| accession | DB | alignment | Evalue | Score | Ident. | link | information | pubmed |
2
|
B5L6L2_MICCH (B5L6L2) |
|
|
9e-80 |
302 |
40% |
|
- Product
- FAD-dependent oxygenase
- Gene
-
- Organism
- Micromonospora chalcea
|
1uniprot[Pubmed] 18586939 Cloning and characterization of the tetrocarcin A gene cluster from Micromonospora chalcea NRRL 11289 reveals a highly conserved strategy for tetronate biosynthesis in spirotetronate antibiotics.(J. Bacteriol.) [2008] |
|
3
|
Q0RMN5_FRAAA (Q0RMN5) |
|
|
4e-78 |
296 |
40% |
|
- Product
- Putative polyketide oxygenase/hydroxylase
- Gene
- FRAAL2565
- Organism
- Frankia alni (strain ACN14a)
|
1uniprot[Pubmed] 17151343 Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography.(Genome Res.) [2007] |
|
4
|
B3TMQ4_9ACTO (B3TMQ4) |
|
|
2e-77 |
294 |
40% |
|
- Product
- FAD-dependent oxidoreductase
- Gene
- KijA
- Organism
- Actinomadura kijaniata
|
1uniprot[Pubmed] 17985890 Elucidation of the kijanimicin gene cluster: insights into the biosynthesis of spirotetronate antibiotics and nitrosugars.(J. Am. Chem. Soc.) [2007] |
|
5
|
Q0R4M1_STRAT (Q0R4M1) |
|
|
8e-76 |
289 |
39% |
|
- Product
- ChlE3
- Gene
-
- Organism
- Streptomyces antibioticus
|
1uniprot[Pubmed] 16793515 Genetic characterization of the chlorothricin gene cluster as a model for spirotetronate antibiotic biosynthesis.(Chem. Biol.) [2006] |
|
6
|
C4NYJ7_9ACTO (C4NYJ7) |
|
|
1e-73 |
281 |
39% |
|
- Product
- SaqE
- Gene
- saqE
- Organism
- Micromonospora sp. Tu 6368
|
1uniprot[Pubmed] 17497146 A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.(Appl. Microbiol. Biotechnol.) [2007] | 2uniprot[Pubmed] 19384899 Cloning and sequencing of the biosynthetic gene cluster for saquayamycin z and galtamycin B and the elucidation of the assembly of their saccharide chains.(Chembiochem) [2009] | [pubmed all]
|
9
|
D2XDX8_9PSEU (D2XDX8) |
|
|
9e-72 |
276 |
38% |
|
- Product
- AzicO4
- Gene
- azicO4
- Organism
- Kibdelosporangium sp. MJ126-NF4
|
1uniprot[Pubmed] 19928906 Biosynthetic studies of aziridine formation in azicemicins.(J. Am. Chem. Soc.) [2009] |
|
11
|
Q9AMJ5_STRAT (Q9AMJ5) |
|
|
6e-70 |
270 |
39% |
|
- Product
- Putative oxygenase SimA7
- Gene
- simA7
- Organism
- Streptomyces antibioticus
|
1uniprot[Pubmed] 11959542 [Medline] 21955989 Biosynthetic gene cluster of simocyclinone, a natural multihybrid antibiotic.(Antimicrob. Agents Chemother.) [2002] |
|
12
|
Q3S8P7_STRRM (Q3S8P7) |
|
|
6e-70 |
270 |
37% |
|
- Product
- OxyS
- Gene
- oxyS
- Organism
- Streptomyces rimosus
|
1uniprot[Pubmed] 16597959 Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase.(Appl. Environ. Microbiol.) [2006] |
|
13
|
Q58PK7_STRRM (Q58PK7) |
|
|
2e-69 |
268 |
36% |
|
- Product
- Anhydrotetracycline oxygenase
- Gene
- otcC
- Organism
- Streptomyces rimosus
|
1uniprot[Pubmed] 16148009 Ablation of the otcC gene encoding a post-polyketide hydroxylase from the oxytetracyline biosynthetic pathway in Streptomyces rimosus results in novel polyketides with altered chain length.(J. Biol. Chem.) [2005] |
|
16
|
C7QAE9_CATAD (C7QAE9) |
|
|
8e-68 |
262 |
37% |
|
- Product
- Monooxygenase FAD-binding
- Gene
- Caci_3543
- Organism
- Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)
|
1uniprot Complete genome sequence of Catenulispora acidiphila type strain (ID 139908).(Stand. Genomic Sci.) [2009] |
