BLAST table : Phosl_00230

DBUniProtKB
accessionDBalignmentEvalueScoreIdent.linkproductgeneorganismec
1
 Q6V1M3_9ACTO
(Q6V1M3)		 
[query] 1 - 692 (692)
[subject] 1 - 692 (692)
 0.0 1353   100% PlmM plmM Streptomyces sp. HK803
2
 B5GGE1_9ACTO
(B5GGE1)		 
[query] 1 - 686 (692)
[subject] 1 - 683 (687)
 0.0 728   65% 2,4-dienoyl-coa reductase (NADH) SSBG_03350 Streptomyces sp. SPB74
3
 F3Z6E3_9ACTO
(F3Z6E3)		 
[query] 1 - 686 (692)
[subject] 1 - 683 (687)
 0.0 726   66% Putative 2,4-dienoyl-CoA reductase (NADPH) STTU_5671 Streptomyces sp. Tu6071
4
 D9UEB2_9ACTO
(D9UEB2)		 
[query] 1 - 686 (692)
[subject] 1 - 681 (685)
 0.0 724   66% PlmM SSLG_00924 Streptomyces sp. SPB78
5
 D7P5V1_9ACTO
(D7P5V1)		 
[query] 1 - 686 (692)
[subject] 1 - 646 (667)
 1e-173 613   55% AsuB4 asuB4 Streptomyces nodosus subsp. asukaensis
6
 A0LU60_ACIC1
(A0LU60)		 
[query] 2 - 687 (692)
[subject] 8 - 689 (705)
 1e-156 557   52% 2,4-dienoyl-CoA reductase Acel_1198 Acidothermus cellulolyticus (strain ATCC 43068 / 11B) 1.3.1.34
7
 F7U2Q6_9BACL
(F7U2Q6)		 
[query] 1 - 686 (692)
[subject] 19 - 684 (684)
 1e-149 532   45% 2,4-dienoyl-CoA reductase fadH
BRLA_c48750		 Brevibacillus laterosporus LMG 15441 1.3.1.34
8
 C0ZGX5_BREBN
(C0ZGX5)		 
[query] 4 - 679 (692)
[subject] 5 - 660 (667)
 1e-141 506   44% Putative 2,4-dienoyl-CoA reductase [NADPH] BBR47_40570 Brevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599) 1.3.1.34
9
 D5WXT9_BACT2
(D5WXT9)		 
[query] 1 - 686 (692)
[subject] 1 - 695 (695)
 1e-139 501   42% NADH:flavin oxidoreductase/NADH oxidase Btus_1271 Bacillus tusciae (strain DSM 2912 / NBRC 15312 / T2)
10
 F4CVH4_9PSEU
(F4CVH4)		 
[query] 2 - 683 (692)
[subject] 7 - 672 (675)
 1e-134 484   44% 2,4-dienoyl-CoA reductase (NADPH) Psed_1556 Pseudonocardia dioxanivorans CB1190 1.3.1.34
11
 C7RNF5_ACCPU
(C7RNF5)		 
[query] 2 - 683 (692)
[subject] 6 - 671 (674)
 1e-132 478   42% NADH:flavin oxidoreductase/NADH oxidase CAP2UW1_4099 Accumulibacter phosphatis (strain UW-1)
12
 C8WSC1_ALIAD
(C8WSC1)		 
[query] 2 - 686 (692)
[subject] 10 - 668 (669)
 1e-132 477   44% NADH:flavin oxidoreductase/NADH oxidase Aaci_2399 Alicyclobacillus acidocaldarius subsp. acidocaldarius (strain ATCC 27009 / DSM 446 / 104-1A)
Bacillus acidocaldarius
13
 A3WNB0_9GAMM
(A3WNB0)		 
[query] 1 - 686 (692)
[subject] 7 - 676 (676)
 1e-132 476   40% NADH:flavin oxidoreductase, Old Yellow Enzyme family protein OS145_10515 Idiomarina baltica OS145
14
 C4K9M3_THASP
(C4K9M3)		 
[query] 2 - 690 (692)
[subject] 4 - 676 (967)
 1e-131 475   41% NADH:flavin oxidoreductase/NADH oxidase Tmz1t_2497 Thauera sp. (strain MZ1T)
15
 B5FFI3_VIBFM
(B5FFI3)		 
[query] 2 - 686 (692)
[subject] 3 - 667 (667)
 1e-131 475   39% 2,4-dienoyl-coa reductase (Nadph) VFMJ11_1762 Vibrio fischeri (strain MJ11) 1.3.1.34
16
 Q5E4A9_VIBF1
(Q5E4A9)		 
[query] 2 - 686 (692)
[subject] 3 - 667 (667)
 1e-131 474   39% 2,4-dienoyl-CoA reductase, NADH and FMN-linked fadH
VF_1642		 Vibrio fischeri (strain ATCC 700601 / ES114) 1.3.1.34
17
 Q0HIY3_SHESM
(Q0HIY3)		 
[query] 2 - 686 (692)
[subject] 3 - 672 (672)
 1e-130 472   39% 2,4-dienoyl-CoA reductase Shewmr4_1910 Shewanella sp. (strain MR-4) 1.3.1.34
18
 F8IIQ7_ALIAC
(F8IIQ7)		 
[query] 2 - 686 (692)
[subject] 10 - 668 (669)
 1e-130 471   44% NADH:flavin oxidoreductase/NADH oxidase fadH
TC41_2688		 Alicyclobacillus acidocaldarius
Bacillus acidocaldarius
19
 A8APX9_CITK8
(A8APX9)		 
[query] 2 - 683 (692)
[subject] 3 - 669 (672)
 1e-130 471   41% Putative uncharacterized protein CKO_04487 Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
20
 A0KWM7_SHESA
(A0KWM7)		 
[query] 2 - 686 (692)
[subject] 3 - 672 (672)
 1e-130 470   38% 2,4-dienoyl-CoA reductase Shewana3_1965 Shewanella sp. (strain ANA-3) 1.3.1.34
21
 Q1ZRT2_PHOAS
(Q1ZRT2)		 
[query] 2 - 686 (692)
[subject] 6 - 670 (670)
 1e-130 470   40% Putative 2,4-dienoyl-CoA reductase VAS14_05978 Photobacterium angustum (strain S14 / CCUG 15956)
Vibrio sp. (strain S14 / CCUG 15956)
22
 Q0HUZ9_SHESR
(Q0HUZ9)		 
[query] 2 - 686 (692)
[subject] 3 - 672 (672)
 1e-130 469   38% 2,4-dienoyl-CoA reductase Shewmr7_2068 Shewanella sp. (strain MR-7) 1.3.1.34
23
 Q1QZ72_CHRSD
(Q1QZ72)		 
[query] 2 - 686 (692)
[subject] 4 - 670 (670)
