BLAST table : A4793_00310

DB	UniProtKB

	accession	Evalue	Score	Ident.	link	product	gene	organism	ec
1	O33805_STRTO (O33805)	0.0	668	100%	UniProt GenBank	D-lactate dehydrogenase	DLDHStoy	Streptomyces toyocaensis
2	Q6ZZK3_ACTTI (Q6ZZK3)	1e-133	480	72%	UniProt GenBank	D-lactate dehydrogenase		Actinoplanes teichomyceticus
3	Q70B06_ACTTI (Q70B06)	1e-133	479	72%	UniProt GenBank	VanH protein	tcp2	Actinoplanes teichomyceticus
4	Q9Z6H3_AMYOR (Q9Z6H3)	1e-132	477	72%	UniProt GenBank	D-lactate dehydrogenase	vanH	Amycolatopsis orientalis Nocardia orientalis
5	C7QDM8_CATAD (C7QDM8)	1e-132	474	73%	UniProt GenBank	D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding	Caci_5794	Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)
6	D2PMX4_KRIFD (D2PMX4)	1e-130	471	71%	UniProt GenBank	D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein	Kfla_3619	Kribbella flavida (strain DSM 17836 / JCM 10339 / NBRC 14399)
7	D3PUW4_STANL (D3PUW4)	1e-130	470	72%	UniProt GenBank	D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein	Snas_5355	Stackebrandtia nassauensis (strain DSM 44728 / NRRL B-16338 / NBRC 102104 / LLR-40K-21)
8	E9L1F0_9ZZZZ (E9L1F0)	1e-130	469	72%	UniProt GenBank	Putative uncharacterized protein	CA37-6	uncultured organism CA37
9	A8L666_FRASN (A8L666)	1e-130	468	72%	UniProt GenBank	D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding	Franean1_7138	Frankia sp. (strain EAN1pec)
10	F8STW7_AMYOR (F8STW7)	1e-130	467	72%	UniProt GenBank	D-lactate dehydrogenase	vanH	Amycolatopsis orientalis Nocardia orientalis
11	B5I694_9ACTO (B5I694)	1e-128	464	72%	UniProt GenBank	D-isomer specific 2-hydroxyacid dehydrogenase	SSEG_10120	Streptomyces sviceus ATCC 29083
12	E9L1K0_9ZZZZ (E9L1K0)	1e-127	460	74%	UniProt GenBank	Putative uncharacterized protein	CA878-1	uncultured organism CA878
13	D8HIR1_AMYMU (D8HIR1)	1e-127	460	72%	UniProt GenBank	D-lactate dehydrogenase	vanH AMED_8290	Amycolatopsis mediterranei (strain U-32)
14	Q20FL8_9PSEU (Q20FL8)	1e-127	459	69%	UniProt GenBank	VanH	vanH	Amycolatopsis coloradensis
15	D6EPN4_STRLI (D6EPN4)	1e-126	457	71%	UniProt GenBank	D-lactate dehydrogenase	SSPG_04066	Streptomyces lividans TK24
16	Q9XAK8_STRCO (Q9XAK8)	1e-126	456	71%	UniProt GenBank	Putative D-lactate dehydrogenase	SCO3594	Streptomyces coelicolor
17	D6TBG8_9CHLR (D6TBG8)	1e-124	451	67%	UniProt GenBank	D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding	Krac_9314	Ktedonobacter racemifer DSM 44963
18	D3EYW7_CONWI (D3EYW7)	1e-120	437	68%	UniProt GenBank	D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein	Cwoe_1413	Conexibacter woesei (strain DSM 14684 / JCM 11494 / NBRC 100937 / ID131577)
19	E9L1P9_9ZZZZ (E9L1P9)	1e-118	429	68%	UniProt GenBank	Putative uncharacterized protein	CA915-7	uncultured organism CA915
20	D9VBI3_9ACTO (D9VBI3)	1e-118	428	67%	UniProt GenBank	VanH protein	SSMG_01116	Streptomyces sp. AA4
21	D5US98_TSUPD (D5US98)	1e-118	428	66%	UniProt GenBank	D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein	Tpau_0524	Tsukamurella paurometabola (strain ATCC 8368 / DSM 20162 / JCM 10117 / NBRC 16120 / NCTC 13040) Corynebacterium paurometabolum
22	E9UYS6_9ACTO (E9UYS6)	1e-115	420	65%	UniProt GenBank	D-lactate dehydrogenase	NBCG_03947	Nocardioidaceae bacterium Broad-1
23	Q4U1V8_9BACL (Q4U1V8)	1e-110	401	58%	UniProt GenBank	VanH	vanH	Paenibacillus apiarius
24	Q4U1W6_PANTH (Q4U1W6)	1e-106	390	59%	UniProt GenBank	VanH	vanH	Paenibacillus thiaminolyticus Bacillus thiaminolyticus
25	Q9LA09_PAEPP (Q9LA09)	1e-105	387	57%	UniProt GenBank	Putative lactate dehydrogenase VanHE	vanHE	Paenibacillus popilliae Bacillus popilliae
26	Q9RMA5_BACCI (Q9RMA5)	1e-104	384	58%	UniProt GenBank	Vanh protein	vanH	Bacillus circulans
27	Q7BWD8_STAAU (Q7BWD8)	1e-103	380	57%	UniProt GenBank	Vancomycin resistance protein VanH	vanH VRA0039	Staphylococcus aureus
28	Q7B609_ENTFC (Q7B609)	1e-103	380	57%	UniProt GenBank	Dehydrogenase Dehydrogenase VanH Pyruvate dehydrogenase VanH VanH protein Vancomycin resistance protein VanH / D-lactate dehydrogenase	vanH SAP083A_023	Enterococcus faecium Streptococcus faecium	1.1.1.28 niceE keggE
29	Q0WYK8_ENTFA (Q0WYK8)	1e-103	380	57%	UniProt GenBank	VanH VanH protein Vanomycin resistance	vanH	Enterococcus faecalis Streptococcus faecalis
30	E4JIF2_ENTFC (E4JIF2)	1e-103	380	57%	UniProt GenBank	4-phosphoerythronate dehydrogenase	HMPREF9524_01954	Enterococcus faecium TX0133a01
31	E4ISK2_ENTFC (E4ISK2)	1e-103	380	57%	UniProt GenBank	4-phosphoerythronate dehydrogenase	HMPREF9522_01952	Enterococcus faecium TX0082
32	E4IL21_ENTFC (E4IL21)	1e-103	380	57%	UniProt GenBank	4-phosphoerythronate dehydrogenase	HMPREF9527_02785	Enterococcus faecium TX0133C
