Teicp2_00180 Teicp2_00180   Teicp2_00200 Teicp2_00200

Teicp2_00190 : CDS information

close this sectionLocation

Organism
StrainATCC 31121 (=NBRC 13999)
Entry nameTeicoplanin
Contig
Start / Stop / Direction26,849 / 30,034 / + [in whole cluster]
26,849 / 30,034 / + [in contig]
Location26849..30034 [in whole cluster]
26849..30034 [in contig]
TypeCDS
Length3,186 bp (1,061 aa)
Click on the icon to see Genetic map.

close this sectionAnnotation

Category1.2 NRPS
Productnon-ribosomal peptide synthetase
Product (GenBank)non-ribosomal peptide synthetase
Gene
Gene (GenBank)tcp10
EC number
Keyword
Note
Note (GenBank)
  • contains module 3(condensation, adenylation and thiolation domains)
Reference
ACC
PmId
[11386360] Teicoplanin biosynthesis genes in Actinoplanes teichomyceticus. (Antonie Van Leeuwenhoek. , 2000)
[14702401] Organization of the teicoplanin gene cluster in Actinoplanes teichomyceticus. (Microbiology. , 2004)
comment
ATCC 31121株teicoplanin生合成gene clusterの同定論文。

tcp ORF10: NRPS, module 3

teicoplanin heptapeptide骨格を合成するNRPS4つのうち2つ目。
実験確認なし。
Related Reference
ACC
Q6ZZJ5
NITE
Teicp_00130
PmId
[15113000] Biosynthetic gene cluster of the glycopeptide antibiotic teicoplanin: characterization of two glycosyltransferases and the key acyltransferase. (Chem Biol. , 2004)
comment
DSM 43866株teicoplanin生合成gene clusterの同定論文。