|
17
|
A9FKP5_SORC5 (A9FKP5) |
|
|
8e-68 |
262 |
36% |
|
- Product
- Putative monooxygenase
- Gene
- yhjG3
sce4973
- Organism
- Sorangium cellulosum (strain So ce56)
Polyangium cellulosum (strain So ce56)
|
1uniprot[Pubmed] 17965706 Complete genome sequence of the myxobacterium Sorangium cellulosum.(Nat. Biotechnol.) [2007] |
|
18
|
D2XDX3_9PSEU (D2XDX3) |
|
|
2e-67 |
261 |
36% |
|
- Product
- AzicO3
- Gene
- azicO3
- Organism
- Kibdelosporangium sp. MJ126-NF4
|
1uniprot[Pubmed] 19928906 Biosynthetic studies of aziridine formation in azicemicins.(J. Am. Chem. Soc.) [2009] |
|
19
|
D3UA07_9ACTO (D3UA07) |
|
|
5e-67 |
260 |
38% |
|
- Product
- FAD-dependent monooxygenase
- Gene
-
- Organism
- Streptomyces flaveolus
|
1uniprot Cloning, sequencing and characterization of the biosynthetic gene cluster of sanglifehrin A, a potent cyclophilin inhibitor.(Mol. Biosyst.) [2010] |
|
22
|
Q93LY7_9ACTO (Q93LY7) |
|
|
6e-67 |
259 |
36% |
|
- Product
- Polyketide oxygenase PgaE
- Gene
- pgaE
- Organism
- Streptomyces sp. PGA64
|
1uniprot[Pubmed] 12654660 [Medline] 22540650 Engineering anthracycline biosynthesis toward angucyclines.(Antimicrob. Agents Chemother.) [2003] | 2uniprot[Pubmed] 15515887 Partial activation of a silent angucycline-type gene cluster from a rubromycin beta producing Streptomyces sp. PGA64.(J. Antibiot.) [2004] | 3uniprot[Pubmed] 17669423 Crystal structures of two aromatic hydroxylases involved in the early tailoring steps of angucycline biosynthesis.(J. Mol. Biol.) [2007] | [pubmed all]
|
24
|
D7RFJ3_AMYOR (D7RFJ3) |
|
|
9e-66 |
256 |
37% |
|
- Product
- Putative oxygenase
- Gene
- bexE
- Organism
- Amycolatopsis orientalis subsp. vinearia
|
1uniprot[Pubmed] 20443562 A biosynthetic pathway for BE-7585A, a 2-thiosugar-containing angucycline-type natural product.(J. Am. Chem. Soc.) [2010] |
|
27
|
Q47QL5_THEFY (Q47QL5) |
|
|
2e-65 |
254 |
36% |
|
- Product
- Putative uncharacterized protein
- Gene
- Tfu_1216
- Organism
- Thermobifida fusca (strain YX)
|
1uniprot[Pubmed] 17209016 Genome sequence and analysis of the soil cellulolytic actinomycete Thermobifida fusca YX.(J. Bacteriol.) [2007] |
|
28
|
Q9S1P2_STRCO (Q9S1P2) |
|
|
3e-65 |
254 |
38% |
|
- Product
- Putative monooxygenase
- Gene
- SCO0249
- Organism
- Streptomyces coelicolor
|
1uniprot[Pubmed] 12000953 [Medline] 21996410 Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).(Nature) [2002] |
|
29
|
Q56HA5_STRAU (Q56HA5) |
|
|
3e-65 |
254 |
36% |
|
- Product
- Aur1A
- Gene
- aur1A
- Organism
- Streptomyces aureofaciens
|
1uniprot[Pubmed] 12384301 [Medline] 22271582 Cloning and characterization of a polyketide synthase gene cluster involved in biosynthesis of a proposed angucycline-like polyketide auricin in Streptomyces aureofaciens CCM 3239.(Gene) [2002] | 2uniprot[Pubmed] 16079347 Characterization of a regulatory gene essential for the production of the angucycline-like polyketide antibiotic auricin in Streptomyces aureofaciens CCM 3239.(Microbiology) [2005] | 3uniprot[Pubmed] 20466770 The role of the TetR-family transcriptional regulator Aur1R in negative regulation of the auricin gene cluster in Streptomyces aureofaciens CCM 3239.(Microbiology) [2010] | [pubmed all]
|
34
|
Q9ZGD9_STRCY (Q9ZGD9) |
|
|
6e-64 |
249 |
37% |
|
- Product
- Oxygenase homolog
- Gene
- lanE
