PKS BLAST table : Teicp

DB	UniProtKB

	accession	Evalue	Score	Ident.	link	product	gene	organism	ec
1	Q6ZZK2_ACTTI (Q6ZZK2)	0.0	702	100%	UniProt GenBank	D-alanine--D-alanine ligase 1 D-Ala-D-Ala ligase 1 D-alanylalanine synthetase 1	ddl1	Actinoplanes teichomyceticus	6.3.2.4 niceE keggE
2	Q70B05_ACTTI (Q70B05)	0.0	696	99%	UniProt GenBank	D-alanine--D-alanine ligase 2 D-Ala-D-Ala ligase 2 D-alanylalanine synthetase 2	tcp3 ddl2	Actinoplanes teichomyceticus	6.3.2.4 niceE keggE
3	E9L1E9_9ZZZZ (E9L1E9)	1e-173	610	86%	UniProt GenBank	Putative uncharacterized protein	CA37-5	uncultured organism CA37
4	E9L1P5_9ZZZZ (E9L1P5)	1e-162	574	79%	UniProt GenBank	Putative uncharacterized protein	CA915-3	uncultured organism CA915
5	VANL_STRCO (Q9XAK7)	1e-156	556	76%	UniProt GenBank	Putative D-alanine--D-lactate ligase Vancomycin resistance-like protein	SCO3595 SC66T3.06	Streptomyces coelicolor	6.3.2.- niceE keggE
6	D6EPN3_STRLI (D6EPN3)	1e-155	554	76%	UniProt GenBank	D-alanine--D-alanine ligase 1 D-Ala-D-Ala ligase 1 D-alanylalanine synthetase 1	ddl1 SSPG_04065	Streptomyces lividans TK24	6.3.2.4 niceE keggE
7	D6TBG9_9CHLR (D6TBG9)	1e-154	550	75%	UniProt GenBank	D-alanine--D-alanine ligase 1 D-Ala-D-Ala ligase 1 D-alanylalanine synthetase 1	ddl1 Krac_9315	Ktedonobacter racemifer DSM 44963	6.3.2.4 niceE keggE
8	E9L1K1_9ZZZZ (E9L1K1)	1e-154	548	77%	UniProt GenBank	Putative uncharacterized protein	CA878-2	uncultured organism CA878
9	A8L665_FRASN (A8L665)	1e-153	545	74%	UniProt GenBank	D-alanine--D-alanine ligase 3 D-Ala-D-Ala ligase 3 D-alanylalanine synthetase 3	ddl3 Franean1_7137	Frankia sp. (strain EAN1pec)	6.3.2.4 niceE keggE
10	O33806_STRTO (O33806)	1e-151	539	76%	UniProt GenBank	D-alanine--D-alanine ligase D-Ala-D-Ala ligase D-alanylalanine synthetase	DdlM ddl	Streptomyces toyocaensis	6.3.2.4 niceE keggE
11	C7QDM7_CATAD (C7QDM7)	1e-150	536	72%	UniProt GenBank	D-alanine--D-alanine ligase 1 D-Ala-D-Ala ligase 1 D-alanylalanine synthetase 1	ddl1 Caci_5793	Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)	6.3.2.4 niceE keggE
12	D3EYW8_CONWI (D3EYW8)	1e-148	528	74%	UniProt GenBank	D-alanine--D-alanine ligase 1 D-Ala-D-Ala ligase 1 D-alanylalanine synthetase 1	ddl1 Cwoe_1414	Conexibacter woesei (strain DSM 14684 / JCM 11494 / NBRC 100937 / ID131577)	6.3.2.4 niceE keggE
13	Q9S611_AMYOR (Q9S611)	1e-147	527	73%	UniProt GenBank	D-alanine--D-alanine ligase D-Ala-D-Ala ligase D-alanylalanine synthetase	ddlN ddl vanA	Amycolatopsis orientalis Nocardia orientalis	6.3.2.4 niceE keggE
14	B8FPP6_DESHD (B8FPP6)	1e-146	523	74%	UniProt GenBank	D-alanine--D-alanine ligase 1 D-Ala-D-Ala ligase 1 D-alanylalanine synthetase 1	ddl1 Dhaf_1664	Desulfitobacterium hafniense (strain DCB-2 / DSM 10664)	6.3.2.4 niceE keggE
15	D2PMX5_KRIFD (D2PMX5)	1e-146	523	73%	UniProt GenBank	D-alanine--D-alanine ligase 2 D-Ala-D-Ala ligase 2 D-alanylalanine synthetase 2	ddl2 Kfla_3620	Kribbella flavida (strain DSM 17836 / JCM 10339 / NBRC 14399)	6.3.2.4 niceE keggE
16	D9VBI2_9ACTO (D9VBI2)	1e-146	521	72%	UniProt GenBank	D-alanine--D-alanine ligase 2 D-Ala-D-Ala ligase 2 D-alanylalanine synthetase 2	ddl2 SSMG_01115	Streptomyces sp. AA4	6.3.2.4 niceE keggE
17	B5I695_9ACTO (B5I695)	1e-145	520	72%	UniProt GenBank	D-alanine--D-alanine ligase 2 D-Ala-D-Ala ligase 2 D-alanylalanine synthetase 2	ddl2 SSEG_10121	Streptomyces sviceus ATCC 29083	6.3.2.4 niceE keggE
18	D8HIR0_AMYMU (D8HIR0)	1e-145	519	74%	UniProt GenBank	D-alanine--D-alanine ligase 2 D-Ala-D-Ala ligase 2 D-alanylalanine synthetase 2	ddlA ddl2 AMED_8289	Amycolatopsis mediterranei (strain U-32)	6.3.2.4 niceE keggE
19	E9UYS7_9ACTO (E9UYS7)	1e-144	516	73%	UniProt GenBank	D-alanine--D-alanine ligase D-Ala-D-Ala ligase D-alanylalanine synthetase	ddl NBCG_03948	Nocardioidaceae bacterium Broad-1	6.3.2.4 niceE keggE
20	Q20FL7_9PSEU (Q20FL7)	1e-144	514	74%	UniProt GenBank	D-alanine--D-alanine ligase 1 D-Ala-D-Ala ligase 1 D-alanylalanine synthetase 1	ddlN ddl1	Amycolatopsis coloradensis	6.3.2.4 niceE keggE
21	Q6IWG3_9PSEU (Q6IWG3)	1e-143	513	74%	UniProt GenBank	D-alanine--D-alanine ligase 2 D-Ala-D-Ala ligase 2 D-alanylalanine synthetase 2	ddlN ddl2	Amycolatopsis coloradensis	6.3.2.4 niceE keggE
22	Q24R63_DESHY (Q24R63)	1e-140	501	70%	UniProt GenBank	D-alanine--D-alanine ligase 2 D-Ala-D-Ala ligase 2 D-alanylalanine synthetase 2	ddl2 DSY3690	Desulfitobacterium hafniense (strain Y51)	6.3.2.4 niceE keggE
23	D3PUW5_STANL (D3PUW5)	1e-139	499	68%	UniProt GenBank	D-alanine/D-alanine ligase	Snas_5356	Stackebrandtia nassauensis (strain DSM 44728 / NRRL B-16338 / NBRC 102104 / LLR-40K-21)	6.3.2.4 niceE keggE
24	D5US97_TSUPD (D5US97)	1e-138	494	69%	UniProt GenBank	D-alanine--D-alanine ligase 1 D-Ala-D-Ala ligase 1 D-alanylalanine synthetase 1	ddl1 Tpau_0523	Tsukamurella paurometabola (strain ATCC 8368 / DSM 20162 / JCM 10117 / NBRC 16120 / NCTC 13040) Corynebacterium paurometabolum	6.3.2.4 niceE keggE
25	O52073_PAEPP (O52073)	1e-133	478	63%	UniProt GenBank	D-alanine--D-alanine ligase D-Ala-D-Ala ligase D-alanylalanine synthetase	vanE ddl	Paenibacillus popilliae Bacillus popilliae	6.3.2.4 niceE keggE
26	C4NZP6_ENTFC (C4NZP6)	1e-132	475	64%	UniProt GenBank	D-alanine--D-alanine ligase 4 D-Ala-D-Ala ligase 4 D-alanylalanine synthetase 4	vanB ddl4	Enterococcus faecium Streptococcus faecium	6.3.2.4 niceE keggE
27	Q5MPR1_9CLOT (Q5MPR1)	1e-131	474	64%	UniProt GenBank	D-alanine--D-alanine ligase D-Ala-D-Ala ligase D-alanylalanine synthetase	vanB ddl	Clostridium sp. MLG480	6.3.2.4 niceE keggE
28	C7WYV3_ENTFA (C7WYV3)	1e-131	473	64%	UniProt GenBank	D-alanine--D-alanine ligase 2 D-Ala-D-Ala ligase 2 D-alanylalanine synthetase 2	ddl2 EFGG_02746	Enterococcus faecalis Merz96	6.3.2.4 niceE keggE
29	VANB_ENTFA (Q06893)	1e-131	473	64%	UniProt GenBank	Vancomycin B-type resistance protein VanB D-alanine--D-lactate ligase VanB ligase	vanB vanB2 EF_2294	Enterococcus faecalis Streptococcus faecalis	6.1.2.1 niceE keggE
30	Q5MPR3_9CLOT (Q5MPR3)	1e-131	473	64%	UniProt GenBank	D-alanine--D-alanine ligase D-Ala-D-Ala ligase D-alanylalanine synthetase	vanB ddl	Clostridium sp. MLG856-1	6.3.2.4 niceE keggE
31	Q5MPQ8_9CLOT (Q5MPQ8)	1e-131	473	64%	UniProt GenBank	D-alanine--D-alanine ligase D-Ala-D-Ala ligase D-alanylalanine synthetase	vanB ddl	Clostridium sp. MLG392	6.3.2.4 niceE keggE
32	Q5MPQ7_9CLOT (Q5MPQ7)	1e-131	473	64%	UniProt GenBank	D-alanine--D-alanine ligase D-Ala-D-Ala ligase D-alanylalanine synthetase	vanB ddl	Clostridium sp. MLG661	6.3.2.4 niceE keggE
