GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS RN | 56-72-4 |
| Chemical Name | O-3-Chloro-4-methylcoumarin-7-yl O,O-diethyl phosphorothioate [chlorpyrifos] |
| Substance ID | H27-B-014/C-035B_P |
| Classification year (FY) | FY2015 |
| Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
| New/Revised | Revised |
| Classification result in other fiscal year | FY2008 |
| Download of Excel format | Excel file |
REFERENCE INFORMATION
| Item | Information |
|---|---|
| Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| UN GHS document (External link) | UN GHS document |
| Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
| Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
| Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive properties. |
| 2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | "Solids" according to GHS definition. |
| 3 | Aerosols | Not applicable |
- |
- | - | Not an aerosol product. |
| 4 | Oxidizing gases | Not applicable |
- |
- | - | "Solids" according to GHS definition. |
| 5 | Gases under pressure | Not applicable |
- |
- | - | "Solids" according to GHS definition. |
| 6 | Flammable liquids | Not applicable |
- |
- | - | "Solids" according to GHS definition. |
| 7 | Flammable solids | Classification not possible |
- |
- | - | It is flammable (HSDB (Access on June 2015)), but the classification is not possible due to no data. |
| 8 | Self-reactive substances and mixtures | Classification not possible |
- |
- | - | It contains P-O (phosphites) in chemical structure, but the classification is not possible due to no data. |
| 9 | Pyrophoric liquids | Not applicable |
- |
- | - | "Solids" according to GHS definition. |
| 10 | Pyrophoric solids | Not classified |
- |
- | - | Because it is written that it does not ignite easily (HSDB (Access on June 2015)) although it is flammable, it was judged that it does not ignite in contact with air at normal temperatures without an ignition source. |
| 11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | No established test method suitable for solid substances with a melting point of 140 degrees C or lower. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | It is estimated that it does not react vigorously with water from water solubility data measured. Water solubility: 1.5 mg/L (HSDB (Access on June 2015)). |
| 13 | Oxidizing liquids | Not applicable |
- |
- | - | "Solids" according to GHS definition. |
| 14 | Oxidizing solids | Classification not possible |
- |
- | - | It is an organic compound which does not contain fluorine or chlorine but contains oxygen, and the element (O) is chemically bonded to an element (P) other than carbon or hydrogen, but the classification is not possible due to no data. |
| 15 | Organic peroxides | Not applicable |
- |
- | - | It is an organic compound that does not contain bivalent -O-O- structure in the molecule. |
| 16 | Corrosive to metals | Classification not possible |
- |
- | - | No established test method suitable for solid substances. |
| Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity (Oral) | Category 2 |
 Danger |
H300 | P301+P310 P264 P270 P321 P330 P405 P501 |
Six LD50 values of 41 mg/kg (males), 16 mg/kg (females) (PATTY (6th, 2012), ACGIH (7th, 2006)), 37 mg/kg (females), 139 mg/kg (males) (ACGIH (7th, 2006)), > 240 mg/kg (males), 17 mg/kg (females) (PATTY (6th, 2012), EPA Pesticide (2006), ACGIH (7th, 2006)) were reported for rats. It was classified in Category 2 to which most of the data (4) correspond. |
| 1 | Acute toxicity (Dermal) | Category 3 |
Danger |
H311 | P302+P352 P361+P364 P280 P312 P321 P405 P501 |
Three LD50 values of 860 mg/kg (ACGIH (7th, 2006)) and > 2,400 mg/kg (males, females) (PATTY (6th, 2012), EPA Pesticide (2006), ACGIH (7th, 2006)) for rats, and 500 mg/kg (ACGIH (7th, 2006)) for rabbits were reported. It was classified in Category 3 to which most of the data (2) correspond. |
| 1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | "Solids" according to GHS definition. |
| 1 | Acute toxicity (Inhalation: Vapours) | Not applicable |
- |
- | - | "Solids" according to GHS definition. |
| 1 | Acute toxicity (Inhalation: Dusts and mists) | Category 2 |
Danger |
H330 | P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501 |
From reported of LC50 values (1 hour) of 1.081 mg/L (males) (converted to a 4-hour equivalent: 0.27 mg/L) and 0.341 mg/L (females) (converted to a 4-hour equivalent: 0.085 mg/L) for rats (PATTY (6th, 2012), EPA Pesticide (2006), ACGIH (7th, 2006)), it was classified in Category 2. Besides, a reference value of mist/dust was applied because it is a solid. |
