on postnatal day 4) were observed in pups born. Furthermore, at the highest dose (500 mg/kg/day), effects on the testes and epididymides in males (a decrease in weight, seminiferous tubular atrophy and hyperplasia of interstitial cells in the testes, decreased sperm in the lumen of epididymides, etc.) and prolonged estrous cycles in females were observed. At this dose, no maternal animals delivered their offspring, and at necropsy, complete embryonic death and early embryonic resorption were observed in all maternal animals (Toxicity Testing Results for Existing Chemical Substances under the Chemical Substances Control Law (year unknown), SIAR (2005), CLH Report (2011), AICIS (previous NICNAS) IMAP (2018)). (2) In a range finding developmental toxicity study with female rats dosed by gavage (n=8 animals/group, 5 doses from 10 to 1,000 mg/kg/day, days 6 to 15 of gestation), reduced body weight gain and decreased food consumption were observed at or above 500 mg/kg/day and systemic symptoms (impaired mobility, decreased muscle tone, absence of pain response) were additionally observed at 1,000 mg/kg/day in maternal animals. As for developmental effects, a decrease in fetal weight and an increased incidence of tail anomaly (filamentous tail) were observed (4/8 litters, 5/124 fetuses: no statistically-significant difference) at 100 mg/kg/day at which no maternal toxicity was observed, and total early resorptions were observed at or above 500 mg/kg/day (SIAR (2005), CLH Report (2011)). [Reference Data, etc.] (3) The ECHA RAC (Committee for Risk Assessment of the European Chemicals Agency) concluded that, based on some evidence for effects on pregnancy outcome and parturition and testicular toxicity in (1), classification in Category 2 for fertility and reproductive function was justified, and based on total early resorptions and fetotoxicity in (2), it fulfilled the criteria for Category 1B (ECHA RAC Opinion (2012)). (4) In the EU, it was classified in Repr. 1B (EU-CLP Classification Results (Accessed Dec. 2021)).	FY2021	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
8	Specific target organ toxicity - Single exposure	Category 3 (Narcotic effects)	Warning	H336	P304+P340 P403+P233 P261 P271 P312 P405 P501	According to DHP 13th (2002), the substance was characterized as "fatal dose: 2300mg/kg, irritation: +, CHS effects: +", which indicates its effects on the central nervous system at the doses above the guidance values. The oral administration of 2000mg/kg to rats caused decreased locomotor activity and hypotonia 1 hour after administration, which disappeared the following day (SIDS (2005)). In addition, the following symptoms were noted: loss of coordination, prostration, vasodilation at 2.38mg/L/4hr (vapour) (PATTY (5th, 2001)); narcotic effects in acute toxicity tests using mice (LD50 = 2300mg/kg) (RTECS (2000)); and acute symptoms via inhalation such as giddiness, drowsiness, and unconsciousness (ICSC (J) (1994)). Based on these documents, the substance was classified into Category 3 (narcotic effects).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Specific target organ toxicity - Repeated exposure	Category 2 (spleen, testis)	Warning	H373	P260 P314 P501	In 2 studies in which rats underwent 13-week inhalation exposure (vapour) at 50-500ppm (0.209-2.089mg/L/6hr), hypoactivity and intermittent whole spasms occurred and hyperactivity followed. Intermittent systemic spasm occurred in a dose-dependent fashion (SIDS (2005)), and the symptom became hardly noticeable in 1 hour. Since 500 ppm is only slightly above the upper limit of the Category 2 guidance values, these observed neurotoxic effects are considered to be not serious. 28-day repeated oral administration tests using rats resulted in capsulitis of the spleen and necrosis of seminiferous epithelium of testes at 150mg/kg/day (90-day correction: 46.7mg/kg/day) or above (Toxicity Testing Reports of Environmental Chemicals (Chemicals Investigation Promoting Council) (accessed in May 2008). From these results, the substance was classified into Category 2 (spleen, testis).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Not classified	- -	-	-	Based on its 96-hour LC50 > 100mg/L for fish (medaka), 48-hour EC50 > 92mg/L for crustaceans (Daphnia magna), and 72-hour EC50 > 100mg/L for algae (Pseudokirchneriella subcapitata) (Test for the Ecological Effect of Chemical Substances (Ministry of the Environment), 2002), the substance was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Hazardous to the aquatic environment Long term (Chronic)	Not classified	- -	-	-	It is water soluble (water solubility > 250g/L (SIDS, 2006)) and its classification for acute toxicity is "Not classified". Based on the information, the substance was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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