Item | Information |
---|---|
CAS RN | 2275-23-2 |
Chemical Name | O,O-Dimethyl S-2-[1-(N-methylcarbamoyl)ethylthio]ethyl phosphorothioate; Vamidothion |
Substance ID | R02-B-051-MHLW, MOE |
Classification year (FY) | FY2020 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | Revised |
Classification result in other fiscal year | FY2006 |
Download of Excel format | Excel file |
Item | Information |
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Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified." |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified." |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. It was classified as "Not classified." |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified." |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified." |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified." |
7 | Flammable solids | Classification not possible |
- |
- | - | No data available. Besides, there is information that it is combustible (ICSC (2001)). |
8 | Self-reactive substances and mixtures | Type G |
- |
- | - | There is a chemical group associated with self-reactive properties (P-O) present in the molecule, but because it is classified in Division 6.1 in UNRTDG (UN2783), and it is considered to be not applicable to self-reactive substances and mixtures, hazards of the highest precedence, it was classified in Type G. |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified." |
10 | Pyrophoric solids | Not classified |
- |
- | - | Because it is classified in Division 6.1, PG III in UNRTDG (UN 2783), and it does not correspond to pyrophoric substances, hazards of the highest precedence, it was classified as "Not classified." |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Classification is not possible because test methods applicable to solid (melting point <= 140 deg C) substances are not available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | It contains a metalloid (P), but it was classified as "Not classified" because it is estimated that it does not react vigorously with water from obtained data that it is very soluble in water (ICSC (2001)). |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified." |
14 | Oxidizing solids | Classification not possible |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine), which is chemically bonded to the element other than carbon or hydrogen (P). However, the classification is not possible due to no data. |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule. It was classified as "Not classified." |
16 | Corrosive to metals | Classification not possible |
- |
- | - | It is a solid with a melting point of 55 deg C or lower, but the classification is not possible due to no data. |
17 | Desensitized explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified." |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 3 |
Danger |
H301 | P301+P310 P264 P270 P321 P330 P405 P501 |
[Rationale for the Classification] It was classified in Category 3 from (1) - (3). [Evidence Data] (1) LD50 for rats: 103 mg/kg (IPCS PIM G001 (1998)) (2) LD50 for rats: females: 110 mg/kg (JMPR (1985)) (3) LD50 for rats: 64 mg/kg (GESTIS (Access on May 2020), HSDB (Access on May 2020)) |
1 | Acute toxicity (Dermal) | Category 4 |
Warning |
H312 | P302+P352 P362+P364 P280 P312 P321 P501 |
[Rationale for the Classification] It was classified in Category 4 from (1). [Evidence Data] (1) LD50 for rabbits: 1,160 mg/kg (GESTIS (Access on May 2020), JMPR (1973)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified |
- |
- | - | [Rationale for the Classification] Solid (GHS definition). It was classified as "Not classified." |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Category 4 |
Warning |
H332 | P304+P340 P261 P271 P312 |
[Rationale for the Classification] It was classified in Category 4 from (1). Besides, because an exposure concentration was higher than the saturated vapor pressure concentration (2.1E-005 mg/L), a reference value in the unit of mg/L was applied as dust. [Evidence Data] (1) LC50 for rats (4 hours): 1.73 mg/L (JMPR (1985), GESTIS (Access on May 2020)) (2) Vapor pressure of this substance: 1.4E-006 mmHg (25 deg C) (HSDB (Access on May 2020)) (converted value for the saturated vapor pressure concentration: 2.1E-005 mg/L) |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
4 | Skin sensitization | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
5 | Germ cell mutagenicity | Not classified |
- |
- | - | [Rationale for the Classification] From (1), (2), there was no clear knowledge to classify it in Category 2, and it was classified as "Not classified." [Evidence Data] (1) As for in vivo, it was reported to be negative in a micronucleus test with mouse bone marrow cells (JMPR (1985)). (2) As for in vitro, it was reported to be positive and negative in bacterial reverse mutation tests and positive in a chromosomal aberration test and a sister chromatid exchange test using cultured mammalian cells (same as the above). |
6 | Carcinogenicity | Not classified |
- |
- | - | [Rationale for the Classification] There were no classification results by domestic and international organizations. There was no available report in humans. It was classified as "Not classified" from (1). The classification result was changed due to the use of a new information source. [Evidence Data] (1) In carcinogenicity tests by 2-year diet administration of this substance to male and female rats and mice, no carcinogenicity was observed in either species (JMPR (1982)). |
7 | Reproductive toxicity | Not classified |
- |