33	E2YNW1_ENTFA (E2YNW1)	1e-103	380	57%	UniProt GenBank	4-phosphoerythronate dehydrogenase	HMPREF9492_02154	Enterococcus faecalis DAPTO 512
34	E2YB53_ENTFA (E2YB53)	1e-103	380	57%	UniProt GenBank	4-phosphoerythronate dehydrogenase	HMPREF9493_00791	Enterococcus faecalis DAPTO 516
35	D4RFM0_ENTFC (D4RFM0)	1e-103	380	57%	UniProt GenBank	D-specific alpha-keto acid dehydrogenase, vancomycin resistance protein VanH	EfmE1679_0617	Enterococcus faecium E1679
36	D4QQA7_ENTFC (D4QQA7)	1e-103	380	57%	UniProt GenBank	Vancomycin resistance protein VanH	EfmE1071_0108	Enterococcus faecium E1071
37	D4EY58_ENTFA (D4EY58)	1e-103	380	57%	UniProt GenBank	D-specific alpha-keto acid dehydrogenase	HMPREF9377_02491	Enterococcus faecalis R712
38	D4EIM6_ENTFA (D4EIM6)	1e-103	380	57%	UniProt GenBank	D-specific alpha-keto acid dehydrogenase	HMPREF9376_00486	Enterococcus faecalis S613
39	C9CGP1_ENTFC (C9CGP1)	1e-103	380	57%	UniProt GenBank	D-isomer specific 2-hydroxyacid dehydrogenase	EFPG_05423	Enterococcus faecium 1,230,933
40	C9C612_ENTFC (C9C612)	1e-103	380	57%	UniProt GenBank	Vancomycin resistance protein VanH	EFTG_02042	Enterococcus faecium 1,231,410
41	C9BR19_ENTFC (C9BR19)	1e-103	380	57%	UniProt GenBank	Vancomycin resistance protein VanH	EFQG_02529	Enterococcus faecium 1,231,502
42	C7VPN9_ENTFA (C7VPN9)	1e-103	380	57%	UniProt GenBank	Vancomycin resistance protein VanH	EFHG_05030	Enterococcus faecalis HIP11704
43	VANH_ENTFC (Q05709)	1e-103	380	57%	UniProt GenBank	D-specific alpha-keto acid dehydrogenase Vancomycin resistance protein vanH	vanH	Enterococcus faecium Streptococcus faecium	1.1.1.- niceE keggE
44	E3USG9_ENTFC (E3USG9)	1e-103	380	57%	UniProt GenBank	Vancomycin resistance protein VanH	pLG1-0096	Enterococcus faecium Streptococcus faecium
45	Q5BP14_PANTH (Q5BP14)	1e-103	380	58%	UniProt GenBank	D-specific dehydrogenase	vanH	Paenibacillus thiaminolyticus Bacillus thiaminolyticus
46	B8XGS2_ENTFC (B8XGS2)	1e-101	374	54%	UniProt GenBank	VanHM	vanHM	Enterococcus faecium Streptococcus faecium
47	C7WYV4_ENTFA (C7WYV4)	9e-96	355	55%	UniProt GenBank	VanHB	EFGG_02747	Enterococcus faecalis Merz96
48	VANH_ENTFA (Q47748)	9e-96	355	55%	UniProt GenBank	D-specific alpha-keto acid dehydrogenase Vancomycin B-type resistance protein vanHB	vanHB EF_2295	Enterococcus faecalis Streptococcus faecalis	1.1.1.- niceE keggE
49	Q6IWG4_9PSEU (Q6IWG4)	3e-95	353	72%	UniProt GenBank	D-lactate dehydrogenase	vanH	Amycolatopsis coloradensis
50	C4NZP5_ENTFC (C4NZP5)	4e-95	352	55%	UniProt GenBank	Dehydrogenase	vanHB	Enterococcus faecium Streptococcus faecium
51	Q9XBX3_ENTFC (Q9XBX3)	1e-94	351	54%	UniProt GenBank	D-lactate dehydrogenase VanHD D-specific alpha-keto acid dehydrogenase	vanHD	Enterococcus faecium Streptococcus faecium
52	Q9EYV9_ENTFC (Q9EYV9)	1e-94	350	55%	UniProt GenBank	D-2-hydroxyacid dehydrogenase	vanHB2	Enterococcus faecium Streptococcus faecium
53	Q56R49_9CLOT (Q56R49)	1e-94	350	55%	UniProt GenBank	VanHB	vanHB	Clostridium sp. CCRI-9842
54	C0X1V1_ENTFA (C0X1V1)	1e-94	350	55%	UniProt GenBank	Possible D-lactate dehydrogenase	ldhD HMPREF0348_0486	Enterococcus faecalis TX0104	1.1.1.28 niceE keggE
55	Q9S3S8_ENTFC (Q9S3S8)	3e-94	350	54%	UniProt GenBank	D-lactate dehydrogenase	vanHD	Enterococcus faecium Streptococcus faecium
56	A8RJ03_9FIRM (A8RJ03)	3e-94	350	54%	UniProt GenBank	D-lactate dehydrogenase	vanHD	Ruminococcus gauvreauii
57	Q32ZB1_9ACTN (Q32ZB1)	6e-94	348	54%	UniProt GenBank	VanHB	vanHB	Eggerthella lenta
58	Q32ZA1_9CLOT (Q32ZA1)	6e-94	348	54%	UniProt GenBank	VanHB	vanHB	Clostridium sp. MLG245
59	Q32Z91_ENTFC (Q32Z91)	6e-94	348	54%	UniProt GenBank	VanHB	vanHB	Enterococcus faecium Streptococcus faecium
60	D0APH6_ENTFC (D0APH6)	6e-94	348	54%	UniProt GenBank	VanHB	EFXG_01481	Enterococcus faecium C68
61	B6ZHJ3_ENTFA (B6ZHJ3)	6e-94	348	54%	UniProt GenBank	VanH protein	vanH	Enterococcus faecalis Streptococcus faecalis
62	Q3S3G4_ENTGA (Q3S3G4)	8e-94	348	53%	UniProt GenBank	VanHD	vanHD	Enterococcus gallinarum
63	Q6RVF8_ENTFC (Q6RVF8)	2e-93	347	53%	UniProt GenBank	VanHD5	vanHD5	Enterococcus faecium Streptococcus faecium
64	Q9XCR5_ENTFC (Q9XCR5)	1e-92	344	54%	UniProt GenBank	D-lactate dehydrogenase	vanHD	Enterococcus faecium Streptococcus faecium
65	Q18PA5_9ENTE (Q18PA5)	3e-92	342	53%	UniProt GenBank	D-lactate dehydrogenase	vanHD	Enterococcus raffinosus
66	Q9L8Y1_ENTFA (Q9L8Y1)	6e-92	342	54%	UniProt GenBank	VanHB	vanHB	Enterococcus faecalis Streptococcus faecalis
67	Q9EZR0_ENTFC (Q9EZR0)	3e-91	340	53%	UniProt GenBank	Alpha keto acid dehydrogenase D-lactate dehydrogenase	vanHD4 vanHD	Enterococcus faecium Streptococcus faecium