- Organism
- Streptomyces cyanogenus
|
1uniprot[Pubmed] 9933932 [Medline] 99132695 Cloning and characterization of a gene cluster from Streptomyces cyanogenus S136 probably involved in landomycin biosynthesis.(FEMS Microbiol. Lett.) [1999] |
|
35
|
A4FIN7_SACEN (A4FIN7) |
|
|
8e-64 |
249 |
38% |
|
- Product
- Monooxygenase, FAD-binding protein
- Gene
- SACE_4643
- Organism
- Saccharopolyspora erythraea (strain NRRL 23338)
|
1uniprot[Pubmed] 17369815 Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338.(Nat. Biotechnol.) [2007] |
|
37
|
Q6VMI4_STRAM (Q6VMI4) |
|
|
3e-63 |
248 |
37% |
|
- Product
- Putative oxygenase
- Gene
- alpK
DSMT0188
- Organism
- Streptomyces ambofaciens
|
1uniprot[Pubmed] 14742212 Functional angucycline-like antibiotic gene cluster in the terminal inverted repeats of the Streptomyces ambofaciens linear chromosome.(Antimicrob. Agents Chemother.) [2004] | 2uniprot[Pubmed] 16952952 Intraspecific variability of the terminal inverted repeats of the linear chromosome of Streptomyces ambofaciens.(J. Bacteriol.) [2006] | [pubmed all]
|
38
|
Q1RQR7_STRAM (Q1RQR7) |
|
|
3e-63 |
248 |
37% |
|
- Product
- Putative oxygenase
- Gene
- alpK
SAMT0168 SAMT0169
- Organism
- Streptomyces ambofaciens ATCC 23877
|
1uniprot[Pubmed] 16952952 Intraspecific variability of the terminal inverted repeats of the linear chromosome of Streptomyces ambofaciens.(J. Bacteriol.) [2006] | 2uniprot[Pubmed] 16956972 Evolution of the terminal regions of the Streptomyces linear chromosome.(Mol. Biol. Evol.) [2006] | 3uniprot Multiple biosynthetic and uptake systems mediate siderophore-dependent iron acquisition in Streptomyces coelicolor A3(2) and Streptomyces ambofaciens ATCC 23877.(Microbiology (Mosc.)) [2006] | [pubmed all]
|
41
|
C0JWD4_9ACTO (C0JWD4) |
|
|
7e-63 |
246 |
37% |
|
- Product
- PokO4
- Gene
- pokO4
- Organism
- Streptomyces diastatochromogenes
|
1uniprot[Pubmed] 19266534 Organisation of the Biosynthetic Gene Cluster and Tailoring Enzymes in the Biosynthesis of the Tetracyclic Quinone Glycoside Antibiotic Polyketomycin.(Chembiochem) [2009] |
|
42
|
Q1RQU9_STRAM (Q1RQU9) |
|
|
1e-62 |
246 |
36% |
|
- Product
- Putative oxygenase
- Gene
- SAMT0136
SAMT0137
- Organism
- Streptomyces ambofaciens ATCC 23877
|
1uniprot[Pubmed] 16952952 Intraspecific variability of the terminal inverted repeats of the linear chromosome of Streptomyces ambofaciens.(J. Bacteriol.) [2006] | 2uniprot[Pubmed] 16956972 Evolution of the terminal regions of the Streptomyces linear chromosome.(Mol. Biol. Evol.) [2006] | 3uniprot Multiple biosynthetic and uptake systems mediate siderophore-dependent iron acquisition in Streptomyces coelicolor A3(2) and Streptomyces ambofaciens ATCC 23877.(Microbiology (Mosc.)) [2006] | [pubmed all]
|
45
|
Q6VMJ3_STRAM (Q6VMJ3) |
|
|
3e-62 |
244 |
36% |
|
- Product
- Putative oxygenase
- Gene
- alpG
DSMT0179
- Organism
- Streptomyces ambofaciens
|
1uniprot[Pubmed] 14742212 Functional angucycline-like antibiotic gene cluster in the terminal inverted repeats of the Streptomyces ambofaciens linear chromosome.(Antimicrob. Agents Chemother.) [2004] | 2uniprot[Pubmed] 16952952 Intraspecific variability of the terminal inverted repeats of the linear chromosome of Streptomyces ambofaciens.(J. Bacteriol.) [2006] | [pubmed all]
|
46
|
Q1RQS6_STRAM (Q1RQS6) |
|
|
3e-62 |
