NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN
Chemical Name	Tetrachlorodifluoroethane; CFC-112
Substance ID	m-nite-nocas-0005_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	Containing no chemical groups with explosive properties	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Classified as "solid" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Classified as "solid" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Classified as "solid" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Classified as "solid" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Flammable solids	Not classified	- -	-	-	Non-flammable (ICSC (2004)).	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	Containing no chemical groups with explosive or self-reactive properties	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Classified as "solid" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Pyrophoric solids	Not classified	- -	-	-	Non-flammable (ICSC (2004)).	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Self-heating substances and mixtures	Not classified	- -	-	-	Non-flammable (ICSC (2004)).	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)	FY2006	GHS Classification Manual （10 Feb, 2006）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Classified as "solid" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Organic compounds containing fluorine and chlorine (but not oxygen), with the fluorine and chlorine bound to carbon and hydrogen (but not to other elements)	FY2006	GHS Classification Manual （10 Feb, 2006）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no "-O-O-" structure	FY2006	GHS Classification Manual （10 Feb, 2006）
16	Corrosive to metals	Classification not possible	- -	-	-	No data available on substances with melting point of <55degC (melting point: 40.6degC (1,2,2,2-tetrachloro-1,1-difluoroethane, ICSC (2004)), melting point: 26degC (1,1,2,2-tetrachloro-1,2-difluoroethane, ICSC (2004))).	FY2006	GHS Classification Manual （10 Feb, 2006）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	1,1,1,2-Tetrachloro-2,2-difluoroethane yields the rat LD50 (oral route) value of >8,000mg/kg (HSDB (2006)), which is "Not classified." 1,1,2,2-Tetrachloro-1,2-difluoroethane yields the mouse LD50 (oral route) value of 800mg/kg (HSDB (2006)), which is classified as Category 4. Based on the lower of the two testing data (800mg/kg), tetrachlorodifluoroethane is included in Category 4.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Gases)	Classification not possible	- -	-	-	Due to the fact that the substance is a solid according to the GHS definition and inhalation of its gas is not expected.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Vapours)	-	- Warning	-	-	1,1,1,2-Tetrachloro-2,2-difluoroethane yields the rat LC50 (inhalation route) value of 125.04mg/L (4 hours) (ACGIH (7th, 2001)), which is classified as Category 5 (saturated vapour concentration of 659mg/L under a saturated vapour pressure of 8.00 kPa (25degC) (HSDB (2006))). 1,1,2,2-Tetrachloro-1,2-difluoroethane yields the LC50 value of 25mg/L (4 hours) calculated from the mouse LC50 of 50mg/L (2 hour inhalation) (RTECS (2006)), which is classified as Category 5 (saturated vapour concentration of 555mg/L under a saturated vapour pressure of 6.73kPa (25degC) (HSDB (2006))).	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Skin corrosion/irritation	Category 3	- Warning	-	-	Based on the description in the report on rabbit skin irritation tests (EHC (1990)): Caused "histological changes in skin musculature" (1,1,1,2-Tetrachloro-2,2-difluoroethane). Based on the description in the report on rabbit skin irritation tests (exposure duration unknown) (EHC (1990)): Caused "skin erythema but no systematic or histological effects." Also based on the evidence of "mild" irritation from guinea pig skin irritation tests (24 hour application) and the evidence of human health effects: "Mildly irritating to the respiratory tract and skin" (RTECS (2006)) (1,1,2,2-Tetrachloro-1,2-difluoroethane).	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	Based on the description in the report on rabbit eye irritation tests (HSDB (2006)): "Mild conjunctival irritation." Also based on the description of the human health effects (HSDB (2006)): "Mildly irritating to the eye." The substance is thus considered a mild eye irritant (1,1,2,2-Tetrachloro-1,2-difluoroethane).	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Skin sensitization	Classification not possible	- -	-	-	According to the description in EHC (1990), a skin sensitization tests showed no indication of sensitization in guinea pigs. However, classification is not possible, with only one set of data showing "negative" available (1,1,2,2-Tetrachloro-1,2-difluoroethane).	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Germ cell mutagenicity	Not classified	- -	-	-	Based on negative data on multi-generation mutagenicity tests (dominant lethal tests), described in EHC 113 (1990), DFGOT vol.1 (1990) and NTP DB (Access on July 2006).	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Carcinogenicity	Classification not possible	- -	-	-	Classification not possible based on expert judgment in the absence of existing classification, though EHC 113 (1990) and DFGOT vol.1 (1990) provide some toxicity data.	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Reproductive toxicity	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Specific target organ toxicity - Single exposure	Category 2 (respiratory organs, cardiovascular system, central nervous system)	Warning	H371	P308+P311 P260 P264 P270 P405 P501	Based on the human evidence: "Acute inhalation exposure to high concentrations can cause pulmonary edema; may adversely affect the cardiovascular/central nervous system, causing cardiopathy and central nervous depression; may involve a lowering of consciousness" (ICSC (J) (2003)). However, since the referenced study is assigned a priority rating of 2, these effects are classified into Category 2.	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	Insufficient data available	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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