 1e-129 468   43% 2,4-dienoyl-CoA reductase Csal_0879 Chromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768) 1.3.1.34
24
 D0MRH2_PHYIT
(D0MRH2)		 
[query] 2 - 687 (692)
[subject] 4 - 676 (703)
 1e-129 468   38% 2,4-dienoyl-CoA reductase PITG_00703 Phytophthora infestans (strain T30-4)
Potato late blight fungus
25
 D0HJ19_VIBMI
(D0HJ19)		 
[query] 1 - 686 (692)
[subject] 1 - 666 (666)
 1e-129 468   40% 2,4-dienoyl-CoA reductase [NADPH] VMA_002550 Vibrio mimicus VM223 1.3.1.34
26
 Q2C5X3_9GAMM
(Q2C5X3)		 
[query] 2 - 686 (692)
[subject] 6 - 670 (670)
 1e-129 467   40% Putative 2,4-dienoyl-CoA reductase SKA34_19925 Photobacterium sp. SKA34
27
 Q8EEG3_SHEON
(Q8EEG3)		 
[query] 2 - 686 (692)
[subject] 3 - 672 (672)
 1e-129 467   38% 2,4-dienoyl-CoA reductase, putative SO_2419 Shewanella oneidensis
28
 B7DNL5_9BACL
(B7DNL5)		 
[query] 2 - 686 (692)
[subject] 10 - 668 (669)
 1e-129 467   44% NADH:flavin oxidoreductase/NADH oxidase AaLAA1DRAFT_0590 Alicyclobacillus acidocaldarius LAA1
29
 E4TRG5_MARTH
(E4TRG5)		 
[query] 2 - 686 (692)
[subject] 6 - 674 (674)
 1e-129 466   38% 2,4-dienoyl-CoA reductase Ftrac_0697 Marivirga tractuosa (strain ATCC 23168 / DSM 4126 / NBRC 15989 / NCIMB 1408 / VKM B-1430 / H-43)
Microscilla tractuosa
Flexibacter tractuosus		 1.3.1.34
30
 F7RVR0_9GAMM
(F7RVR0)		 
[query] 2 - 686 (692)
[subject] 5 - 673 (673)
 1e-129 466   41% NADH:flavin oxidoreductase A28LD_0331 Idiomarina sp. A28L
31
 D2YGL8_VIBMI
(D2YGL8)		 
[query] 1 - 686 (692)
[subject] 23 - 688 (688)
 1e-128 465   40% 2,4-dienoyl-CoA reductase fadH
VMB_26650		 Vibrio mimicus VM603
32
 D0GT22_VIBMI
(D0GT22)		 
[query] 1 - 686 (692)
[subject] 23 - 688 (688)
 1e-128 464   40% 2,4-dienoyl-CoA reductase [NADPH] VII_001834 Vibrio mimicus MB451 1.3.1.34
33
 E3G1T3_ENTCS
(E3G1T3)		 
[query] 2 - 679 (692)
[subject] 4 - 666 (673)
 1e-128 464   41% NADH:flavin oxidoreductase/NADH oxidase Entcl_0611 Enterobacter cloacae (strain SCF1)
34
 A3TPZ4_9MICO
(A3TPZ4)		 
[query] 2 - 686 (692)
[subject] 4 - 677 (677)
 1e-128 464   42% 2,4-dienoyl-CoA reductase JNB_17258 Janibacter sp. HTCC2649
35
 Q21X86_RHOFD
(Q21X86)		 
[query] 2 - 683 (692)
[subject] 4 - 670 (832)
 1e-128 464   41% 2,4-dienoyl-CoA reductase Rfer_1891 Rhodoferax ferrireducens (strain DSM 15236 / ATCC BAA-621 / T118) 1.3.1.34
36
 B7VLB8_VIBSL
(B7VLB8)		 
[query] 1 - 686 (692)
[subject] 5 - 670 (670)
 1e-128 463   39% 2,4-dienoyl-CoA reductase [NADPH] VS_0938 Vibrio splendidus (strain LGP32)
Vibrio splendidus (strain Mel32)
37
 A3UXW3_VIBSP
(A3UXW3)		 
[query] 1 - 686 (692)
[subject] 4 - 669 (669)
 1e-127 462   39% 2,4-dienoyl-CoA reductase V12B01_20658 Vibrio splendidus 12B01
38
 F8VF87_SALBN
(F8VF87)		 
[query] 2 - 686 (692)
[subject] 3 - 672 (672)
 1e-127 461   40% Putative 2,4-dienoyl-CoA reductase fadH
SBG_2854		 Salmonella bongori 1.3.1.34
39
 B8CMF8_SHEPW
(B8CMF8)		 
[query] 2 - 679 (692)
[subject] 3 - 664 (671)
 1e-127 461   38% 2,4-dienoyl-CoA reductase, putative swp_2472 Shewanella piezotolerans (strain WP3 / JCM 13877) 1.3.1.34
40
 D7B0B7_NOCDD
(D7B0B7)		 
[query] 2 - 683 (692)
[subject] 4 - 666 (669)
 1e-127 461   42% NADH:flavin oxidoreductase/NADH oxidase Ndas_4822 Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488)
Actinomadura dassonvillei		 1.3.1.34
41
 Q7P1P4_CHRVO
(Q7P1P4)		 
[query] 2 - 686 (692)
[subject] 4 - 673 (673)
 1e-127 461   41% 2,4-dienoyl-CoA reductase FadH1 fadH
CV_0169		 Chromobacterium violaceum 1.3.1.34
42
 A5L6G3_9GAMM
(A5L6G3)		 
[query] 1 - 686 (692)
[subject] 4 - 669 (669)
 1e-127 461   39% 2,4-dienoyl-CoA reductase VSWAT3_15584 Vibrionales bacterium SWAT-3
43
 Q5QX72_IDILO
(Q5QX72)		 
[query] 22 - 686 (692)
[subject] 1 - 649 (649)
 1e-127 461   40% NADH:flavin oxidoreductases, Old Yellow Enzyme family IL1748 Idiomarina loihiensis
44
 B5REH6_SALG2
(B5REH6)		 
[query] 2 - 686 (692)
[subject] 3 - 672 (672)
 1e-127 461   40% 2,4-dienoyl-CoA reductase [NADPH] (Ec 1.3.1.34) (2,4-dienoyl coenzyme A reductase) fadH
SG3115		 Salmonella gallinarum (strain 287/91 / NCTC 13346) 1.3.1.34
45
 B5QZ54_SALEP
(B5QZ54)		 
[query] 2 - 686 (692)
[subject] 3 - 672 (672)
 1e-127 461   40% 2,4-dienoyl-CoA reductase [NADPH] (Ec 1.3.1.34) (2,4-dienoyl coenzyme A reductase) fadH
SEN3061		 Salmonella enteritidis PT4 (strain P125109) 1.3.1.34
