NITE - Chemical Management Field

GHS Classification Results by the Japanese Government

GENERAL INFORMATION

Item	Information
CAS RN	1314-84-7
Chemical Name	Trizinc diphosphide
Substance ID	R01-B-034
Classification year (FY)	FY2019
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	*	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified (Not applicable)."
2	Flammable gases	*	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."
3	Aerosols	*	- -	-	-	Not aerosol products. It was classified as "Not classified (Not applicable)."
4	Oxidizing gases	*	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."
5	Gases under pressure	*	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."
6	Flammable liquids	*	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."
7	Flammable solids	*	- -	-	-	It was classified as "Not classified" from information that it is not combustible (ICSC (2001)).
8	Self-reactive substances and mixtures	*	- -	-	-	There are no chemical groups associated with explosive or self-reactive properties present in the molecule. It was classified as "Not classified (Not applicable)."
9	Pyrophoric liquids	*	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."
10	Pyrophoric solids	*	- -	-	-	It was classified as "Not classified" from information that it is not combustible (ICSC (2001)).
11	Self-heating substances and mixtures	*	- -	-	-	It was classified as "Not classified" from information that it is not combustible (ICSC (2001)).
12	Substances and mixtures which, in contact with water, emit flammable gases	Category 1	Danger	H260	P302+P335+P334 P231+P232 P370+P378 P402+P404 P223 P280 P501	It was classified in Category 1 because it is classified in Division 4.3, Subsidiary Risk 6.1, PG I in UNRTDG (UN1714).
13	Oxidizing liquids	*	- -	-	-	Solid (GHS definition). It was classified as "Not classified (Not applicable)."
14	Oxidizing solids	*	- -	-	-	Inorganic compounds containing no oxygen or halogen atoms. It was classified as "Not classified (Not applicable)."
15	Organic peroxides	*	- -	-	-	Inorganic substance. It was classified as "Not classified (Not applicable)."
16	Corrosive to metals	*	- -	-	-	Classification is not possible because test methods applicable to solid substances are not available.
17	Desensitized explosives	*	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified."

