BLAST table : Teicp_00070

DB	UniProtKB

	accession	Evalue	Score	Ident.	link	product	gene	organism	ec
1	Q6ZZK1_ACTTI (Q6ZZK1)	1e-117	424	100%	UniProt GenBank	Dipeptidase VanX protein	tcp4	Actinoplanes teichomyceticus
2	E9L1E8_9ZZZZ (E9L1E8)	1e-102	374	86%	UniProt GenBank	Putative uncharacterized protein	CA37-4	uncultured organism CA37
3	Q20FL6_9PSEU (Q20FL6)	3e-99	364	83%	UniProt GenBank	VanX	vanX	Amycolatopsis coloradensis
4	Q9ZI81_STRTO (Q9ZI81)	3e-96	354	79%	UniProt GenBank	D-ala-D-ala dipeptidase	vanXst	Streptomyces toyocaensis
5	E9L1K2_9ZZZZ (E9L1K2)	1e-95	353	81%	UniProt GenBank	Putative uncharacterized protein	CA878-3	uncultured organism CA878
6	D3PUW6_STANL (D3PUW6)	8e-94	347	80%	UniProt GenBank	D-Ala-D-Ala dipeptidase	Snas_5357	Stackebrandtia nassauensis (strain DSM 44728 / NRRL B-16338 / NBRC 102104 / LLR-40K-21)	3.4.13.22 niceE keggE
7	VANX_STRCO (Q9XAK6)	7e-93	343	80%	UniProt GenBank	D-alanyl-D-alanine dipeptidase	vanX SCO3596 SC66T3.07	Streptomyces coelicolor	3.4.13.22 niceE keggE
8	D6EPN2_STRLI (D6EPN2)	1e-92	343	79%	UniProt GenBank	D-alanyl-D-alanine dipeptidase	SSPG_04064	Streptomyces lividans TK24
9	C7QDM6_CATAD (C7QDM6)	5e-92	340	79%	UniProt GenBank	Peptidase M15D vanX D-ala-D-ala dipeptidase	Caci_5792	Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)
10	F8STW9_AMYOR (F8STW9)	6e-92	340	78%	UniProt GenBank	D-alanyl-D-alanine dipeptidase	vanX	Amycolatopsis orientalis Nocardia orientalis
11	D8HIQ9_AMYMU (D8HIQ9)	1e-91	339	78%	UniProt GenBank	D-alanyl-D-alanine dipeptidase	vanA AMED_8288	Amycolatopsis mediterranei (strain U-32)
12	Q9Z6H2_AMYOR (Q9Z6H2)	2e-91	338	78%	UniProt GenBank	D-alanyl-D-alanine dipeptidase	vanX	Amycolatopsis orientalis Nocardia orientalis
13	B5I696_9ACTO (B5I696)	4e-91	337	77%	UniProt GenBank	D-alanine dipeptidase	SSEG_10122	Streptomyces sviceus ATCC 29083
14	Q6IWG2_9PSEU (Q6IWG2)	2e-90	335	82%	UniProt GenBank	D-alanyl-D-alanine dipeptidase	vanX	Amycolatopsis coloradensis
15	D2PMX6_KRIFD (D2PMX6)	3e-90	335	76%	UniProt GenBank	D-Ala-D-Ala dipeptidase	Kfla_3621	Kribbella flavida (strain DSM 17836 / JCM 10339 / NBRC 14399)	3.4.13.22 niceE keggE
16	B8FPP3_DESHD (B8FPP3)	2e-89	332	75%	UniProt GenBank	Peptidase M15D vanX D-ala-D-ala dipeptidase	Dhaf_1661	Desulfitobacterium hafniense (strain DCB-2 / DSM 10664)
17	A8L664_FRASN (A8L664)	2e-89	332	77%	UniProt GenBank	Peptidase M15D vanX D-ala-D-ala dipeptidase	Franean1_7136	Frankia sp. (strain EAN1pec)
18	D9VBI1_9ACTO (D9VBI1)	2e-88	329	76%	UniProt GenBank	D-Ala-D-Ala dipeptidase	SSMG_01114	Streptomyces sp. AA4
19	E9UYS8_9ACTO (E9UYS8)	2e-88	328	75%	UniProt GenBank	D-Ala-D-Ala dipeptidase	NBCG_03949	Nocardioidaceae bacterium Broad-1
20	Q24R59_DESHY (Q24R59)	3e-88	328	74%	UniProt GenBank	Putative uncharacterized protein	DSY3694	Desulfitobacterium hafniense (strain Y51)
21	D3EYW9_CONWI (D3EYW9)	5e-88	327	75%	UniProt GenBank	D-Ala-D-Ala dipeptidase	Cwoe_1415	Conexibacter woesei (strain DSM 14684 / JCM 11494 / NBRC 100937 / ID131577)	3.4.13.22 niceE keggE
22	E9L1P4_9ZZZZ (E9L1P4)	2e-87	325	82%	UniProt GenBank	Putative uncharacterized protein	CA915-2	uncultured organism CA915
23	D5US96_TSUPD (D5US96)	1e-85	319	73%	UniProt GenBank	D-Ala-D-Ala dipeptidase	Tpau_0522	Tsukamurella paurometabola (strain ATCC 8368 / DSM 20162 / JCM 10117 / NBRC 16120 / NCTC 13040) Corynebacterium paurometabolum	3.4.13.22 niceE keggE
24	A8RJ09_9FIRM (A8RJ09)	1e-77	293	67%	UniProt GenBank	D,D dipeptidase	vanXD	Ruminococcus gauvreauii
25	Q9XCR3_ENTFC (Q9XCR3)	3e-77	291	67%	UniProt GenBank	D,D dipeptidase	vanXD	Enterococcus faecium Streptococcus faecium
26	Q9S3S6_ENTFC (Q9S3S6)	5e-77	291	67%	UniProt GenBank	D,D dipeptidase	vanXD	Enterococcus faecium Streptococcus faecium
27	C3TSE7_ENTFC (C3TSE7)	1e-76	290	67%	UniProt GenBank	D,D-dipeptidase VanXD	vanXD	Enterococcus faecium Streptococcus faecium
28	Q6RVF6_ENTFC (Q6RVF6)	1e-76	290	68%	UniProt GenBank	VanXD5	vanXD5	Enterococcus faecium Streptococcus faecium
29	Q9LA08_PAEPP (Q9LA08)	2e-76	289	66%	UniProt GenBank	Putative D,D-dipeptidase Putative D,D-dipeptidase VanXE	vanXE vanXf	Paenibacillus popilliae Bacillus popilliae
30	Q8GF03_ENTFC (Q8GF03)	6e-75	284	67%	UniProt GenBank	D,D-dipeptidase	vanXD	Enterococcus faecium Streptococcus faecium
31	Q18PA3_9ENTE (Q18PA3)	6e-75	284	67%	UniProt GenBank	D, D-dipeptidase	vanXD	Enterococcus raffinosus
32	Q4U1W4_PANTH (Q4U1W4)	1e-74	283	66%	UniProt GenBank	VanX	vanX	Paenibacillus thiaminolyticus Bacillus thiaminolyticus
33	Q5BP12_PANTH (Q5BP12)	2e-74	282	65%	UniProt GenBank	D,D-dipeptidase	vanX	Paenibacillus thiaminolyticus Bacillus thiaminolyticus
