NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	999-61-1
Chemical Name	2-Hydroxypropyl acrylate
Substance ID	m-nite-999-61-1_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive properties.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not an aerosol product.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Not classified	- -	-	-	A flash point is 97 degrees C (closed cup) (ACGIH (7th, 2001)).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Classification not possible	- -	-	-	There is an unsaturated bond (olefins) in the chemical structure, but the classification is not possible due to no data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an ignition point of 210 degrees C (GESTIS (Access on July 2015)).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	No established test method suitable for liquid substances.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Not containing metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	It is an organic compound which does not contain fluorine or chlorine but contains oxygen, and the oxygen is not chemically bonded to the elements other than carbon or hydrogen.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	It is an organic compound that does not contain bivalent -O-O- structure in the molecule.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	Due to no data, the classification is not possible.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	Two LD50 values of 250 to 500 mg/kg, 590 to 1,300 mg/kg (ACGIH (7th, 2001)) for rats were reported for a mixture of this substance and its isomer. Because one corresponds to Category 3 or 4, and the other corresponds to Category 4, it was classified in Category 4 to which most of the data correspond.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Category 2	Danger	H310	P302+P352 P361+P364 P262 P264 P270 P280 P310 P321 P405 P501	Two LD50 values of 170mg/kg and 250 mg/kg (ACGIH (7th, 2001)) were reported for rabbits. They correspond to Category 2 and 3, and it was classified in Category 2 to which lower LD50 value corresponds.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	The classification is not possible due to lack of data. It is reported that 7 to 8-hour inhalation in rats to the saturated vapour (room temperature) of this substance (supposing that the saturated vapour concentration is 9.8x10-4 ppm, converted to a 4-hour equivalent: 1.3-1.4x10-3 ppm) resulted in no death, and deaths were observed after 4-hour inhalation to the saturated vapour of this substance (650 ppm) generated at 100 degrees C (ACGIH (7th, 2001)), but the category cannot be determined. Besides, a vapour is assumed from the information "tested on the saturated vapour."	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Due to lack of data, the classification is not possible.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	It is reported that in a skin irritation test using rabbits, moderate edema and moderate to severe necrosis were observed after this substance (170 to 250 mg/kg) was locally applied, and moderate chemical burns were found after application of a 10% aqueous solution (ACGIH (7th, 2001)). Moreover, it is reported that moderate irritation was found after open application of an isomer mixture containing 75% this substance (25% 1-hydroxy-2-propyl acrylate) to rabbit skin (DFGOT vol. 16 (2001)). Furthermore, it is reported that severe deep-seated necrosis was observed after 15-minute or 4-hour occlusive application of an isomer mixture containing 66% this substance (33% 1-hydroxy-2-propyl acrylate, 1% free acrylic acid or 1-hydroxy-3-propyl acrylate) (animal species: unknown) (DFGOT vol. 16 (2001)). From the above reports, the substance was classified in Category 1. Besides, it is classified in "Skin. Corr. 1B H314" in EU CLP classification (ECHA CL Inventory (Access on September 2015)).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	It is reported that severe eye irritation and corneal damage were observed after application of this substance (0.1 mL) into rabbit eyes (ACGIH (7th, 2001)), and that marked eye irritation was found after exposure to the vapour of this substance in rats (HSDB (Access on August 2015)). Moreover, this substance was classified in Category 1 in Skin Corrosion/Irritation. From the above, it was classified in Category 1.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	Due to lack of data, the classification is not possible.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	It is reported that it was sensitizing in a sensitization test using guinea pigs (ACGIH (7th, 2001)), and it was only weakly sensitizing in the other sensitization test using guinea pigs (ACGIH (7th, 2001)). Moreover, there are multiple reports from human patch tests using an isomer mixture of hydroxypropyl acrylate reporting that it is sensitizing (DFGOT vol. 16 (2001)). ACGIH (7th, 2001) classified this substance as a sensitizer. As above, due to positive reports from sensitization tests using this substance as well as multiple positive reactions reported in human patch tests using an isomer mixture, this substance was classified in Category 1. Besides, it is classified in "Skin Sens. 1 H317" in EU CLP classification (ECHA CL Inventory (Access on September 2015)).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	The classification is not possible due to lack of data. There are no in vivo data, and as for in vitro, negative and positive results were reported in a bacterial reverse mutation test (DFGOT vol. 16 (2001); PATTY (6th, 2012)).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Classification not possible	- -	-	-	Due to lack of data, the classification is not possible.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Classification not possible	- -	-	-	Due to lack of data, the classification is not possible.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Category 3 (Respiratory tract irritation)	Warning	H335	P304+P340 P403+P233 P261 P271 P312 P405 P501	From the information that this substance is irritating to the respiratory tract (ACGIH (7th, 2001), DFGOT vol. 16 (2001), PATTY (6th, 2012)), it was classified in Category 3 (respiratory tract irritation). The previous classification was revised.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Category 1 (respiratory organs)	Danger	H372	P260 P264 P270 P314 P501	There is no information for this substance alone. As information for an isomer mixture of propyl acrylate (this substance = 74%, 1-hydroxy-2-propyl acrylate = 25%, acrylic acid = 0.73%), in a 1-month (20 to 21 administration) inhalation toxicity test using dogs, rats, rabbits, and mice, effects on the respiratory system such as squamous epithelial metaplasia and ulceration in the mucous membranes of the nasal concha, mucopurulent rhinitis, nasal mucosa inflammation, laryngitis, tracheitis, bronchitis, and pneumonia were observed at 5 ppm (converted to a Guidance value equivalent: 0.006 mg/m3) within a range of Category 1 or higher in dogs, rats, and rabbits (DFGOT vol. 16 (2001)). As above, because effects on respiratory organs were found within a range of Category 1, the substance was classified in Category 1 (respiratory system).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	Due to lack of data, the classification is not possible.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 2	- -	H401	P273 P501	From 96-hour LC50 = 3100 micro g/L for fish (Pimephales promelas) (HSDB, 2012; AQUIRE, 2016), it was classified in Category 2.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Not classified	- -	-	-	Reliable chronic toxicity data were not obtained. Due to rapid degradability (readily degradable: a degradation rate by 28-day BOD = 83%, a degradation rate by TOC = 93%, a degradation rate by HPLC = 100% (Official Bulletin of Economy, Trade and Industry, 2001)), a low bioaccumulation estimate (LogPow = 0.35 (PHYSPROP Database, 2009)) although acute toxicity Category 2, it was classified as "Not classified."	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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