244 |
36% |
|
- Product
- Putative oxygenase
- Gene
- alpG
SAMT0159 SAMT0160
- Organism
- Streptomyces ambofaciens ATCC 23877
|
1uniprot[Pubmed] 16952952 Intraspecific variability of the terminal inverted repeats of the linear chromosome of Streptomyces ambofaciens.(J. Bacteriol.) [2006] | 2uniprot[Pubmed] 16956972 Evolution of the terminal regions of the Streptomyces linear chromosome.(Mol. Biol. Evol.) [2006] | 3uniprot Multiple biosynthetic and uptake systems mediate siderophore-dependent iron acquisition in Streptomyces coelicolor A3(2) and Streptomyces ambofaciens ATCC 23877.(Microbiology (Mosc.)) [2006] | [pubmed all]
|
47
|
Q47KZ8_THEFY (Q47KZ8) |
|
|
8e-62 |
243 |
37% |
|
- Product
- Putative rifampin monooxygenase
- Gene
- Tfu_2841
- Organism
- Thermobifida fusca (strain YX)
|
1uniprot[Pubmed] 17209016 Genome sequence and analysis of the soil cellulolytic actinomycete Thermobifida fusca YX.(J. Bacteriol.) [2007] |
|
48
|
Q0S0L2_RHOSR (Q0S0L2) |
|
|
8e-62 |
243 |
36% |
|
- Product
- Probable FAD-dependent monooxygenase
- Gene
- RHA1_ro07160
- Organism
- Rhodococcus sp. (strain RHA1)
|
1uniprot[Pubmed] 17030794 The complete genome of Rhodococcus sp. RHA1 provides insights into a catabolic powerhouse.(Proc. Natl. Acad. Sci. U.S.A.) [2006] |
|
49
|
Q0JWC9_STRAM (Q0JWC9) |
|
|
1e-61 |
242 |
36% |
|
- Product
- Putative oxygenase
- Gene
- DSMT0156
- Organism
- Streptomyces ambofaciens
|
1uniprot[Pubmed] 16952952 Intraspecific variability of the terminal inverted repeats of the linear chromosome of Streptomyces ambofaciens.(J. Bacteriol.) [2006] |
|
50
|
D6MSW1_9ACTO (D6MSW1) |
|
|
1e-61 |
242 |
35% |
|
- Product
- SsfO1
- Gene
- ssfO1
- Organism
- Streptomyces sp. SF2575
|
1uniprot[Pubmed] 19908837 Biochemical analysis of the biosynthetic pathway of an anticancer tetracycline SF2575.(J. Am. Chem. Soc.) [2009] |
|
53
|
F2RC22_STRVP (F2RC22) |
|
|
3e-61 |
241 |
33% |
|
- Product
- 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
- Gene
- SVEN_5987
- Organism
- Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)
|
1uniprot[Pubmed] 21463507 Genome-wide analysis of the role of GlnR in Streptomyces venezuelae provides new insights into global nitrogen regulation in actinomycetes.(BMC Genomics) [2011] |
|
55
|
D2ASL9_STRRD (D2ASL9) |
|
|
5e-61 |
240 |
37% |
|
- Product
- Putative monooxygenase
- Gene
- Sros_5796
- Organism
- Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)
|
1uniprot Complete genome sequence of Streptosporangium roseum type strain (NI 9100T).(Stand. Genomic Sci.) [2010] |
|
58
|
Q93FA8_STRAT (Q93FA8) |
|
|
7e-61 |
239 |
36% |
|
- Product
- Sim7
- Gene
- sim7
- Organism
- Streptomyces antibioticus
|
1uniprot[Pubmed] 12115055 [Medline] 22109063 Cloning and analysis of the simocyclinone biosynthetic gene cluster of Streptomyces antibioticus Tu 6040.(Arch. Microbiol.) [2002] |
|
60
|
E4N5W7_KITSK (E4N5W7) |
|
|
1e-60 |
239 |
37% |
|
- Product
- Putative monooxygenase
- Gene
- KSE_07580
- Organism
- Kitasatospora setae (strain ATCC 33774 / DSM 43861 / JCM 3304 / KCC A-0304 / NBRC 14216 / KM-6054)
Streptomyces setae
|
1uniprot[Pubmed] 21059706 Genome sequence of Kitasatospora setae NBRC 14216T: an evolutionary snapshot of the family Streptomycetaceae.(DNA Res.) [2010] |
|
64
|
D8HR95_AMYMU (D8HR95) |
|
|
2e-60 |
238 |
36% |
|
- Product
