BLAST table : Adria_00090

DBUniProtKB
accessionDBalignmentEvalueScoreIdent.linkproductgeneorganismec
1
 Q54820_STRPE
(Q54820)		 
[query] 1 - 61 (61)
[subject] 1 - 61 (61)
 9e-26 120   100% DnrM protein dnrM Streptomyces peucetius
2
 C6K8M1_STRPE
(C6K8M1)		 
[query] 1 - 61 (61)
[subject] 1 - 61 (61)
 9e-26 120   100% Truncated TDP-D-glucose 4,6-dehydratase dnmM Streptomyces peucetius ATCC 27952
3
 D9UBQ9_STRPR
(D9UBQ9)		 
[query] 1 - 61 (61)
[subject] 1 - 56 (335)
 3e-07 58.9 57% dTDP-glucose 4,6-dehydratase cpp25 Streptomyces pristinaespiralis 4.2.1.46
4
 B5HIU1_STRPR
(B5HIU1)		 
[query] 1 - 61 (61)
[subject] 1 - 56 (335)
 3e-07 58.9 57% dTDP-glucose 4,6-dehydratase SSDG_05078 Streptomyces pristinaespiralis ATCC 25486 4.2.1.46
5
 D1XFK5_9ACTO
(D1XFK5)		 
[query] 1 - 34 (61)
[subject] 1 - 34 (328)
 5e-07 58.2 79% dTDP-glucose 4,6-dehydratase SACTEDRAFT_1465 Streptomyces sp. SA3_actE 4.2.1.46
6
 B5H782_STRPR
(B5H782)		 
[query] 1 - 34 (61)
[subject] 1 - 34 (328)
 5e-07 57.8 82% dTDP-glucose 4,6-dehydratase SSDG_01263 Streptomyces pristinaespiralis ATCC 25486 4.2.1.46
7
 B5HXA7_9ACTO
(B5HXA7)		 
[query] 1 - 34 (61)
[subject] 1 - 34 (328)
 9e-07 57.4 76% dTDP-glucose 4,6-dehydratase SSEG_09375 Streptomyces sviceus ATCC 29083 4.2.1.46
8
 C5J046_STRPE
(C5J046)		 
[query] 1 - 34 (61)
[subject] 1 - 34 (328)
 3e-06 55.5 74% dTDP-glucose 4,6-dehydratase rmbB Streptomyces peucetius ATCC 27952 4.2.1.46
9
 D6MSX9_9ACTO
(D6MSX9)		 
[query] 1 - 54 (61)
[subject] 1 - 52 (327)
 5e-06 54.7 57% dTDP-glucose 4,6-dehydratase ssfS2 Streptomyces sp. SF2575 4.2.1.46
10
 D9W4I2_9ACTO
(D9W4I2)		 
[query] 1 - 57 (61)
[subject] 1 - 61 (328)
 9e-06 53.9 52% dTDP-glucose 4,6-dehydratase SSNG_07062 Streptomyces sp. C 4.2.1.46
11
 D6A3M1_9ACTO
(D6A3M1)		 
[query] 4 - 34 (61)
[subject] 28 - 58 (353)
 2e-05 52.8 77% dTDP-glucose 4,6-dehydratase SSFG_04776 Streptomyces ghanaensis ATCC 14672 4.2.1.46
12
 D9Y1L8_9ACTO
(D9Y1L8)		 
[query] 3 - 34 (61)
[subject] 11 - 42 (337)
 2e-05 52.4 78% dTDP-glucose 4,6-dehydratase SSRG_04187 Streptomyces griseoflavus Tu4000 4.2.1.46
13
 Q194R3_STRAA
(Q194R3)		 Jump to Mith_00070 
[query] 2 - 34 (61)
[subject] 3 - 35 (331)
 4e-05 51.6 79% dTDP-glucose 4,6-dehydratase mtmE Streptomyces argillaceus 4.2.1.46
14
 D1H0B0_9ACTO
(D1H0B0)		 
[query] 2 - 47 (61)
[subject] 3 - 46 (328)
 6e-05 50.8 57% dTDP-glucose 4,6-dehydratase chryE Streptomyces albaduncus 4.2.1.46
15
 D3Y166_STRPT
(D3Y166)		 
[query] 1 - 57 (61)
[subject] 40 - 100 (368)
 8e-05 50.4 52% dTDP-glucose 4,6-dehydratase strE Streptomyces platensis 4.2.1.46
16
 B1W376_STRGG
(B1W376)		 
[query] 1 - 53 (61)
[subject] 1 - 61 (329)
 9e-05 50.4 54% dTDP-glucose 4,6-dehydratase strE
SGR_5929		 Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350) 4.2.1.46
17
 Q53ID3_STRGR
(Q53ID3)		 
[query] 1 - 53 (61)
[subject] 1 - 61 (329)
 9e-05 50.4 54% dTDP-glucose 4,6-dehydratase strE
SG7F10.19c		 Streptomyces griseus subsp. griseus 4.2.1.46
18
 RMLB_STRGR
(P29782)		 
[query] 1 - 53 (61)
[subject] 1 - 61 (328)
 9e-05 50.4 54% dTDP-glucose 4,6-dehydratase strE Streptomyces griseus 4.2.1.46
19
 D6KEK4_9ACTO
(D6KEK4)		 
[query] 1 - 61 (61)
[subject] 1 - 56 (325)
 0.0002 49.3 56% dTDP-glucose 4,6-dehydratase SSTG_05379 Streptomyces sp. e14 4.2.1.46
20
 Q7X2H7_9ACTO
(Q7X2H7)		 Jump to Gilvo_00130 
[query] 4 - 55 (61)
[subject] 5 - 54 (336)