68	D8GQW1_CLOLD (D8GQW1)	3e-79	300	43%	UniProt GenBank	Predicted alpha-keto acid dehydrogenase	CLJU_c32190	Clostridium ljungdahlii (strain ATCC 55383 / DSM 13528 / PETC)	1.1.1.- niceE keggE
69	F8TEP1_9CLOT (F8TEP1)	7e-79	298	43%	UniProt GenBank	Lactate dehydrogenase	ldhA	Clostridium ragsdalei
70	F8TEP0_9CLOT (F8TEP0)	1e-78	298	42%	UniProt GenBank	Lactate dehydrogenase	ldhA	Clostridium autoethanogenum
71	A6LTK2_CLOB8 (A6LTK2)	3e-77	293	43%	UniProt GenBank	D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding	Cbei_1506	Clostridium beijerinckii (strain ATCC 51743 / NCIMB 8052) Clostridium acetobutylicum
72	C4IG43_CLOBU (C4IG43)	5e-77	292	43%	UniProt GenBank	D-lactate dehydrogenase	CLP_1995	Clostridium butyricum E4 str. BoNT E BL5262
73	B1QS98_CLOBU (B1QS98)	5e-77	292	43%	UniProt GenBank	D-specific alpha-keto acid dehydrogenase	CBY_1054	Clostridium butyricum 5521	1.1.1.- niceE keggE
74	B9E3C5_CLOK1 (B9E3C5)	1e-76	291	43%	UniProt GenBank	Putative uncharacterized protein	CKR_1949	Clostridium kluyveri (strain NBRC 12016)
75	A5MZD1_CLOK5 (A5MZD1)	1e-76	291	43%	UniProt GenBank	Predicted alpha-keto acid dehydrogenase	CKL_2215	Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680)	1.1.1.- niceE keggE
76	Q97IU7_CLOAB (Q97IU7)	8e-76	288	42%	UniProt GenBank	Lactate dehydrogenase	CA_C1543	Clostridium acetobutylicum
77	F0K4H7_CLOAE (F0K4H7)	8e-76	288	42%	UniProt GenBank	Lactate dehydrogenase	CEA_G1558	Clostridium acetobutylicum (strain EA 2018)
78	F7ZN42_CLOAB (F7ZN42)	8e-76	288	42%	UniProt GenBank	Lactate dehydrogenase	vanH SMB_G1568	Clostridium acetobutylicum DSM 1731
79	D6HLX1_9FIRM (D6HLX1)	3e-72	276	43%	UniProt GenBank	D-lactate dehydrogenase	HMPREF0863_00792	Erysipelotrichaceae bacterium 5_2_54FAA
80	F7JZ09_9FIRM (F7JZ09)	5e-72	275	43%	UniProt GenBank	Putative uncharacterized protein	HMPREF0991_02380	Lachnospiraceae bacterium 2_1_58FAA
81	A7B7R9_RUMGN (A7B7R9)	5e-72	275	43%	UniProt GenBank	Putative uncharacterized protein	RUMGNA_03635	Ruminococcus gnavus ATCC 29149
82	F7KJK1_9FIRM (F7KJK1)	6e-72	275	45%	UniProt GenBank	Putative uncharacterized protein	HMPREF0994_06035	Lachnospiraceae bacterium 3_1_57FAA_CT1
83	F0YYI4_9CLOT (F0YYI4)	2e-71	273	44%	UniProt GenBank	D-specific alpha-keto acid dehydrogenase (Vancomycinresistance protein VanH)	HMPREF0240_01903	Clostridium sp. D5
84	B5CR62_9FIRM (B5CR62)	3e-71	273	44%	UniProt GenBank	Putative uncharacterized protein	RUMLAC_01962	Ruminococcus lactaris ATCC 29176
85	B1C249_9FIRM (B1C249)	1e-70	271	44%	UniProt GenBank	Putative uncharacterized protein	CLOSPI_01306	Clostridium spiroforme DSM 1552
86	E4LZC8_9CLOT (E4LZC8)	1e-69	268	42%	UniProt GenBank	4-phosphoerythronate dehydrogenase	pdxB HMPREF9406_1554	Clostridium sp. HGF2	1.1.1.290 niceE keggE
87	E2SJI7_9FIRM (E2SJI7)	4e-69	266	41%	UniProt GenBank	D-lactate dehydrogenase	HMPREF0983_01194	Erysipelotrichaceae bacterium 3_1_53
88	Q893I3_CLOTE (Q893I3)	2e-68	264	41%	UniProt GenBank	D-lactate dehydrogenase	CTC_01840	Clostridium tetani	1.1.1.28 niceE keggE
89	F7JGI7_9FIRM (F7JGI7)	6e-67	259	42%	UniProt GenBank	Putative uncharacterized protein	HMPREF0990_02196	Lachnospiraceae bacterium 1_1_57FAA
90	F3AYQ9_9FIRM (F3AYQ9)	6e-67	259	42%	UniProt GenBank	Putative uncharacterized protein	HMPREF1025_02863	Lachnospiraceae bacterium 3_1_46FAA
91	E5XJA6_9FIRM (E5XJA6)	6e-67	259	42%	UniProt GenBank	D-isomer specific 2-hydroxyacid dehydrogenase	HMPREF1026_02211	Lachnospiraceae bacterium 8_1_57FAA
92	A5KPY1_9FIRM (A5KPY1)	7e-67	258	42%	UniProt GenBank	Putative uncharacterized protein	RUMTOR_02317	Ruminococcus torques ATCC 27756
93	C1P7N1_BACCO (C1P7N1)	1e-65	254	42%	UniProt GenBank	D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding	BcoaDRAFT_3862	Bacillus coagulans 36D1
94	C3RQ64_9FIRM (C3RQ64)	2e-65	254	40%	UniProt GenBank	D-lactate dehydrogenase	MBAG_02883	Coprobacillus sp. D7
95	B0N5J3_9FIRM (B0N5J3)	2e-65	254	40%	UniProt GenBank	Putative uncharacterized protein	CLORAM_01907	Clostridium ramosum DSM 1402
96	B0N595_9FIRM (B0N595)	2e-65	254	42%	UniProt GenBank	Putative uncharacterized protein	CLORAM_01807	Clostridium ramosum DSM 1402
97	B7AVZ1_9BACE (B7AVZ1)	2e-65	254	42%	UniProt GenBank	Putative uncharacterized protein	BACPEC_02891	Bacteroides pectinophilus ATCC 43243
98	C3RKL6_9FIRM (C3RKL6)	2e-64	250	42%	UniProt GenBank	Lactate dehydrogenase	MBAG_01285	Coprobacillus sp. D7
99	E7EIH7_BACCO (E7EIH7)	3e-64	250	42%	UniProt GenBank	D-lactate dehydrogenase	ldhA	Bacillus coagulans
100	E5BSX0_9FUSO (E5BSX0)	1e-63	248	36%	UniProt GenBank	D-lactate dehydrogenase	FUAG_01157	Fusobacterium ulcerans ATCC 49185