34	C7WYV2_ENTFA (C7WYV2)	7e-74	280	64%	UniProt GenBank	D,D-dipeptidase	EFGG_02745	Enterococcus faecalis Merz96
35	VANX_ENTFA (Q47749)	7e-74	280	64%	UniProt GenBank	D-alanyl-D-alanine dipeptidase Vancomycin B-type resistance protein vanXB	vanXB vanX EF_2293	Enterococcus faecalis Streptococcus faecalis	3.4.13.22 niceE keggE
36	Q714P5_ENTFC (Q714P5)	2e-73	279	64%	UniProt GenBank	D,D-dipeptidase	vanXB	Enterococcus faecium Streptococcus faecium
37	B6ZHJ5_ENTFA (B6ZHJ5)	3e-73	278	64%	UniProt GenBank	VanX protein	vanX	Enterococcus faecalis Streptococcus faecalis
38	Q7BWD6_STAAU (Q7BWD6)	5e-73	278	64%	UniProt GenBank	Vancomycin B-type resistance protein VanX	vanX VRA0041	Staphylococcus aureus
39	Q0WYK6_ENTFA (Q0WYK6)	5e-73	278	64%	UniProt GenBank	VanX VanX protein Vancomycin resistance	vanX	Enterococcus faecalis Streptococcus faecalis
40	D4RFM2_ENTFC (D4RFM2)	5e-73	278	64%	UniProt GenBank	D-alanyl-D-alanine dipeptidase	EfmE1679_0619	Enterococcus faecium E1679
41	C7VPN7_ENTFA (C7VPN7)	5e-73	278	64%	UniProt GenBank	Vancomycin B-type resistance protein VanX	EFHG_05028	Enterococcus faecalis HIP11704
42	A1JV21_ENTFC (A1JV21)	5e-73	278	64%	UniProt GenBank	D,D-dipeptidase VanX VanX VanX protein	vanX	Enterococcus faecium Streptococcus faecium
43	VANX_ENTFC (Q06241)	5e-73	278	64%	UniProt GenBank	D-alanyl-D-alanine dipeptidase Vancomycin B-type resistance protein vanX	vanX	Enterococcus faecium Streptococcus faecium	3.4.13.22 niceE keggE
44	C9CGP3_ENTFC (C9CGP3)	5e-73	278	64%	UniProt GenBank	D-ala-D-ala dipeptidase	EFPG_05425	Enterococcus faecium 1,230,933
45	Q8KSE2_ENTFC (Q8KSE2)	7e-73	277	64%	UniProt GenBank	D-Ala-D-Ala dipeptidase D-ala-D-ala dipeptidase VanX Vancomycin B-type resistance protein VanX	vanX SAP083A_021 pLG1-0094	Enterococcus faecium Streptococcus faecium
46	E4JIF4_ENTFC (E4JIF4)	7e-73	277	64%	UniProt GenBank	D-Ala-D-Ala dipeptidase	HMPREF9524_01956	Enterococcus faecium TX0133a01
47	E4ISK4_ENTFC (E4ISK4)	7e-73	277	64%	UniProt GenBank	D-Ala-D-Ala dipeptidase	HMPREF9522_01954	Enterococcus faecium TX0082
48	E4IL19_ENTFC (E4IL19)	7e-73	277	64%	UniProt GenBank	D-Ala-D-Ala dipeptidase	HMPREF9527_02783	Enterococcus faecium TX0133C
49	E2YNV9_ENTFA (E2YNV9)	7e-73	277	64%	UniProt GenBank	D-Ala-D-Ala dipeptidase	HMPREF9492_02152	Enterococcus faecalis DAPTO 512
50	E2YB55_ENTFA (E2YB55)	7e-73	277	64%	UniProt GenBank	D-Ala-D-Ala dipeptidase	HMPREF9493_00793	Enterococcus faecalis DAPTO 516
51	D4QQA5_ENTFC (D4QQA5)	7e-73	277	64%	UniProt GenBank	D-Ala-D-Ala dipeptidase VanZ	EfmE1071_0106	Enterococcus faecium E1071
52	D4EY56_ENTFA (D4EY56)	7e-73	277	64%	UniProt GenBank	D-Ala-D-Ala dipeptidase	HMPREF9377_02489	Enterococcus faecalis R712
53	D4EIM4_ENTFA (D4EIM4)	7e-73	277	64%	UniProt GenBank	D-Ala-D-Ala dipeptidase	HMPREF9376_00484	Enterococcus faecalis S613
54	C9C610_ENTFC (C9C610)	7e-73	277	64%	UniProt GenBank	D-Ala-D-Ala dipeptidase	EFTG_02040	Enterococcus faecium 1,231,410
55	C9BR21_ENTFC (C9BR21)	7e-73	277	64%	UniProt GenBank	D-Ala-D-Ala dipeptidase	EFQG_02531	Enterococcus faecium 1,231,502
56	Q9EYV8_ENTFC (Q9EYV8)	1e-72	276	64%	UniProt GenBank	D,D-dipeptidase VanXB	vanXB2 vanXB	Enterococcus faecium Streptococcus faecium
57	Q32ZB0_9ACTN (Q32ZB0)	1e-72	276	64%	UniProt GenBank	VanXB	vanXB	Eggerthella lenta
58	Q32ZA0_9CLOT (Q32ZA0)	1e-72	276	64%	UniProt GenBank	VanXB	vanXB	Clostridium sp. MLG245
59	D0APH4_ENTFC (D0APH4)	1e-72	276	64%	UniProt GenBank	VanXB	EFXG_01479	Enterococcus faecium C68
60	C0X1V3_ENTFA (C0X1V3)	1e-72	276	64%	UniProt GenBank	D-Ala-D-Ala dipeptidase	vanXB HMPREF0348_0488	Enterococcus faecalis TX0104	3.4.13.22 niceE keggE
61	Q9RMA2_BACCI (Q9RMA2)	1e-72	276	64%	UniProt GenBank	Vanx protein	vanX	Bacillus circulans
62	Q9L8X9_ENTFA (Q9L8X9)	1e-72	276	64%	UniProt GenBank	VanXB	vanXB	Enterococcus faecalis Streptococcus faecalis
63	Q56R47_9CLOT (Q56R47)	2e-72	276	64%	UniProt GenBank	VanXB	vanXB	Clostridium sp. CCRI-9842
64	B8XGS4_ENTFC (B8XGS4)	1e-71	273	63%	UniProt GenBank	VanXM	vanXM	Enterococcus faecium Streptococcus faecium
65	Q3S3G2_ENTGA (Q3S3G2)	2e-71	272	65%	UniProt GenBank	VanXD	vanXD	Enterococcus gallinarum
66	C7EME6_ENTFC (C7EME6)	3e-69	265	65%	UniProt GenBank	D,D-dipeptidase	vanX	Enterococcus faecium Streptococcus faecium
67	C7EME7_ENTFC (C7EME7)	5e-69	264	65%	UniProt GenBank	D,D-dipeptidase	vanX	Enterococcus faecium Streptococcus faecium
68	Q4U1V6_9BACL (Q4U1V6)	7e-66	254	66%	UniProt GenBank	VanX	vanX	Paenibacillus apiarius
69	Q9L8H7_ENTFA (Q9L8H7)	1e-63	246	65%	UniProt GenBank	VanXb	vanXb	Enterococcus faecalis Streptococcus faecalis