- FAD-dependent oxidoreductase
- Gene
- AMED_4222
- Organism
- Amycolatopsis mediterranei (strain U-32)
|
1uniprot[Pubmed] 20567260 Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010] |
|
65
|
Q5U913_9ACTO (Q5U913) |
|
|
2e-60 |
238 |
33% |
|
- Product
- JadH
- Gene
- jadH
- Organism
- Streptomyces venezuelae
|
1uniprot[Pubmed] 15817470 Functional analyses of oxygenases in jadomycin biosynthesis and identification of JadH as a bifunctional oxygenase/dehydrase.(J. Biol. Chem.) [2005] |
|
66
|
D8I7G5_AMYMU (D8I7G5) |
|
|
3e-60 |
237 |
34% |
|
- Product
- 3-(3-hydroxy-phenyl)propionate hydroxylase
- Gene
- mhpA
AMED_5632
- Organism
- Amycolatopsis mediterranei (strain U-32)
|
1uniprot[Pubmed] 20567260 Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010] |
|
67
|
F2R776_STRVP (F2R776) |
|
|
3e-60 |
237 |
35% |
|
- Product
- Rifampin monooxygenase
- Gene
- SVEN_0481
- Organism
- Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)
|
1uniprot[Pubmed] 21463507 Genome-wide analysis of the role of GlnR in Streptomyces venezuelae provides new insights into global nitrogen regulation in actinomycetes.(BMC Genomics) [2011] |
|
68
|
Q2HR18_9ACTO (Q2HR18) |
|
|
3e-60 |
237 |
35% |
|
- Product
- Putative oxygenase
- Gene
- schP10
- Organism
- Streptomyces sp. SCC 2136
|
1uniprot Angucyclines Sch 47554 and Sch 47555 from Streptomyces sp. SCC-2136: Cloning, Sequencing, and Characterization.(Mol. Cells) [2006] | 2uniprot Molecular cloning and characterization of biosynthetic genes cluster of Sch 47554 from Streptomyces sp. SCC 2136. [2004] |
|
69
|
Q53657_STRAU (Q53657) |
|
|
5e-60 |
236 |
36% |
|
- Product
- 6-hydroxylation enzyme of tetracycline
- Gene
- cts8
- Organism
- Streptomyces aureofaciens
|
1uniprot[Pubmed] 7612997 [Medline] 95337551 Cloning and nucleotide sequence of the gene responsible for chlorination of tetracycline.(Biosci. Biotechnol. Biochem.) [1995] |
|
71
|
Q8KU28_9NOCA (Q8KU28) |
|
|
6e-60 |
236 |
35% |
|
- Product
- Flavin-type hydroxylase
- Gene
-
- Organism
- Rhodococcus sp. NCIMB 9784
|
1uniprot[Pubmed] 12081961 [Medline] 22077259 Identification of a new class of cytochrome P450 from a Rhodococcus sp.(J. Bacteriol.) [2002] |
|
72
|
Q5YTV5_NOCFA (Q5YTV5) |
|
|
7e-60 |
236 |
35% |
|
- Product
- Putative rifampin monooxygenase
- Gene
- rox
NFA_35380
- Organism
- Nocardia farcinica
|
1uniprot[Pubmed] 15466710 The complete genomic sequence of Nocardia farcinica IFM 10152.(Proc. Natl. Acad. Sci. U.S.A.) [2004] |
|
74
|
Q194P4_STRAA (Q194P4) |
|
|
2e-59 |
234 |
36% |
|
- Product
- Oxygenase
- Gene
- mtmOIV
- Organism
- Streptomyces argillaceus
|
1uniprot[Pubmed] 8654997 [Medline] 96257259 Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996] | 2uniprot[Pubmed] 8757400 [Medline] 96335144 An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996] | 3uniprot[Pubmed] 9150235 [Medline] 97294479 Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997] | 4uniprot[Pubmed] 9733697 [Medline] 98406047 Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998] | 5uniprot[Pubmed] 10102355 [Medline] 99200478 Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999] | 6uniprot[Pubmed] 9889148 [Medline] 99111236 Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999] | 7uniprot[Pubmed] 10660060 [Medline] 20123456 Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000] | 