| 2 | Skin corrosion/irritation | Not classified |
- |
- | - | It is reported that it is not irritating in skin irritation using rabbits (EPA Pesticide (2006)). Moreover, it is written that this substance is not irritating to skin (ACGIH (7th, 2006), PATTY (6th, 2012)). From the above results, it was classified as "Not classified." |
| 3 | Serious eye damage/eye irritation | Category 2B |
Warning |
H320 | P305+P351+P338 P337+P313 P264 |
It is reported that slight irritation was observed in an eye irritation test using rabbits, and it resolved within seven days (EPA Pesticide (2006)). Moreover, it is written that this substance is slightly irritating to eyes (ACGIH (7th, 2006), PATTY (6th, 2012)). From the above results, it was classified in Category 2B. |
| 4 | Respiratory sensitization | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. |
| 4 | Skin sensitization | Classification not possible |
- |
- | - | The classification is not possible due to lack of data. Besides, it is reported that it was not sensitizing in a skin sensitization test using rabbits (EPA Pesticide (2006)), but it was regarded as insufficient data to be used for the classification due to unknown details on test methods and so on. |
| 5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government, it was classified as "Classification not possible." As for in vivo, a micronucleus test using mouse bone marrow cells after oral administration was negative (EPA Pesticide (2000), ACGIH (7th, 2006), PATTY (6th, 2012)). As for in vitro, a bacterial reverse mutation test, a mouse lymphoma test, a chromosomal aberration test, and a sister chromatid exchange test in cultured mammalian cells were all negative. (EPA Pesticide (2000), ACGIH (7th, 2006), PATTY (6th, 2012), NTP DB (Access on July 2015)) |
| 6 | Carcinogenicity | Classification not possible |
- |
- | - | As the existing classification in human carcinogenicity, it was classified in A4 by ACGIH (ACGIH (7th, 2006)), NL by EPA (EPA Pesticide (2006)). As test results in experimental animals, in a 2-year carcinogenicity test using rats and mice in an oral route (in the diet), any dose group did not show increased tumor incidence, and there are no significant toxic effects in either rats or mice except weight gain reduction observed in female rats in a high dose group (20 ppm) (NTP TR96 (1979), ACGIH (7th, 2006), PATTY (6th, 2012)). However, because it is written that in the other 2-year diet administration test using rats, decreased plasma and red blood cell cholinesterase activity was observed in females at 5 ppm or higher of a concentration in diet and males at 25 ppm (ACGIH (7th, 2006)), dose selection in the carcinogenicity test by NTP was considered to be appropriate. As above although it corresponds to "Not classified" from the EPA classification result, by prioritizing the ACGIH classification result, the substance was classified as "Classification not possible" in accordance with the GHS classification guidance for the Japanese government which was revised after the previous classification. |
| 7 | Reproductive toxicity | Classification not possible |
- |
- | - | There is no information on reproductive effects in humans. As for experimental animals, in a two-generation reproductive toxicity test using rats in an oral route (in the diet), decreased plasma and red blood cell cholinesterase activity was observed in parent animals, but toxic effects on sexual function and fertility were not found (EPA Pesticide (2000), ACGIH (7th, 2006), PATTY (6th, 2012)). Moreover, in a developmental toxicity test in pregnant rats or rabbits in gavage administration during an organogenetic period, maternal animals showed tremors in rats, and death and abortion in rabbits, but developmental effects were not observed in fetuses of either rats or rabbits (EPA Pesticide (2000), ACGIH (7th, 2006), PATTY (6th, 2012)). As above, from the existing test results using experimental animals, there is no evidence which causes concern about serious reproductive/developmental toxicity. However, because this substance is a substance targeting the nervous system, and postnatal developmental effects were not sufficiently evaluated like a developmental neurotoxicity, the substance was classified as "Classification not possible" due to lack of data in this hazard class. |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (nervous system) |
 Danger |