accession

alignment

Evalue

Score

Ident.

link

information

pubmed

O33805_STRTO
(O33805)

0.0

668

100%

Product: D-lactate dehydrogenase
Gene: DLDHStoy
Organism: Streptomyces toyocaensis

[pubmed all]
1uniprot[Pubmed] 9177243 [Medline] 97322398 D-Ala-D-Ala ligases from glycopeptide antibiotic-producing organisms are highly homologous to the enterococcal vancomycin-resistance ligases VanA and VanB.(Proc. Natl. Acad. Sci. U.S.A.) [1997]
2uniprot[Pubmed] 12060705 [Medline] 22080153 Assembling the glycopeptide antibiotic scaffold: the biosynthesis of A47934 from Streptomyces toyocaensis NRRL15009.(Proc. Natl. Acad. Sci. U.S.A.) [2002]

Q6ZZK3_ACTTI
(Q6ZZK3)

1e-133

480

72%

Product: D-lactate dehydrogenase
Gene
Organism: Actinoplanes teichomyceticus

1uniprot[Pubmed] 15113000
Biosynthetic gene cluster of the glycopeptide antibiotic teicoplanin: characterization of two glycosyltransferases and the key acyltransferase.(Chem. Biol.) [2004]

Q70B06_ACTTI
(Q70B06)