teiB: Peptide synthetase; module 3

teicoplanin heptapeptide骨格を合成するNRPS4つのうち2つ目。
実験確認なし。

close this sectionPKS/NRPS Module

A3 L-3,5-dihydroxyphenylglycine(Dpg)
C14..309
A488..878
PCP954..1020

close this sectionSequence

selected fasta
>non-ribosomal peptide synthetase [non-ribosomal peptide synthetase]
MTTPTTSPGSALAEVWPLSPMQEGMLYHASFDDAAPDIYVIQQSQIIDGPLDTERFRRSW
EVLLHRHAALRASFHRRKSGETVQLIPREVRLPWAERDLSGLPEKAALAEVGEIAAKERA
ERFDLTKPPLLRLMLIRLGPQRHCLVTTSHHLLMDGWSRAILESELLHVYASGGTVSGLP
PAGSYRHYLSWLGRQDREAARSAWRAELSGADGSALGIAERPGKAPELPAREVLRHSPEF
TSALVDFARRHGLTLNTLVQGAWAVVLARLARRTDVVFGATVSGRPAELPGVEQLVGLFI
NTVPVRVRLDAGQPVLEMLTELQKRQSALISHQHLGLPEIQKLGGASFDTIVVFENYVDP
AAAPDSPRGLRLTLREFHQASPYAITLGVMPGESLETDVQYPPETLDARIAEEALYGLAR
VLEQIIAEPGAAVGRLDVVSAAGRQLTVERWNETGDAVDAPSPVDLFRRQVRRAPDATAV
TAGDRAWSFKELDEWSGRLARALTDRGVRRGDRVGVMLERSAEVLAAWLGVWKAGAAFVP
VDPGYPADRVEFMLADSAVAAVLCRESTAGAVPAGHELIDMDRVGEGVAAPVAIGADDLA
YVMYTSGSTGKPKGVAVAHGGVAALAGDPVWEVGAGDAVLMHAPHTFDASLYDVWVPLVS
GARVMLAEPGVVDAQRLAAHVADGLTAVNFTAGQFRALAQESPESFAGLRDVLAGGDVVP
LGAVERVRQACPGLRVWHTYGPTETTLCATWKKIEPGDRLGSTLPIGRPLPGRRLYVLDV
FLRPLPPGVAGDLYIAGAGVAQGYLGRPALTAERFVADPFAAGERMYRTGDVAYWTGDGE
LVFAGRADNQVKIRGYRVEPGEIETVLAEQPGVDQAVVLARDGRLIGYVVPGGEVDPVRL
RERVARVLPEYMVPAAVMVLDALPVTPNGKLDREALPDPDFSRRVSGREPRTGVERALCG
LFAEVLGLERVGVDDSFFELGGDSITSMQLAARARRDGMAFGAREVFQHRTPAGIAAIVD
SGNEPAAGGDGEATWTPVRRFGLVDLDQQEVEELESEFGDR
selected fasta
>non-ribosomal peptide synthetase [non-ribosomal peptide synthetase]
GTGACAACTCCGACTACGTCCCCAGGATCGGCGCTCGCGGAGGTCTGGCCGCTGTCACCG
ATGCAGGAGGGGATGCTCTACCATGCCTCGTTCGACGACGCGGCCCCCGACATCTACGTC
ATCCAGCAATCGCAGATCATCGACGGCCCTCTGGACACCGAGCGATTCCGGAGGTCCTGG
GAGGTCCTTCTCCACCGGCACGCGGCGCTGCGAGCGAGTTTCCACCGCCGGAAGTCCGGT
GAGACCGTCCAGCTGATCCCCCGTGAGGTCCGGCTTCCCTGGGCCGAACGTGACCTGTCC
GGCCTGCCCGAGAAGGCGGCGCTGGCCGAGGTGGGCGAGATCGCGGCGAAGGAGCGCGCC
GAAAGGTTCGACCTCACGAAGCCTCCCCTGCTGCGGTTGATGCTGATCCGCCTCGGCCCG
CAGCGGCACTGTCTGGTGACCACGAGCCATCACCTGCTCATGGACGGGTGGTCGCGGGCC
ATCCTGGAATCGGAGCTGCTCCATGTCTACGCGTCCGGTGGCACCGTCTCGGGGCTGCCG
CCCGCCGGCTCGTACCGTCACTATCTGTCATGGTTGGGTCGGCAGGACCGGGAGGCCGCC
CGATCGGCATGGCGCGCGGAGCTGTCCGGCGCCGACGGATCCGCGCTCGGAATCGCGGAG
CGGCCAGGGAAGGCTCCGGAGCTGCCGGCACGCGAGGTGCTCCGCCATTCACCGGAGTTC
ACGTCCGCTCTCGTGGACTTCGCCCGCCGCCACGGGTTGACGCTCAACACGCTGGTGCAG
GGCGCCTGGGCGGTGGTGCTGGCCCGATTGGCGCGCCGCACGGACGTGGTGTTCGGCGCG
ACGGTGTCGGGACGCCCCGCGGAGCTGCCCGGCGTGGAACAGCTTGTGGGCCTGTTCATC
AACACCGTGCCGGTGCGAGTCCGGCTGGACGCCGGGCAGCCGGTCCTGGAGATGTTGACG
GAGCTGCAGAAACGGCAGTCCGCGCTGATCTCGCATCAGCATCTCGGATTGCCGGAGATC
CAGAAGCTCGGCGGGGCGAGTTTCGACACGATCGTCGTCTTCGAAAACTATGTCGATCCG
GCCGCGGCGCCGGATTCTCCGCGCGGCCTGCGCCTGACCCTGCGAGAGTTCCACCAGGCG
TCGCCGTATGCGATCACGCTGGGAGTGATGCCGGGCGAGAGCCTCGAGACCGACGTGCAG
TATCCCCCGGAGACGCTCGATGCCCGGATCGCCGAGGAAGCCCTGTACGGGCTGGCCCGC
GTCCTGGAACAGATCATCGCCGAGCCGGGAGCGGCGGTGGGCCGCCTCGACGTGGTGAGT
GCGGCCGGCCGGCAGCTGACCGTCGAGCGGTGGAACGAGACCGGCGACGCGGTGGACGCG
CCGTCCCCGGTCGATCTCTTCCGCCGGCAGGTGCGGCGGGCACCCGACGCGACGGCCGTG
ACGGCCGGGGACCGGGCCTGGTCGTTCAAGGAGCTCGACGAATGGTCCGGCCGGCTGGCG
CGGGCCCTGACGGATCGGGGTGTCCGGCGCGGCGACCGGGTCGGGGTGATGCTGGAGCGG
TCGGCCGAGGTGCTGGCGGCATGGCTCGGGGTGTGGAAGGCGGGAGCCGCGTTCGTGCCG
GTCGATCCGGGCTACCCGGCGGACCGGGTGGAGTTCATGCTGGCCGACTCCGCGGTCGCG
GCGGTGCTGTGCCGGGAGTCGACCGCGGGTGCGGTGCCGGCGGGTCACGAGCTGATCGAC
ATGGACCGGGTCGGCGAGGGCGTGGCCGCGCCGGTCGCGATCGGAGCCGACGATCTGGCG
TACGTCATGTACACGTCCGGATCCACCGGCAAGCCCAAGGGCGTGGCCGTCGCGCACGGG
GGTGTGGCGGCATTGGCCGGTGATCCGGTCTGGGAGGTGGGGGCCGGCGACGCGGTGCTG
ATGCACGCTCCGCACACCTTCGACGCGTCGCTCTACGACGTGTGGGTGCCGCTGGTCTCC
GGCGCGCGGGTGATGCTCGCCGAGCCGGGCGTGGTCGACGCGCAGCGGCTCGCCGCACAC
GTGGCGGATGGTCTCACCGCGGTGAACTTCACCGCCGGTCAGTTCCGGGCGCTGGCACAG
GAGTCGCCGGAATCCTTCGCCGGACTGCGCGACGTGCTCGCGGGTGGAGACGTGGTGCCG
CTCGGCGCGGTGGAGCGGGTCCGGCAGGCGTGCCCCGGGCTACGGGTCTGGCACACGTAC
GGCCCGACGGAGACCACGCTGTGCGCGACGTGGAAGAAGATCGAGCCGGGTGACCGGCTG
GGCTCGACGCTGCCGATCGGCCGGCCGCTGCCGGGCCGTCGGCTGTACGTGCTGGACGTC
TTCCTGCGTCCGCTGCCGCCGGGCGTCGCGGGTGATCTCTACATCGCGGGCGCCGGCGTG
GCCCAGGGCTACCTCGGGCGTCCGGCGCTGACCGCCGAGCGGTTCGTCGCCGACCCGTTC
GCCGCGGGCGAGCGGATGTACCGGACCGGGGACGTGGCGTACTGGACCGGTGACGGCGAG
CTGGTGTTCGCCGGGCGCGCCGACAACCAGGTCAAGATCCGTGGCTATCGGGTGGAACCG
GGCGAGATCGAGACGGTGCTGGCCGAGCAGCCGGGCGTCGACCAGGCGGTGGTGCTGGCC
CGCGACGGCCGTTTGATCGGCTACGTGGTGCCCGGCGGCGAGGTGGATCCGGTACGGCTG
CGCGAGCGGGTCGCCCGGGTGTTGCCGGAGTACATGGTCCCGGCGGCGGTGATGGTCCTG
GACGCCCTGCCGGTGACTCCGAACGGGAAGCTGGACCGGGAGGCTCTGCCGGATCCGGAC
TTCAGCCGACGCGTCTCCGGCCGGGAGCCGCGTACCGGGGTCGAGCGGGCGCTGTGCGGT
CTCTTCGCCGAGGTGCTGGGTCTGGAACGGGTCGGGGTCGACGACAGCTTCTTCGAACTC
GGCGGAGATTCGATCACCTCGATGCAGCTCGCCGCACGCGCCCGCCGCGACGGGATGGCC
TTCGGCGCGCGAGAGGTGTTCCAGCACCGGACGCCGGCCGGGATCGCGGCGATCGTCGAT
TCCGGGAACGAGCCGGCGGCCGGTGGCGACGGCGAGGCGACGTGGACGCCGGTGCGGCGG
TTCGGCCTCGTCGACCTGGACCAGCAGGAGGTCGAAGAACTCGAGTCCGAGTTCGGCGAC
CGTTGA
[3] C14..309
[3] A488..878
[3] L-3,5-dihydroxyphenylglycine(Dpg)648..748
[3] PCP954..1020
[3] C40..927
[3] A1462..2634
[3] L-3,5-dihydroxyphenylglycine(Dpg)1942..2244
[3] PCP2860..3060