H370 | P308+P311 P260 P264 P270 P321 P405 P501 |
Toxicity effects of this substance are typical of organophosphate poisoning. First, plasma and red blood cell acetylcholinesterase inhibition occurred. Toxicity signs by cholinesterase inhibition rapidly occurred, and they were caused by neuromuscular stimulation which is reversible (above EPA Pesticide (2006), ACGIH (7th, 2006), PATTY (6th, 2012)). Moreover, clinical signs in humans in exposure to this substance were caused by muscarinic effects (parasympathetic effects), nicotinic effects (sympathetic and motor effects), and central nervous system effects, and a headache, weakness, dizziness, visual disorder, psychic effects (psychosis), dyspnea, paralysis, convulsions, and coma were observed. It is reported that acute toxicity by this substance resulted from accidents of unintentional or intentional oral ingestion or inhalation exposure to contaminated food according to human case reports (HSDB (Access on June 2015)). As for human cases, total six poisoning cases by ingesting this substance were reported. These were all toxicity signs typical of organophosphate, and there were nausea, vomiting, and abdominal pain one hour after ingestion, toxicity signs by cholinesterase inhibition (sweating, urination, miosis, bronchorrhea, and hypersalivation) after two hours, and a death of one person after three hours, but other patients recovered by treatment. The visual disorder was observed in other cases but resolved by treatment. (above ACGIH (7th, 2006), PATTY (6th, 2012)). As for experimental animals, in oral administration in chicken at 100 mg/kg, marked acute toxicity occurred in all animals which died within 1-8 days, and delayed neurotoxicity was not observed. However, in a dermal application at 50-500 mg/kg (doses corresponding to Category 1) delayed neurotoxicity was found, and incoordination, paralysis, and death were reported (above ACGIH (7th, 2006), PATTY (6th, 2012)). From the above, because this substance has effects on nervous system, it was classified in Category 1 (nervous system). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (nervous system) |
Danger |
H372 | P260 P264 P270 P314 P501 |
There is no human information. As for experimental animals, at 0.25-1.2 mg/kg/day in a 13-week and 2-year repeated oral administration toxicity test using rats, and at 0.775 mg/kg/day in a 1-year repeated oral administration toxicity test using dogs, plasma and red blood cell cholinesterase activity inhibition was observed, but brain cholinesterase activity inhibition was not found. In a 21-day repeated dermal administration toxicity test using rats, the following was observed (EPA Pesticide (2000), ACGIH (7th, 2006)): plasma and red blood cell cholinesterase activity inhibition at less than 2 mg/kg/day (converted to a 90-day equivalent: 0.47 mg/kg/day); brain cholinesterase activity inhibition at 20 mg/kg/day (converted to a 90-day equivalent: 4.7 mg/kg/day); and cholinergic effects (muscle fasciculation, tremors) at 20 mg/kg/day (converted to a 90-day equivalent: 4.7 mg/kg/day). From the above, red blood cell and brain cholinesterase activity inhibition and cholinergic effects were found within a range of Category 1. Therefore, the substance was classified in Category 1 (nervous system). |
| 10 | Aspiration hazard | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. |
| Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment (Acute) | Category 1 |
 Warning |
H400 | P273 P391 P501 |
From LC50 = 0.074 micro g/L for crustacea (Gammarus lacustris) (US EPA: RED, 2000), it was classified in Category 1. |
| 11 | Hazardous to the aquatic environment (Long-term) | Category 1 |
Warning |
H410 | P273 P391 P501 |
Due to being not rapid degradable (BIOWIN), MATC (Life-Cycle Study) = 50.5 ng/L for crustacea (Daphnia magna) (US EPA: RED, 2000), it was classified in Category 1. |
| 12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data. |
NOTE:
| * A blank or "-" in a cell of classification denotes that the classification of the hazard class was not conducted. * Hazard_statement_and/or_Precautionary_statement will show when hovering the mouse over a code of Hazard_statement_and/or_Precautionary_statement. Hazard_statement_and/or_Precautionary_statement are also provided in the Excel file. * Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. * Codes assigned to each of the hazard statements and codes for each of the precautionary statement are based on the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) in United Nations. |