1e-133

479

72%

Product: VanH protein
Gene: tcp2
Organism: Actinoplanes teichomyceticus

1uniprot[Pubmed] 14702401
Organization of the teicoplanin gene cluster in Actinoplanes teichomyceticus.(Microbiology) [2004]

Q9Z6H3_AMYOR
(Q9Z6H3)

1e-132

477

72%

Product: D-lactate dehydrogenase
Gene: vanH
Organism: Amycolatopsis orientalis
Nocardia orientalis

1uniprot[Pubmed] 9736537 [Medline] 98409705
Glycopeptide antibiotic resistance genes in glycopeptide-producing organisms.(Antimicrob. Agents Chemother.) [1998]

C7QDM8_CATAD
(C7QDM8)

1e-132

474

73%

Product: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
Gene: Caci_5794
Organism: Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)

1uniprot
Complete genome sequence of Catenulispora acidiphila type strain (ID 139908).(Stand. Genomic Sci.) [2009]

D3PUW4_STANL
(D3PUW4)

1e-130

470

72%

Product: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein
Gene: Snas_5355
Organism: Stackebrandtia nassauensis (strain DSM 44728 / NRRL B-16338 / NBRC 102104 / LLR-40K-21)

1uniprot
Complete genome sequence of Stackebrandtia nassauensis type strain (LLR-40K-21T).(Stand. Genomic Sci.) [2009]

E9L1F0_9ZZZZ
(E9L1F0)

1e-130

469

72%

Product: Putative uncharacterized protein
Gene: CA37-6
Organism: uncultured organism CA37

1uniprot[Pubmed] 20945895
Tailoring enzyme-rich environmental DNA clones: a source of enzymes for generating libraries of unnatural natural products.(J. Am. Chem. Soc.) [2010]

A8L666_FRASN
(A8L666)

1e-130

468

72%

Product: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
Gene: Franean1_7138
Organism: Frankia sp. (strain EAN1pec)

1uniprot[Pubmed] 17151343
Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography.(Genome Res.) [2007]

E9L1K0_9ZZZZ
(E9L1K0)

1e-127

460

74%

Product: Putative uncharacterized protein
Gene: CA878-1
Organism: uncultured organism CA878

1uniprot[Pubmed] 20945895
Tailoring enzyme-rich environmental DNA clones: a source of enzymes for generating libraries of unnatural natural products.(J. Am. Chem. Soc.) [2010]

D8HIR1_AMYMU
(D8HIR1)

1e-127

460

72%

Product: D-lactate dehydrogenase
Gene: vanH
AMED_8290
Organism: Amycolatopsis mediterranei (strain U-32)

1uniprot[Pubmed] 20567260
Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010]

Q20FL8_9PSEU
(Q20FL8)

1e-127

459

69%

Product: VanH
Gene: vanH
Organism: Amycolatopsis coloradensis

1uniprot[Pubmed] 16476725
Heterologous expression of glycopeptide resistance vanHAX gene clusters from soil bacteria in Enterococcus faecalis.(J. Antimicrob. Chemother.) [2006]

Q9XAK8_STRCO
(Q9XAK8)

1e-126

456

71%

Product: Putative D-lactate dehydrogenase
Gene: SCO3594
Organism: Streptomyces coelicolor

1uniprot[Pubmed] 12000953 [Medline] 21996410
Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).(Nature) [2002]

E9L1P9_9ZZZZ
(E9L1P9)

1e-118

429

68%

Product: Putative uncharacterized protein
Gene: CA915-7
Organism: uncultured organism CA915

1uniprot[Pubmed] 20945895
Tailoring enzyme-rich environmental DNA clones: a source of enzymes for generating libraries of unnatural natural products.(J. Am. Chem. Soc.) [2010]

Q4U1V8_9BACL
(Q4U1V8)

1e-110

401

58%

Product: VanH
Gene: vanH
Organism: Paenibacillus apiarius

1uniprot[Pubmed] 16189102
Glycopeptide resistance vanA operons in Paenibacillus strains isolated from soil.(Antimicrob. Agents Chemother.) [2005]

Q4U1W6_PANTH
(Q4U1W6)

1e-106

390

59%

Product: VanH
Gene: vanH
Organism: Paenibacillus thiaminolyticus
Bacillus thiaminolyticus

1uniprot[Pubmed] 16189102
Glycopeptide resistance vanA operons in Paenibacillus strains isolated from soil.(Antimicrob. Agents Chemother.) [2005]

Q9LA09_PAEPP
(Q9LA09)

1e-105

387

57%

Product: Putative lactate dehydrogenase VanHE
Gene: vanHE
Organism: Paenibacillus popilliae
Bacillus popilliae

[pubmed all]
1uniprot[Pubmed] 10681342 [Medline] 20145393 The biopesticide Paenibacillus popilliae has a vancomycin resistance gene cluster homologous to the enterococcal VanA vancomycin resistance gene cluster.(Antimicrob. Agents Chemother.) [2000]
2uniprot[Pubmed] 15980329 Putative VanRS-like two-component regulatory system associated with the inducible glycopeptide resistance cluster of Paenibacillus popilliae.(Antimicrob. Agents Chemother.) [2005]

Q9RMA5_BACCI
(Q9RMA5)

1e-104

384

58%

Product: Vanh protein
Gene: vanH
Organism: Bacillus circulans

1uniprot[Pubmed] 9687406 [Medline] 98353334
vanA gene cluster in a vancomycin-resistant clinical isolate of Bacillus circulans.(Antimicrob. Agents Chemother.) [1998]

Q7BWD8_STAAU
(Q7BWD8)

