Fred_00190 Fred_00190   Fred_00210 Fred_00210

Fred_00200 : CDS information

close this sectionLocation

Organism
StrainATCC 49344
Entry nameFredericamycin
Contig
Start / Stop / Direction16,559 / 16,876 / + [in whole cluster]
16,559 / 16,876 / + [in contig]
Location16559..16876 [in whole cluster]
16559..16876 [in contig]
TypeCDS
Length318 bp (105 aa)
Click on the icon to see Genetic map.

close this sectionAnnotation

Category5.4 hypothetical protein
Producthypothetical protein
Product (GenBank)putative monooxygenase
GenefdmQ
Gene (GenBank)
EC number
Keyword
Note
Note (GenBank)
  • FdmQ
Reference
ACC
PmId
[16305230] Cloning, sequencing, analysis, and heterologous expression of the fredericamycin biosynthetic gene cluster from Streptomyces griseus. (J Am Chem Soc. , 2005)
comment
Fredericamycin(FDM) gene clusterの同定論文。

fdmQ: oxygenase

FdmJ, L, M, M1, P, Qはantibiotic monooxygenase domainを持つ。
(interpro:26.0でIPR007138 Antibiotic biosynthesis monooxygenase domainが確認できるのはFdmJ, P, Qのみ）

fdmC-fdmT3のfragmentをS.albusへ導入し、FDM-A産生に十分であることを確認している。

close this sectionSequence

selected fasta
>hypothetical protein [putative monooxygenase]
MDGTTSRVRVMLYLRASEDQAPAVAEAYHRISADLAGTPGLLGNELLREVSDPGAFAVLS
DWESLPAFQAWESGSAHRGTTSPLREYQDSARARPFALFEVAATY
selected fasta
>hypothetical protein [putative monooxygenase]
ATGGACGGTACGACGAGCCGGGTCAGGGTCATGCTGTACCTGCGCGCGAGCGAGGACCAG
GCGCCGGCCGTGGCGGAGGCGTACCACCGGATCAGCGCGGACCTGGCGGGCACGCCCGGG
CTGCTTGGCAACGAGCTGCTGCGGGAGGTCAGCGACCCGGGGGCCTTCGCCGTGCTCAGC
GACTGGGAGAGCCTGCCGGCCTTCCAGGCGTGGGAGAGCGGCTCGGCGCACCGGGGCACG
ACCTCGCCGCTGCGGGAGTACCAGGACAGCGCCAGGGCACGGCCCTTCGCCCTGTTCGAG
GTGGCCGCCACCTACTGA

close this sectionFeature

BLASTP
Database:UniProtKB:2011_09 		show BLAST table
InterPro
Database:interpro:38.0
IPR007138 Antibiotic biosynthesis monooxygenase (Domain)
[8-78] 2.7e-14 PF03992
PF03992   ABM
IPR011008 Dimeric alpha-beta barrel (Domain)
[8-105] 6.39998633403535e-17 SSF54909
SSF54909   Dimer_A_B_barrel
SignalP
[1-27] 0.224 Signal
Bacteria, Gram-positive   
TMHMM No significant hit
Fred_00190 Fred_00190   Fred_00210 Fred_00210
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