33	Q58F99_ENTFC (Q58F99)	1e-131	473	64%	UniProt GenBank	D-alanine--D-alanine ligase 10 D-Ala-D-Ala ligase 10 D-alanylalanine synthetase 10	vanB ddl10	Enterococcus faecium Streptococcus faecium	6.3.2.4 niceE keggE
34	B6ZHJ4_ENTFA (B6ZHJ4)	1e-131	473	64%	UniProt GenBank	D-alanine--D-alanine ligase 4 D-Ala-D-Ala ligase 4 D-alanylalanine synthetase 4	vanB2 ddl4	Enterococcus faecalis Streptococcus faecalis	6.3.2.4 niceE keggE
35	Q5MPQ4_9CLOT (Q5MPQ4)	1e-131	472	64%	UniProt GenBank	D-alanine--D-alanine ligase D-Ala-D-Ala ligase D-alanylalanine synthetase	vanB ddl	Clostridium sp. MLG101	6.3.2.4 niceE keggE
36	Q84CN3_ENTFC (Q84CN3)	1e-131	472	64%	UniProt GenBank	D-alanine--D-alanine ligase 15 D-Ala-D-Ala ligase 15 D-alanylalanine synthetase 15	vanB2 ddl15	Enterococcus faecium Streptococcus faecium	6.3.2.4 niceE keggE
37	Q9L8Y0_ENTFA (Q9L8Y0)	1e-131	472	64%	UniProt GenBank	D-alanine--D-alanine ligase 13 D-Ala-D-Ala ligase 13 D-alanylalanine synthetase 13	vanB ddl13	Enterococcus faecalis Streptococcus faecalis	6.3.2.4 niceE keggE
38	P97205_ENTFC (P97205)	1e-131	471	64%	UniProt GenBank	D-alanine--D-alanine ligase 8 D-Ala-D-Ala ligase 8 D-alanylalanine synthetase 8	vanB2 ddl8 vanB	Enterococcus faecium Streptococcus faecium	6.3.2.4 niceE keggE
39	Q5MPQ3_9CLOT (Q5MPQ3)	1e-130	470	63%	UniProt GenBank	D-alanine--D-alanine ligase D-Ala-D-Ala ligase D-alanylalanine synthetase	vanB ddl	Clostridium sp. MLG245	6.3.2.4 niceE keggE
40	Q5MPQ2_ENTFC (Q5MPQ2)	1e-130	470	63%	UniProt GenBank	D-alanine--D-alanine ligase 11 D-Ala-D-Ala ligase 11 D-alanylalanine synthetase 11	vanB ddl11	Enterococcus faecium Streptococcus faecium	6.3.2.4 niceE keggE
41	Q6DT39_PANTH (Q6DT39)	1e-130	470	62%	UniProt GenBank	D-alanine--D-alanine ligase 2 D-Ala-D-Ala ligase 2 D-alanylalanine synthetase 2	vanA ddl2	Paenibacillus thiaminolyticus Bacillus thiaminolyticus	6.3.2.4 niceE keggE
42	Q9EYW3_ENTFC (Q9EYW3)	1e-130	469	63%	UniProt GenBank	D-alanine--D-alanine ligase 18 D-Ala-D-Ala ligase 18 D-alanylalanine synthetase 18	vanB2 ddl18	Enterococcus faecium Streptococcus faecium	6.3.2.4 niceE keggE
43	Q5MPR0_9CLOT (Q5MPR0)	1e-130	469	63%	UniProt GenBank	D-alanine--D-alanine ligase D-Ala-D-Ala ligase D-alanylalanine synthetase	vanB ddl	Clostridium sp. MLG080-1	6.3.2.4 niceE keggE
44	Q5MPQ9_9FIRM (Q5MPQ9)	1e-130	469	63%	UniProt GenBank	D-alanine--D-alanine ligase D-Ala-D-Ala ligase D-alanylalanine synthetase	vanB ddl	Ruminococcus sp. MLG080-3	6.3.2.4 niceE keggE
45	Q56R48_9CLOT (Q56R48)	1e-130	469	63%	UniProt GenBank	D-alanine--D-alanine ligase D-Ala-D-Ala ligase D-alanylalanine synthetase	vanB ddl	Clostridium sp. CCRI-9842	6.3.2.4 niceE keggE
46	Q9EYW2_ENTFC (Q9EYW2)	1e-130	468	63%	UniProt GenBank	D-alanine--D-alanine ligase 17 D-Ala-D-Ala ligase 17 D-alanylalanine synthetase 17	vanB2 ddl17	Enterococcus faecium Streptococcus faecium	6.3.2.4 niceE keggE
47	D0APH5_ENTFC (D0APH5)	1e-130	468	63%	UniProt GenBank	D-alanine--D-alanine ligase 2 D-Ala-D-Ala ligase 2 D-alanylalanine synthetase 2	ddl2 EFXG_01480	Enterococcus faecium C68	6.3.2.4 niceE keggE
48	Q9EU36_ENTFC (Q9EU36)	1e-129	468	63%	UniProt GenBank	D-alanine--D-alanine ligase 16 D-Ala-D-Ala ligase 16 D-alanylalanine synthetase 16	vanB2 ddl16	Enterococcus faecium Streptococcus faecium	6.3.2.4 niceE keggE
49	Q7BHZ7_ENTFA (Q7BHZ7)	1e-129	468	63%	UniProt GenBank	D-alanine--D-alanine ligase 10 D-Ala-D-Ala ligase 10 D-alanylalanine synthetase 10	vanB2 ddl10	Enterococcus faecalis Streptococcus faecalis	6.3.2.4 niceE keggE
50	Q5MPQ5_9ACTN (Q5MPQ5)	1e-129	467	63%	UniProt GenBank	D-alanine--D-alanine ligase D-Ala-D-Ala ligase D-alanylalanine synthetase	vanB ddl	Eggerthella lenta	6.3.2.4 niceE keggE
51	Q5MPQ6_9CLOT (Q5MPQ6)	1e-129	467	63%	UniProt GenBank	D-alanine--D-alanine ligase D-Ala-D-Ala ligase D-alanylalanine synthetase	vanB ddl	Clostridium sp. MLG055	6.3.2.4 niceE keggE
52	Q5BP13_PANTH (Q5BP13)	1e-129	467	61%	UniProt GenBank	D-alanine--D-alanine ligase 1 D-Ala-D-Ala ligase 1 D-alanylalanine synthetase 1	vanA ddl1	Paenibacillus thiaminolyticus Bacillus thiaminolyticus	6.3.2.4 niceE keggE
53	C0X1V2_ENTFA (C0X1V2)	1e-129	467	64%	UniProt GenBank	D-alanine--D-alanine ligase 1 D-Ala-D-Ala ligase 1 D-alanylalanine synthetase 1	ddl1 HMPREF0348_0487	Enterococcus faecalis TX0104	6.3.2.4 niceE keggE
54	Q6DRQ2_9BACL (Q6DRQ2)	1e-129	467	62%	UniProt GenBank	D-alanine--D-alanine ligase D-Ala-D-Ala ligase D-alanylalanine synthetase	vanA ddl	Paenibacillus apiarius	6.3.2.4 niceE keggE
55	Q9EZQ9_ENTFC (Q9EZQ9)	1e-129	466	62%	UniProt GenBank	D-alanine--D-alanine ligase 19 D-Ala-D-Ala ligase 19 D-alanylalanine synthetase 19	vanD4 ddl19 vanD	Enterococcus faecium Streptococcus faecium	6.3.2.4 niceE keggE
56	Q7BWD7_STAAU (Q7BWD7)	1e-129	465	62%	UniProt GenBank	D-alanine--D-alanine ligase D-Ala-D-Ala ligase D-alanylalanine synthetase	vanA ddl VRA0040	Staphylococcus aureus	6.3.2.4 niceE keggE
57	Q7B608_ENTFC (Q7B608)	1e-129	465	62%	UniProt GenBank	D-alanine--D-alanine ligase 14 D-Ala-D-Ala ligase 14 D-alanylalanine synthetase 14	vanA ddl14	Enterococcus faecium Streptococcus faecium	6.3.2.4 niceE keggE
58	Q0WYK7_ENTFA (Q0WYK7)	1e-129	465	62%	UniProt GenBank	D-alanine--D-alanine ligase 5 D-Ala-D-Ala ligase 5 D-alanylalanine synthetase 5	vanA ddl5	Enterococcus faecalis Streptococcus faecalis	6.3.2.4 niceE keggE
59	D4RFM1_ENTFC (D4RFM1)	1e-129	465	62%	UniProt GenBank	D-alanine--D-alanine ligase 1 D-Ala-D-Ala ligase 1 D-alanylalanine synthetase 1	ddl1 EfmE1679_0618	Enterococcus faecium E1679	6.3.2.4 niceE keggE
60	D4QQA6_ENTFC (D4QQA6)	1e-129	465	62%	UniProt GenBank	D-alanine--D-alanine ligase 1 D-Ala-D-Ala ligase 1 D-alanylalanine synthetase 1	ddl1 EfmE1071_0107	Enterococcus faecium E1071	6.3.2.4 niceE keggE
61	C9C611_ENTFC (C9C611)	1e-129	465	62%	UniProt GenBank	D-alanine--D-alanine ligase 2 D-Ala-D-Ala ligase 2 D-alanylalanine synthetase 2	ddl2 EFTG_02041	Enterococcus faecium 1,231,410	6.3.2.4 niceE keggE
62	C7VPN8_ENTFA (C7VPN8)	1e-129	465	62%	UniProt GenBank	D-alanine--D-alanine ligase 2 D-Ala-D-Ala ligase 2 D-alanylalanine synthetase 2	ddl2 EFHG_05029	Enterococcus faecalis HIP11704	6.3.2.4 niceE keggE
63	VANA_ENTFC (P25051)	1e-129	465	62%	UniProt GenBank	Vancomycin/teicoplanin A-type resistance protein VanA D-alanine--D-lactate ligase VanA ligase	vanA	Enterococcus faecium Streptococcus faecium	6.1.2.1 niceE keggE