46
 B5FHV4_SALDC
(B5FHV4)		 
[query] 2 - 686 (692)
[subject] 3 - 672 (672)
 1e-127 461   40% FAD/FMN-binding/pyridine nucleotide-disulphide oxidoreductase family protein SeD_A3576 Salmonella dublin (strain CT_02021853)
47
 F2G0H9_SALGL
(F2G0H9)		 
[query] 2 - 686 (692)
[subject] 3 - 672 (672)
 1e-127 461   40% 2,4-dienoyl-CoA reductase [NADPH] fadh
SG9_3157		 Salmonella enterica subsp. enterica serovar Gallinarum str. SG9
48
 F2FLB1_SALDU
(F2FLB1)		 
[query] 2 - 686 (692)
[subject] 3 - 672 (672)
 1e-127 461   40% 2,4-dienoyl-CoA reductase [NADPH] fadh
SD3246_3464		 Salmonella enterica subsp. enterica serovar Dublin str. SD3246
49
 A3Y3P3_9VIBR
(A3Y3P3)		 
[query] 1 - 686 (692)
[subject] 4 - 669 (669)
 1e-127 460   39% 2,4-dienoyl-CoA reductase MED222_02577 Vibrio sp. MED222
50
 A4WER7_ENT38
(A4WER7)		 
[query] 2 - 686 (692)
[subject] 4 - 673 (673)
 1e-127 460   40% 2,4-dienoyl-CoA reductase Ent638_3539 Enterobacter sp. (strain 638) 1.3.1.34
51
 B6EIH3_ALISL
(B6EIH3)		 
[query] 2 - 683 (692)
[subject] 3 - 664 (667)
 1e-127 460   39% 2,4-dienoyl-CoA reductase [NADPH] fadH
VSAL_I2156		 Aliivibrio salmonicida (strain LFI1238)
Vibrio salmonicida (strain LFI1238)		 1.3.1.34
52
 B4T689_SALNS
(B4T689)		 
[query] 2 - 686 (692)
[subject] 3 - 672 (672)
 1e-127 460   40% FAD/FMN-binding/pyridine nucleotide-disulphide oxidoreductase family protein SNSL254_A3480 Salmonella newport (strain SL254)
53
 B5NQV4_SALET
(B5NQV4)		 
[query] 2 - 686 (692)
[subject] 3 - 672 (672)
 1e-127 460   40% Oxidoreductase, FAD/FMN-binding family SeKB_A3415 Salmonella enterica subsp. enterica serovar Kentucky str. CDC 191
54
 B3Y9Z4_SALET
(B3Y9Z4)		 
[query] 2 - 686 (692)
[subject] 3 - 672 (672)
 1e-127 460   40% FAD/FMN-binding/pyridine nucleotide-disulphide oxidoreductase family protein SeKA_A2811 Salmonella enterica subsp. enterica serovar Kentucky str. CVM29188
55
 A5F6Q6_VIBC3
(A5F6Q6)		 
[query] 1 - 686 (692)
[subject] 19 - 684 (684)
 1e-127 460   39% 2,4-dienoyl-CoA reductase fadH
VC0395_A1578		 Vibrio cholerae serotype O1 (strain ATCC 39541 / Ogawa 395 / O395) 1.3.1.34
56
 D7HI96_VIBCH
(D7HI96)		 
[query] 1 - 686 (692)
[subject] 19 - 684 (684)
 1e-127 460   39% 2,4-dienoyl-CoA reductase A53_02895 Vibrio cholerae MAK 757
57
 C6YEF8_VIBCH
(C6YEF8)		 
[query] 1 - 686 (692)
[subject] 19 - 684 (684)
 1e-127 460   39% 2,4-dienoyl-CoA reductase VchoM_01225 Vibrio cholerae MO10
58
 A3GSZ3_VIBCH
(A3GSZ3)		 
[query] 1 - 686 (692)
[subject] 19 - 684 (684)
 1e-127 460   39% 2,4-dienoyl-CoA reductase fadH
A5C_2025		 Vibrio cholerae NCTC 8457 1.3.1.34
59
 A1FA91_VIBCH
(A1FA91)		 
[query] 1 - 686 (692)
[subject] 19 - 684 (684)
 1e-127 460   39% 2,4-dienoyl-CoA reductase fadH
VC274080_2034		 Vibrio cholerae 2740-80 1.3.1.34
60
 C9Q1U7_9VIBR
(C9Q1U7)		 
[query] 1 - 686 (692)
[subject] 1 - 666 (666)
 1e-127 459   40% 2,4-dienoyl-CoA reductase [NADPH] VCJ_000077 Vibrio sp. RC341 1.3.1.34
61
 C2IV36_VIBCH
(C2IV36)		 
[query] 1 - 686 (692)
[subject] 1 - 666 (666)
 1e-127 459   39% 2,4-dienoyl-CoA reductase [NADPH] VCB_003029 Vibrio cholerae TMA 21 1.3.1.34
62
 C0PYZ2_SALPC
(C0PYZ2)		 
[query] 2 - 686 (692)
[subject] 3 - 672 (672)
 1e-127 459   40% 2,4-dieonyl-coa reductase fadH
SPC_3295		 Salmonella paratyphi C (strain RKS4594)
63
 Q9KQK5_VIBCH
(Q9KQK5)		 
[query] 1 - 686 (692)
[subject] 1 - 666 (666)
 1e-127 459   39% 2,4-dienoyl-CoA reductase VC_1993 Vibrio cholerae
64
 C3NP32_VIBCJ
(C3NP32)		 
[query] 1 - 686 (692)
[subject] 1 - 666 (666)
 1e-127 459   39% 2,4-dienoyl-CoA reductase (NADPH) VCD_002375 Vibrio cholerae serotype O1 (strain MJ-1236) 1.3.1.34
65
 C3M245_VIBC3
(C3M245)		 
[query] 1 - 686 (692)
[subject] 1 - 666 (666)
 1e-127 459   39% 2,4-dienoyl-CoA reductase fadH
VC395_2108		 Vibrio cholerae serotype O1 (strain ATCC 39541 / Ogawa 395 / O395) 1.3.1.34
66
 C3LNU4_VIBCM
(C3LNU4)		 
[query] 1 - 686 (692)
[subject] 1 - 666 (666)
 1e-127 459   39% 2,4-dienoyl-CoA reductase fadH
VCM66_1917		 Vibrio cholerae serotype O1 (strain M66-2) 1.3.1.34
67
 D0HN67_VIBCH
(D0HN67)		 
[query] 1 - 686 (692)
[subject] 1 - 666 (666)
 1e-127 459   39% 2,4-dienoyl-CoA reductase [NADPH] VIG_001201 Vibrio cholerae INDRE 91/1 1.3.1.34
68
 D0H3V7_VIBCH
(D0H3V7)		 
[query] 1 - 686 (692)