close this sectionFeature

BLASTP
Database:UniProtKB:2011_09 		show BLAST table
InterPro
Database:interpro:38.0
IPR000873 AMP-dependent synthetase/ligase (Domain)
[488-878] 1e-108 PF00501
PF00501   AMP-binding
IPR001242 Condensation domain (Domain)
[14-309] 1.70000000000001e-59 PF00668
PF00668   Condensation
IPR006162 Phosphopantetheine attachment site (PTM)
[979-994] PS00012
PS00012   PHOSPHOPANTETHEINE
IPR009081 Acyl carrier protein-like (Domain)
[957-1017] 7.79999999999999e-13 PF00550
PF00550   PP-binding
[954-1020] PS50075
PS50075   ACP_DOMAIN
[946-1022] 2.7e-25 G3DSA:1.10.1200.10
G3DSA:1.10.1200.10   ACP_like
[947-1021] 2.49999811956465e-19 SSF47336
SSF47336   ACP_like
IPR010071 Amino acid adenylation domain (Domain)
[488-878] 8.19999999999987e-128 TIGR01733
TIGR01733   AA-adenyl-dom
IPR020459 AMP-binding (Domain)
[597-608] 4.69999810630989e-05 PR00154 [609-617] 4.69999810630989e-05 PR00154
PR00154   AMPBINDING
IPR020845 AMP-binding, conserved site (Conserved_site)
[602-613] PS00455
PS00455   AMP_BINDING
SignalP No significant hit
TMHMM No significant hit
Teicp2_00180 Teicp2_00180   Teicp2_00200 Teicp2_00200
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