1e-103

380

57%

Product: Vancomycin resistance protein VanH
Gene: vanH
VRA0039
Organism: Staphylococcus aureus

1uniprot[Pubmed] 14645850
Genetic analysis of a high-level vancomycin-resistant isolate of Staphylococcus aureus.(Science) [2003]

Q7B609_ENTFC
(Q7B609)

1e-103

380

57%

Product: Dehydrogenase
Dehydrogenase VanH
Pyruvate dehydrogenase
VanH
VanH protein
Vancomycin resistance protein VanH / D-lactate dehydrogenase
Gene: vanH
SAP083A_023
Organism: Enterococcus faecium
Streptococcus faecium

[pubmed all]
1uniprot[Pubmed] 17116680 Comparative DNA analysis of two vanA plasmids from Enterococcus faecium strains isolated from poultry and a poultry farmer in Norway.(Antimicrob. Agents Chemother.) [2007]
2uniprot[Pubmed] 18462926 Genetic diversity of Tn1546-like elements in clinical isolates of vancomycin-resistant enterococci.(Int. J. Antimicrob. Agents) [2008]
3uniprot[Pubmed] 17951264 Molecular characterization of vancomycin-resistant enterococci in Hangzhou, China.(J. Antimicrob. Chemother.) [2007]
4uniprot[Pubmed] 19846656 Heteroresistance to teicoplanin in Enterococcus faecium harboring the vanA gene.(J. Clin. Microbiol.) [2009]
5uniprot[Pubmed] 18511120 The toxin-antitoxin system w-e-z ensures stable maintenance of vanA plasmids in an antibiotic-free environment.(Plasmid) [2008]
6uniprot Tn1546 is part of a larger plasmid-encoded genetic unit horizontally disseminated among clonal Enterococcus faecium lineages.(J. Antimicrob. Chemother.) [2010]
7uniprot[Pubmed] 21030436 Txe, an endoribonuclease of the enterococcal Axe-Txe toxin-antitoxin system, cleaves mRNA and inhibits protein synthesis.(Microbiology) [2011]

Q0WYK8_ENTFA
(Q0WYK8)

1e-103

380

57%

Product: VanH
VanH protein
Vanomycin resistance
Gene: vanH
Organism: Enterococcus faecalis
Streptococcus faecalis

[pubmed all]
1uniprot[Pubmed] 17021204 Pheromone-responsive conjugative vancomycin resistance plasmids in Enterococcus faecalis isolates from humans and chicken feces.(Appl. Environ. Microbiol.) [2006]
2uniprot[Pubmed] 20660665 Dissemination of an Enterococcus Inc18-Like vanA plasmid associated with vancomycin-resistant Staphylococcus aureus.(Antimicrob. Agents Chemother.) [2010]

D4RFM0_ENTFC
(D4RFM0)

1e-103

380

57%

Product: D-specific alpha-keto acid dehydrogenase, vancomycin resistance protein VanH
Gene: EfmE1679_0617
Organism: Enterococcus faecium E1679

1uniprot[Pubmed] 20398277
Pyrosequencing-based comparative genome analysis of the nosocomial pathogen Enterococcus faecium and identification of a large transferable pathogenicity island.(BMC Genomics) [2010]

D4QQA7_ENTFC
(D4QQA7)

1e-103

380

57%

Product: Vancomycin resistance protein VanH
Gene: EfmE1071_0108
Organism: Enterococcus faecium E1071

VANH_ENTFC
(Q05709)

1e-103

380

57%

Product: D-specific alpha-keto acid dehydrogenase
Vancomycin resistance protein vanH
Gene: vanH
Organism: Enterococcus faecium
Streptococcus faecium

[pubmed all]
1uniprot[Pubmed] 1908809 [Medline] 91348521 Structural relationship between the vancomycin resistance protein VanH and 2-hydroxycarboxylic acid dehydrogenases.(Gene) [1991]
2uniprot[Pubmed] 8380148 [Medline] 93106944 Characterization of Tn1546, a Tn3-related transposon conferring glycopeptide resistance by synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147.(J. Bacteriol.) [1993]
3uniprot[Pubmed] 1931965 [Medline] 92031480 Molecular basis for vancomycin resistance in Enterococcus faecium BM4147: biosynthesis of a depsipeptide peptidoglycan precursor by vancomycin resistance proteins VanH and VanA.(Biochemistry) [1991]
4uniprot[Pubmed] 1522072 [Medline] 92394903 The cytoplasmic peptidoglycan precursor of vancomycin-resistant Enterococcus faecalis terminates in lactate.(J. Bacteriol.) [1992]
5uniprot[Pubmed] 1556077 [Medline] 92210502 The VanS-VanR two-component regulatory system controls synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147.(J. Bacteriol.) [1992]

E3USG9_ENTFC
(E3USG9)

1e-103

380

57%

Product: Vancomycin resistance protein VanH
Gene: pLG1-0096
Organism: Enterococcus faecium
Streptococcus faecium

1uniprot[Pubmed] 20951641
A multiresistance megaplasmid pLG1 bearing a hylEfm genomic island in hospital Enterococcus faecium isolates.(Int. J. Med. Microbiol.) [2011]

B8XGS2_ENTFC
(B8XGS2)

1e-101

374

54%

Product: VanHM
Gene: vanHM
Organism: Enterococcus faecium
Streptococcus faecium

1uniprot[Pubmed] 20733041
vanM, a new glycopeptide resistance gene cluster found in Enterococcus faecium.(Antimicrob. Agents Chemother.) [2010]