[subject] 1 - 666 (666)
 1e-127 459   39% 2,4-dienoyl-CoA reductase [NADPH] VIJ_001119 Vibrio cholerae RC27 1.3.1.34
69
 C6RXT7_VIBCH
(C6RXT7)		 
[query] 1 - 686 (692)
[subject] 1 - 666 (666)
 1e-127 459   39% 2,4-dienoyl-CoA reductase [NADPH] VCH_001602 Vibrio cholerae CIRS101 1.3.1.34
70
 C2JGN5_VIBCH
(C2JGN5)		 
[query] 1 - 686 (692)
[subject] 1 - 666 (666)
 1e-127 459   39% 2,4-dienoyl-CoA reductase [NADPH] VCF_003148 Vibrio cholerae BX 330286 1.3.1.34
71
 C2ILZ0_VIBCH
(C2ILZ0)		 
[query] 1 - 686 (692)
[subject] 1 - 666 (666)
 1e-127 459   39% 2,4-dienoyl-CoA reductase [NADPH] VCC_003010 Vibrio cholerae RC9 1.3.1.34
72
 A6AEM2_VIBCH
(A6AEM2)		 
[query] 1 - 686 (692)
[subject] 1 - 666 (666)
 1e-127 459   39% 2,4-dienoyl-CoA reductase fadH
A59_2075		 Vibrio cholerae 623-39 1.3.1.34
73
 A3H2F6_VIBCH
(A3H2F6)		 
[query] 1 - 686 (692)
[subject] 1 - 666 (666)
 1e-127 459   39% 2,4-dienoyl-CoA reductase
2,4-dienoyl-CoA reductase [NADPH]		 fadH
A5E_2292
VCE_003256		 Vibrio cholerae B33 1.3.1.34
74
 A2PBS6_VIBCH
(A2PBS6)		 
[query] 1 - 686 (692)
[subject] 19 - 684 (684)
 1e-127 459   39% 2,4-dienoyl-CoA reductase fadH
A55_2200		 Vibrio cholerae 1587 1.3.1.34
75
 A1ESH4_VIBCH
(A1ESH4)		 
[query] 1 - 686 (692)
[subject] 1 - 666 (666)
 1e-127 459   39% 2,4-dienoyl-CoA reductase fadH
VCV52_1958		 Vibrio cholerae V52 1.3.1.34
76
 A8FVP6_SHESH
(A8FVP6)		 
[query] 2 - 686 (692)
[subject] 3 - 671 (671)
 1e-127 459   38% NADH:flavin oxidoreductase/NADH oxidase Ssed_2310 Shewanella sediminis (strain HAW-EB3)
77
 D1P1P3_9ENTR
(D1P1P3)		 
[query] 2 - 686 (692)
[subject] 8 - 677 (677)
 1e-126 459   39% 2,4-dienoyl-CoA reductase PROVRUST_06115 Providencia rustigianii DSM 4541
78
 B4TIU7_SALHS
(B4TIU7)		 
[query] 2 - 686 (692)
[subject] 3 - 672 (672)
 1e-126 459   40% FAD/FMN-binding/pyridine nucleotide-disulphide oxidoreductase family protein SeHA_C3514 Salmonella heidelberg (strain SL476)
79
 B5Q5R0_SALVI
(B5Q5R0)		 
[query] 2 - 686 (692)
[subject] 3 - 672 (672)
 1e-126 459   40% Oxidoreductase, FAD/FMN-binding family SeV_B1835 Salmonella enterica subsp. enterica serovar Virchow str. SL491
80
 B5P4F7_SALET
(B5P4F7)		 
[query] 2 - 686 (692)
[subject] 3 - 672 (672)
 1e-126 459   40% Oxidoreductase, FAD/FMN-binding family SeHB_A3378 Salmonella enterica subsp. enterica serovar Heidelberg str. SL486
81
 Q57JP0_SALCH
(Q57JP0)		 
[query] 2 - 686 (692)
[subject] 3 - 672 (672)
 1e-126 459   40% 2,4-dieonyl-coa reductase fadH
SCH_3166		 Salmonella choleraesuis
82
 E8NMI4_SALET
(E8NMI4)		 
[query] 2 - 686 (692)
[subject] 3 - 672 (672)
 1e-126 459   40% 2,4-dieonyl-coa reductase fadH
SCA50_3368		 Salmonella enterica subsp. enterica serovar Choleraesuis str. SCSA50
83
 B4TVV3_SALSV
(B4TVV3)		 
[query] 2 - 686 (692)
[subject] 3 - 672 (672)
 1e-126 459   40% FAD/FMN-binding/pyridine nucleotide-disulphide oxidoreductase family protein SeSA_A3410 Salmonella schwarzengrund (strain CVM19633)
84
 B5CG86_SALET
(B5CG86)		 
[query] 2 - 686 (692)
[subject] 3 - 672 (672)
 1e-126 459   40% Oxidoreductase, FAD/FMN-binding family protein SeSB_A3578 Salmonella enterica subsp. enterica serovar Schwarzengrund str. SL480
85
 D7HA43_VIBCH
(D7HA43)		 
[query] 1 - 686 (692)
[subject] 19 - 684 (684)
 1e-126 459   39% 2,4-dienoyl-CoA reductase VCRC385_02256 Vibrio cholerae RC385
86
 F5S256_9ENTR
(F5S256)		 
[query] 2 - 686 (692)
[subject] 4 - 673 (673)
 1e-126 458   40% 2,4-dienoyl-CoA reductase fadH
HMPREF9086_3966		 Enterobacter hormaechei ATCC 49162 1.3.1.34
87
 E8GYY7_SALMO
(E8GYY7)		 
[query] 2 - 686 (692)
[subject] 3 - 672 (672)
 1e-126 458   40% Putative uncharacterized protein SEEM8287_11637 Salmonella enterica subsp. enterica serovar Montevideo str. IA_2010008287
88
 E8GEI4_SALMO
(E8GEI4)		 
[query] 2 - 686 (692)
[subject] 3 - 672 (672)
 1e-126 458   40% Putative uncharacterized protein SEEM8285_20777 Salmonella enterica subsp. enterica serovar Montevideo str. IA_2010008285
89
 E8G422_SALMO
(E8G422)		 
[query] 2 - 686 (692)
[subject] 3 - 672 (672)
 1e-126 458   40% Putative uncharacterized protein SEEM8284_02761 Salmonella enterica subsp. enterica serovar Montevideo str. IA_2010008284
90
 E8FVW2_SALMO
(E8FVW2)		 
[query] 2 - 686 (692)
[subject] 3 - 672 (672)