70	Q9K3C8_ENTFC (Q9K3C8)	1e-63	246	65%	UniProt GenBank	VanXb	vanXb	Enterococcus faecium Streptococcus faecium
71	Q9L8I1_ENTFA (Q9L8I1)	2e-63	246	64%	UniProt GenBank	VanXb	vanXb	Enterococcus faecalis Streptococcus faecalis
72	Q9L8H9_ENTGA (Q9L8H9)	2e-63	246	64%	UniProt GenBank	VanXb	vanXb	Enterococcus gallinarum
73	Q9K2T8_ENTFC (Q9K2T8)	2e-63	246	64%	UniProt GenBank	VanXb	vanXb	Enterococcus faecium Streptococcus faecium
74	Q9L8I3_ENTFA (Q9L8I3)	2e-63	245	64%	UniProt GenBank	VanXb	vanXb	Enterococcus faecalis Streptococcus faecalis
75	Q8KRA2_9STRE (Q8KRA2)	3e-63	245	65%	UniProt GenBank	D,D-dipeptidase VanXb	vanXb	Streptococcus lutetiensis
76	Q8KHV2_STRGY (Q8KHV2)	4e-63	244	65%	UniProt GenBank	D,D-dipeptidase VanXb	vanXb	Streptococcus gallolyticus Streptococcus bovis biotype I
77	Q9L3K2_ENTFC (Q9L3K2)	6e-52	207	63%	UniProt GenBank	Dipeptidase	vanXB2	Enterococcus faecium Streptococcus faecium
78	A0LZ24_GRAFK (A0LZ24)	4e-49	198	48%	UniProt GenBank	D-alanyl-D-alanine dipeptidase	vanX GFO_0641	Gramella forsetii (strain KT0803)	3.4.13.- niceE keggE
79	C0BFM5_9BACT (C0BFM5)	7e-49	197	46%	UniProt GenBank	Peptidase M15D vanX D-ala-D-ala dipeptidase	Flav2ADRAFT_1160	Flavobacteria bacterium MS024-2A
80	E3GIB2_EUBLK (E3GIB2)	6e-48	194	46%	UniProt GenBank	D-Ala-D-Ala dipeptidase	ELI_0380	Eubacterium limosum (strain KIST612)
81	A0LFK7_SYNFM (A0LFK7)	2e-47	193	47%	UniProt GenBank	VanX D-Ala-D-Ala dipeptidase. Metallo peptidase. MEROPS family M15D	Sfum_0509	Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB)
82	O87665_ENTFC (O87665)	2e-47	192	65%	UniProt GenBank	Vancomycin resistance protein	vanX	Enterococcus faecium Streptococcus faecium
83	D5BL81_ZUNPS (D5BL81)	2e-47	192	47%	UniProt GenBank	D-alanyl-D-alanine dipeptidase	ZPR_3697	Zunongwangia profunda (strain DSM 18752 / CCTCC AB 206139 / SM-A87)
84	E6VWS4_DESAO (E6VWS4)	1e-45	186	47%	UniProt GenBank	D-Ala-D-Ala dipeptidase	Daes_2690	Desulfovibrio aespoeensis (strain ATCC 700646 / DSM 10631 / Aspo-2)	3.4.13.22 niceE keggE
85	Q1MRM8_LAWIP (Q1MRM8)	1e-45	186	43%	UniProt GenBank	Svh	LI0292	Lawsonia intracellularis (strain PHE/MN1-00)
86	A4BYY2_9FLAO (A4BYY2)	1e-45	186	44%	UniProt GenBank	Putative uncharacterized protein	PI23P_07115	Polaribacter irgensii 23-P
87	F5V6F1_METAL (F5V6F1)	1e-44	184	44%	UniProt GenBank	D-Ala-D-Ala dipeptidase	MetalDRAFT_2404	Methylomicrobium album BG8	3.4.13.22 niceE keggE
88	D7VKN3_9SPHI (D7VKN3)	1e-44	183	45%	UniProt GenBank	D-alanyl-D-alanine dipeptidase	vanX HMPREF0766_11552	Sphingobacterium spiritivorum ATCC 33861	3.4.13.- niceE keggE
89	D3SC75_THISK (D3SC75)	8e-44	181	45%	UniProt GenBank	D-Ala-D-Ala dipeptidase	TK90_0077	Thioalkalivibrio sp. (strain K90mix)	3.4.13.22 niceE keggE
90	C5AUE7_METEA (C5AUE7)	8e-44	181	47%	UniProt GenBank	D-alanyl-D-alanine dipeptidase	MexAM1_META1p0607	Methylobacterium extorquens (strain ATCC 14718 / DSM 1338 / AM1)	3.4.13.- niceE keggE
91	F6GE83_9FLAO (F6GE83)	1e-43	180	40%	UniProt GenBank	D-Ala-D-Ala dipeptidase	Lacal_1844	Lacinutrix sp. 5H-3-7-4	3.4.13.22 niceE keggE
92	A2U1F8_9FLAO (A2U1F8)	2e-43	179	41%	UniProt GenBank	D-ala-D-ala dipeptidase	MED152_03330	Polaribacter sp. MED152
93	C2G5F4_9SPHI (C2G5F4)	4e-43	178	43%	UniProt GenBank	D-alanyl-D-alanine dipeptidase	vanX HMPREF0765_4810	Sphingobacterium spiritivorum ATCC 33300	3.4.13.- niceE keggE
94	A9W0Y9_METEP (A9W0Y9)	4e-43	178	47%	UniProt GenBank	Peptidase M15D vanX D-ala-D-ala dipeptidase	Mext_0840	Methylobacterium extorquens (strain PA1)
95	B7L0J6_METC4 (B7L0J6)	1e-42	177	47%	UniProt GenBank	Peptidase M15D vanX D-ala-D-ala dipeptidase	Mchl_0800	Methylobacterium chloromethanicum (strain CM4 / NCIMB 13688)
96	B1Z7X0_METPB (B1Z7X0)	1e-42	176	49%	UniProt GenBank	Peptidase M15D vanX D-ala-D-ala dipeptidase	Mpop_0763	Methylobacterium populi (strain ATCC BAA-705 / NCIMB 13946 / BJ001)
97	A8PK95_9COXI (A8PK95)	2e-42	176	43%	UniProt GenBank	D-alanyl-D-alanine dipeptidase (D-Ala-D-Aladipeptidase) (Vancomycin B-type resistance protein VanX)	RICGR_0278	Rickettsiella grylli
98	A7ID13_XANP2 (A7ID13)	2e-42	176	48%	UniProt GenBank	Peptidase M15D vanX D-ala-D-ala dipeptidase	Xaut_0653	Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)
99	A8UQB5_9FLAO (A8UQB5)	1e-41	173	40%	UniProt GenBank	Peptidase M15D, vanX D-ala-D-ala dipeptidase	FBALC1_05163	Flavobacteriales bacterium ALC-1
100	C7CD73_METED (C7CD73)	2e-41	173	45%	UniProt GenBank	D-alanyl-D-alanine dipeptidase	METDI0978	Methylobacterium extorquens (strain DSM 5838 / DM4) Methylobacterium dichloromethanicum (strain DM4)	3.4.13.- niceE keggE