VANH_ENTFA
(Q47748)

9e-96

355

55%

Product: D-specific alpha-keto acid dehydrogenase
Vancomycin B-type resistance protein vanHB
Gene: vanHB
EF_2295
Organism: Enterococcus faecalis
Streptococcus faecalis

[pubmed all]
1uniprot[Pubmed] 8631706 [Medline] 96200099 Regulation of VanB-type vancomycin resistance gene expression by the VanS(B)-VanR(B) two-component regulatory system in Enterococcus faecalis V583.(J. Bacteriol.) [1996]
2uniprot[Pubmed] 12663927 [Medline] 22550857 Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus faecalis.(Science) [2003]

Q6IWG4_9PSEU
(Q6IWG4)

3e-95

353

72%

Product: D-lactate dehydrogenase
Gene: vanH
Organism: Amycolatopsis coloradensis

1uniprot[Pubmed] 15200859
Antimicrobial resistance gene delivery in animal feeds.(Emerg. Infect. Dis.) [2004]

C4NZP5_ENTFC
(C4NZP5)

4e-95

352

55%

Product: Dehydrogenase
Gene: vanHB
Organism: Enterococcus faecium
Streptococcus faecium

1uniprot[Pubmed] 19273676
VanB-type Enterococcus faecium clinical isolate successively inducibly resistant to, dependent on, and constitutively resistant to vancomycin.(Antimicrob. Agents Chemother.) [2009]

Q9XBX3_ENTFC
(Q9XBX3)

1e-94

351

54%

Product: D-lactate dehydrogenase VanHD
D-specific alpha-keto acid dehydrogenase
Gene: vanHD
Organism: Enterococcus faecium
Streptococcus faecium

[pubmed all]
1uniprot[Pubmed] 10479146 [Medline] 99408840 A cluster of VanD vancomycin-resistant Enterococcus faecium: molecular characterization and clinical epidemiology.(J. Infect. Dis.) [1999]
2uniprot[Pubmed] 19258279 New combinations of mutations in VanD-Type vancomycin-resistant Enterococcus faecium, Enterococcus faecalis, and Enterococcus avium strains.(Antimicrob. Agents Chemother.) [2009]

Q9EYV9_ENTFC
(Q9EYV9)

1e-94

350

55%

Product: D-2-hydroxyacid dehydrogenase
Gene: vanHB2
Organism: Enterococcus faecium
Streptococcus faecium

1uniprot[Pubmed] 11376048 [Medline] 21270249
High prevalence of VanB2 vancomycin-resistant Enterococcus faecium in Taiwan.(J. Clin. Microbiol.) [2001]

Q56R49_9CLOT
(Q56R49)

1e-94

350

55%

Product: VanHB
Gene: vanHB
Organism: Clostridium sp. CCRI-9842

1uniprot[Pubmed] 15731199
Characterization of a Tn5382-like transposon containing the vanB2 gene cluster in a Clostridium strain isolated from human faeces.(J. Antimicrob. Chemother.) [2005]

Q9S3S8_ENTFC
(Q9S3S8)

3e-94

350

54%

Product: D-lactate dehydrogenase
Gene: vanHD
Organism: Enterococcus faecium
Streptococcus faecium

1uniprot[Pubmed] 10835012 [Medline] 20295129
Molecular characterization of the vanD gene cluster and a novel insertion element in a vancomycin-resistant enterococcus isolated in Canada.(J. Clin. Microbiol.) [2000]

A8RJ03_9FIRM
(A8RJ03)

3e-94

350

54%

Product: D-lactate dehydrogenase
Gene: vanHD
Organism: Ruminococcus gauvreauii

1uniprot[Pubmed] 17724150
vanD and vanG-Like Gene Clusters in a Ruminococcus Species Isolated from Human Bowel Flora.(Antimicrob. Agents Chemother.) [2007]

Q32ZB1_9ACTN
(Q32ZB1)

6e-94

348

54%

Product: VanHB
Gene: vanHB
Organism: Eggerthella lenta

1uniprot[Pubmed] 15616278
Comparison of three PCR primer sets for identification of vanB gene carriage in feces and correlation with carriage of vancomycin-resistant enterococci: interference by vanB-containing anaerobic bacilli.(Antimicrob. Agents Chemother.) [2005]

2uniprot
Molecular characterization of vanB elements in naturally-occurring gut anaerobes.(Antimicrob. Agents Chemother.) [2005]

Q32ZA1_9CLOT
(Q32ZA1)

6e-94

348

54%

Product: VanHB
Gene: vanHB
Organism: Clostridium sp. MLG245

2uniprot
Molecular characterization of vanB elements in naturally-occurring gut anaerobes.(Antimicrob. Agents Chemother.) [2005]

Q32Z91_ENTFC
(Q32Z91)

6e-94

348

54%

Product: VanHB
Gene: vanHB
Organism: Enterococcus faecium
Streptococcus faecium

2uniprot
Molecular characterization of vanB elements in naturally-occurring gut anaerobes.(Antimicrob. Agents Chemother.) [2005]

B6ZHJ3_ENTFA
(B6ZHJ3)

6e-94

348

54%

Product: VanH protein
Gene: vanH
Organism: Enterococcus faecalis
Streptococcus faecalis

1uniprot[Pubmed] 19029325
Isolation of VanB-type Enterococcus faecalis strains from nosocomial infections: first report of the isolation and identification of the pheromone-responsive plasmids pMG2200, Encoding VanB-type vancomycin resistance and a Bac41-type bacteriocin, and pMG2201, encoding erythromycin resistance and cytolysin (Hly/Bac).(Antimicrob. Agents Chemother.) [2009]