- | - | [Rationale for the Classification] Based on (1) to (3), it was classified as "Not classified." A new information source was used and the classification results were changed. [Evidence Data] (1) In a two-generation reproduction toxicity test with rats dosed by gavage, no effect on reproduction was observed even at doses at which inhibition of cholinesterase (ChE) activity (inhibition of erythrocyte and plasma ChE activity at middle and high doses, inhibition of brain ChE activity at a high dose) was observed in F0 and F1 parental animals. In F1 weanlings, inhibition of erythrocyte and plasma ChE activity was observed (to a lesser extent than in parents) only at a high dose (JMPR (1988)). (2) In a developmental toxicity study with female rats dosed by gavage on days 6-15 of gestation, no effect was observed in fetuses even at a dose at which maternal toxicity (decreases in body weight and food consumption) was observed (JMPR (1985)). (3) In a developmental toxicity study with female rabbits dosed by gavage on days 6-18 of gestation, no effect was observed in fetuses even at a dose at which maternal toxicity (diarrhea, decreases in body weight and food consumption) was observed (JMPR (1985)). |
8 | Specific target organ toxicity - Single exposure | Category 2 (nervous system) |
Warning |
H371 | P308+P311 P260 P264 P270 P405 P501 |
[Rationale for the Classification] Only (1) was available as the data for this substance. This substance is an organophosphorus pesticide and it was considered to have an inhibitory action on cholinesterase activity. Therefore, it was classified in Category 2 (nervous system). [Evidence Data] (1) Eighteen people using this substance on crops were examined. As a result, the concentration of the product in air was 0.024 mg/m3 at a distance of 50 meters from the point of application. Symptoms recorded were a very slight drops in pulse rate and arterial blood pressure in 8 subjects (JMPR (1985), HSDB (Access on May 2020)). [Reference Data, etc.] (2) Exposure to organophosphorus pesticides, including this substance, in humans caused muscarinic manifestations (increased bronchial secretion, excessive sweating, salivation, lachrymation, pinpoint pupils, bronchoconstriction, abdominal cramps (vomiting and diarrhea), bradycardia), nicotinic manifestations (fasciculation of fine muscles, tachycardia), and central nervous system manifestations (headache, dizziness, restlessness, anxiety, mental confusion, convulsions, coma, depression of the respiratory center). Mild poisoning might include only muscarinic and nicotinic signs. Severe cases showed central nervous system involvement. The combination of the above-mentioned symptoms caused respiratory failure, sometimes leading to pulmonary edema (EHC 63 (1986)). (3) Organophosphorus pesticides, such as this substance, are absorbed by all routes, including inhalation, ingestion, and dermal absorption. The toxicological effects of the organophosphorus pesticides are due to the inhibition of acetylcholinesterase in the nervous system, resulting in respiratory, myocardial, and neuromuscular transmission impairment (IPCS PIM G001 (1998)). |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (nervous system) |
Danger |
H372 | P260 P264 P270 P314 P501 |
[Rationale for the Classification] Based on (1) to (5), it was classified in Category 1 (nervous system). [Evidence Data] (1) This substance is an organophosphorus insecticide. Organophosphorus insecticides are potent cholinesterase (ChE) enzyme inhibitors (HSDB (Access on 2020)). (2) This substance was administered to 6 to 11 healthy male and female volunteers in aqueous solution (9.6 or 37.2 microg/kg/day) for 3 weeks, and orally administered to other groups in aqueous solution (78.8 or 122.8 microg/kg/day) for 5 weeks. As a result, no clinical symptoms were found which could be caused by the administration. No decrease in plasma ChE activity was observed in any groups, but a decrease in erythrocyte ChE activity was observed in three subjects receiving 122.8 microg/kg/day (JMPR (1973)). (3) In a three-month oral toxicity test of this substance with rats dosed by gavage at 2, 5 and 10 mg/kg/day (all within the range for Category 1), inhibition of serum acetylcholinesterase (AChE) activity (2 mg/kg/day group: 35%; 5 mg/kg/day group: 12%: 10 mg/kg/day group: 8%) was observed (JMPR (1973)). (4) This substance was orally administered to rats and mice at doses of 0.1 to 100 ppm for 24 months. As a result, no signs of toxicity were observed in any tests, but decreases in serum and erythrocyte ChE activity were observed at or above 10 ppm (rats: 0.5 mg/kg/day, mice: 1.5 mg/kg/day, within the range for Category 1), and a decrease in brain ChE activity was also observed in male rats at or above 10 ppm (0.5 mg/kg/day, within the range for Category 1) and in male and female mice at 100 ppm (15 mg/kg/day, within the range for Category 2) (JMPR (1982)). (5) This substance was orally administered to dogs for 52 weeks. As a result, inhibition of plasma and erythrocyte ChE activity was observed at or above 0.5 mg/kg/day (within the range for Category 1), and stiff gait of the hind legs and inhibition of brain ChE activity (20 to 30%) were observed at 5.0 mg/kg/day (within the range for Category 1) (JMPR (1988)). |
10 | Aspiration hazard | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Classification not possible |
- |
- | - | No data available. |
11 | Hazardous to the aquatic environment Long term (Chronic) | Classification not possible |
- |
- | - | No data available. |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. |
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