accession

alignment

Evalue

Score

Ident.

link

information

pubmed

Q6ZZK1_ACTTI
(Q6ZZK1)

1e-117

424

100%

Product: Dipeptidase
VanX protein
Gene: tcp4
Organism: Actinoplanes teichomyceticus

[pubmed all]
1uniprot[Pubmed] 15113000 Biosynthetic gene cluster of the glycopeptide antibiotic teicoplanin: characterization of two glycosyltransferases and the key acyltransferase.(Chem. Biol.) [2004]
2uniprot[Pubmed] 14702401 Organization of the teicoplanin gene cluster in Actinoplanes teichomyceticus.(Microbiology) [2004]

E9L1E8_9ZZZZ
(E9L1E8)

1e-102

374

86%

Product: Putative uncharacterized protein
Gene: CA37-4
Organism: uncultured organism CA37

1uniprot[Pubmed] 20945895
Tailoring enzyme-rich environmental DNA clones: a source of enzymes for generating libraries of unnatural natural products.(J. Am. Chem. Soc.) [2010]

Q20FL6_9PSEU
(Q20FL6)

3e-99

364

83%

Product: VanX
Gene: vanX
Organism: Amycolatopsis coloradensis

1uniprot[Pubmed] 16476725
Heterologous expression of glycopeptide resistance vanHAX gene clusters from soil bacteria in Enterococcus faecalis.(J. Antimicrob. Chemother.) [2006]

Q9ZI81_STRTO
(Q9ZI81)

3e-96

354

79%

Product: D-ala-D-ala dipeptidase
Gene: vanXst
Organism: Streptomyces toyocaensis

[pubmed all]
1uniprot[Pubmed] 9177243 [Medline] 97322398 D-Ala-D-Ala ligases from glycopeptide antibiotic-producing organisms are highly homologous to the enterococcal vancomycin-resistance ligases VanA and VanB.(Proc. Natl. Acad. Sci. U.S.A.) [1997]
2uniprot[Pubmed] 12060705 [Medline] 22080153 Assembling the glycopeptide antibiotic scaffold: the biosynthesis of A47934 from Streptomyces toyocaensis NRRL15009.(Proc. Natl. Acad. Sci. U.S.A.) [2002]