 1e-126 458   40% Putative uncharacterized protein SEEM8283_11286 Salmonella enterica subsp. enterica serovar Montevideo str. IA_2010008283
91
 E8FBZ2_SALMO
(E8FBZ2)		 
[query] 2 - 686 (692)
[subject] 3 - 672 (672)
 1e-126 458   40% Putative uncharacterized protein SEEM8282_00120 Salmonella enterica subsp. enterica serovar Montevideo str. IA_2010008282
92
 E8F6I0_SALMO
(E8F6I0)		 
[query] 2 - 686 (692)
[subject] 3 - 672 (672)
 1e-126 458   40% Putative uncharacterized protein SEEM9199_20640 Salmonella enterica subsp. enterica serovar Montevideo str. IA_2009159199
93
 E8EP79_SALMO
(E8EP79)		 
[query] 2 - 686 (692)
[subject] 3 - 672 (672)
 1e-126 458   40% Putative uncharacterized protein SEEM1156_00572 Salmonella enterica subsp. enterica serovar Montevideo str. 315731156
94
 E8EFJ3_SALMO
(E8EFJ3)		 
[query] 2 - 686 (692)
[subject] 3 - 672 (672)
 1e-126 458   40% Putative uncharacterized protein SEEM5258_06635 Salmonella enterica subsp. enterica serovar Montevideo str. 2009085258
95
 E8E4Z5_SALMO
(E8E4Z5)		 
[query] 2 - 686 (692)
[subject] 3 - 672 (672)
 1e-126 458   40% Putative uncharacterized protein SEEM3312_06748 Salmonella enterica subsp. enterica serovar Montevideo str. 2009083312
96
 E8DT61_SALMO
(E8DT61)		 
[query] 2 - 686 (692)
[subject] 3 - 672 (672)
 1e-126 458   40% Putative uncharacterized protein SEEM0052_19239 Salmonella enterica subsp. enterica serovar Montevideo str. MB111609-0052
97
 E8DL87_SALMO
(E8DL87)		 
[query] 2 - 686 (692)
[subject] 3 - 672 (672)
 1e-126 458   40% Putative uncharacterized protein SEEM0055_22235 Salmonella enterica subsp. enterica serovar Montevideo str. MB110209-0055
98
 E8CZC8_SALMO
(E8CZC8)		 
[query] 2 - 686 (692)
[subject] 3 - 672 (672)
 1e-126 458   40% Putative uncharacterized protein SEEM0047_10230 Salmonella enterica subsp. enterica serovar Montevideo str. MB102109-0047
99
 E8CVW6_SALMO
(E8CVW6)		 
[query] 2 - 686 (692)
[subject] 3 - 672 (672)
 1e-126 458   40% Putative uncharacterized protein SEEM0077_03974 Salmonella enterica subsp. enterica serovar Montevideo str. MB101509-0077
100
 E8CC79_SALMO
(E8CC79)		 
[query] 2 - 686 (692)
[subject] 3 - 672 (672)
 1e-126 458   40% Putative uncharacterized protein SEEM6152_09423 Salmonella enterica subsp. enterica serovar Montevideo str. 556152
accessionDBalignmentEvalueScoreIdent.linkinformationpubmed
1
 Q6V1M3_9ACTO
(Q6V1M3)		 
[query] 1 - 692 (692)
[subject] 1 - 692 (692)
 0.0 1353   100%
Product
PlmM
Gene
plmM
Organism
Streptomyces sp. HK803
1uniprot[Pubmed] 12819191 [Medline] 22841069
Enhancement and selective production of phoslactomycin B, a protein phosphatase IIa inhibitor, through identification and engineering of the corresponding biosynthetic gene cluster.(J. Biol. Chem.) [2003]
5
 D7P5V1_9ACTO
(D7P5V1)		 
[query] 1 - 686 (692)
[subject] 1 - 646 (667)
 1e-173 613   55%
Product
AsuB4
Gene
asuB4
Organism
Streptomyces nodosus subsp. asukaensis
1uniprot[Pubmed] 20522559
Biochemical and genetic insights into asukamycin biosynthesis.(J. Biol. Chem.) [2010]
16
 Q5E4A9_VIBF1
(Q5E4A9)		 
[query] 2 - 686 (692)
[subject] 3 - 667 (667)
 1e-131 474   39%
Product
2,4-dienoyl-CoA reductase, NADH and FMN-linked
Gene
fadH
VF_1642
Organism
Vibrio fischeri (strain ATCC 700601 / ES114)
1uniprot[Pubmed] 15703294
Complete genome sequence of Vibrio fischeri: a symbiotic bacterium with pathogenic congeners.(Proc. Natl. Acad. Sci. U.S.A.) [2005]
21
 Q1ZRT2_PHOAS
(Q1ZRT2)		 
[query] 2 - 686 (692)
[subject] 6 - 670 (670)
 1e-130 470   40%
Product
Putative 2,4-dienoyl-CoA reductase
Gene
VAS14_05978
Organism
Photobacterium angustum (strain S14 / CCUG 15956)
Vibrio sp. (strain S14 / CCUG 15956)
1uniprot[Pubmed] 19805210
The genomic basis of trophic strategy in marine bacteria.(Proc. Natl. Acad. Sci. U.S.A.) [2009]
24
 D0MRH2_PHYIT
(D0MRH2)		 
[query] 2 - 687 (692)
[subject] 4 - 676 (703)
 1e-129 468   38%
Product
2,4-dienoyl-CoA reductase
Gene
PITG_00703
Organism
Phytophthora infestans (strain T30-4)
Potato late blight fungus
1uniprot[Pubmed] 19741609
Genome sequence and analysis of the Irish potato famine pathogen Phytophthora infestans.(Nature) [2009]
25
 D0HJ19_VIBMI
(D0HJ19)		 
[query] 1 - 686 (692)
[subject] 1 - 666 (666)
 1e-129 468   40%
Product
2,4-dienoyl-CoA reductase [NADPH]
