NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	98-07-7
Chemical Name	Benzylidyne trichloride
Substance ID	m-nite-98-07-7_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Flammable liquids	Not classified	- -	-	-	Flash point: >93degC	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive or self-reactive properties present in the molecule.	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Pyrophoric liquids	Not classified	- -	-	-	Flash point: 211degC (ICSC(J) (1995))	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Self-heating substances and mixtures	Not classified	- -	-	-	UNRTDG Class: 8	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2006	GHS Classification Manual （10 Feb, 2006）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Organic compounds containing chlorine (but not oxygen and fluorine) chemically bonded only to carbon and hydrogen (but not to other elements).	FY2006	GHS Classification Manual （10 Feb, 2006）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Containing no -0-0- structure	FY2006	GHS Classification Manual （10 Feb, 2006）
16	Corrosive to metals	Classification not possible	- -	-	-	Although classified into the class 8 according to UNRTDG, there is no data used as the basis of metal corrosiveness.	FY2006	GHS Classification Manual （10 Feb, 2006）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	Calculated based on rat LD50 value: 736mg/kg (CERI Hazard Data (2002)), ACGIH (7th, 2001), DFGOT vol.6 (1994)), 1249mg/kg (SIDS (2004)), 1590mg/kg (SIDS (2004)), and 702mg/kg (SIDS (2004)). Since the calculated values was 718.3mg/kg, it was set as Category 4.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Dermal)	-	- Warning	-	-	Based on rabbit LD50 value: 4000mg/kg (CERI Hazard Data (2002), SIDS (2004), DFGOT vol.6 (1994)), and rat LD50 value: >5000mg/kg (SIDS (2004)), the lower value was adopted and it was set as Category 5.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Vapours)	Category 1	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	Lowar value was adaptted based on the rat LC50 with 4-hour exposure: 0.53mg/L (SIDS (2004)) and rat LC50 with 1 hour exposure: 8.39mg/L (4-hour equivalent is 4.2mg/L) (SIDS (2004), DFGOT vol.6 (1994)). 0.53mg/L was indicated steam with almost no mist from the vapor pressure. So it was classified according to the ppm concentration standard. It was classified as Category 1 based on the equivalent value (conversion coefficient: 1ppm =7.99mg/m3) was 66ppm.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	It was classified as Category 2 from descriptions that irritation was observed in the application test on rabbit skin (CERI Hazard Data (2002) and SIDS (2004)) and from the report of human skin irritation (IARC 29 (1982) and CERI Hazard Data (2002)).	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Serious eye damage/eye irritation	Category 2A	Warning	H319	P305+P351+P338 P337+P313 P264 P280	From Descriptions that severe irritation was acknowledged by apply to the eye of the rabbit on CERI Hazard Data (2002) and SIDS (2004), and that change acknowledged by apply to the eye of the rabbit was recovered within 14 days on SIDS (2004), and that IARC 29 (1982) and CERI Hazard Data(2002) had eye or mucosal irritation reports in humans. So it was set as Category 2A.	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Skin sensitization	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Germ cell mutagenicity	Category 2	Warning	H341	P308+P313 P201 P202 P280 P405 P501	The substance was classified as Category 2. Because there are positive results from the chromosome aberration tests using rat bone-marrow cells, which are in vivo mutagenicity tests using somatic cells (CERI Hazard Data (2002), SIDS (2004), DFGOT vol.6 (1994)), and there is no positive result from in vivo genotoxicity tests using germ cells.	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Carcinogenicity	Category 1B	Danger	H350	P308+P313 P201 P202 P280 P405 P501	It is classified into 1 in Japan Society for Occupational Health (2005) and is classified into B-2 according to EPA (IRIS (Access on Oct 2005)). But it is classified into A2 according to IARC 29 (1982), and into 2A according to ACGIH (7th, 2001), and into R according to NTP (NTP RoC (11th, 2005)), and classified into category 2 according to EU (EU ANNEX-I (Access on Oct 2005)). So it was set as Category 1B.	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	Since there is the description that there was skeletal malformation of embryo in the dose no general toxicity to maternal animals in the teratogenicity test of rat oral administration during organogenesis stage (SIDS (2004) and CERI Hazard Data (2002)), it is classified into the Category 2.	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Specific target organ toxicity - Single exposure	Category 3 (narcotic effects, respiratory tract irritation)	Warning	H336 H335	P304+P340 P403+P233 P261 P271 P312 P405 P501	In the description that excitability of the central nervous system was observed by inhalation exposure at low concentration in the range of guidance value of Category 1in rat and mouse in CERI Hazard Data (2002), ACGIH (7th, 2001), IARC 29 (1982) and DFGOT vol.6 (1994), it was judged that it has anesthetic actions. Moreover, due to the descriptions that the airway mucosa irritation was observed by inhalation exposure in rat and mouse in CERI Hazard Data (2002), ACGIH (7th, 2001), IARC 29 (1982), and DFGOT vol.6 (1994), and that it has the respiratory irritantation and the mucosa irritation in human in IARC 29 (1982) and CERI Hazard Data (2002), it is judged it has respiratory irritation, it was classified into Category 3 (anesthesia action, respiratory irritant).	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Specific target organ toxicity - Repeated exposure	Category 1 (liver, kidney, thyroid, blood, respiratory organs)	Danger	H372	P260 P264 P270 P314 P501	Due to the descriptions that in CERI Hazard Data (2002), SIDS (2004), and DFGOT vol.6 (1994), by the oral feeding administration tests using the rats, histologic changes was observed in the liver, the kidney and the thyroid gland, and that in CERI Hazard Data (2002), SIDS (2004), ACGIH (7th, 2001), IARC 29 (1982), or DFGOT vol.6 (1994), by the inhalation exposure test using the rat, leukopenia, mild anemia, renal dysfunction, bronchitis, pneumonia, or the fatty change of liver were observed, the liver, the kidney, thyroid, blood and respiratory systems were considered as target organs. Since all effects were observed by exposure within the guidance value of Category 1, these were classified into Category 1.	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Aspiration hazard	Category 2	Warning	-	-	Since description of "there is a risk of causing chemical pneumonitis by aspiration in swallowing fluid "( ICSC (J) (1995)) was judged to be described based on the evidence of humans etc., we classified into Category 2.	FY2006	GHS Classification Manual （10 Feb, 2006）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 3	- -	H402	P273 P501	From 24-hour EC50 = 50 mg/L for crustacea (Daphnia magna) (SIDS, 2005), it was classified in Category 3.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
11	Hazardous to the aquatic environment Long term (Chronic)	Not classified	- -	-	-	Reliable chronic toxicity data were not obtained. Benzylidyne trichloride rapidly hydrolyzes in water into benzoic acid which is judged to be rapidly degradable (a degradation rate by BOD: 85% (the existing chemicals survey program, 1979)) and hydrochloric acid (SIDS, 2005). Though benzylidyne trichloride is classified in Category 3 in acute toxicity, the benzoic acid as a decomposition product has rapid degradability and a low bioaccumulation estimate (BCF for benzoic acid = 10 (SIDS, 2005)), therefore, it was classified as "Not classified." Besides, 48-hour EC50 of pH-adjusted benzylidyne trichloride was > 100 mg/L for crustacea (Daphnia magna) (SIDS, 2005).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in Annexes to the Montreal Protocol.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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