E9L1K2_9ZZZZ
(E9L1K2)

1e-95

353

81%

Product: Putative uncharacterized protein
Gene: CA878-3
Organism: uncultured organism CA878

1uniprot[Pubmed] 20945895
Tailoring enzyme-rich environmental DNA clones: a source of enzymes for generating libraries of unnatural natural products.(J. Am. Chem. Soc.) [2010]

D3PUW6_STANL
(D3PUW6)

8e-94

347

80%

Product: D-Ala-D-Ala dipeptidase
Gene: Snas_5357
Organism: Stackebrandtia nassauensis (strain DSM 44728 / NRRL B-16338 / NBRC 102104 / LLR-40K-21)

1uniprot
Complete genome sequence of Stackebrandtia nassauensis type strain (LLR-40K-21T).(Stand. Genomic Sci.) [2009]

VANX_STRCO
(Q9XAK6)

7e-93

343

80%

Product: D-alanyl-D-alanine dipeptidase
Gene: vanX
SCO3596
SC66T3.07
Organism: Streptomyces coelicolor

[pubmed all]
1uniprot[Pubmed] 11881895 [Medline] 21873347 Molecular cloning and functional characterisation of VanX, a D-alanyl-D-alanine dipeptidase from Streptomyces coelicolor A3(2).(Res. Microbiol.) [2002]
2uniprot[Pubmed] 12000953 [Medline] 21996410 Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).(Nature) [2002]

C7QDM6_CATAD
(C7QDM6)

5e-92

340

79%

Product: Peptidase M15D vanX D-ala-D-ala dipeptidase
Gene: Caci_5792
Organism: Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)

1uniprot
Complete genome sequence of Catenulispora acidiphila type strain (ID 139908).(Stand. Genomic Sci.) [2009]

D8HIQ9_AMYMU
(D8HIQ9)

1e-91

339

78%

Product: D-alanyl-D-alanine dipeptidase
Gene: vanA
AMED_8288
Organism: Amycolatopsis mediterranei (strain U-32)

1uniprot[Pubmed] 20567260
Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010]

Q9Z6H2_AMYOR
(Q9Z6H2)

2e-91

338

78%

Product: D-alanyl-D-alanine dipeptidase
Gene: vanX
Organism: Amycolatopsis orientalis
Nocardia orientalis

1uniprot[Pubmed] 9736537 [Medline] 98409705
Glycopeptide antibiotic resistance genes in glycopeptide-producing organisms.(Antimicrob. Agents Chemother.) [1998]

Q6IWG2_9PSEU
(Q6IWG2)

2e-90

335

82%

Product: D-alanyl-D-alanine dipeptidase
Gene: vanX
Organism: Amycolatopsis coloradensis

1uniprot[Pubmed] 15200859
Antimicrobial resistance gene delivery in animal feeds.(Emerg. Infect. Dis.) [2004]

A8L664_FRASN
(A8L664)

2e-89

332

77%

Product: Peptidase M15D vanX D-ala-D-ala dipeptidase
Gene: Franean1_7136
Organism: Frankia sp. (strain EAN1pec)

1uniprot[Pubmed] 17151343
Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography.(Genome Res.) [2007]

Q24R59_DESHY
(Q24R59)

3e-88

328

74%

Product: Putative uncharacterized protein
Gene: DSY3694
Organism: Desulfitobacterium hafniense (strain Y51)

1uniprot[Pubmed] 16513756
Complete genome sequence of the dehalorespiring bacterium Desulfitobacterium hafniense Y51 and comparison with Dehalococcoides ethenogenes 195.(J. Bacteriol.) [2006]

E9L1P4_9ZZZZ
(E9L1P4)

2e-87

325

82%

Product: Putative uncharacterized protein
Gene: CA915-2
Organism: uncultured organism CA915

1uniprot[Pubmed] 20945895
Tailoring enzyme-rich environmental DNA clones: a source of enzymes for generating libraries of unnatural natural products.(J. Am. Chem. Soc.) [2010]

A8RJ09_9FIRM
(A8RJ09)

1e-77

293

67%

Product: D,D dipeptidase
Gene: vanXD
Organism: Ruminococcus gauvreauii

1uniprot[Pubmed] 17724150
vanD and vanG-Like Gene Clusters in a Ruminococcus Species Isolated from Human Bowel Flora.(Antimicrob. Agents Chemother.) [2007]

Q9XCR3_ENTFC
(Q9XCR3)

3e-77

291

67%

Product: D,D dipeptidase
Gene: vanXD
Organism: Enterococcus faecium
Streptococcus faecium

1uniprot[Pubmed] 10368136 [Medline] 99296571
Characterization of the vanD glycopeptide resistance gene cluster from Enterococcus faecium BM4339.(J. Bacteriol.) [1999]

Q9S3S6_ENTFC
(Q9S3S6)

5e-77

291

67%

Product: D,D dipeptidase
Gene: vanXD
Organism: Enterococcus faecium
Streptococcus faecium

1uniprot[Pubmed] 10835012 [Medline] 20295129
Molecular characterization of the vanD gene cluster and a novel insertion element in a vancomycin-resistant enterococcus isolated in Canada.(J. Clin. Microbiol.) [2000]

C3TSE7_ENTFC
(C3TSE7)

1e-76

290

67%

Product: D,D-dipeptidase VanXD
Gene: vanXD
Organism: Enterococcus faecium
Streptococcus faecium

1uniprot[Pubmed] 19258279
New combinations of mutations in VanD-Type vancomycin-resistant Enterococcus faecium, Enterococcus faecalis, and Enterococcus avium strains.(Antimicrob. Agents Chemother.) [2009]

Q6RVF6_ENTFC
(Q6RVF6)

1e-76

290

68%

Product: VanXD5
Gene: vanXD5
Organism: Enterococcus faecium
Streptococcus faecium

