Borre_00420 : CDS information

Location

Organism	Streptomyces parvulus
Strain	Tü4055
Entry name	Borrelidin
Contig	AJ580915
Start / Stop / Direction	73,037 / 73,942 / + [in whole cluster] 73,037 / 73,942 / + [in contig]
Location	73037..73942 [in whole cluster] 73037..73942 [in contig]
Type	CDS
Length	906 bp (301 aa)

Annotation

Category	5.1 general function
Product	putative methyltransferase
Product (GenBank)	hypothetical protein
Gene
Gene (GenBank)
EC number	2.1.1.-
Keyword
Note
Note (GenBank)	ORFB21
Reference	ACC Q70HX5 PmId [15112998] Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tu4055: cluster analysis and assignment of functions. (Chem Biol. , 2004) comment Borrelidin生合成gene clusterのクローニング。 orfB21: closest similar to hypo borrelidin非産生であるS.coelicolorのタンパクに明らかな類似があるが、遺伝子配置は異なるもの。
Family/Domain	FD IPR011610, IPR007213 comment [IPR011610] S-adenosyl-L-methionine-dependent methyltransferase, putative (Family) [IPR007213] Leucine carboxyl methyltransferase (Family) function; methyltransferase activity

Sequence

>putative methyltransferase [hypothetical protein]
MTGTAPQYTDVEGVNGGVGLTAFLVAAARAIETHRDDSLAQDVYAEHFVRAAPACADWPV
RIEQVPDGDGNPLWGRFARYFGLRTRALDDFLLRSVRTGPRQVVLLGAGLDTRAFRLDWP
SQCAVFEIDRTGVLAFKQQVLTDLAATPRVERVPVPVDLRADWAGALTAAGFDPAAPSVW
LAEGLLFYLPGPAESLLVDTVDRLTTDGSALAFEAKLEKDLLAYRDSAIYTATREQIGID
LLRLFDKGPRPDSAGELAARGWSTSMHTPFVFTHRYGRGPLPEPNDALEGNRWVFARKPG
P

>putative methyltransferase [hypothetical protein]
ATGACCGGCACGGCGCCGCAGTACACGGACGTGGAAGGCGTGAACGGAGGTGTGGGCCTG
ACGGCCTTCCTGGTCGCCGCCGCGCGGGCGATCGAGACCCATCGCGACGACAGTCTGGCC
CAGGACGTCTACGCGGAACACTTCGTGCGCGCCGCCCCGGCGTGCGCGGACTGGCCGGTG
CGCATCGAGCAGGTCCCCGACGGGGACGGCAACCCGCTGTGGGGACGGTTCGCCCGCTAT
TTCGGCCTGCGGACCCGGGCCCTCGACGACTTCCTGCTCCGGTCGGTCCGGACGGGCCCC
CGACAGGTGGTGCTGCTGGGCGCGGGGTTGGACACCCGTGCCTTCCGGCTCGACTGGCCG
TCGCAGTGCGCGGTCTTCGAGATCGACCGGACGGGCGTGCTCGCCTTCAAACAGCAGGTG
CTCACGGACCTGGCGGCAACCCCGAGAGTGGAGCGCGTCCCCGTTCCGGTCGATCTGCGC
GCGGACTGGGCCGGCGCGCTGACCGCGGCCGGCTTCGACCCCGCGGCGCCCAGCGTCTGG
CTGGCCGAGGGACTGCTCTTCTATCTGCCGGGCCCCGCCGAGTCGCTTCTCGTCGACACG
GTGGACCGGCTGACCACCGACGGCAGCGCGCTGGCCTTCGAGGCCAAGCTGGAGAAGGAC
CTGCTGGCGTACCGCGACAGTGCGATCTACACGGCGACGCGCGAGCAGATCGGCATCGAC
CTCCTCCGCCTCTTCGACAAGGGGCCCCGACCCGACTCCGCGGGTGAGCTGGCGGCCAGA
GGCTGGTCCACCTCGATGCACACGCCCTTCGTCTTCACCCACCGGTACGGACGCGGTCCC
CTCCCCGAGCCGAACGACGCGCTGGAGGGGAACCGATGGGTCTTCGCCCGCAAGCCCGGG
CCCTGA

Feature

BLASTP Database:UniProtKB:2011_09	show BLAST table
InterPro Database:interpro:38.0	IPR007213 Leucine carboxyl methyltransferase (Family) PF04072 LCM IPR011610 S-adenosyl-L-methionine-dependent methyltransferase, putative (Family) TIGR00027 Mthyl_TIGR00027
SignalP	Bacteria, Gram-positive Bacteria, Gram-negative Eukaryota
TMHMM	No significant hit

Borre_00410 Borre_00430