Meilingmycin : Cluster information
Compound
| Entry name | Meilingmycin |
|---|---|
| PKS Type | TypeI modular |
| Starter Unit | Meilingmycins A, B, D, E: malonyl-CoA Meilingmycin C: methylmalonyl-CoA |
| Chain Length | 13 |
| Sugar Unit | none |
| Classification | Other Macrocyclic Lactone |
| Activity | Anthelmintic |
| Composition | Meilingmycin A: C36H50O9 |
Original source
| Organism | Streptomyces nanchangensis |
|---|---|
| Strain | NS3226 |
| Contig | FJ952082 |
PKS/NRPS Module
| Meili_00790 meiA1 | 0 |  | malonyl-CoA for Meilingmycins A, B, D, and E methylmalonyl-CoA for Meilingmycin C |
| 1 |  | methylmalonyl-CoA not conserved YASHS(S->C) | |
| 2 |  | malonyl-CoA not conserved HAFHS(H->G) | |
| Meili_00240 meiA2 | 3 |  | malonyl-CoA not conserved HAFHS(H->G) |
| 4 | | malonyl-CoA not conserved HAFHS(H->G) | |
| 5 | | malonyl-CoA not conserved HAFHS(H->G) | |
| 6 |  | methylmalonyl-CoA not conserved YASHS(S->C) | |
| Meili_00310 meiA3 | 7 | | methylmalonyl-CoA not conserved YASHS(S->C) |
| 8 | | malonyl-CoA not conserved HAFHS(H->G) | |
| 9 | | methylmalonyl-CoA not conserved YASHS(S->C) | |
| Meili_00270 meiA4 | 10 |  | malonyl-CoA |
| 11 | | methylmalonyl-CoA not conserved YASHS(Y->W) | |
| 12 |  | malonyl-CoA |
Reference
- Cloning of separate meilingmycin biosynthesis gene clusters by use of acyltransferase-ketoreductase didomain PCR amplification.
- He Y, Sun Y, Liu T, Zhou X, Bai L, Deng Z[PMID: 20348291]Appl Environ Microbiol. 76 (2010) 3283-92
- Spiroketal formation and modification in avermectin biosynthesis involves a dual activity of AveC.
- Sun P, Zhao Q, Yu F, Zhang H, Wu Z, Wang Y, Wang Y, Zhang Q, Liu W[PMID: 23294008]J Am Chem Soc. 135 (2013) 1540-8
Data download
| Compound name | Genomic nucleotide sequence |
Nucleotide sequences of the coding regions | Translation of the coding sequences | List of genes/ORFs | GBK | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
 Meilingmycin |
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History
- 2016-01-27[Update]
- 2013-05-28[Update]
- 2012-03-28[Release]