1uniprot[Pubmed] 15308604
Enterococcus faecium N03-0072 carries a new VanD-type vancomycin resistance determinant: characterization of the VanD5 operon.(J. Antimicrob. Chemother.) [2004]

Q9LA08_PAEPP
(Q9LA08)

2e-76

289

66%

Product: Putative D,D-dipeptidase
Putative D,D-dipeptidase VanXE
Gene: vanXE
vanXf
Organism: Paenibacillus popilliae
Bacillus popilliae

[pubmed all]
1uniprot[Pubmed] 10681342 [Medline] 20145393 The biopesticide Paenibacillus popilliae has a vancomycin resistance gene cluster homologous to the enterococcal VanA vancomycin resistance gene cluster.(Antimicrob. Agents Chemother.) [2000]
2uniprot[Pubmed] 15980329 Putative VanRS-like two-component regulatory system associated with the inducible glycopeptide resistance cluster of Paenibacillus popilliae.(Antimicrob. Agents Chemother.) [2005]

Q8GF03_ENTFC
(Q8GF03)

6e-75

284

67%

Product: D,D-dipeptidase
Gene: vanXD
Organism: Enterococcus faecium
Streptococcus faecium

1uniprot[Pubmed] 12499162 [Medline] 22386893
VanD-type vancomycin-resistant Enterococcus faecium 10/96A.(Antimicrob. Agents Chemother.) [2003]

Q18PA3_9ENTE
(Q18PA3)

6e-75

284

67%

Product: D, D-dipeptidase
Gene: vanXD
Organism: Enterococcus raffinosus

1uniprot[Pubmed] 17000737
First VanD-Type vancomycin-resistant Enterococcus raffinosus isolate.(Antimicrob. Agents Chemother.) [2006]

Q4U1W4_PANTH
(Q4U1W4)

1e-74

283

66%

Product: VanX
Gene: vanX
Organism: Paenibacillus thiaminolyticus
Bacillus thiaminolyticus

1uniprot[Pubmed] 16189102
Glycopeptide resistance vanA operons in Paenibacillus strains isolated from soil.(Antimicrob. Agents Chemother.) [2005]

VANX_ENTFA
(Q47749)

7e-74

280

64%

Product: D-alanyl-D-alanine dipeptidase
Vancomycin B-type resistance protein vanXB
Gene: vanXB
vanX
EF_2293
Organism: Enterococcus faecalis
Streptococcus faecalis

[pubmed all]
1uniprot[Pubmed] 8631706 [Medline] 96200099 Regulation of VanB-type vancomycin resistance gene expression by the VanS(B)-VanR(B) two-component regulatory system in Enterococcus faecalis V583.(J. Bacteriol.) [1996]
2uniprot[Pubmed] 12663927 [Medline] 22550857 Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus faecalis.(Science) [2003]

Q714P5_ENTFC
(Q714P5)

2e-73

279

64%

Product: D,D-dipeptidase
Gene: vanXB
Organism: Enterococcus faecium
Streptococcus faecium

1uniprot[Pubmed] 14617162 [Medline] 22983133
A six amino acid deletion, partially overlapping the VanSB G2 ATP-binding motif, leads to constitutive glycopeptide resistance in VanB-type Enterococcus faecium.(Mol. Microbiol.) [2003]

B6ZHJ5_ENTFA
(B6ZHJ5)

3e-73

278

64%

Product: VanX protein
Gene: vanX
Organism: Enterococcus faecalis
Streptococcus faecalis

1uniprot[Pubmed] 19029325
Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2201, encoding erythromycin resistance and cytolysin (Hly/Bac).(Antimicrob. Agents Chemother.) [2009]

Q7BWD6_STAAU
(Q7BWD6)

5e-73

278

64%

Product: Vancomycin B-type resistance protein VanX
Gene: vanX
VRA0041
Organism: Staphylococcus aureus

1uniprot[Pubmed] 14645850
Genetic analysis of a high-level vancomycin-resistant isolate of Staphylococcus aureus.(Science) [2003]

Q0WYK6_ENTFA
(Q0WYK6)

5e-73

278

64%

Product: VanX
VanX protein
Vancomycin resistance
Gene: vanX
Organism: Enterococcus faecalis
Streptococcus faecalis

[pubmed all]
1uniprot[Pubmed] 17021204 Pheromone-responsive conjugative vancomycin resistance plasmids in Enterococcus faecalis isolates from humans and chicken feces.(Appl. Environ. Microbiol.) [2006]
2uniprot[Pubmed] 20660665 Dissemination of an Enterococcus Inc18-Like vanA plasmid associated with vancomycin-resistant Staphylococcus aureus.(Antimicrob. Agents Chemother.) [2010]

D4RFM2_ENTFC
(D4RFM2)

5e-73

278

64%

Product: D-alanyl-D-alanine dipeptidase
Gene: EfmE1679_0619
Organism: Enterococcus faecium E1679

1uniprot[Pubmed] 20398277
Pyrosequencing-based comparative genome analysis of the nosocomial pathogen Enterococcus faecium and identification of a large transferable pathogenicity island.(BMC Genomics) [2010]

A1JV21_ENTFC
(A1JV21)

5e-73

278

64%

Product: D,D-dipeptidase VanX
VanX
VanX protein
Gene: vanX
Organism: Enterococcus faecium
Streptococcus faecium

[pubmed all]
1uniprot[Pubmed] 17116680 Comparative DNA analysis of two vanA plasmids from Enterococcus faecium strains isolated from poultry and a poultry farmer in Norway.(Antimicrob. Agents Chemother.) [2007]
2uniprot[Pubmed] 17951264 Molecular characterization of vancomycin-resistant enterococci in Hangzhou, China.(J. Antimicrob. Chemother.) [2007]
3uniprot[Pubmed] 19846656 Heteroresistance to teicoplanin in Enterococcus faecium harboring the vanA gene.(J. Clin. Microbiol.) [2009]
4uniprot[Pubmed] 18511120 The toxin-antitoxin system w-e-z ensures stable maintenance of vanA plasmids in an antibiotic-free environment.(Plasmid) [2008]
5uniprot Tn1546 is part of a larger plasmid-encoded genetic unit horizontally disseminated among clonal Enterococcus faecium lineages.(J. Antimicrob. Chemother.) [2010]