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Category 2	Danger	H300	P301+P310 P264 P270 P321 P330 P405 P501	[Rationale for the Classification] Based on (1)-(4), it was classified in Category 2. [Evidence Data] (1) LD50 for rats: 13-35 mg/kg (EPA Pesticide (1998)) (2) LD50 for rats: male: 12.00 mg/kg, female: 15.72 mg/kg (HSDB (Access on June 2019)) (3) LD50 for rats: 40.5 mg/kg (HSDB (Access on June 2019)) (4) LD50 for rats: 45.7 mg/kg (HSDB (Access on June 2019))
1	Acute toxicity (Dermal)	*	- -	-	-	[Rationale for the Classification] Based on (1), it was classified as "Not classified." [Evidence Data] (1) LD50 for rabbits: 2,000-5,000 mg/kg (EPA Pesticide (1998), IPCS PIM 865 (1997), HSDB (Access on June 2019))
1	Acute toxicity (Inhalation: Gases)	*	- -	-	-	[Rationale for the Classification] Solid (GHS definition). It was classified as "Not classified (Not applicable)."
1	Acute toxicity (Inhalation: Vapours)	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
1	Acute toxicity (Inhalation: Dusts and mists)	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
2	Skin corrosion/irritation	*	- -	-	-	[Rationale for the Classification] Based on (1), it was classified as "Not classified." [Evidence Data] (1) This substance (94%) was not irritating in a skin irritation test with rabbits (EPA Pesticide (1998)). [Reference Data, etc.] (2) Powder of this substance was mildly irritating in a skin irritation test (Draize method) with rabbits (EHC 73 (1988)).
3	Serious eye damage/eye irritation	Category 2	Warning	H319	P305+P351+P338 P337+P313 P264 P280	[Rationale for the Classification] Based on (1), it was classified in Category 2. Besides, since the previous classification was based on data from formulations, the category was changed by new data. [Evidence Data] (1) Slight conjunctival redness, chemosis and discharge were observed in a rabbit eye irritation test with this substance (94% active ingredient) (EPA Pesticide (1998), HSDB (Access on June 2019)). [Reference Data, etc.] (2) This substance is neither an eye irritant nor a skin sensitizer (EFSA J. 8 (7) 1671 (2010)).
4	Respiratory sensitization	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
4	Skin sensitization	*	- -	-	-	[Rationale for the Classification] Based on (1), it was classified as "Not classified." [Evidence Data] (1) This substance is neither an eye irritant nor a skin sensitizer (EFSA J. 8 (7) 1671 (2010)).
5	Germ cell mutagenicity	*	- -	-	-	[Rationale for the Classification] A mouse micronucleus test was negative in (1), but a mouse lymphoma TK assay was positive in (2). Therefore, the classification is not possible due to insufficient data to assess in vivo effects. [Evidence Data] (1) As for in vivo, there is a negative result in a mouse micronucleus test (EPA Pesticide (1998)). (2) As for in vitro, it is reported that a bacterial reverse mutation test was negative, and a mouse lymphoma TK assay was positive (EPA Pesticide (1998)).
6	Carcinogenicity	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.
7	Reproductive toxicity	*	- -	-	-	[Rationale for the Classification] Based on (1), though no developmental effects were observed even at the dose at which maternal toxicity was observed, it was classified as "Classification not possible," due to lack of information on effects on sexual function and fertility. [Evidence Data] (1) In a developmental toxicity test in which female rats were administered by gavage on gestational Days 6-15, though maternal toxicity (deaths (9/25 animals), body weight and food intake reductions) was observed, no effect on embryos/fetuses was observed (EPA Pesticide (1998), GESTIS (Access on August 2019)). [Reference Data, etc.] (2) There is a report with details unknown that in a test in which rats were dosed by feeding for 22 days, no impairment of fertility was observed even at the dose where deaths were observed in some parental animals (GESTIS (Access on August 2019)).
8	Specific target organ toxicity - Single exposure	Category 1 (central nervous system, respiratory organs, blood system, liver, kidney)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	[Rationale for the Classification] Based on (1) and (2), it was classified in Category 1 (central nervous system, respiratory organs, blood system, liver, kidney). Since the effect on the cardiovascular system may be a secondary effect, it was excluded. The classification result was changed from the previous classification by the use of a new information source. [Evidence Data] (1) This substance decomposes to hydrogen phosphide (phosphine, CAS RN 7803-51-2) in vivo. It is described that the main target organs of phosphine are the respiratory system (cough, sore throat, dyspnea, pulmonary edema, etc.) and the central nervous system (headache, vertigo, tremors, unsteady gait, convulsions, coma, etc.) (IPCS, PIM 865 (1997)). (2) Among 20 patients who developed poisoning by ingestion of this substance, 10 patients died after ingestion of 4.5-180 g. The main clinical manifestations were metabolic acidosis, methemoglobinemia, hypocalcemic tetani, reduced blood coagulation, pulmonary edema, and gastrointestinal, neuropsychiatric and cardiovascular disorders. In postmortem findings, pulmonary congestion and edema, hemorrhagic changes in the intestinal epithelium, centrilobular congestion and necrosis and discoloration of the liver, and patchy necrosis of the proximal convoluted tubules of the kidneys were observed (IPCS, PIM 865 (1997)).
9	Specific target organ toxicity - Repeated exposure	Category 1 (central nervous system, blood system, kidney), Category 2 (liver)	Danger Warning	H372 H373	P260 P264 P270 P314 P501	[Rationale for the Classification] Based on (1), chronic exposure to humans may cause effects on the central nervous system. As for experimental animals, it was considered that the target organs were the kidney based on (2), and the blood system and liver based on (3). Therefore, it was classified in Category 1 (central nervous system, blood system, kidney), Category 2 (liver). The classification result was changed from the previous classification by the use of new information sources. [Evidence Data] (1) Workers who were repeatedly exposed to this substance, may develop neuropsychiatric symptoms (anxiety, impotence or rapid onset fatigue) (GESTIS (Access on August 2019)). (2) In a 90-day gavage administration test with rats, mortality or moribundity, salivation, and hypothermia, and hydronephrosis (in males) were observed at or above 1.0 mg/kg/day, and pyelonephritis was observed in males at 3.0 mg/kg/day (EPA Pesticide (1998)). These dosages are all within the range of Category 1. (3) In a test in which female weaning rats were dosed by feeding for 13 weeks, deaths and increased relative weights of the liver, heart and thyroid were observed at or above 200 ppm (converted guidance value: 10 mg/kg/day, within the range of Category 1), increases in the serum zinc and the liver ALP levels were observed at 500 ppm (converted guidance value: 25 mg/kg/day, within the range of Category 2). Moreover, dose-dependent hematological changes (decreases in hemoglobin concentration, red cell count and hematocrit (no description of an effect level)) were observed (EHC 73 (1988)). Since effects on the blood system were dose-dependent, it was judged to appear at the dose within the range of Category 1. [Reference Data, etc.] (4) In a test in which rats were dosed with this substance (dosing period, etc. were unspecified), at 300 mg/kg, deaths (6/6 animals) were observed 2 weeks after administration. At 200 mg/kg, reduced body weight gain and deaths (2/6 animals) were observed, and histopathological examination revealed liver damage in the peripheral and central lobular areas, and congestion with hemorrhage or exudate in the alveolar spaces in the lungs (EHC 73 (1988)).
10	Aspiration hazard	*	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	Classification not possible due to lack of data.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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