64	E3USG8_ENTFC (E3USG8)	1e-129	464	62%	UniProt GenBank	D-alanine--D-alanine ligase 6 D-Ala-D-Ala ligase 6 D-alanylalanine synthetase 6	ddl6 pLG1-0095	Enterococcus faecium Streptococcus faecium	6.3.2.4 niceE keggE
65	C3VIB4_ENTFC (C3VIB4)	1e-129	464	62%	UniProt GenBank	D-alanine--D-alanine ligase 2 D-Ala-D-Ala ligase 2 D-alanylalanine synthetase 2	vanA ddl2	Enterococcus faecium Streptococcus faecium	6.3.2.4 niceE keggE
66	E4JIF3_ENTFC (E4JIF3)	1e-128	463	62%	UniProt GenBank	D-alanine--D-alanine ligase 2 D-Ala-D-Ala ligase 2 D-alanylalanine synthetase 2	ddl2 HMPREF9524_01955	Enterococcus faecium TX0133a01	6.3.2.4 niceE keggE
67	E4ISK3_ENTFC (E4ISK3)	1e-128	463	62%	UniProt GenBank	D-alanine--D-alanine ligase 2 D-Ala-D-Ala ligase 2 D-alanylalanine synthetase 2	ddl2 HMPREF9522_01953	Enterococcus faecium TX0082	6.3.2.4 niceE keggE
68	E4IL20_ENTFC (E4IL20)	1e-128	463	62%	UniProt GenBank	D-alanine--D-alanine ligase 2 D-Ala-D-Ala ligase 2 D-alanylalanine synthetase 2	ddl2 HMPREF9527_02784	Enterococcus faecium TX0133C	6.3.2.4 niceE keggE
69	E2YNW0_ENTFA (E2YNW0)	1e-128	463	62%	UniProt GenBank	D-alanine--D-alanine ligase 2 D-Ala-D-Ala ligase 2 D-alanylalanine synthetase 2	ddl2 HMPREF9492_02153	Enterococcus faecalis DAPTO 512	6.3.2.4 niceE keggE
70	E2YB54_ENTFA (E2YB54)	1e-128	463	62%	UniProt GenBank	D-alanine--D-alanine ligase 1 D-Ala-D-Ala ligase 1 D-alanylalanine synthetase 1	ddl1 HMPREF9493_00792	Enterococcus faecalis DAPTO 516	6.3.2.4 niceE keggE
71	D4EY57_ENTFA (D4EY57)	1e-128	463	62%	UniProt GenBank	D-alanine--D-alanine ligase 2 D-Ala-D-Ala ligase 2 D-alanylalanine synthetase 2	ddl2 HMPREF9377_02490	Enterococcus faecalis R712	6.3.2.4 niceE keggE
72	D4EIM5_ENTFA (D4EIM5)	1e-128	463	62%	UniProt GenBank	D-alanine--D-alanine ligase 1 D-Ala-D-Ala ligase 1 D-alanylalanine synthetase 1	ddl1 HMPREF9376_00485	Enterococcus faecalis S613	6.3.2.4 niceE keggE
73	D2JBE4_ENTFC (D2JBE4)	1e-128	463	62%	UniProt GenBank	D-alanine--D-alanine ligase 5 D-Ala-D-Ala ligase 5 D-alanylalanine synthetase 5	vanA ddl5 SAP083A_022	Enterococcus faecium Streptococcus faecium	6.3.2.4 niceE keggE
74	C9CGP2_ENTFC (C9CGP2)	1e-128	463	62%	UniProt GenBank	D-alanine--D-alanine ligase 2 D-Ala-D-Ala ligase 2 D-alanylalanine synthetase 2	ddl2 EFPG_05424	Enterococcus faecium 1,230,933	6.3.2.4 niceE keggE
75	C9BR20_ENTFC (C9BR20)	1e-128	463	62%	UniProt GenBank	D-alanine--D-alanine ligase 2 D-Ala-D-Ala ligase 2 D-alanylalanine synthetase 2	ddl2 EFQG_02530	Enterococcus faecium 1,231,502	6.3.2.4 niceE keggE
76	Q60FX7_9ENTE (Q60FX7)	1e-128	462	62%	UniProt GenBank	D-alanine--D-alanine ligase 3 D-Ala-D-Ala ligase 3 D-alanylalanine synthetase 3	VanD ddl3 vanD	Enterococcus raffinosus	6.3.2.4 niceE keggE
77	Q9RMA6_BACCI (Q9RMA6)	1e-126	454	61%	UniProt GenBank	D-alanine--D-alanine ligase D-Ala-D-Ala ligase D-alanylalanine synthetase	vanA ddl	Bacillus circulans	6.3.2.4 niceE keggE
78	B8XGS3_ENTFC (B8XGS3)	1e-125	453	60%	UniProt GenBank	D-alanine--D-alanine ligase 1 D-Ala-D-Ala ligase 1 D-alanylalanine synthetase 1	vanM ddl1	Enterococcus faecium Streptococcus faecium	6.3.2.4 niceE keggE
79	Q6RVF7_ENTFC (Q6RVF7)	1e-125	453	61%	UniProt GenBank	D-alanine--D-alanine ligase 13 D-Ala-D-Ala ligase 13 D-alanylalanine synthetase 13	vanD5 ddl13	Enterococcus faecium Streptococcus faecium	6.3.2.4 niceE keggE
80	A8RJ06_9FIRM (A8RJ06)	1e-125	452	60%	UniProt GenBank	D-alanine--D-alanine ligase 2 D-Ala-D-Ala ligase 2 D-alanylalanine synthetase 2	vanD ddl2	Ruminococcus gauvreauii	6.3.2.4 niceE keggE
81	Q9XCR4_ENTFC (Q9XCR4)	1e-125	452	59%	UniProt GenBank	D-alanine--D-alanine ligase 23 D-Ala-D-Ala ligase 23 D-alanylalanine synthetase 23	vanD ddl23	Enterococcus faecium Streptococcus faecium	6.3.2.4 niceE keggE
82	Q9XBX2_ENTFC (Q9XBX2)	1e-124	449	59%	UniProt GenBank	D-alanine--D-alanine ligase 22 D-Ala-D-Ala ligase 22 D-alanylalanine synthetase 22	vanD ddl22	Enterococcus faecium Streptococcus faecium	6.3.2.4 niceE keggE
83	Q3S3G3_ENTGA (Q3S3G3)	1e-123	447	58%	UniProt GenBank	D-alanine--D-alanine ligase 7 D-Ala-D-Ala ligase 7 D-alanylalanine synthetase 7	vanD ddl7	Enterococcus gallinarum	6.3.2.4 niceE keggE
84	Q9S3S7_ENTFC (Q9S3S7)	1e-123	445	59%	UniProt GenBank	D-alanine--D-alanine ligase 21 D-Ala-D-Ala ligase 21 D-alanylalanine synthetase 21	vanD ddl21	Enterococcus faecium Streptococcus faecium	6.3.2.4 niceE keggE
85	C7EME8_STAAU (C7EME8)	1e-117	426	62%	UniProt GenBank	D-alanine:D-lactate ligase	vanA	Staphylococcus aureus
86	Q8VNM0_ENTFC (Q8VNM0)	1e-106	390	62%	UniProt GenBank	D-Ala:D-Lac ligase	vanB2	Enterococcus faecium Streptococcus faecium
87	Q8VNM1_ENTFC (Q8VNM1)	1e-105	387	61%	UniProt GenBank	D-Ala:D-Lac ligase	vanB2	Enterococcus faecium Streptococcus faecium
88	Q64H41_ENTFA (Q64H41)	1e-101	372	62%	UniProt GenBank	VanB		Enterococcus faecalis Streptococcus faecalis
89	Q6LC20_ENTFC (Q6LC20)	1e-100	369	63%	UniProt GenBank	Vancomycin resistance protein B	vanB	Enterococcus faecium Streptococcus faecium
90	O34728_ENTFC (O34728)	5e-99	365	62%	UniProt GenBank	Vancomycin resistance protein B	vanB	Enterococcus faecium Streptococcus faecium
91	O32595_ENTFC (O32595)	7e-99	365	62%	UniProt GenBank	Vancomycin resistance protein B	vanB	Enterococcus faecium Streptococcus faecium
92	P96760_ENTFA (P96760)	1e-96	357	63%	UniProt GenBank	Vancomycin resistance protein	vanB	Enterococcus faecalis Streptococcus faecalis
93	A2TJI8_ENTFC (A2TJI8)	2e-96	357	60%	UniProt GenBank	Vancomycin resistance protein A	vanA	Enterococcus faecium Streptococcus faecium
94	A2TJJ0_ENTFA (A2TJJ0)	1e-95	354	60%	UniProt GenBank	Vancomycin resistance protein A	vanA	Enterococcus faecalis Streptococcus faecalis
95	B9VGY5_STAHA (B9VGY5)	2e-95	353	65%	UniProt GenBank	VanA	vanA	Staphylococcus haemolyticus
96	Q51332_9CELL (Q51332)	2e-92	344	60%	UniProt GenBank	VanA2 protein	vanA2	Oerskovia turbata
97	Q64H40_ENTFA (Q64H40)	1e-87	328	61%	UniProt GenBank	VanB		Enterococcus faecalis Streptococcus faecalis
98	E2IY98_ENTFC (E2IY98)	2e-82	310	63%	UniProt GenBank	Vancomycin resistance protein A		Enterococcus faecium Streptococcus faecium
99	E2IY92_ENTFA (E2IY92)	2e-80	303	62%	UniProt GenBank	Vancomycin resistance protein A		Enterococcus faecalis Streptococcus faecalis
100	D6DF14_CLOSC (D6DF14)	2e-80	303	44%	UniProt GenBank	D-alanine--D-alanine ligase 1 D-Ala-D-Ala ligase 1 D-alanylalanine synthetase 1	ddl1 CLS_04660	Clostridium saccharolyticum	6.3.2.4 niceE keggE