VANX_ENTFC
(Q06241)

5e-73

278

64%

Product: D-alanyl-D-alanine dipeptidase
Vancomycin B-type resistance protein vanX
Gene: vanX
Organism: Enterococcus faecium
Streptococcus faecium

[pubmed all]
1uniprot[Pubmed] 8380148 [Medline] 93106944 Characterization of Tn1546, a Tn3-related transposon conferring glycopeptide resistance by synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147.(J. Bacteriol.) [1993]
2uniprot[Pubmed] 7854121 [Medline] 95157250 Glycopeptide resistance mediated by enterococcal transposon Tn1546 requires production of VanX for hydrolysis of D-alanyl-D-alanine.(Mol. Microbiol.) [1994]
3uniprot[Pubmed] 7873524 [Medline] 95178467 Overexpression, purification, and characterization of VanX, a D-, D-dipeptidase which is essential for vancomycin resistance in Enterococcus faecium BM4147.(Biochemistry) [1995]

Q8KSE2_ENTFC
(Q8KSE2)

7e-73

277

64%

Product: D-Ala-D-Ala dipeptidase
D-ala-D-ala dipeptidase
VanX
Vancomycin B-type resistance protein VanX
Gene: vanX
SAP083A_021
pLG1-0094
Organism: Enterococcus faecium
Streptococcus faecium

[pubmed all]
1uniprot[Pubmed] 20951641 A multiresistance megaplasmid pLG1 bearing a hylEfm genomic island in hospital Enterococcus faecium isolates.(Int. J. Med. Microbiol.) [2011]
2uniprot[Pubmed] 21030436 Txe, an endoribonuclease of the enterococcal Axe-Txe toxin-antitoxin system, cleaves mRNA and inhibits protein synthesis.(Microbiology) [2011]

D4QQA5_ENTFC
(D4QQA5)

7e-73

277

64%

Product: D-Ala-D-Ala dipeptidase VanZ
Gene: EfmE1071_0106
Organism: Enterococcus faecium E1071

Q9EYV8_ENTFC
(Q9EYV8)

1e-72

276

64%

Product: D,D-dipeptidase
VanXB
Gene: vanXB2
vanXB
Organism: Enterococcus faecium
Streptococcus faecium

[pubmed all]
1uniprot[Pubmed] 11376048 [Medline] 21270249 High prevalence of VanB2 vancomycin-resistant Enterococcus faecium in Taiwan.(J. Clin. Microbiol.) [2001]
2uniprot[Pubmed] 19273676 VanB-type Enterococcus faecium clinical isolate successively inducibly resistant to, dependent on, and constitutively resistant to vancomycin.(Antimicrob. Agents Chemother.) [2009]
3uniprot[Pubmed] 15616278 Comparison of three PCR primer sets for identification of vanB gene carriage in feces and correlation with carriage of vancomycin-resistant enterococci: interference by vanB-containing anaerobic bacilli.(Antimicrob. Agents Chemother.) [2005]
4uniprot Molecular characterization of vanB elements in naturally-occurring gut anaerobes.(Antimicrob. Agents Chemother.) [2005]

Q32ZB0_9ACTN
(Q32ZB0)

1e-72

276

64%

Product: VanXB
Gene: vanXB
Organism: Eggerthella lenta

1uniprot[Pubmed] 15616278
Comparison of three PCR primer sets for identification of vanB gene carriage in feces and correlation with carriage of vancomycin-resistant enterococci: interference by vanB-containing anaerobic bacilli.(Antimicrob. Agents Chemother.) [2005]

2uniprot
Molecular characterization of vanB elements in naturally-occurring gut anaerobes.(Antimicrob. Agents Chemother.) [2005]

Q32ZA0_9CLOT
(Q32ZA0)

1e-72

276

64%

Product: VanXB
Gene: vanXB
Organism: Clostridium sp. MLG245

2uniprot
Molecular characterization of vanB elements in naturally-occurring gut anaerobes.(Antimicrob. Agents Chemother.) [2005]

Q9RMA2_BACCI
(Q9RMA2)

1e-72

276

64%

Product: Vanx protein
Gene: vanX
Organism: Bacillus circulans

1uniprot[Pubmed] 9687406 [Medline] 98353334
vanA gene cluster in a vancomycin-resistant clinical isolate of Bacillus circulans.(Antimicrob. Agents Chemother.) [1998]

Q9L8X9_ENTFA
(Q9L8X9)

1e-72

276

64%

Product: VanXB
Gene: vanXB
Organism: Enterococcus faecalis
Streptococcus faecalis

1uniprot[Pubmed] 10846226 [Medline] 20307505
Characterization of transposon Tn1549, conferring VanB-type resistance in Enterococcus spp.(Microbiology) [2000]

Q56R47_9CLOT
(Q56R47)

2e-72

276

64%

Product: VanXB
Gene: vanXB
Organism: Clostridium sp. CCRI-9842

1uniprot[Pubmed] 15731199
Characterization of a Tn5382-like transposon containing the vanB2 gene cluster in a Clostridium strain isolated from human faeces.(J. Antimicrob. Chemother.) [2005]

B8XGS4_ENTFC
(B8XGS4)

1e-71

273

63%

Product: VanXM
Gene: vanXM
Organism: Enterococcus faecium
Streptococcus faecium

1uniprot[Pubmed] 20733041
vanM, a new glycopeptide resistance gene cluster found in Enterococcus faecium.(Antimicrob. Agents Chemother.) [2010]

Q3S3G2_ENTGA
(Q3S3G2)

2e-71

272

65%

Product: VanXD
Gene: vanXD
Organism: Enterococcus gallinarum

1uniprot[Pubmed] 16495270
Enterococcus gallinarum N04-0414 harbors a VanD-type vancomycin resistance operon and does not contain a D-alanine:D-alanine 2 (ddl2) gene.(Antimicrob. Agents Chemother.) [2006]