8uniprot[Pubmed] 11254130 [Medline] 21148776 The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001] | 9uniprot[Pubmed] 12733914 [Medline] 22619809 Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003] | 10uniprot[Pubmed] 9917296 [Medline] 99115752 The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999] | 11uniprot[Pubmed] 11853433 [Medline] 21843297 Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002] | 12uniprot[Pubmed] 10652287 [Medline] 20119254 Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000] | 13uniprot[Pubmed] 10779713 [Medline] 20243461 Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000] | 14uniprot[Pubmed] 12022840 [Medline] 22017994 Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002] | 15uniprot[Pubmed] 12813091 [Medline] 22697398 Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003] | 16uniprot[Pubmed] 8807845 [Medline] 97113238 Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996] | 17uniprot[Pubmed] 14660589 MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004] | 18uniprot[Pubmed] 9375253 [Medline] 98042823 Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997] | 19uniprot[Pubmed] 15712316 Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005] | 20uniprot[Pubmed] 10760873 The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000] | 21uniprot[Pubmed] 19364090 Crystal structure of Baeyer-Villiger monooxygenase MtmOIV, the key enzyme of the mithramycin biosynthetic pathway .(Biochemistry) [2009] | [pubmed all]
|
78
|
F4FF57_VERMA (F4FF57) |
|
|
3e-59 |
234 |
35% |
|
- Product
- FAD-dependent monooxygenase
- Gene
- VAB18032_19300
- Organism
- Verrucosispora maris (strain AB-18-032)
|
1uniprot[Pubmed] 21551311 Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.(J. Bacteriol.) [2011] |
|
80
|
D4FUS4_BACNA (D4FUS4) |
|
|
4e-59 |
233 |
35% |
|
- Product
- Putative uncharacterized protein yhjG
- Gene
- yhjG
BSNT_01781
- Organism
- Bacillus subtilis subsp. natto BEST195
|
1uniprot[Pubmed] 20398357 Whole genome assembly of a natto production strain Bacillus subtilis natto from very short read data.(BMC Genomics) [2010] |
|
84
|
Q8KSX5_9ACTO (Q8KSX5) |
|
|
1e-58 |
232 |
34% |
|
- Product
- Putative FAD-dependent monooxygenase GrhO6
- Gene
- grhO6
- Organism
- Streptomyces sp. JP95
|
1uniprot[Pubmed] 12323376 [Medline] 22235582 A gene cluster from a marine Streptomyces encoding the biosynthesis of the aromatic spiroketal polyketide griseorhodin A.(Chem. Biol.) [2002] |
|
85
|
E2Q7Q1_STRCL (E2Q7Q1) |
|
|
1e-58 |
232 |
38% |
|
- Product
- Putative monooxygenase
- Gene
- SCLAV_4360
- Organism
- Streptomyces clavuligerus ATCC 27064
|
1uniprot[Pubmed] 20624727 The sequence of a 1.8-mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways.(Genome Biol. Evol.) [2010] |
|
87
|
YHJG_BACSU (O07561) |
|
|
2e-58 |
231 |
34% |
|
- Product
- Uncharacterized aromatic compound monooxygenase yhjG
- Gene
- yhjG
BSU10500
- Organism
- Bacillus subtilis
|
1uniprot[Pubmed] 9579061 [Medline] 98240224 The 172 kb prkA-addAB region from 83 degrees to 97 degrees of the Bacillus subtilis chromosome contains several dysfunctional genes, the glyB marker, many genes encoding transporter proteins, and the ubiquitous hit gene.(Microbiology) [1998] | 2uniprot[Pubmed] 9384377 [Medline] 98044033 The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.(Nature) [1997] | [pubmed all]
