NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN
Chemical Name	Poly(oxyethylene) alkyl ether (alkyl C=12-15)
Substance ID	m-nite-nocas-0007_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)
Sample SDS by MHLW (External link)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	Containing no chemical groups with explosive properties	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Classified as "liquid" according to GHS definition (poly(oxyethylene)dodecyl ether, when 10 moles of ethylene oxide added (EO10))	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Classified as "liquid" according to GHS definition (poly(oxyethylene)dodecyl ether, when 10 moles of ethylene oxide added (EO10)).	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Classified as "liquid" according to GHS definition (poly(oxyethylene)dodecyl ether, when 10 moles of ethylene oxide added (EO10)).	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Flammable liquids	Not classified	- -	-	-	The flash point is >93degC (c.c.) (NFPA (2002)) (poly(oxyethylene)dodecyl ether (the number of ethylene oxide units unknown)).	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Classified as "liquid" according to GHS definition (poly(oxyethylene)dodecyl ether, when 10 moles of ethylene oxide added (EO10)).	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	Containing no chemical groups with explosive or self-reactive properties	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Pyrophoric liquids	Not classified	- -	-	-	Considered non-pyrophoric when in contact with air at ordinary temperatures since the substance is used as laundry detergents (CERI-NITE Hazard Assessment (2006))	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Classified as "liquid" according to GHS definition (poly(oxyethylene)dodecyl ether, when 10 moles of ethylene oxide added (EO10)).	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test method applicable to liquid substances are not available (solidification point: 16degC (poly(oxyethylene)dodecyl ether, when 10 moles of ethylene oxide added, HSDB (2006)), test temperature: 140degC).	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)	FY2006	GHS Classification Manual （10 Feb, 2006）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Organic compounds containing oxygen (but not fluorine and chlorine), with oxygen bound to carbon and hydrogen (but not to other elements)	FY2006	GHS Classification Manual （10 Feb, 2006）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Classified as "liquid" according to GHS definition (poly(oxyethylene)dodecyl ether, when 10 moles of ethylene oxide added (EO10)).	FY2006	GHS Classification Manual （10 Feb, 2006）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no "-O-O-" structure	FY2006	GHS Classification Manual （10 Feb, 2006）
16	Corrosive to metals	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	Based on the rat LD50 (oral route) value of 544mg/kg representing the lower of the two testing data, 544mg/kg (alkyl C14-15, EO11) and 9,800mg/kg (alkyl C10,12,14, EO2-7) (CERI-NITE Hazard Assessment No.89 (2005)).	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	As suggested in public comments, the lung injury observed in a dermal study of rabbits was caused by swallowing of forage particles and entry into the airway by rabbits, and it is thought that it was not a direct dermal impact. Therefore, it is classified from a dermal study of rats without adopting the above dermal study of rabbits as the GHS classification. Since there is no mortality even in LD50: >2,000 (mg/kg) and 8,000 mg/kg of rats, it was classified into "Not classified".	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Due to the fact that the substance is a liquid according to the GHS criteria and inhalation of its gas is not expected..	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Dusts and mists)	Category 4	Warning	H332	P304+P340 P261 P271 P312	Based on the rat LC50 (inhalation route) value of 1.5mg/L (alkyl C12-13, EO6) (4 hours).	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	Based on the description in the report on rabbit skin irritation tests (CERI-NITE Hazard Assessment No.89 (2005)): "Two undiluted test materials with different chain lengths (Alkyl C12-13, EO chain length unknown; C12-15, EO chain length unknown) produced moderate to severe irritation when applied for 24 (not 4) hours."	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	Based on the description in the report on rabbit eye irritation tests (CERI-NITE Hazard Assessment No.89 (2005)): "Two test materials with different chain lengths (Alkyl C12-13, EO6; C14-15, EO7) produced severe irritation when applied neat. The reactions persisted for at least 35 days." Both materials are "very strongly irritating, with effects not resolving within 21 days," and thus considered to be "irreversible."	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Skin sensitization	Classification not possible	- -	-	-	Insufficient data available	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Germ cell mutagenicity	Not classified	- -	-	-	Based on the absence of data on multi-generation mutagenicity tests and in vivo germ cell mutagenicity tests, and negative data in in vivo somatic cell mutagenicity tests (chromosome aberration tests and micronucleus tests), described in CERI-NITE Hazard Assessment No.89 (2005).	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Carcinogenicity	Classification not possible	- -	-	-	Classification not possible based on a judgment made by experts in the absence of existing classification, though CERI-NITE Hazard Assessment No.89 (2005) presents some toxicity data.	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Reproductive toxicity	Not classified	- -	-	-	Based on no evidence of reproductive effects observed in rat reproductive toxicity studies and teratogenicity studies, described in CERI-NITE Hazard Assessment No.89 (2005).	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Specific target organ toxicity - Single exposure	Category 3 (Narcotic effects)	Warning	H336	P304+P340 P403+P233 P261 P271 P312 P405 P501	Based on the evidence from animal studies including "somnolency, increased mobility," and "ataxia" (RTECS 2006).	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	Insufficient data available	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	C14AE1: It was classified into Category 1 from 48 hours EC50=0.14mg/L of the crustacea (Daphnia magna) (CERI/NITE Hazard Assessment Report (2005)). C14-15AE7: It was classified into Category 1 from 48 hours LC50=0.62mg/L of the crustacea (Daphnia magna) (CERI/NITE Hazard Assessment Report (2005)). C12-15AE12: It was classified into Category 2 from 48 hours EC50=1.4mg/L of the crustacea (Daphnia magna) (CERI/NITE Hazard Assessment Report (2005)). [NOTE] Since the toxicity of polyoxyethylene alkyl ether increases as ethylene oxide chain length decreases, it pointed to the category of several ethylene oxide chain length. In addition, polyoxyethylene alkyl ether described as CmAEn (m: alkyl carbon numbers, n: mole numbers of added ethylene oxide.).	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	C14-15AE7: Although the acute toxicity was Category 1 and it had potential to rapidly degrade (the decomposition by BOD(C12AE40): 74% (CERI/NITE Hazard Assessment Report (2005))), since it had potential to bioaccumulate (BCF=700-800(C14AE7) (CERI/NITE Hazard Assessment Report (2005))), it was classified into Category 1. C14AE1, C12-15AE12: Although it had potential to rapidly degrade (the decomposition by BOD(C12AE40): 74% (CERI/NITE Hazard Assessment Report (2005))), since there was no data about bioaccumulation of each component (as the bioaccumulation depends on alkyl carbon numbers and mole numbers of added ethylene oxide), classification is not possible. [NOTE] Since the toxicity of polyoxyethylene alkyl ether increases as ethylene oxide chain length decreases, it pointed to the category of several ethylene oxide chain length. In addition, polyoxyethylene alkyl ether described as CmAEn (m: alkyl carbon numbers, n: mole numbers of added ethylene oxide.).	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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