Gene
VMA_002550
Organism
Vibrio mimicus VM223
1uniprot[Pubmed] 21078967
Comparative genomics of clinical and environmental Vibrio mimicus.(Proc. Natl. Acad. Sci. U.S.A.) [2010]
27
 Q8EEG3_SHEON
(Q8EEG3)		 
[query] 2 - 686 (692)
[subject] 3 - 672 (672)
 1e-129 467   38%
Product
2,4-dienoyl-CoA reductase, putative
Gene
SO_2419
Organism
Shewanella oneidensis
1uniprot[Pubmed] 12368813 [Medline] 22297686
Genome sequence of the dissimilatory metal ion-reducing bacterium Shewanella oneidensis.(Nat. Biotechnol.) [2002]
31
 D2YGL8_VIBMI
(D2YGL8)		 
[query] 1 - 686 (692)
[subject] 23 - 688 (688)
 1e-128 465   40%
Product
2,4-dienoyl-CoA reductase
Gene
fadH
VMB_26650
Organism
Vibrio mimicus VM603
1uniprot[Pubmed] 19860885
Genomic taxonomy of Vibrios.(BMC Evol. Biol.) [2009]
32
 D0GT22_VIBMI
(D0GT22)		 
[query] 1 - 686 (692)
[subject] 23 - 688 (688)
 1e-128 464   40%
Product
2,4-dienoyl-CoA reductase [NADPH]
Gene
VII_001834
Organism
Vibrio mimicus MB451
1uniprot[Pubmed] 21078967
Comparative genomics of clinical and environmental Vibrio mimicus.(Proc. Natl. Acad. Sci. U.S.A.) [2010]
34
 A3TPZ4_9MICO
(A3TPZ4)		 
[query] 2 - 686 (692)
[subject] 4 - 677 (677)
 1e-128 464   42%
Product
2,4-dienoyl-CoA reductase
Gene
JNB_17258
Organism
Janibacter sp. HTCC2649
1uniprot[Pubmed] 21075932
Genome sequence of the Marine Janibacter Sp. Strain HTCC2649.(J. Bacteriol.) [2011]
39
 B8CMF8_SHEPW
(B8CMF8)		 
[query] 2 - 679 (692)
[subject] 3 - 664 (671)
 1e-127 461   38%
Product
2,4-dienoyl-CoA reductase, putative
Gene
swp_2472
Organism
Shewanella piezotolerans (strain WP3 / JCM 13877)
1uniprot[Pubmed] 18398463
Environmental adaptation: genomic analysis of the piezotolerant and psychrotolerant deep-sea iron reducing bacterium Shewanella piezotolerans WP3.(PLoS ONE) [2008]
40
 D7B0B7_NOCDD
(D7B0B7)		 
[query] 2 - 683 (692)
[subject] 4 - 666 (669)
 1e-127 461   42%
Product
NADH:flavin oxidoreductase/NADH oxidase
Gene
Ndas_4822
Organism
Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488)
Actinomadura dassonvillei
1uniprot
Complete genome sequence of Nocardiopsis dassonvillei type strain (IMRU 509T).(Stand. Genomic Sci.) [2010]
41
 Q7P1P4_CHRVO
(Q7P1P4)		 
[query] 2 - 686 (692)
[subject] 4 - 673 (673)
 1e-127 461   41%
Product
2,4-dienoyl-CoA reductase FadH1
Gene
fadH
CV_0169
Organism
Chromobacterium violaceum
1uniprot[Pubmed] 14500782 [Medline] 22882880
The complete genome sequence of Chromobacterium violaceum reveals remarkable and exploitable bacterial adaptability.(Proc. Natl. Acad. Sci. U.S.A.) [2003]
43
 Q5QX72_IDILO
(Q5QX72)		 
[query] 22 - 686 (692)
[subject] 1 - 649 (649)
 1e-127 461   40%
Product
NADH:flavin oxidoreductases, Old Yellow Enzyme family
Gene
IL1748
Organism
Idiomarina loihiensis
1uniprot[Pubmed] 15596722
Genome sequence of the deep-sea gamma-proteobacterium Idiomarina loihiensis reveals amino acid fermentation as a source of carbon and energy.(Proc. Natl. Acad. Sci. U.S.A.) [2004]
44
 B5REH6_SALG2
(B5REH6)		 
[query] 2 - 686 (692)
[subject] 3 - 672 (672)
 1e-127 461   40%
Product
2,4-dienoyl-CoA reductase [NADPH] (Ec 1.3.1.34) (2,4-dienoyl coenzyme A reductase)
Gene
fadH
SG3115
Organism
Salmonella gallinarum (strain 287/91 / NCTC 13346)
1uniprot[Pubmed] 18583645
Comparative genome analysis of Salmonella enteritidis PT4 and Salmonella gallinarum 287/91 provides insights into evolutionary and host adaptation pathways.(Genome Res.) [2008]
45
 B5QZ54_SALEP
(B5QZ54)		 
[query] 2 - 686 (692)
[subject] 3 - 672 (672)
 1e-127 461   40%
Product
2,4-dienoyl-CoA reductase [NADPH] (Ec 1.3.1.34) (2,4-dienoyl coenzyme A reductase)
Gene
fadH
SEN3061
Organism
Salmonella enteritidis PT4 (strain P125109)
1uniprot[Pubmed] 18583645
Comparative genome analysis of Salmonella enteritidis PT4 and Salmonella gallinarum 287/91 provides insights into evolutionary and host adaptation pathways.(Genome Res.) [2008]
47
 F2G0H9_SALGL
(F2G0H9)		 
[query] 2 - 686 (692)
[subject] 3 - 672 (672)
 1e-127 461   40%
Product
2,4-dienoyl-CoA reductase [NADPH]
Gene
fadh
SG9_3157
Organism
Salmonella enterica subsp. enterica serovar Gallinarum str. SG9
1uniprot[Pubmed] 21478351
Genome Sequences of Salmonella enterica Serovar Typhimurium, Choleraesuis, Dublin, and Gallinarum Strains of Well- Defined Virulence in Food-Producing Animals.(J. Bacteriol.) [2011]