2

Q70B05_ACTTI
(Q70B05)

0.0

696

99%

Product: D-alanine--D-alanine ligase 2
D-Ala-D-Ala ligase 2
D-alanylalanine synthetase 2
Gene: tcp3
ddl2
Organism: Actinoplanes teichomyceticus

1uniprot[Pubmed] 14702401
Organization of the teicoplanin gene cluster in Actinoplanes teichomyceticus.(Microbiology) [2004]

3

E9L1E9_9ZZZZ
(E9L1E9)

1e-173

610

86%

Product: Putative uncharacterized protein
Gene: CA37-5
Organism: uncultured organism CA37

1uniprot[Pubmed] 20945895
Tailoring enzyme-rich environmental DNA clones: a source of enzymes for generating libraries of unnatural natural products.(J. Am. Chem. Soc.) [2010]

4

E9L1P5_9ZZZZ
(E9L1P5)

1e-162

574

79%

Product: Putative uncharacterized protein
Gene: CA915-3
Organism: uncultured organism CA915

1uniprot[Pubmed] 20945895
Tailoring enzyme-rich environmental DNA clones: a source of enzymes for generating libraries of unnatural natural products.(J. Am. Chem. Soc.) [2010]

5

VANL_STRCO
(Q9XAK7)

1e-156

556

76%

Product: Putative D-alanine--D-lactate ligase
Vancomycin resistance-like protein
Gene: SCO3595
SC66T3.06
Organism: Streptomyces coelicolor

1uniprot[Pubmed] 12000953 [Medline] 21996410
Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).(Nature) [2002]

8

E9L1K1_9ZZZZ
(E9L1K1)

1e-154

548

77%

Product: Putative uncharacterized protein
Gene: CA878-2
Organism: uncultured organism CA878

1uniprot[Pubmed] 20945895
Tailoring enzyme-rich environmental DNA clones: a source of enzymes for generating libraries of unnatural natural products.(J. Am. Chem. Soc.) [2010]

9

A8L665_FRASN
(A8L665)

1e-153

545

74%

Product: D-alanine--D-alanine ligase 3
D-Ala-D-Ala ligase 3
D-alanylalanine synthetase 3
Gene: ddl3
Franean1_7137
Organism: Frankia sp. (strain EAN1pec)

1uniprot[Pubmed] 17151343
Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography.(Genome Res.) [2007]

10

O33806_STRTO
(O33806)

1e-151

539

76%

Product: D-alanine--D-alanine ligase
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene: DdlM
ddl
Organism: Streptomyces toyocaensis

[pubmed all]
1uniprot[Pubmed] 9177243 [Medline] 97322398 D-Ala-D-Ala ligases from glycopeptide antibiotic-producing organisms are highly homologous to the enterococcal vancomycin-resistance ligases VanA and VanB.(Proc. Natl. Acad. Sci. U.S.A.) [1997]
2uniprot[Pubmed] 12060705 [Medline] 22080153 Assembling the glycopeptide antibiotic scaffold: the biosynthesis of A47934 from Streptomyces toyocaensis NRRL15009.(Proc. Natl. Acad. Sci. U.S.A.) [2002]

11

C7QDM7_CATAD
(C7QDM7)

1e-150

536

72%

Product: D-alanine--D-alanine ligase 1
D-Ala-D-Ala ligase 1
D-alanylalanine synthetase 1
Gene: ddl1
Caci_5793
Organism: Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)

1uniprot
Complete genome sequence of Catenulispora acidiphila type strain (ID 139908).(Stand. Genomic Sci.) [2009]

13

Q9S611_AMYOR
(Q9S611)

