NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN
Chemical Name	polybrominated biphenyl
Substance ID	m-nite-nocas-0009_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)
Sample SDS by MHLW (External link)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Flammable solids	Not classified	- -	-	-	Non-flammable (HSDB (2003))	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive or self-reactive properties present in the molecule.	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Pyrophoric solids	Not classified	- -	-	-	Not classified because of "Not flammable" (HSDB, 2003)	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Self-heating substances and mixtures	Not classified	- -	-	-	Not classified because of non-flammable (HSDB, 2003)	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2006	GHS Classification Manual （10 Feb, 2006）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Containing no oxygen , chlorine and fluorine.	FY2006	GHS Classification Manual （10 Feb, 2006）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Containing no -0-0- structure	FY2006	GHS Classification Manual （10 Feb, 2006）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2006	GHS Classification Manual （10 Feb, 2006）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	There are 21500, 2000, >5000, >20000 mg/kg (EHC 152 (1994)), >2000 mg/kg (IARC 41 (1986)) and 17000 mg/kg (PATTY (5th, 2001)) as rat LD50, and it was set as the outside of Category based on these data.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	There are rabbit LD50s: 5000, 5000, > 10000, >10000, >8000mg/kg (EHC 152 (1994)), and there is rat LD50 >5000mg/kg (EHC 152 (1994)). It was set as the outside of Category based on these data.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Dusts and mists)	Not classified	- -	-	-	Based on the report that there is no mortality (EHC 152 (1994)) by 71 and 200mg/L (1h) (converted value for 4 hours are 17.8 and 50mg/L, respectively) in rats, it was set as the outside of Category.	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Skin corrosion/irritation	Category 3	- Warning	-	-	With a single or two-week repetition application, slight erythemas and edemas were observed on rabbit or guinea pig skin (EHC 152 (1994), ATSDR (2004)), and skin reactions was not observed depending on test conditions (ATSDR (2004)), therefore, it was classified as Category 3.	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	Based on what by applying to the eyes of the rabbit, slight irritations, temporary redness, and edema corneal are acknowledged (ATSDR (2004), it was set as Category 2B.	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Skin sensitization	Not classified	- -	-	-	We classified it as Out Of Category since sensitizing property is not acknowledged in the skin sensitivity test using guinea pigs (EHC 152 (1994)).	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Germ cell mutagenicity	Not classified	- -	-	-	Based on the descriptions (EHC 152 (1994), NTP DB (2006)) that it gave negative for all of the in vivo mutagenicity tests (the chromosomal aberration test using the spermatogenic cells and marrow cells of the rat, the chromosomal aberration test using the mouse marrow cells, and micronucleus examination using the marrow cells of the mouse) using the germ cells and somatic cells, we classified it as Out Of Category.	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Carcinogenicity	Category 2	Warning	H351	P308+P313 P201 P202 P280 P405 P501	It was set as 2 based on being classified into 2B according to IARC (1987).	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	A cleft palate, a diaphragmatic hernia, a cerebral hernia and malformation of hydronephrosis to fetus in rat or mouse organogenetic period administration test are reported (EHC 152 (1994)), moreover, in pregnant period and/or lacting period administration test, lowering the rates of implantation, increasing the embryo resorptions, increasing the a fetal death, and increasing the weaning infant mortality are also described (EHC 152 (1994), ATSDR (2004)). However, since description was not seen about the general toxicity to parent, it was classified into Category 2.	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Specific target organ toxicity - Single exposure	Category 1 (liver)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	It is reported that a single-time oral administration of 10 - 13.3mg/kg of 3,3',4,4'-tetrabrominated biphenyl or 3,3',4,4',5,5'-hexabrominated biphenyl to a rat causes effects which mainly include diffuse cytomegaly and cytoplasmic vacuolation accompanied by sinusoidal obstruction in liver (EHC 152 (1994)). Therefore we classified it as Category 1 (liver). In addition, oral administration of FireMaster FF-1 showed the similar effects on liver in rats (PATTY (5th, 2001)).	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Specific target organ toxicity - Repeated exposure	Category 1 (liver, thyroid, kidney, nervous system, skin)	Danger	H372	P260 P264 P270 P314 P501	To rats or mice, in repeated oral administrations of the dosage below 10 mg/kg/day (as 90-day medication), liver hypertrophy accompanied by an elevations of liver enzymes, histological changesuch as vacuolization and hepatocyte hypertrophy [finding of liver] (EHC 152 (1994)), histological change such as hyperplasia accompanied by a thyroid hormones (T3, T4) decrease etc. [thyroid findings] (EHC 152(1994), ATSDR (2004)), chronic renal impairment [kidney findings] (EHC 152 (1994), and a locomotor activity decrease, decrease of the grip and the extensor reaction of front limb and hind limb (NTP TR398 (1993)) [nervous systems] are observed. On the other hand, huge and various surveillance study concerning the health of the humans are performed after the pollution accident in Michigan, U.S. Then, an evelation of liver enzymes, such as GPT and GOT, liver hypertrophy [finding of liver] (ATSDR (2004)), a hypothyroidism [thyroid findings] (EHC 152 (1994)), neurological symptoms, such as fatigue, concentration-lacking and depression, muscle weakness [nervous system findings] (EHC 152 (1994), ATSDR (2004)), and as systemic symptoms, skin condition such as acne, release, exfoliation, and erythema [skin observation] (ATSDR (2004)) are reported. It was classified into Category 1 (liver,thyroid,kidney,nervous systems,skin) based on the above informations.	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data available.	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

To GHS Information