|
89
|
Q0JWC6_STRAM (Q0JWC6) |
|
|
4e-58 |
230 |
35% |
|
- Product
- Putative oxygenase
- Gene
- DSMT0159
- Organism
- Streptomyces ambofaciens
|
1uniprot[Pubmed] 16952952 Intraspecific variability of the terminal inverted repeats of the linear chromosome of Streptomyces ambofaciens.(J. Bacteriol.) [2006] |
|
91
|
E1UQV7_BACAS (E1UQV7) |
|
|
5e-58 |
230 |
33% |
|
- Product
- Putative aromatic compound monooxygenase/hydroxylase
- Gene
- yhjG
BAMF_1141
- Organism
- Bacillus amyloliquefaciens (strain ATCC 23350 / DSM 7 / NBRC 15535 / NRRL B-14393)
|
1uniprot[Pubmed] 21262282 Genome sequence of B. amyloliquefaciens type strain DSM7(T) reveals differences to plant-associated B. amyloliquefaciens FZB42.(J. Biotechnol.) [2011] |
|
92
|
F4EPH1_BACAM (F4EPH1) |
|
|
5e-58 |
230 |
33% |
|
- Product
- Putative aromatic compound monooxygenase/hydroxylase
- Gene
- yhjG
LL3_01140
- Organism
- Bacillus amyloliquefaciens
Bacillus velezensis
|
1uniprot[Pubmed] 21551302 Complete Genome Sequence of Bacillus amyloliquefaciens LL3, Which Exhibits Glutamic Acid-Independent Production of Poly-{gamma}-Glutamic Acid.(J. Bacteriol.) [2011] |
|
93
|
F4E4V2_BACAM (F4E4V2) |
|
|
5e-58 |
230 |
33% |
|
- Product
- Putative uncharacterized protein yhjG
- Gene
- yhjG
BAMTA208_04940
- Organism
- Bacillus amyloliquefaciens TA208
|
1uniprot[Pubmed] 21515778 Complete Genome Sequence of Bacillus amyloliquefaciens TA208, a Strain for Industrial Production of Guanosine and Ribavirin.(J. Bacteriol.) [2011] |
|
94
|
E8VGB4_BACST (E8VGB4) |
|
|
8e-58 |
229 |
34% |
|
- Product
- Putative uncharacterized protein
- Gene
- BSn5_17135
- Organism
- Bacillus subtilis (strain BSn5)
|
1uniprot[Pubmed] 21317323 Complete genome sequence of Bacillus subtilis BSn5, an endophytic bacterium of Amorphophallus konjac with antimicrobial activity to plant pathogen Erwinia carotovora subsp. carotovora.(J. Bacteriol.) [2011] |
|
96
|
F3NH12_9ACTO (F3NH12) |
|
|
1e-57 |
229 |
35% |
|
- Product
- FAD-dependent monooxygenase
- Gene
- SGM_2426
- Organism
- Streptomyces griseoaurantiacus M045
|
1uniprot[Pubmed] 21551298 Draft Genome Sequence of the Marine Bacterium Streptomyces griseoaurantiacus M045, Which Produces Novel Manumycin-Type Antibiotics with a pABA Core Component.(J. Bacteriol.) [2011] |
|
98
|
Q0R4M9_STRAT (Q0R4M9) |
|
|
1e-57 |
228 |
35% |
|
- Product
- ChlE1
- Gene
-
- Organism
- Streptomyces antibioticus
|
1uniprot[Pubmed] 16793515 Genetic characterization of the chlorothricin gene cluster as a model for spirotetronate antibiotic biosynthesis.(Chem. Biol.) [2006] |
|
100
|
Q1RQU6_STRAM (Q1RQU6) |
|
|
2e-57 |
228 |
35% |
|
- Product
- Putative oxygenase
- Gene
- SAMT0139
SAMT0140
- Organism
- Streptomyces ambofaciens ATCC 23877
|
1uniprot[Pubmed] 16952952 Intraspecific variability of the terminal inverted repeats of the linear chromosome of Streptomyces ambofaciens.(J. Bacteriol.) [2006] | 2uniprot[Pubmed] 16956972 Evolution of the terminal regions of the Streptomyces linear chromosome.(Mol. Biol. Evol.) [2006] | 3uniprot Multiple biosynthetic and uptake systems mediate siderophore-dependent iron acquisition in Streptomyces coelicolor A3(2) and Streptomyces ambofaciens ATCC 23877.(Microbiology (Mosc.)) [2006] | [pubmed all]
|