1e-147

527

73%

Product: D-alanine--D-alanine ligase
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene: ddlN
ddl
vanA
Organism: Amycolatopsis orientalis
Nocardia orientalis

[pubmed all]
1uniprot[Pubmed] 9736537 [Medline] 98409705 Glycopeptide antibiotic resistance genes in glycopeptide-producing organisms.(Antimicrob. Agents Chemother.) [1998]
2uniprot[Pubmed] 9177243 [Medline] 97322398 D-Ala-D-Ala ligases from glycopeptide antibiotic-producing organisms are highly homologous to the enterococcal vancomycin-resistance ligases VanA and VanB.(Proc. Natl. Acad. Sci. U.S.A.) [1997]

18

D8HIR0_AMYMU
(D8HIR0)

1e-145

519

74%

Product: D-alanine--D-alanine ligase 2
D-Ala-D-Ala ligase 2
D-alanylalanine synthetase 2
Gene: ddlA
ddl2
AMED_8289
Organism: Amycolatopsis mediterranei (strain U-32)

1uniprot[Pubmed] 20567260
Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010]

20

Q20FL7_9PSEU
(Q20FL7)

1e-144

514

74%

Product: D-alanine--D-alanine ligase 1
D-Ala-D-Ala ligase 1
D-alanylalanine synthetase 1
Gene: ddlN
ddl1
Organism: Amycolatopsis coloradensis

1uniprot[Pubmed] 16476725
Heterologous expression of glycopeptide resistance vanHAX gene clusters from soil bacteria in Enterococcus faecalis.(J. Antimicrob. Chemother.) [2006]

21

Q6IWG3_9PSEU
(Q6IWG3)

1e-143

513

74%

Product: D-alanine--D-alanine ligase 2
D-Ala-D-Ala ligase 2
D-alanylalanine synthetase 2
Gene: ddlN
ddl2
Organism: Amycolatopsis coloradensis

1uniprot[Pubmed] 15200859
Antimicrobial resistance gene delivery in animal feeds.(Emerg. Infect. Dis.) [2004]

22

Q24R63_DESHY
(Q24R63)

1e-140

501

70%

Product: D-alanine--D-alanine ligase 2
D-Ala-D-Ala ligase 2
D-alanylalanine synthetase 2
Gene: ddl2
DSY3690
Organism: Desulfitobacterium hafniense (strain Y51)

1uniprot[Pubmed] 16513756
Complete genome sequence of the dehalorespiring bacterium Desulfitobacterium hafniense Y51 and comparison with Dehalococcoides ethenogenes 195.(J. Bacteriol.) [2006]

23

D3PUW5_STANL
(D3PUW5)

1e-139

499

68%

Product: D-alanine/D-alanine ligase
Gene: Snas_5356
Organism: Stackebrandtia nassauensis (strain DSM 44728 / NRRL B-16338 / NBRC 102104 / LLR-40K-21)

1uniprot
Complete genome sequence of Stackebrandtia nassauensis type strain (LLR-40K-21T).(Stand. Genomic Sci.) [2009]

25

O52073_PAEPP
(O52073)

1e-133

478

63%

Product: D-alanine--D-alanine ligase
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene: vanE
ddl
Organism: Paenibacillus popilliae
Bacillus popilliae

[pubmed all]
1uniprot[Pubmed] 10681342 [Medline] 20145393 The biopesticide Paenibacillus popilliae has a vancomycin resistance gene cluster homologous to the enterococcal VanA vancomycin resistance gene cluster.(Antimicrob. Agents Chemother.) [2000]
2uniprot[Pubmed] 15980329 Putative VanRS-like two-component regulatory system associated with the inducible glycopeptide resistance cluster of Paenibacillus popilliae.(Antimicrob. Agents Chemother.) [2005]

26

C4NZP6_ENTFC
(C4NZP6)

1e-132

475

64%

Product: D-alanine--D-alanine ligase 4
D-Ala-D-Ala ligase 4
D-alanylalanine synthetase 4
Gene: vanB
ddl4
Organism: Enterococcus faecium
Streptococcus faecium

1uniprot[Pubmed] 19273676
VanB-type Enterococcus faecium clinical isolate successively inducibly resistant to, dependent on, and constitutively resistant to vancomycin.(Antimicrob. Agents Chemother.) [2009]

27

Q5MPR1_9CLOT
(Q5MPR1)

1e-131

474

64%

Product: D-alanine--D-alanine ligase
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene: vanB
ddl
Organism: Clostridium sp. MLG480

1uniprot[Pubmed] 15616278
Comparison of three PCR primer sets for identification of vanB gene carriage in feces and correlation with carriage of vancomycin-resistant enterococci: interference by vanB-containing anaerobic bacilli.(Antimicrob. Agents Chemother.) [2005]

29

VANB_ENTFA
(Q06893)

1e-131

473

64%

Product: Vancomycin B-type resistance protein VanB
D-alanine--D-lactate ligase
VanB ligase
Gene: vanB
vanB2
EF_2294
Organism: Enterococcus faecalis
Streptococcus faecalis

[pubmed all]
1uniprot[Pubmed] 8125347 [Medline] 94171087 Sequence of the vanB and ddl genes encoding D-alanine:D-lactate and D-alanine:D-alanine ligases in vancomycin-resistant Enterococcus faecalis V583.(Gene) [1994]
2uniprot[Pubmed] 8631706 [Medline] 96200099 Regulation of VanB-type vancomycin resistance gene expression by the VanS(B)-VanR(B) two-component regulatory system in Enterococcus faecalis V583.(J. Bacteriol.) [1996]
3uniprot[Pubmed] 12663927 [Medline] 22550857 Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus faecalis.(Science) [2003]
4uniprot[Pubmed] 7957913 Purification and characterization of the VanB ligase associated with type B vancomycin resistance in Enterococcus faecalis V583.(FEBS Lett.) [1994]
5uniprot[Pubmed] 8440477 [Medline] 93178969 The vanB gene of vancomycin-resistant Enterococcus faecalis V583 is structurally related to genes encoding D-Ala:D-Ala ligases and glycopeptide-resistance proteins VanA and VanC.(Gene) [1993]
6uniprot[Pubmed] 8215270 [Medline] 94028785 A gene conferring resistance to vancomycin but not teicoplanin in isolates of Enterococcus faecalis and Enterococcus faecium demonstrates homology with vanB, vanA, and vanC genes of enterococci.(Antimicrob. Agents Chemother.) [1993]

30

Q5MPR3_9CLOT
(Q5MPR3)

1e-131

473

64%

Product: D-alanine--D-alanine ligase
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene: vanB
ddl
Organism: Clostridium sp. MLG856-1

1uniprot[Pubmed] 15616278
Comparison of three PCR primer sets for identification of vanB gene carriage in feces and correlation with carriage of vancomycin-resistant enterococci: interference by vanB-containing anaerobic bacilli.(Antimicrob. Agents Chemother.) [2005]

31

Q5MPQ8_9CLOT
(Q5MPQ8)

1e-131

473

64%

Product: D-alanine--D-alanine ligase
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene: vanB
ddl
Organism: Clostridium sp. MLG392

1uniprot[Pubmed] 15616278
Comparison of three PCR primer sets for identification of vanB gene carriage in feces and correlation with carriage of vancomycin-resistant enterococci: interference by vanB-containing anaerobic bacilli.(Antimicrob. Agents Chemother.) [2005]

32

Q5MPQ7_9CLOT
(Q5MPQ7)

1e-131

473

64%

Product: D-alanine--D-alanine ligase
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene: vanB
ddl
Organism: Clostridium sp. MLG661

1uniprot[Pubmed] 15616278
Comparison of three PCR primer sets for identification of vanB gene carriage in feces and correlation with carriage of vancomycin-resistant enterococci: interference by vanB-containing anaerobic bacilli.(Antimicrob. Agents Chemother.) [2005]

34

B6ZHJ4_ENTFA
(B6ZHJ4)

1e-131

473

64%

Product: D-alanine--D-alanine ligase 4
D-Ala-D-Ala ligase 4
D-alanylalanine synthetase 4
Gene: vanB2
ddl4
Organism: Enterococcus faecalis
Streptococcus faecalis

1uniprot[Pubmed] 19029325
Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2201, encoding erythromycin resistance and cytolysin (Hly/Bac).(Antimicrob. Agents Chemother.) [2009]

35

Q5MPQ4_9CLOT
(Q5MPQ4)