Q3S3G4_ENTGA
(Q3S3G4)

8e-94

348

53%

Product: VanHD
Gene: vanHD
Organism: Enterococcus gallinarum

1uniprot[Pubmed] 16495270
Enterococcus gallinarum N04-0414 harbors a VanD-type vancomycin resistance operon and does not contain a D-alanine:D-alanine 2 (ddl2) gene.(Antimicrob. Agents Chemother.) [2006]

Q6RVF8_ENTFC
(Q6RVF8)

2e-93

347

53%

Product: VanHD5
Gene: vanHD5
Organism: Enterococcus faecium
Streptococcus faecium

1uniprot[Pubmed] 15308604
Enterococcus faecium N03-0072 carries a new VanD-type vancomycin resistance determinant: characterization of the VanD5 operon.(J. Antimicrob. Chemother.) [2004]

Q9XCR5_ENTFC
(Q9XCR5)

1e-92

344

54%

Product: D-lactate dehydrogenase
Gene: vanHD
Organism: Enterococcus faecium
Streptococcus faecium

1uniprot[Pubmed] 10368136 [Medline] 99296571
Characterization of the vanD glycopeptide resistance gene cluster from Enterococcus faecium BM4339.(J. Bacteriol.) [1999]

Q18PA5_9ENTE
(Q18PA5)

3e-92

342

53%

Product: D-lactate dehydrogenase
Gene: vanHD
Organism: Enterococcus raffinosus

1uniprot[Pubmed] 17000737
First VanD-Type vancomycin-resistant Enterococcus raffinosus isolate.(Antimicrob. Agents Chemother.) [2006]

Q9L8Y1_ENTFA
(Q9L8Y1)

6e-92

342

54%

Product: VanHB
Gene: vanHB
Organism: Enterococcus faecalis
Streptococcus faecalis

1uniprot[Pubmed] 10846226 [Medline] 20307505
Characterization of transposon Tn1549, conferring VanB-type resistance in Enterococcus spp.(Microbiology) [2000]

Q9EZR0_ENTFC
(Q9EZR0)

3e-91

340

53%

Product: Alpha keto acid dehydrogenase
D-lactate dehydrogenase
Gene: vanHD4
vanHD
Organism: Enterococcus faecium
Streptococcus faecium

[pubmed all]
1uniprot[Pubmed] 11083656 [Medline] 20536225 Characterization of a divergent vanD-type resistance element from the first glycopeptide-resistant strain of Enterococcus faecium isolated in Brazil.(Antimicrob. Agents Chemother.) [2000]
2uniprot[Pubmed] 12499162 [Medline] 22386893 VanD-type vancomycin-resistant Enterococcus faecium 10/96A.(Antimicrob. Agents Chemother.) [2003]

D8GQW1_CLOLD
(D8GQW1)

3e-79

300

43%

Product: Predicted alpha-keto acid dehydrogenase
Gene: CLJU_c32190
Organism: Clostridium ljungdahlii (strain ATCC 55383 / DSM 13528 / PETC)

1uniprot[Pubmed] 20616070
Clostridium ljungdahlii represents a microbial production platform based on syngas.(Proc. Natl. Acad. Sci. U.S.A.) [2010]

F8TEP1_9CLOT
(F8TEP1)

7e-79

298

43%

Product: Lactate dehydrogenase
Gene: ldhA
Organism: Clostridium ragsdalei

1uniprot
2,3-butanediol production by acetogenic bacteria, an alternative route to chemical synthesis using industrial waste gas.(Appl. Environ. Microbiol.) [2011]

F8TEP0_9CLOT
(F8TEP0)

1e-78

298

42%

Product: Lactate dehydrogenase
Gene: ldhA
Organism: Clostridium autoethanogenum

1uniprot
2,3-butanediol production by acetogenic bacteria, an alternative route to chemical synthesis using industrial waste gas.(Appl. Environ. Microbiol.) [2011]

A5MZD1_CLOK5
(A5MZD1)

1e-76

291

43%

Product: Predicted alpha-keto acid dehydrogenase
Gene: CKL_2215
Organism: Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680)

1uniprot[Pubmed] 18218779
The genome of Clostridium kluyveri, a strict anaerobe with unique metabolic features.(Proc. Natl. Acad. Sci. U.S.A.) [2008]

Q97IU7_CLOAB
(Q97IU7)

8e-76

288

42%

Product: Lactate dehydrogenase
Gene: CA_C1543
Organism: Clostridium acetobutylicum

1uniprot[Pubmed] 11466286 [Medline] 21359325
Genome sequence and comparative analysis of the solvent-producing bacterium Clostridium acetobutylicum.(J. Bacteriol.) [2001]

F0K4H7_CLOAE
(F0K4H7)

8e-76

288

42%

Product: Lactate dehydrogenase
Gene: CEA_G1558
Organism: Clostridium acetobutylicum (strain EA 2018)

1uniprot[Pubmed] 21284892
Comparative genomic and transcriptomic analysis revealed genetic characteristics related to solvent formation and xylose utilization in Clostridium acetobutylicum EA 2018.(BMC Genomics) [2011]

Q893I3_CLOTE
(Q893I3)

2e-68

264

41%

Product: D-lactate dehydrogenase
Gene: CTC_01840
Organism: Clostridium tetani

1uniprot[Pubmed] 12552129 [Medline] 22457253
The genome sequence of Clostridium tetani, the causative agent of tetanus disease.(Proc. Natl. Acad. Sci. U.S.A.) [2003]