48
 F2FLB1_SALDU
(F2FLB1)		 
[query] 2 - 686 (692)
[subject] 3 - 672 (672)
 1e-127 461   40%
Product
2,4-dienoyl-CoA reductase [NADPH]
Gene
fadh
SD3246_3464
Organism
Salmonella enterica subsp. enterica serovar Dublin str. SD3246
1uniprot[Pubmed] 21478351
Genome Sequences of Salmonella enterica Serovar Typhimurium, Choleraesuis, Dublin, and Gallinarum Strains of Well- Defined Virulence in Food-Producing Animals.(J. Bacteriol.) [2011]
62
 C0PYZ2_SALPC
(C0PYZ2)		 
[query] 2 - 686 (692)
[subject] 3 - 672 (672)
 1e-127 459   40%
Product
2,4-dieonyl-coa reductase
Gene
fadH
SPC_3295
Organism
Salmonella paratyphi C (strain RKS4594)
1uniprot[Pubmed] 19229335
Salmonella paratyphi C: genetic divergence from Salmonella choleraesuis and pathogenic convergence with Salmonella typhi.(PLoS ONE) [2009]
63
 Q9KQK5_VIBCH
(Q9KQK5)		 
[query] 1 - 686 (692)
[subject] 1 - 666 (666)
 1e-127 459   39%
Product
2,4-dienoyl-CoA reductase
Gene
VC_1993
Organism
Vibrio cholerae
1uniprot[Pubmed] 10952301 [Medline] 20406833
DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae.(Nature) [2000]
64
 C3NP32_VIBCJ
(C3NP32)		 
[query] 1 - 686 (692)
[subject] 1 - 666 (666)
 1e-127 459   39%
Product
2,4-dienoyl-CoA reductase (NADPH)
Gene
VCD_002375
Organism
Vibrio cholerae serotype O1 (strain MJ-1236)
1uniprot[Pubmed] 19720995
Comparative genomics reveals mechanism for short-term and long-term clonal transitions in pandemic Vibrio cholerae.(Proc. Natl. Acad. Sci. U.S.A.) [2009]
65
 C3M245_VIBC3
(C3M245)		 
[query] 1 - 686 (692)
[subject] 1 - 666 (666)
 1e-127 459   39%
Product
2,4-dienoyl-CoA reductase
Gene
fadH
VC395_2108
Organism
Vibrio cholerae serotype O1 (strain ATCC 39541 / Ogawa 395 / O395)
1uniprot[Pubmed] 19115014
A recalibrated molecular clock and independent origins for the cholera pandemic clones.(PLoS ONE) [2008]
66
 C3LNU4_VIBCM
(C3LNU4)		 
[query] 1 - 686 (692)
[subject] 1 - 666 (666)
 1e-127 459   39%
Product
2,4-dienoyl-CoA reductase
Gene
fadH
VCM66_1917
Organism
Vibrio cholerae serotype O1 (strain M66-2)
1uniprot[Pubmed] 19115014
A recalibrated molecular clock and independent origins for the cholera pandemic clones.(PLoS ONE) [2008]
73
 A3H2F6_VIBCH
(A3H2F6)		 
[query] 1 - 686 (692)
[subject] 1 - 666 (666)
 1e-127 459   39%
Product
2,4-dienoyl-CoA reductase
2,4-dienoyl-CoA reductase [NADPH]
Gene
fadH
A5E_2292
VCE_003256
Organism
Vibrio cholerae B33
1uniprot[Pubmed] 19850044
Genomic analysis of a novel integrative conjugative element in Vibrio cholerae.(FEBS Lett.) [2009]
81
 Q57JP0_SALCH
(Q57JP0)		 
[query] 2 - 686 (692)
[subject] 3 - 672 (672)
 1e-126 459   40%
Product
2,4-dieonyl-coa reductase
Gene
fadH
SCH_3166
Organism
Salmonella choleraesuis
1uniprot[Pubmed] 15781495
The genome sequence of Salmonella enterica serovar Choleraesuis, a highly invasive and resistant zoonotic pathogen.(Nucleic Acids Res.) [2005]
82
 E8NMI4_SALET
(E8NMI4)		 
[query] 2 - 686 (692)
[subject] 3 - 672 (672)
 1e-126 459   40%
Product
2,4-dieonyl-coa reductase
Gene
fadH
SCA50_3368
Organism
Salmonella enterica subsp. enterica serovar Choleraesuis str. SCSA50
1uniprot[Pubmed] 21478351
Genome Sequences of Salmonella enterica Serovar Typhimurium, Choleraesuis, Dublin, and Gallinarum Strains of Well- Defined Virulence in Food-Producing Animals.(J. Bacteriol.) [2011]
87
 E8GYY7_SALMO
(E8GYY7)		 
[query] 2 - 686 (692)
[subject] 3 - 672 (672)
 1e-126 458   40%
Product
Putative uncharacterized protein
Gene
SEEM8287_11637
Organism
Salmonella enterica subsp. enterica serovar Montevideo str. IA_2010008287
1uniprot[Pubmed] 21345093
Identification of a salmonellosis outbreak by means of molecular sequencing.(N. Engl. J. Med.) [2011]
88
 E8GEI4_SALMO
(E8GEI4)		 
[query] 2 - 686 (692)
[subject] 3 - 672 (672)
 1e-126 458   40%
Product
Putative uncharacterized protein
Gene
SEEM8285_20777
Organism
Salmonella enterica subsp. enterica serovar Montevideo str. IA_2010008285
1uniprot[Pubmed] 21345093
Identification of a salmonellosis outbreak by means of molecular sequencing.(N. Engl. J. Med.) [2011]
89
 E8G422_SALMO
(E8G422)		 
[query] 2 - 686 (692)
[subject] 3 - 672 (672)
 1e-126 458   40%
Product
Putative uncharacterized protein
Gene