1e-131

472

64%

Product: D-alanine--D-alanine ligase
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene: vanB
ddl
Organism: Clostridium sp. MLG101

1uniprot[Pubmed] 15616278
Comparison of three PCR primer sets for identification of vanB gene carriage in feces and correlation with carriage of vancomycin-resistant enterococci: interference by vanB-containing anaerobic bacilli.(Antimicrob. Agents Chemother.) [2005]

36

Q84CN3_ENTFC
(Q84CN3)

1e-131

472

64%

Product: D-alanine--D-alanine ligase 15
D-Ala-D-Ala ligase 15
D-alanylalanine synthetase 15
Gene: vanB2
ddl15
Organism: Enterococcus faecium
Streptococcus faecium

1uniprot[Pubmed] 15057465
Characterization of the first VanB vancomycin-resistant Enterococcus faecium isolated in a Spanish hospital.(Curr. Microbiol.) [2004]

37

Q9L8Y0_ENTFA
(Q9L8Y0)

1e-131

472

64%

Product: D-alanine--D-alanine ligase 13
D-Ala-D-Ala ligase 13
D-alanylalanine synthetase 13
Gene: vanB
ddl13
Organism: Enterococcus faecalis
Streptococcus faecalis

1uniprot[Pubmed] 10846226 [Medline] 20307505
Characterization of transposon Tn1549, conferring VanB-type resistance in Enterococcus spp.(Microbiology) [2000]

38

P97205_ENTFC
(P97205)

1e-131

471

64%

Product: D-alanine--D-alanine ligase 8
D-Ala-D-Ala ligase 8
D-alanylalanine synthetase 8
Gene: vanB2
ddl8
vanB
Organism: Enterococcus faecium
Streptococcus faecium

[pubmed all]
1uniprot[Pubmed] 14617162 [Medline] 22983133 A six amino acid deletion, partially overlapping the VanSB G2 ATP-binding motif, leads to constitutive glycopeptide resistance in VanB-type Enterococcus faecium.(Mol. Microbiol.) [2003]
2uniprot[Pubmed] 11376048 [Medline] 21270249 High prevalence of VanB2 vancomycin-resistant Enterococcus faecium in Taiwan.(J. Clin. Microbiol.) [2001]

39

Q5MPQ3_9CLOT
(Q5MPQ3)

1e-130

470

63%

Product: D-alanine--D-alanine ligase
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene: vanB
ddl
Organism: Clostridium sp. MLG245

1uniprot[Pubmed] 15616278
Comparison of three PCR primer sets for identification of vanB gene carriage in feces and correlation with carriage of vancomycin-resistant enterococci: interference by vanB-containing anaerobic bacilli.(Antimicrob. Agents Chemother.) [2005]

2uniprot
Molecular characterization of vanB elements in naturally-occurring gut anaerobes.(Antimicrob. Agents Chemother.) [2005]

40

Q5MPQ2_ENTFC
(Q5MPQ2)

1e-130

470

63%

Product: D-alanine--D-alanine ligase 11
D-Ala-D-Ala ligase 11
D-alanylalanine synthetase 11
Gene: vanB
ddl11
Organism: Enterococcus faecium
Streptococcus faecium

1uniprot[Pubmed] 15616278
Comparison of three PCR primer sets for identification of vanB gene carriage in feces and correlation with carriage of vancomycin-resistant enterococci: interference by vanB-containing anaerobic bacilli.(Antimicrob. Agents Chemother.) [2005]

2uniprot
Molecular characterization of vanB elements in naturally-occurring gut anaerobes.(Antimicrob. Agents Chemother.) [2005]

41

Q6DT39_PANTH
(Q6DT39)

1e-130

470

62%

Product: D-alanine--D-alanine ligase 2
D-Ala-D-Ala ligase 2
D-alanylalanine synthetase 2
Gene: vanA
ddl2
Organism: Paenibacillus thiaminolyticus
Bacillus thiaminolyticus

[pubmed all]
1uniprot[Pubmed] 15561881 Members of the genera Paenibacillus and Rhodococcus harbor genes homologous to enterococcal glycopeptide resistance genes vanA and vanB.(Antimicrob. Agents Chemother.) [2004]
2uniprot[Pubmed] 16189102 Glycopeptide resistance vanA operons in Paenibacillus strains isolated from soil.(Antimicrob. Agents Chemother.) [2005]

42

Q9EYW3_ENTFC
(Q9EYW3)

1e-130

469

63%

Product: D-alanine--D-alanine ligase 18
D-Ala-D-Ala ligase 18
D-alanylalanine synthetase 18
Gene: vanB2
ddl18
Organism: Enterococcus faecium
Streptococcus faecium

1uniprot[Pubmed] 11376048 [Medline] 21270249
High prevalence of VanB2 vancomycin-resistant Enterococcus faecium in Taiwan.(J. Clin. Microbiol.) [2001]

43

Q5MPR0_9CLOT
(Q5MPR0)

1e-130

469

63%

Product: D-alanine--D-alanine ligase
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene: vanB
ddl
Organism: Clostridium sp. MLG080-1

1uniprot[Pubmed] 15616278
Comparison of three PCR primer sets for identification of vanB gene carriage in feces and correlation with carriage of vancomycin-resistant enterococci: interference by vanB-containing anaerobic bacilli.(Antimicrob. Agents Chemother.) [2005]

44

Q5MPQ9_9FIRM
(Q5MPQ9)

1e-130

469

63%

Product: D-alanine--D-alanine ligase
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene: vanB
ddl
Organism: Ruminococcus sp. MLG080-3

1uniprot[Pubmed] 15616278
Comparison of three PCR primer sets for identification of vanB gene carriage in feces and correlation with carriage of vancomycin-resistant enterococci: interference by vanB-containing anaerobic bacilli.(Antimicrob. Agents Chemother.) [2005]

45

Q56R48_9CLOT
(Q56R48)

1e-130

469

63%

Product: D-alanine--D-alanine ligase
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene: vanB
ddl
Organism: Clostridium sp. CCRI-9842

1uniprot[Pubmed] 15731199
Characterization of a Tn5382-like transposon containing the vanB2 gene cluster in a Clostridium strain isolated from human faeces.(J. Antimicrob. Chemother.) [2005]

46

Q9EYW2_ENTFC
(Q9EYW2)

1e-130

468

63%

Product: D-alanine--D-alanine ligase 17
D-Ala-D-Ala ligase 17
D-alanylalanine synthetase 17
Gene: vanB2
ddl17
Organism: Enterococcus faecium
Streptococcus faecium

1uniprot[Pubmed] 11376048 [Medline] 21270249
High prevalence of VanB2 vancomycin-resistant Enterococcus faecium in Taiwan.(J. Clin. Microbiol.) [2001]

48

Q9EU36_ENTFC
(Q9EU36)

1e-129

468

63%

Product: D-alanine--D-alanine ligase 16
D-Ala-D-Ala ligase 16
D-alanylalanine synthetase 16
Gene: vanB2
ddl16
Organism: Enterococcus faecium
Streptococcus faecium

1uniprot[Pubmed] 11376048 [Medline] 21270249
High prevalence of VanB2 vancomycin-resistant Enterococcus faecium in Taiwan.(J. Clin. Microbiol.) [2001]

49

Q7BHZ7_ENTFA
(Q7BHZ7)

1e-129

468

63%

Product: D-alanine--D-alanine ligase 10
D-Ala-D-Ala ligase 10
D-alanylalanine synthetase 10
Gene: vanB2
ddl10
Organism: Enterococcus faecalis
Streptococcus faecalis

1uniprot[Pubmed] 11376048 [Medline] 21270249
High prevalence of VanB2 vancomycin-resistant Enterococcus faecium in Taiwan.(J. Clin. Microbiol.) [2001]

50

Q5MPQ5_9ACTN
(Q5MPQ5)

1e-129

467

63%

Product: D-alanine--D-alanine ligase
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene: vanB
ddl
Organism: Eggerthella lenta

1uniprot[Pubmed] 15616278
Comparison of three PCR primer sets for identification of vanB gene carriage in feces and correlation with carriage of vancomycin-resistant enterococci: interference by vanB-containing anaerobic bacilli.(Antimicrob. Agents Chemother.) [2005]

2uniprot
Molecular characterization of vanB elements in naturally-occurring gut anaerobes.(Antimicrob. Agents Chemother.) [2005]

51

Q5MPQ6_9CLOT
(Q5MPQ6)

