NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	98-94-2
Chemical Name	N,N-Dimethylcyclohexylamine
Substance ID	m-nite-98-94-2_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Category 3	Warning	H226	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	Based on a flash point of 42.2 deg C (closed cup) (ICSC (J) (2002)), it was classified in Category 3. It is classified in Class 8, Subsidiary risk 3, PGII in UNRTDG (UN 2264).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 215 deg C (ICSC (J) (2002)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Organic compounds containing no oxygen, fluorine or chlorine	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 3	Danger	H301	P301+P310 P264 P270 P321 P330 P405 P501	There are 2 reports of LD50 values of 272-289 mg/kg (SIAP (2012)) and 348 mg/kg (PATTY (6th, 2012)) for rats. One corresponds to Category 3, and the other corresponds to Category 4. Since the category with higher hazard was adopted, it was classified in Category 3. The category was changed from the previous classification by using the new information source.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Category 3	Danger	H311	P302+P352 P361+P364 P280 P312 P321 P405 P501	Based on the reports of LD50 values of 370 mg/kg (PATTY (6th, 2012)) and 380 mg/kg (SIAP (2012)) for rats, it was classified in Category 3.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Category 2	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	Based on the report of an LC50 value by 2-hour inhalation of 1900 mg/m3 (365.1 ppm, converted 4-hour equivalent value: 258.2 ppm) for rats, it was classified in Category 2. Besides, since the LC50 value is lower than 90% of the saturated vapor pressure concentration (3,960 ppm), the reference value in units of ppm was applied as vapour with little mist.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	Based on a report that it was corrosive in a skin irritation test with rabbits, and a description that the 5 g/L aqueous solution of this substance was pH 12 (GESTIS (Access on May 2017)), and that the corrosive properties were attributable to the alkaline properties of the aqueous solution of this substance (SIAP (2012)), it was classified in Category 1.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	Based on a report that conjunctival injection, lacrimation, oedema of the conjunctiva and blepharospasm were observed in eye irritation tests with rabbits, and the description that the 5 g/L aqueous solution of this substance was pH 12 (GESTIS (Access on May 2017)), and that the corrosive properties were attributable to the alkaline properties of the aqueous solution of this compound (SIAP (2012)), it was classified in Category 1.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Classification not possible	- -	-	-	There is a report that it is negative in a skin sensitization test with guinea pigs (PATTY (6th, 2012), GESTIS (Access on May 2017)), however, since the experimental conditions such as the number of animals were unknown, it was classified as "Classification not possible."	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Classification not possible	- -	-	-	In a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test (OECD TG 422) with rats by feeding, general toxicity and reproductive toxicity were not seen at up to the highest dose (1,500 ppm), and lowered body weight was observed in pups at the middle dose (500 ppm) or more (SIAP (2012)). The effect on pups was a minor one which is not regarded as evidence for classification. It is difficult to classify it as "Not classified" with only this result since this test is a screening test. It was classified as "Classification not possible" due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Category 1 (central nervous system), Category 3 (respiratory tract irritation)	Danger Warning	H370 H335	P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312	There is no information on single exposure to this substance in humans. As for experimental animals, there are reports that in tests with rats, mice, rabbits and guinea pigs, weakness, tremor, salivation, gasping, and convulsions were observed in either the oral, dermal or inhalation routes, and adding to these symptoms, irritation of the respiratory organs was seen in inhalation exposure (PATTY (6th, 2012)). In these studies, although there is no detailed description of the dosage at which effects were observed, it is reported that the oral LD50 value is 320-620 mg/kg corresponding to Category 2, the dermal LD 50 value and the inhalation LC50 value (converted 4-hour equivalent value) are 370 mg/kg and 149.5-258.2 ppm, respectively, corresponding to Category 1; and it is considered that the effects were seen at doses near or at the LD50 values. In addition, in SIAP (2012), there is no detailed description of dosage in rats, but as toxic symptoms due to oral and dermal acute exposure to quaternary amines including this substance, effects on respiration, gait and standing posture, convulsions, tremor, ataxia, and lethargy were reported. Since the oral and dermal LD50 values of this substance for rats are reported to be 272-289 mg/kg and 380 mg/kg corresponding to Category 1, respectively (SIAP (2012)), it is considered that these effects were seen within the dose range for Category 1 near the LD50 values. From the above, this substance is considered to affect the central nervous system, and to be irritating to the respiratory tract. Therefore, it was classified in Category 1 (central nervous system), Category 3 (respiratory tract irritation).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	There is no information on humans. As for experimental animals, there is a report that in a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test (OECD TG 422) with rats by feeding, neither systemic nor local toxicity occurred at 1500 ppm (male: 91-104 mg/kg/day (converted guidance value: 28-32 mg/kg/day), female: 85-147 mg/kg/day (converted guidance value: 26-46 mg/kg/day)), which is the highest dose for the test and is within the guidance value range for Category 2 (SIAP (2012)). However, since it is the highest dose in the test, the effect at any dose which exceeds this but is within the guidance value range, is unknown. Therefore, the classification was not possible. In addition, in a 9-time inhalation exposure test with rats, there was a report of mild hyperplasia and hypertrophy of the nasal mucosa at 0.39 mg/L (SIAP (2012)). However, this was not adopted for classification because the exposure period was short and the exposure frequency was unknown. From the above, classification was not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, based on the numerical data (viscosity: 1.16 mPa*s (25 deg C), density: 0.85 g/cm3 (20 deg C)) listed in GESTIS (Access on May 2017), the kinematic viscosity is calculated as 1.36 mm2/sec (25/20 deg C).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 2	- -	H401	P273 P501	Although 72-hour EC50 (rate method) >2 mg/L for algae (Desmodesmus subspicatus) (OECD SIDS 2012), the toxicity value for the target substance is judged to be around 2mg/L due to 72-hour EC50 (area method) = 0.79 mg/L for algae. Therefore, it was classified in Category 2.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 2	-	H411	P273 P391 P501	Reliable chronic toxicity data were not obtained. Due to being not rapidly degradable (BIOWIN), and acute toxicity Category 2, it was classified in Category 2.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

To GHS Information