SEEM8284_02761
Organism
Salmonella enterica subsp. enterica serovar Montevideo str. IA_2010008284
1uniprot[Pubmed] 21345093
Identification of a salmonellosis outbreak by means of molecular sequencing.(N. Engl. J. Med.) [2011]
90
 E8FVW2_SALMO
(E8FVW2)		 
[query] 2 - 686 (692)
[subject] 3 - 672 (672)
 1e-126 458   40%
Product
Putative uncharacterized protein
Gene
SEEM8283_11286
Organism
Salmonella enterica subsp. enterica serovar Montevideo str. IA_2010008283
1uniprot[Pubmed] 21345093
Identification of a salmonellosis outbreak by means of molecular sequencing.(N. Engl. J. Med.) [2011]
91
 E8FBZ2_SALMO
(E8FBZ2)		 
[query] 2 - 686 (692)
[subject] 3 - 672 (672)
 1e-126 458   40%
Product
Putative uncharacterized protein
Gene
SEEM8282_00120
Organism
Salmonella enterica subsp. enterica serovar Montevideo str. IA_2010008282
1uniprot[Pubmed] 21345093
Identification of a salmonellosis outbreak by means of molecular sequencing.(N. Engl. J. Med.) [2011]
92
 E8F6I0_SALMO
(E8F6I0)		 
[query] 2 - 686 (692)
[subject] 3 - 672 (672)
 1e-126 458   40%
Product
Putative uncharacterized protein
Gene
SEEM9199_20640
Organism
Salmonella enterica subsp. enterica serovar Montevideo str. IA_2009159199
1uniprot[Pubmed] 21345093
Identification of a salmonellosis outbreak by means of molecular sequencing.(N. Engl. J. Med.) [2011]
93
 E8EP79_SALMO
(E8EP79)		 
[query] 2 - 686 (692)
[subject] 3 - 672 (672)
 1e-126 458   40%
Product
Putative uncharacterized protein
Gene
SEEM1156_00572
Organism
Salmonella enterica subsp. enterica serovar Montevideo str. 315731156
1uniprot[Pubmed] 21345093
Identification of a salmonellosis outbreak by means of molecular sequencing.(N. Engl. J. Med.) [2011]
94
 E8EFJ3_SALMO
(E8EFJ3)		 
[query] 2 - 686 (692)
[subject] 3 - 672 (672)
 1e-126 458   40%
Product
Putative uncharacterized protein
Gene
SEEM5258_06635
Organism
Salmonella enterica subsp. enterica serovar Montevideo str. 2009085258
1uniprot[Pubmed] 21345093
Identification of a salmonellosis outbreak by means of molecular sequencing.(N. Engl. J. Med.) [2011]
95
 E8E4Z5_SALMO
(E8E4Z5)		 
[query] 2 - 686 (692)
[subject] 3 - 672 (672)
 1e-126 458   40%
Product
Putative uncharacterized protein
Gene
SEEM3312_06748
Organism
Salmonella enterica subsp. enterica serovar Montevideo str. 2009083312
1uniprot[Pubmed] 21345093
Identification of a salmonellosis outbreak by means of molecular sequencing.(N. Engl. J. Med.) [2011]
96
 E8DT61_SALMO
(E8DT61)		 
[query] 2 - 686 (692)
[subject] 3 - 672 (672)
 1e-126 458   40%
Product
Putative uncharacterized protein
Gene
SEEM0052_19239
Organism
Salmonella enterica subsp. enterica serovar Montevideo str. MB111609-0052
1uniprot[Pubmed] 21345093
Identification of a salmonellosis outbreak by means of molecular sequencing.(N. Engl. J. Med.) [2011]
97
 E8DL87_SALMO
(E8DL87)		 
[query] 2 - 686 (692)
[subject] 3 - 672 (672)
 1e-126 458   40%
Product
Putative uncharacterized protein
Gene
SEEM0055_22235
Organism
Salmonella enterica subsp. enterica serovar Montevideo str. MB110209-0055
1uniprot[Pubmed] 21345093
Identification of a salmonellosis outbreak by means of molecular sequencing.(N. Engl. J. Med.) [2011]
98
 E8CZC8_SALMO
(E8CZC8)		 
[query] 2 - 686 (692)
[subject] 3 - 672 (672)
 1e-126 458   40%
Product
Putative uncharacterized protein
Gene
SEEM0047_10230
Organism
Salmonella enterica subsp. enterica serovar Montevideo str. MB102109-0047
1uniprot[Pubmed] 21345093
Identification of a salmonellosis outbreak by means of molecular sequencing.(N. Engl. J. Med.) [2011]
99
 E8CVW6_SALMO
(E8CVW6)		 
[query] 2 - 686 (692)
[subject] 3 - 672 (672)
 1e-126 458   40%
Product
Putative uncharacterized protein
Gene
SEEM0077_03974
Organism
Salmonella enterica subsp. enterica serovar Montevideo str. MB101509-0077
1uniprot[Pubmed] 21345093
Identification of a salmonellosis outbreak by means of molecular sequencing.(N. Engl. J. Med.) [2011]
100
 E8CC79_SALMO
(E8CC79)		 
[query] 2 - 686 (692)
[subject] 3 - 672 (672)
 1e-126 458   40%
Product
Putative uncharacterized protein
Gene
SEEM6152_09423
Organism
Salmonella enterica subsp. enterica serovar Montevideo str. 556152
1uniprot[Pubmed] 21345093
Identification of a salmonellosis outbreak by means of molecular sequencing.(N. Engl. J. Med.) [2011]