 0.0005 48.1 54% dTDP-glucose 4,6-dehydratase gilE Streptomyces griseoflavus 4.2.1.46
21
 Q8KNI5_MICEC
(Q8KNI5)		 Jump to Calm_00120 
[query] 2 - 34 (61)
[subject] 3 - 35 (343)
 0.0007 47.8 73% dTDP-glucose 4,6-dehydratase calS3 Micromonospora echinospora
Micromonospora purpurea		 4.2.1.46
22
 D1H0J1_9ACTO
(D1H0J1)		 
[query] 2 - 34 (61)
[subject] 3 - 35 (328)
 0.0007 47.4 73% dTDP-glucose 4,6-dehydratase ravE Streptomyces sp. C23201NS3 4.2.1.46
23
 B5GLJ1_STRCL
(B5GLJ1)		 
[query] 3 - 57 (61)
[subject] 1 - 59 (324)
 0.0008 47.4 47% dTDP-glucose 4,6-dehydratase SCLAV_p1371
SSCG_00215		 Streptomyces clavuligerus ATCC 27064 4.2.1.46
24
 O86866_STRGA
(O86866)		 
[query] 1 - 27 (61)
[subject] 1 - 27 (329)
 0.0008 47.4 78% dTDP-glucose 4,6-dehydratase strE Streptomyces glaucescens 4.2.1.46
accessionDBalignmentEvalueScoreIdent.linkinformationpubmed
1
 Q54820_STRPE
(Q54820)		 
[query] 1 - 61 (61)
[subject] 1 - 61 (61)
 9e-26 120   100%
Product
DnrM protein
Gene
dnrM
Organism
Streptomyces peucetius
1uniprot[Pubmed] 8932700 [Medline] 97086506
The dnrM gene in Streptomyces peucetius contains a naturally occurring frameshift mutation that is suppressed by another locus outside of the daunorubicin-production gene cluster.(Microbiology)
3
 D9UBQ9_STRPR
(D9UBQ9)		 
[query] 1 - 61 (61)
[subject] 1 - 56 (335)
 3e-07 58.9 57%
Product
dTDP-glucose 4,6-dehydratase
Gene
cpp25
Organism
Streptomyces pristinaespiralis
1uniprot[Pubmed] 21342465
Characterization of the 'pristinamycin supercluster' of Streptomyces pristinaespiralis.(Microb Biotechnol) [2011]
9
 D6MSX9_9ACTO
(D6MSX9)		 
[query] 1 - 54 (61)
[subject] 1 - 52 (327)
 5e-06 54.7 57%
Product
dTDP-glucose 4,6-dehydratase
Gene
ssfS2
Organism
Streptomyces sp. SF2575
1uniprot[Pubmed] 19908837
Biochemical analysis of the biosynthetic pathway of an anticancer tetracycline SF2575.(J. Am. Chem. Soc.) [2009]
13
 Q194R3_STRAA
(Q194R3)		 Jump to Mith_00070 
[query] 2 - 34 (61)
[subject] 3 - 35 (331)
 4e-05 51.6 79%
Product
dTDP-glucose 4,6-dehydratase
Gene
mtmE
Organism
Streptomyces argillaceus
1uniprot[Pubmed] 8654997 [Medline] 96257259
Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996]
2uniprot[Pubmed] 8757400 [Medline] 96335144
An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996]
3uniprot[Pubmed] 9150235 [Medline] 97294479
Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997]
4uniprot[Pubmed] 9733697 [Medline] 98406047
Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998]
5uniprot[Pubmed] 10102355 [Medline] 99200478
Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999]
6uniprot[Pubmed] 9889148 [Medline] 99111236
Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999]
7uniprot[Pubmed] 10660060 [Medline] 20123456
Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000]
8uniprot[Pubmed] 11254130 [Medline] 21148776
The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001]
9uniprot[Pubmed] 12733914 [Medline] 22619809
Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003]
10uniprot[Pubmed] 9917296 [Medline] 99115752
The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999]
11uniprot[Pubmed] 11853433 [Medline] 21843297
Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002]
12uniprot[Pubmed] 10652287 [Medline] 20119254
Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000]
13uniprot[Pubmed] 10779713 [Medline] 20243461
Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000]
14uniprot[Pubmed] 12022840 [Medline] 22017994
Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002]
15uniprot[Pubmed] 12813091 [Medline] 22697398
Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003]
16uniprot[Pubmed] 8807845 [Medline] 97113238
Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996]
17uniprot[Pubmed] 14660589
MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004]
18uniprot[Pubmed] 9375253 [Medline] 98042823
Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997]
19uniprot[Pubmed] 15712316
Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005]
20uniprot[Pubmed] 10760873
The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000]
[pubmed all]
15
 D3Y166_STRPT
(D3Y166)		 
[query] 1 - 57 (61)
[subject] 40 - 100 (368)
 8e-05 50.4 52%
Product
dTDP-glucose 4,6-dehydratase
Gene
strE
Organism
Streptomyces platensis
1uniprot[Pubmed] 20067498
Coevolution of antibiotic production and counter-resistance in soil bacteria.(Environ. Microbiol.) [2010]
16
 B1W376_STRGG
(B1W376)		 
[query] 1 - 53 (61)
[subject] 1 - 61 (329)
 9e-05 50.4 54%
Product
dTDP-glucose 4,6-dehydratase
Gene
strE
SGR_5929
Organism
Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
1uniprot[Pubmed] 18375553
Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350.(J. Bacteriol.) [2008]
18
 RMLB_STRGR
(P29782)		 
[query] 1 - 53 (61)
[subject] 1 - 61 (328)
 9e-05 50.4 54%
Product
dTDP-glucose 4,6-dehydratase
Gene
strE
Organism
Streptomyces griseus
1uniprot[Pubmed] 1661369 [Medline] 92092953
Genetics of streptomycin production in Streptomyces griseus: molecular structure and putative function of genes strELMB2N.(Mol. Gen. Genet.) [1991]
20
 Q7X2H7_9ACTO
(Q7X2H7)		 Jump to Gilvo_00130 
[query] 4 - 55 (61)
[subject] 5 - 54 (336)
 0.0005 48.1 54%
Product
dTDP-glucose 4,6-dehydratase
Gene
gilE
Organism
Streptomyces griseoflavus
1uniprot[Pubmed] 12822997 [Medline] 22708304
The complete gene cluster of the antitumor agent gilvocarcin V and its implication for the biosynthesis of the gilvocarcins.(J. Am. Chem. Soc.) [2003]
21
 Q8KNI5_MICEC
(Q8KNI5)		 Jump to Calm_00120 
[query] 2 - 34 (61)
[subject] 3 - 35 (343)
 0.0007 47.8 73%
Product
dTDP-glucose 4,6-dehydratase
Gene
calS3
Organism
Micromonospora echinospora
Micromonospora purpurea
1uniprot[Pubmed] 12183629 [Medline] 22171414
The calicheamicin gene cluster and its iterative type I enediyne PKS.(Science) [2002]
23
 B5GLJ1_STRCL
(B5GLJ1)		 
[query] 3 - 57 (61)
[subject] 1 - 59 (324)
 0.0008 47.4 47%
Product
dTDP-glucose 4,6-dehydratase
Gene
SCLAV_p1371
SSCG_00215
Organism
Streptomyces clavuligerus ATCC 27064
1uniprot
The sequence of a 1.8 Mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways.(Genome Biol. Evol.) [2010]
24
 O86866_STRGA
(O86866)		 
[query] 1 - 27 (61)
[subject] 1 - 27 (329)
 0.0008 47.4 78%
Product
dTDP-glucose 4,6-dehydratase
Gene
strE
Organism
Streptomyces glaucescens
1uniprot[Pubmed] 8628239 [Medline] 96204519
The str gene cluster for the biosynthesis of 5'-hydroxystreptomycin in Streptomyces glaucescens GLA.0 (ETH 22794): new operons and evidence for pathway-specific regulation by StrR.(Mol. Gen. Genet.) [1996]
2uniprot
Streptomycin Production in Streptomycetes: a Progress Report.(INDUSTRIAL MICROORGANISMS. BASIC AND APPLIED MOLECULAR GENETICS) [1993]