1e-129

467

63%

Product: D-alanine--D-alanine ligase
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene: vanB
ddl
Organism: Clostridium sp. MLG055

1uniprot[Pubmed] 15616278
Comparison of three PCR primer sets for identification of vanB gene carriage in feces and correlation with carriage of vancomycin-resistant enterococci: interference by vanB-containing anaerobic bacilli.(Antimicrob. Agents Chemother.) [2005]

54

Q6DRQ2_9BACL
(Q6DRQ2)

1e-129

467

62%

Product: D-alanine--D-alanine ligase
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene: vanA
ddl
Organism: Paenibacillus apiarius

[pubmed all]
1uniprot[Pubmed] 15561881 Members of the genera Paenibacillus and Rhodococcus harbor genes homologous to enterococcal glycopeptide resistance genes vanA and vanB.(Antimicrob. Agents Chemother.) [2004]
2uniprot[Pubmed] 16189102 Glycopeptide resistance vanA operons in Paenibacillus strains isolated from soil.(Antimicrob. Agents Chemother.) [2005]

55

Q9EZQ9_ENTFC
(Q9EZQ9)

1e-129

466

62%

Product: D-alanine--D-alanine ligase 19
D-Ala-D-Ala ligase 19
D-alanylalanine synthetase 19
Gene: vanD4
ddl19
vanD
Organism: Enterococcus faecium
Streptococcus faecium

[pubmed all]
1uniprot[Pubmed] 11083656 [Medline] 20536225 Characterization of a divergent vanD-type resistance element from the first glycopeptide-resistant strain of Enterococcus faecium isolated in Brazil.(Antimicrob. Agents Chemother.) [2000]
2uniprot[Pubmed] 12499162 [Medline] 22386893 VanD-type vancomycin-resistant Enterococcus faecium 10/96A.(Antimicrob. Agents Chemother.) [2003]

56

Q7BWD7_STAAU
(Q7BWD7)

1e-129

465

62%

Product: D-alanine--D-alanine ligase
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene: vanA
ddl
VRA0040
Organism: Staphylococcus aureus

1uniprot[Pubmed] 14645850
Genetic analysis of a high-level vancomycin-resistant isolate of Staphylococcus aureus.(Science) [2003]

57

Q7B608_ENTFC
(Q7B608)

1e-129

465

62%

Product: D-alanine--D-alanine ligase 14
D-Ala-D-Ala ligase 14
D-alanylalanine synthetase 14
Gene: vanA
ddl14
Organism: Enterococcus faecium
Streptococcus faecium

[pubmed all]
1uniprot[Pubmed] 17116680 Comparative DNA analysis of two vanA plasmids from Enterococcus faecium strains isolated from poultry and a poultry farmer in Norway.(Antimicrob. Agents Chemother.) [2007]
2uniprot[Pubmed] 17951264 Molecular characterization of vancomycin-resistant enterococci in Hangzhou, China.(J. Antimicrob. Chemother.) [2007]
3uniprot[Pubmed] 19846656 Heteroresistance to teicoplanin in Enterococcus faecium harboring the vanA gene.(J. Clin. Microbiol.) [2009]
4uniprot[Pubmed] 18511120 The toxin-antitoxin system w-e-z ensures stable maintenance of vanA plasmids in an antibiotic-free environment.(Plasmid) [2008]
5uniprot Tn1546 is part of a larger plasmid-encoded genetic unit horizontally disseminated among clonal Enterococcus faecium lineages.(J. Antimicrob. Chemother.) [2010]

58

Q0WYK7_ENTFA
(Q0WYK7)

1e-129

465

62%

Product: D-alanine--D-alanine ligase 5
D-Ala-D-Ala ligase 5
D-alanylalanine synthetase 5
Gene: vanA
ddl5
Organism: Enterococcus faecalis
Streptococcus faecalis

[pubmed all]
1uniprot[Pubmed] 17021204 Pheromone-responsive conjugative vancomycin resistance plasmids in Enterococcus faecalis isolates from humans and chicken feces.(Appl. Environ. Microbiol.) [2006]
2uniprot[Pubmed] 20660665 Dissemination of an Enterococcus Inc18-Like vanA plasmid associated with vancomycin-resistant Staphylococcus aureus.(Antimicrob. Agents Chemother.) [2010]

59

D4RFM1_ENTFC
(D4RFM1)

1e-129

465

62%

Product: D-alanine--D-alanine ligase 1
D-Ala-D-Ala ligase 1
D-alanylalanine synthetase 1
Gene: ddl1
EfmE1679_0618
Organism: Enterococcus faecium E1679

1uniprot[Pubmed] 20398277
Pyrosequencing-based comparative genome analysis of the nosocomial pathogen Enterococcus faecium and identification of a large transferable pathogenicity island.(BMC Genomics) [2010]

60

D4QQA6_ENTFC
(D4QQA6)

1e-129

465

62%

Product: D-alanine--D-alanine ligase 1
D-Ala-D-Ala ligase 1
D-alanylalanine synthetase 1
Gene: ddl1
EfmE1071_0107
Organism: Enterococcus faecium E1071

1uniprot[Pubmed] 20398277
Pyrosequencing-based comparative genome analysis of the nosocomial pathogen Enterococcus faecium and identification of a large transferable pathogenicity island.(BMC Genomics) [2010]

63

VANA_ENTFC
(P25051)

1e-129

465

62%

Product: Vancomycin/teicoplanin A-type resistance protein VanA
D-alanine--D-lactate ligase
VanA ligase
Gene: vanA
Organism: Enterococcus faecium
Streptococcus faecium

[pubmed all]
1uniprot[Pubmed] 2266943 [Medline] 91094773 The VANA glycopeptide resistance protein is related to D-alanyl-D-alanine ligase cell wall biosynthesis enzymes.(Mol. Gen. Genet.) [1990]
2uniprot[Pubmed] 8380148 [Medline] 93106944 Characterization of Tn1546, a Tn3-related transposon conferring glycopeptide resistance by synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147.(J. Bacteriol.) [1993]
3uniprot[Pubmed] 1931965 [Medline] 92031480 Molecular basis for vancomycin resistance in Enterococcus faecium BM4147: biosynthesis of a depsipeptide peptidoglycan precursor by vancomycin resistance proteins VanH and VanA.(Biochemistry) [1991]
4uniprot[Pubmed] 1522072 [Medline] 92394903 The cytoplasmic peptidoglycan precursor of vancomycin-resistant Enterococcus faecalis terminates in lactate.(J. Bacteriol.) [1992]
5uniprot[Pubmed] 10908650 The molecular basis of vancomycin resistance in clinically relevant Enterococci: crystal structure of D-alanyl-D-lactate ligase (VanA).(Proc. Natl. Acad. Sci. U.S.A.) [2000]

64

E3USG8_ENTFC
(E3USG8)

1e-129

464

62%

Product: D-alanine--D-alanine ligase 6
D-Ala-D-Ala ligase 6
D-alanylalanine synthetase 6
Gene: ddl6
pLG1-0095
Organism: Enterococcus faecium
Streptococcus faecium

1uniprot[Pubmed] 20951641
A multiresistance megaplasmid pLG1 bearing a hylEfm genomic island in hospital Enterococcus faecium isolates.(Int. J. Med. Microbiol.) [2011]

73

D2JBE4_ENTFC
(D2JBE4)

1e-128

463

62%

Product: D-alanine--D-alanine ligase 5
D-Ala-D-Ala ligase 5
D-alanylalanine synthetase 5
Gene: vanA
ddl5
SAP083A_022
Organism: Enterococcus faecium
Streptococcus faecium

1uniprot[Pubmed] 21030436
Txe, an endoribonuclease of the enterococcal Axe-Txe toxin-antitoxin system, cleaves mRNA and inhibits protein synthesis.(Microbiology) [2011]

76

Q60FX7_9ENTE
(Q60FX7)

1e-128

462

62%

Product: D-alanine--D-alanine ligase 3
D-Ala-D-Ala ligase 3
D-alanylalanine synthetase 3
Gene: VanD
ddl3
vanD
Organism: Enterococcus raffinosus

1uniprot[Pubmed] 17000737
First VanD-Type vancomycin-resistant Enterococcus raffinosus isolate.(Antimicrob. Agents Chemother.) [2006]

77

Q9RMA6_BACCI
(Q9RMA6)

1e-126

454

61%

Product: D-alanine--D-alanine ligase
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene: vanA
ddl
Organism: Bacillus circulans

