Item | Information |
---|---|
CAS RN | 99-99-0 |
Chemical Name | p-Nitrotoluene |
Substance ID | m-nite-99-99-0_v2 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified |
- |
- | - | UNRTDG Class: 6.1 | FY2006 | GHS Classification Manual (10 Feb, 2006) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products | FY2006 | GHS Classification Manual (10 Feb, 2006) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
7 | Flammable solids | Classification not possible |
- |
- | - | Although there is information of flash point and ignition point (ICSC (J) (2000) and others), there is no data with defined test method. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
8 | Self-reactive substances and mixtures | Not classified |
- |
- | - | Classified in UNRTDG Class: 6.1 | FY2006 | GHS Classification Manual (10 Feb, 2006) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
10 | Pyrophoric solids | Not classified |
- |
- | - | Flash point: 450degC (ICSC (J), 2000) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances at 140degC are not available. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2006 | GHS Classification Manual (10 Feb, 2006) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
14 | Oxidizing solids | Not classified |
- |
- | - | UNRTDG Class: 6.1 | FY2006 | GHS Classification Manual (10 Feb, 2006) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Containing no -0-0- structure | FY2006 | GHS Classification Manual (10 Feb, 2006) |
16 | Corrosive to metals | Not classified |
- |
- | - | UNRTDG Class: 6.1 | FY2006 | GHS Classification Manual (10 Feb, 2006) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | - |
Warning |
- | - | Calculated based on rat LD50 value: 1960mg/kg, 7100mg/kg (CERI Hazard Data, 2000), 3200mg/kg (SIDS, 2002, IARC 65, 1996), 2144mg/kg (SIDS, 2002, IARC 65, 1996, NTP TR 498, 2002) and >2250mg/kg (SIDS, 2005). Since the calculated values was 2014mg/kg, it was classified to category 5. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | It was set as the outside of Category from the description that death was not observed in both exposure for 24 hours of 20000mg/kg using a rabbit and exposure for 6 hours of 16000mg/kg using rat (SIDS (2005)). | FY2006 | GHS Classification Manual (10 Feb, 2006) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | There is the description that rat LC50 (1 hour) value: >758ppm (4-hour corresponding values 1.06mg/L) (CERI Hazard Data (2000)), and that death was not acknowledged in the test which used rats by 1-hour exposure of 4.167mg/L (4-hour corresponding values 1.042mg/L) and 4-hour exposure of 152ppm (corresponding values 0.851mg/L) (SIDS (2005)). But the category could not be specified from these data. Therefore, it cannot be classified since data is insufficient. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
2 | Skin corrosion/irritation | Not classified |
- |
- | - | In the test applied to the skin of the rabbit on SIDS (2005), from description that irritation was not acknowledged by zero of Draize score, it was carried out the outside of Category. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
3 | Serious eye damage/eye irritation | Not classified |
- |
- | - | There is the description that in the test applied to the eye of the rabbit, effect was not acknowledged in corneal and iris (SIDS (2005)). And Draize score was between 1 and 2. As judging that it is not applicable to the acceptance criteria of irritation, it was set as the outside of Category. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data | FY2006 | GHS Classification Manual (10 Feb, 2006) |
4 | Skin sensitization | Not classified |
- |
- | - | We classified it as Out Of Category based on the description of SIDS (2005) that in single injection adjuvant test and Buehler test using the guinea pigs sensitizing property was not acknowledged. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
5 | Germ cell mutagenicity | Not classified |
- |
- | - | Since there was a negative result with the micronucleus test on rat and mouse red corpuscles which is an in vivo mutagenicity test using somatic cells (SIDS, 2005, NTP DB, 2005), it was classified as out of Category. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
6 | Carcinogenicity | Category 2 |
Warning |
H351 | P308+P313 P201 P202 P280 P405 P501 |
[Rationale for the Classification] Based on (1) to (3), tumor incidence was observed in two animal species, but it was not clear evidence in all cases, and therefore, it was classified in Category 2. Based on the new findings, the classification result was changed. [Evidence Data] (1) It was reported that, in a carcinogenicity study with rats dosed by feeding for two years, at 2,500 ppm, a significant increase in the combined incidence of clitoral gland adenoma or carcinoma was observed in females, and a significant increase in the incidence of subcutaneous fibroma or fibrosarcoma (combined) was observed in males, and as for carcinogenicity of this substance, equivocal evidence was obtained in males, and some evidence was obtained in females (NTP TR498 (2002)). (2) In a test with B6C3F1 mice dosed by feeding for 105 or 106 weeks, at 5,000 ppm, a significant increase in the combined incidence of bronchiolar/alveolar adenoma or carcinoma was observed in males, and as for carcinogenicity of this substance, equivocal evidence was obtained in males. Besides, it was reported that, as preneoplastic lesions related to lung tumor observed in males, alveolar epithelial bronchiolization and hyperplasia were observed in males and females (NTP TR498 (2002)). (3) As for the classification results by domestic and international organizations, the DFG classified it in Category 3 (DFG MAK (2007)) based on the data in (1) and (2). [Reference Data, etc.] (4) In addition, as for the classification results by international organizations, the IARC classified this substance in Group 3 (IARC 65 (1999)). |
FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
7 | Reproductive toxicity | Not classified |
- |
- | - | There is a description that effect on fertility was not observed in the rat oral administration reproduction study at the dose causing systemic toxicity (SIDS (2005)) . Moreover, there is a description that although testicular atrophy with necrosis fubulus seminiferus contortus was observed but no effect on fertility and fetus were observed in rat oral administration reproductive test (CERI hazard data collection (2000), IARC 65 (1996) and SIDS (2005)). As mentioned above, it is classified out of Category. |
FY2006 | GHS Classification Manual (10 Feb, 2006) |
8 | Specific target organ toxicity - Single exposure | Category 1 (blood) |
Danger |
H370 | P308+P311 P260 P264 P270 P321 P405 P501 |
From description in CERI Hazard Data (2000) that methemoglobinemia occurs as acute effects on humans, it was set as Category 1 (blood). | FY2006 | GHS Classification Manual (10 Feb, 2006) |
9 | Specific target organ toxicity - Repeated exposure | Category 2 (blood, liver, immune system) |
Warning |
H373 | P260 P314 P501 |
Based on the description that in the feeding oral administration tests using the rat, the change which suggests the effects on the blood was observed with the dosage in the Category 2 guidance value range (SIDS (2005) and NTP TR 498 (2002)), and the description that in the immunotoxicity study at the 14-days oral administration using the mouse, swelling of hepatocytes and immune dysfunctions were observedwith the dosage in the Category 2 guidance value range (CERI Hazard Data (2000), ACGIH (7th, 2001), IARC 65 (1996), SIDS (2005), NTP TR 498 (2002) and NTP DB (2005)), it was classified into Category 2 (blood, liver, immune systems). | FY2006 | GHS Classification Manual (10 Feb, 2006) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 2 |
- |
H401 | P273 P501 |
It was classified in Category 2 from 48-hour EC50 (immobile) = 4.2 mg/L for crustacea (Daphnia magna) (OECD SIDS: 2003). | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 2 |
- |
H411 | P273 P391 P501 |
It was classified in Category 2 due to being not rapidly degradable (not readily degradable, a degradation rate by BOD: 0.8% (J-CHECK, 1974)), and 21-day NOEC (reproduction) = 0.7 mg/L for crustacea (Daphnia magna) (OECD SIDS: 2003). | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
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