Monen_00120 Monen_00120   Monen_00140 Monen_00140

Monen_00130 : CDS information

close this sectionLocation

Organism
StrainATCC 15413
Entry nameMonensin
Contig
Start / Stop / Direction12,205 / 12,780 / + [in whole cluster]
12,205 / 12,780 / + [in contig]
Location12205..12780 [in whole cluster]
12205..12780 [in contig]
TypeCDS
Length576 bp (191 aa)
Click on the icon to see Genetic map.

close this sectionAnnotation

Category4.1 transcriptional regulator
Productputative TetR family transcriptional regulator
Product (GenBank)putative monensin cluster negative regulator
Gene
Gene (GenBank)monRII
EC number
Keyword
Note
Note (GenBank)
  • putative repressor; DNA binding protein; MonRII
Reference
ACC
PmId
[12940979] Analysis of the biosynthetic gene cluster for the polyether antibiotic monensin in Streptomyces cinnamonensis and evidence for the role of monB and monC genes in oxidative cyclization. (Mol Microbiol. , 2003)
comment
monensin生合成 gene clusterの解析論文。

MonRII: Transcriptional regulator
MonRIIは、tetracenomycin生合成clusterのnegative regulatorであるTcmRに明らかな配列類似を示す。
Related Reference
ACC
P39885
PmId
[1592820] The Streptomyces glaucescens TcmR protein represses transcription of the divergently oriented tcmR and tcmA genes by binding to an intergenic operator region. (J Bacteriol. , 1992)
comment
37th, id34%, 2e-14
Streptomyces glaucescens_tcmR
HTH-type transcriptional regulator tcmR
(Tetracenomycin C transcriptional repressor)

tcmRありなしでのtcmAへの影響、TcmR proteinの結合条件を検討している。
TcmR proteinはtcmA と tcmRの転写を阻害するrepressorとして機能する。

close this sectionSequence

selected fasta
>putative TetR family transcriptional regulator [putative monensin cluster negative regulator]
MPGLRERKKARTKAAIQREAVRLFREQGYTATTIEQIAEAAEVAPSTVFRYFATKQDLVF
SHDYDLPFAMMVQAQSPDLTPIQAERQAIRSMLQDISEQELALQRERFVLILSEPELWGA
SLGNIGQTMQIMSEQVAKRAGRDPRDPAVRAYTGAVFGVMLQVSMDWANDPDMDFATTLD
EALHYLEDLRP
selected fasta
>putative TetR family transcriptional regulator [putative monensin cluster negative regulator]
GTGCCTGGTCTGAGAGAACGCAAGAAGGCCCGGACGAAGGCCGCGATTCAGCGGGAGGCG
GTGCGCTTGTTCAGGGAACAGGGCTACACCGCCACGACCATCGAGCAGATCGCCGAAGCC
GCCGAGGTCGCTCCCAGCACCGTCTTCCGCTACTTCGCGACCAAGCAGGACCTGGTCTTC
TCGCACGACTACGATCTGCCCTTCGCGATGATGGTCCAGGCCCAGTCACCCGACCTGACG
CCGATCCAGGCCGAGCGGCAGGCCATCCGCTCGATGTTGCAGGACATCAGCGAGCAGGAA
CTGGCCCTGCAGCGCGAGCGGTTCGTCCTGATTCTCTCCGAGCCGGAGCTCTGGGGCGCC
AGCCTCGGCAACATCGGCCAGACCATGCAGATCATGAGTGAGCAGGTGGCCAAACGGGCC
GGGCGCGACCCGCGGGACCCCGCGGTCCGCGCCTACACCGGAGCCGTGTTCGGAGTGATG
CTCCAGGTCTCGATGGACTGGGCCAACGATCCGGACATGGACTTCGCGACCACGCTGGAC
GAGGCACTCCACTACCTGGAAGACCTGCGGCCCTGA

close this sectionFeature

BLASTP
Database:UniProtKB:2011_09 		show BLAST table
InterPro
Database:interpro:38.0
IPR001647 DNA-binding HTH domain, TetR-type (Domain)
[10-70] PS50977
PS50977   HTH_TETR_2
[16-29] 4.69999810630989e-07 PR00455 [37-60] 4.69999810630989e-07 PR00455
PR00455   HTHTETR
[17-59] 1.8e-15 PF00440
PF00440   TetR_N
IPR009057 Homeodomain-like (Domain)
[1-60] 3.0999994589937e-14 SSF46689
SSF46689   Homeodomain_like
[4-56] 6.90000000000001e-19 G3DSA:1.10.10.60
G3DSA:1.10.10.60   Homeodomain-rel
IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal (Domain)
[57-188] 9.10000000000001e-31 G3DSA:1.10.357.10
G3DSA:1.10.357.10   TetR_C
SignalP No significant hit
TMHMM No significant hit
Monen_00120 Monen_00120   Monen_00140 Monen_00140
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