1uniprot[Pubmed] 9687406 [Medline] 98353334
vanA gene cluster in a vancomycin-resistant clinical isolate of Bacillus circulans.(Antimicrob. Agents Chemother.) [1998]

78

B8XGS3_ENTFC
(B8XGS3)

1e-125

453

60%

Product: D-alanine--D-alanine ligase 1
D-Ala-D-Ala ligase 1
D-alanylalanine synthetase 1
Gene: vanM
ddl1
Organism: Enterococcus faecium
Streptococcus faecium

1uniprot[Pubmed] 20733041
vanM, a new glycopeptide resistance gene cluster found in Enterococcus faecium.(Antimicrob. Agents Chemother.) [2010]

79

Q6RVF7_ENTFC
(Q6RVF7)

1e-125

453

61%

Product: D-alanine--D-alanine ligase 13
D-Ala-D-Ala ligase 13
D-alanylalanine synthetase 13
Gene: vanD5
ddl13
Organism: Enterococcus faecium
Streptococcus faecium

1uniprot[Pubmed] 15308604
Enterococcus faecium N03-0072 carries a new VanD-type vancomycin resistance determinant: characterization of the VanD5 operon.(J. Antimicrob. Chemother.) [2004]

80

A8RJ06_9FIRM
(A8RJ06)

1e-125

452

60%

Product: D-alanine--D-alanine ligase 2
D-Ala-D-Ala ligase 2
D-alanylalanine synthetase 2
Gene: vanD
ddl2
Organism: Ruminococcus gauvreauii

1uniprot[Pubmed] 17724150
vanD and vanG-Like Gene Clusters in a Ruminococcus Species Isolated from Human Bowel Flora.(Antimicrob. Agents Chemother.) [2007]

81

Q9XCR4_ENTFC
(Q9XCR4)

1e-125

452

59%

Product: D-alanine--D-alanine ligase 23
D-Ala-D-Ala ligase 23
D-alanylalanine synthetase 23
Gene: vanD
ddl23
Organism: Enterococcus faecium
Streptococcus faecium

1uniprot[Pubmed] 10368136 [Medline] 99296571
Characterization of the vanD glycopeptide resistance gene cluster from Enterococcus faecium BM4339.(J. Bacteriol.) [1999]

82

Q9XBX2_ENTFC
(Q9XBX2)

1e-124

449

59%

Product: D-alanine--D-alanine ligase 22
D-Ala-D-Ala ligase 22
D-alanylalanine synthetase 22
Gene: vanD
ddl22
Organism: Enterococcus faecium
Streptococcus faecium

[pubmed all]
1uniprot[Pubmed] 10479146 [Medline] 99408840 A cluster of VanD vancomycin-resistant Enterococcus faecium: molecular characterization and clinical epidemiology.(J. Infect. Dis.) [1999]
2uniprot[Pubmed] 19258279 New combinations of mutations in VanD-Type vancomycin-resistant Enterococcus faecium, Enterococcus faecalis, and Enterococcus avium strains.(Antimicrob. Agents Chemother.) [2009]

83

Q3S3G3_ENTGA
(Q3S3G3)

1e-123

447

58%

Product: D-alanine--D-alanine ligase 7
D-Ala-D-Ala ligase 7
D-alanylalanine synthetase 7
Gene: vanD
ddl7
Organism: Enterococcus gallinarum

1uniprot[Pubmed] 16495270
Enterococcus gallinarum N04-0414 harbors a VanD-type vancomycin resistance operon and does not contain a D-alanine:D-alanine 2 (ddl2) gene.(Antimicrob. Agents Chemother.) [2006]

84

Q9S3S7_ENTFC
(Q9S3S7)

1e-123

445

59%

Product: D-alanine--D-alanine ligase 21
D-Ala-D-Ala ligase 21
D-alanylalanine synthetase 21
Gene: vanD
ddl21
Organism: Enterococcus faecium
Streptococcus faecium

1uniprot[Pubmed] 10835012 [Medline] 20295129
Molecular characterization of the vanD gene cluster and a novel insertion element in a vancomycin-resistant enterococcus isolated in Canada.(J. Clin. Microbiol.) [2000]

86

Q8VNM0_ENTFC
(Q8VNM0)

1e-106

390

62%

Product: D-Ala:D-Lac ligase
Gene: vanB2
Organism: Enterococcus faecium
Streptococcus faecium

1uniprot[Pubmed] 11724832 [Medline] 21646382
Selection of a teicoplanin-resistant Enterococcus faecium mutant during an outbreak caused by vancomycin-resistant enterococci with the vanB phenotype.(J. Clin. Microbiol.) [2001]

87

Q8VNM1_ENTFC
(Q8VNM1)

1e-105

387

61%

Product: D-Ala:D-Lac ligase
Gene: vanB2
Organism: Enterococcus faecium
Streptococcus faecium

1uniprot[Pubmed] 11724832 [Medline] 21646382
Selection of a teicoplanin-resistant Enterococcus faecium mutant during an outbreak caused by vancomycin-resistant enterococci with the vanB phenotype.(J. Clin. Microbiol.) [2001]

88

Q64H41_ENTFA
(Q64H41)

1e-101

372

62%

Product: VanB
Gene
Organism: Enterococcus faecalis
Streptococcus faecalis

1uniprot[Pubmed] 17619103
Vancomycin-Resistant Enterococci in a Chinese Hospital.(Curr. Microbiol.) [2007]

90

O34728_ENTFC
(O34728)

5e-99

365

62%

Product: Vancomycin resistance protein B
Gene: vanB
Organism: Enterococcus faecium
Streptococcus faecium

1uniprot[Pubmed] 9449290 [Medline] 98109344
DNA sequence variation within vanA, vanB, vanC-1, and vanC-2/3 genes of clinical Enterococcus isolates.(Antimicrob. Agents Chemother.) [1998]

91

O32595_ENTFC
(O32595)

7e-99

365

62%

Product: Vancomycin resistance protein B
Gene: vanB
Organism: Enterococcus faecium
Streptococcus faecium

1uniprot[Pubmed] 9449290 [Medline] 98109344
DNA sequence variation within vanA, vanB, vanC-1, and vanC-2/3 genes of clinical Enterococcus isolates.(Antimicrob. Agents Chemother.) [1998]

92

P96760_ENTFA
(P96760)

1e-96

357

63%

Product: Vancomycin resistance protein
Gene: vanB
Organism: Enterococcus faecalis
Streptococcus faecalis

1uniprot[Pubmed] 9041416 [Medline] 97193831
Multiplex PCR detection of vanA, vanB, vanC-1, and vanC-2/3 genes in enterococci.(J. Clin. Microbiol.) [1997]

93

A2TJI8_ENTFC
(A2TJI8)

2e-96

357

60%

Product: Vancomycin resistance protein A
Gene: vanA
Organism: Enterococcus faecium
Streptococcus faecium

1uniprot[Pubmed] 18187222
Low prevalence of vancomycin- and bifunctional aminoglycoside-resistant enterococci isolated from poultry farms in Malaysia.(Int. J. Food Microbiol.) [2008]

94

A2TJJ0_ENTFA
(A2TJJ0)

1e-95

354

60%

Product: Vancomycin resistance protein A
Gene: vanA
Organism: Enterococcus faecalis
Streptococcus faecalis

1uniprot[Pubmed] 18187222
Low prevalence of vancomycin- and bifunctional aminoglycoside-resistant enterococci isolated from poultry farms in Malaysia.(Int. J. Food Microbiol.) [2008]

96

Q51332_9CELL
(Q51332)

2e-92

344

60%

Product: VanA2 protein
Gene: vanA2
Organism: Oerskovia turbata

[pubmed all]
1uniprot[Pubmed] 2266943 [Medline] 91094773 The VANA glycopeptide resistance protein is related to D-alanyl-D-alanine ligase cell wall biosynthesis enzymes.(Mol. Gen. Genet.) [1990]
2uniprot[Pubmed] 8591934 [Medline] 96159633 vanA genes in vancomycin-resistant clinical isolates of Oerskovia turbata and Arcanobacterium (Corynebacterium) haemolyticum.(J. Antimicrob. Chemother.) [1995]

97

Q64H40_ENTFA
(Q64H40)

1e-87

328

61%

Product: VanB
Gene
Organism: Enterococcus faecalis
Streptococcus faecalis

1uniprot[Pubmed] 17619103
Vancomycin-Resistant Enterococci in a Chinese Hospital.(Curr. Microbiol.) [2007]

BLAST table : Teicp_00060