Q4U1V6_9BACL
(Q4U1V6)

7e-66

254

66%

Product: VanX
Gene: vanX
Organism: Paenibacillus apiarius

1uniprot[Pubmed] 16189102
Glycopeptide resistance vanA operons in Paenibacillus strains isolated from soil.(Antimicrob. Agents Chemother.) [2005]

Q9L8H7_ENTFA
(Q9L8H7)

1e-63

246

65%

Product: VanXb
Gene: vanXb
Organism: Enterococcus faecalis
Streptococcus faecalis

1uniprot[Pubmed] 10846225 [Medline] 20307504
Genetic linkage of the vanB2 gene cluster to Tn5382 in vancomycin-resistant enterococci and characterization of two novel insertion sequences.(Microbiology) [2000]

Q9K3C8_ENTFC
(Q9K3C8)

1e-63

246

65%

Product: VanXb
Gene: vanXb
Organism: Enterococcus faecium
Streptococcus faecium

Q9L8I1_ENTFA
(Q9L8I1)

2e-63

246

64%

Product: VanXb
Gene: vanXb
Organism: Enterococcus faecalis
Streptococcus faecalis

Q9L8H9_ENTGA
(Q9L8H9)

2e-63

246

64%

Product: VanXb
Gene: vanXb
Organism: Enterococcus gallinarum

Q9K2T8_ENTFC
(Q9K2T8)

2e-63

246

64%

Product: VanXb
Gene: vanXb
Organism: Enterococcus faecium
Streptococcus faecium

Q9L8I3_ENTFA
(Q9L8I3)

2e-63

245

64%

Product: VanXb
Gene: vanXb
Organism: Enterococcus faecalis
Streptococcus faecalis

Q8KRA2_9STRE
(Q8KRA2)

3e-63

245

65%

Product: D,D-dipeptidase VanXb
Gene: vanXb
Organism: Streptococcus lutetiensis

1uniprot[Pubmed] 12878522 [Medline] 22760131
Transferable vanB2 Tn5382-containing elements in fecal streptococcal strains from veal calves.(Antimicrob. Agents Chemother.) [2003]

Q8KHV2_STRGY
(Q8KHV2)

4e-63

244

65%

Product: D,D-dipeptidase VanXb
Gene: vanXb
Organism: Streptococcus gallolyticus
Streptococcus bovis biotype I

1uniprot[Pubmed] 12878522 [Medline] 22760131
Transferable vanB2 Tn5382-containing elements in fecal streptococcal strains from veal calves.(Antimicrob. Agents Chemother.) [2003]

Q9L3K2_ENTFC
(Q9L3K2)

6e-52

207

63%

Product: Dipeptidase
Gene: vanXB2
Organism: Enterococcus faecium
Streptococcus faecium

1uniprot[Pubmed] 10952577 [Medline] 20408556
Identification and characterization of vanB2 glycopeptide resistance elements in enterococci isolated in Scotland.(Antimicrob. Agents Chemother.) [2000]

A0LZ24_GRAFK
(A0LZ24)

4e-49

198

48%

Product: D-alanyl-D-alanine dipeptidase
Gene: vanX
GFO_0641
Organism: Gramella forsetii (strain KT0803)

1uniprot[Pubmed] 17107561
Whole genome analysis of the marine Bacteroidetes'Gramella forsetii' reveals adaptations to degradation of polymeric organic matter.(Environ. Microbiol.) [2006]

O87665_ENTFC
(O87665)

2e-47

192

65%

Product: Vancomycin resistance protein
Gene: vanX
Organism: Enterococcus faecium
Streptococcus faecium

1uniprot[Pubmed] 9736587 [Medline] 98409755
Differences in the occurrence of two base pair variants of Tn1546 from vancomycin-resistant enterococci from humans, pigs, and poultry.(Antimicrob. Agents Chemother.) [1998]

D5BL81_ZUNPS
(D5BL81)

2e-47

192

47%

Product: D-alanyl-D-alanine dipeptidase
Gene: ZPR_3697
Organism: Zunongwangia profunda (strain DSM 18752 / CCTCC AB 206139 / SM-A87)

1uniprot[Pubmed] 20398413
The complete genome of Zunongwangia profunda SM-A87 reveals its adaptation to the deep-sea environment and ecological role in sedimentary organic nitrogen degradation.(BMC Genomics) [2010]

C5AUE7_METEA
(C5AUE7)

8e-44

181

47%

Product: D-alanyl-D-alanine dipeptidase
Gene: MexAM1_META1p0607
Organism: Methylobacterium extorquens (strain ATCC 14718 / DSM 1338 / AM1)

1uniprot[Pubmed] 19440302
Methylobacterium genome sequences: a reference blueprint to investigate microbial metabolism of C1 compounds from natural and industrial sources.(PLoS ONE) [2009]

A2U1F8_9FLAO
(A2U1F8)

2e-43

179

41%

Product: D-ala-D-ala dipeptidase
Gene: MED152_03330
Organism: Polaribacter sp. MED152

[pubmed all]
1uniprot[Pubmed] 17215843 Light stimulates growth of proteorhodopsin-containing marine Flavobacteria.(Nature) [2007]
2uniprot[Pubmed] 18552178 Genome analysis of the proteorhodopsin-containing marine bacterium Polaribacter sp. MED152 (Flavobacteria).(Proc. Natl. Acad. Sci. U.S.A.) [2008]

100

C7CD73_METED
(C7CD73)

2e-41

173

45%

Product: D-alanyl-D-alanine dipeptidase
Gene: METDI0978
Organism: Methylobacterium extorquens (strain DSM 5838 / DM4)
Methylobacterium dichloromethanicum (strain DM4)

1uniprot[Pubmed] 19440302
Methylobacterium genome sequences: a reference blueprint to investigate microbial metabolism of C1 compounds from natural and industrial sources.(PLoS ONE) [2009]