MUP_00390 : CDS information

Location

Organism	Mycobacterium ulcerans
Strain	Agy99
Entry name	Mycolactone
Contig	BX649209
Start / Stop / Direction	86,312 / 79,080 / - [in whole cluster] 86,312 / 79,080 / - [in contig]
Location	complement(79080..86312) [in whole cluster] complement(79080..86312) [in contig]
Type	CDS
Length	7,233 bp (2,410 aa)

Annotation

Category	1.1 PKS
Product	polyketide synthase
Product (GenBank)	Type I modular polyketide synthase
Gene
Gene (GenBank)	mlsA2
EC number
Keyword
Note
Note (GenBank)	MUP039c, mlsA2, len: 2410 aa. Type I modular polyketide synthase, composed of one extender module (module 9); required for the synthesis of the mycolactone core in M. ulcerans (see Stinear et al., 2003). Similar to part of several e.g. Q9S0R8 Type I polyketide synthase AVES 1 from Streptomyces avermitilis (3972 aa), fasta scores: opt: 3342, E(): 2.1e-187, (40.556% identity in 2160 aa overlap); Q93NW8 AmphA from Streptomyces nodosus (1412 aa), fasta scores: opt: 3171, E(): 9.9e-178, (47.163% identity in 1304 aa overlap). Contains a Pfam match to entry PF00109 ketoacyl-synt: Beta-ketoacyl synthase, N-terminal domain and a Pfam match to entry PF02801 ketoacyl-synt_C: Beta-ketoacyl synthase, C-terminal domain. Contains a Pfam match entry PF00550 pp-binding: Phosphopantetheine attachment site and a Pfam match to entry PF00698 Acyl_transf: Acyl transferase domain.
Reference	ACC Q6MZA5 PmId [14736915] Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans. (Proc Natl Acad Sci U S A. , 2004) [18493665] The unusual macrocycle forming thioesterase of mycolactone. (Mol Biosyst. , 2008) comment [PMID: 14736915](2004) mycolactone合成に必要十分なclusterを有する174kb plasmid pMUM001の報告。 12員環mycolactone coreはMLSA1 and MLSA2によってコードされる。 decarboxylating loading module, 9 extension modulesを含み、integral C-terminal thioesterase cyclase(TE) domainで終結する。 MLSA1: LM, module1-8 MLSA2: module9, TE --- [PMID: 18493665](2008) Mycolactoneと同様にmacrolodeである6-deoxyerythronolide B synthase(DEBS)のTEを主な比較対象として、配列alignment、p-nitrophenyl propionateなどを基質として加水分解を見たTE活性、active-site directed inhibitorsへの感受性を確認している。 DEBSより20倍ほどTE活性はゆっくりで、コンセンサス配列も保存されておらず、TE active site catalytic SerはMLSA2 TEでラベルされない。以上から一般的なmacrocyclizationをするTEとは異なるタイプのものだと言っている。

PKS/NRPS Module

A	9		malonyl-CoA

KS	35..408

AT	590..912

DH	955..1128

ER	1470..1773

KR	1783..1963

ACP	2063..2133

Sequence

>polyketide synthase [Type I modular polyketide synthase]
MVSTEENLRVYLKQVITDLHQMQARLRKIEKQRSERVAVVGMACRFPGGVASADQLWDLV
IAGRDVVGNFPADRGWDVEGLFDPDPDAVGKTYTRYGAFLDDAAGFDAGFFGISPREARA
MDPQQRLLLEVCWEALETAGIPAHTLAGTSTGVFVGAWAQSYGATNSDGAEGYAMTGGST
SVMSGRIAYTLGLEGPAITVDTACSSSLVAIHLACQSLRNNESQLALAGGVTVMSTPAVF
TEFSRQRGLAPDGRCKAFAATADGTGWGEGAAVLVLERLSEARRNNHPVLAIVAGSAINQ
DGASNGLTAPHGPSQQRVINQALANAGLTHDQVDAVEAHGTGTTLGDPIEASALHATYGH
HHTPDQPLWLGSIKSNIGHTQAAAGAAGVVKMIQAITHATLPATLHVDQPSPHIDWSSGT
VRLLTEPIQWPNTDHPRTAAVSSFGISGTNAHLILQQPPTPDTTQTPNTTTGSDPAVGSD
SAVGSDPAVGVLVWPLSARSAPGLSAQAARLYQHLSAHPDLDPIDVAHSLATTRSHHPHR
ATITTSIEHHSENNHDTTDALAALHALANNGTHPLLSRGLLTPQGPGKTVFVFPGQGSQY
PGMGADLYRQFPVFAHALDEVAAALNPHLDVALLEVMFSQQDTAMAQLLDQTFYAQPALF
ALGTALHRLFTHAGIHPDYLLGHSIGELTAAYAAGVLSLQDAATLVTSRGRLMQSCTPGG
TMLALQASEAEVQPLLEGLDHAVSIAAINGATSIVLSGDHDSLEQIGEHFITQDRRTTRL
QVSHAFHSPHMDPILEQFRQIAAQLTFSAPTLPILSNLTGQIARHDQLASPDYWTQQLRN
TVRFHDTVAALLGAGEQVFLELSPHPVLTQAITDTVEQAGGGGAAVPALRKDRPDAVAFA
AALGQLHCHGISPSWNVLYCQARPLTLPTYAFQHQRYWLLPTAGDFSGANTHAMHPLLDT
ATELAENRGWVFTGRISPRTQPWLNEHAVESAVLFPGTGFVELALHVADRAGYSSVNELI
VHTPLLLAGHDTADLQITVTDTDDMGRQSLNIHSHPHIGHDNTTTGDEQPEWVLHASAVL
TAQTTDHNHLPLTPVPWPPPGTAAIEVDDFYDDLAAQGYNYGPTFQGVQRIWRDHATPDV
IYAEVELPEDTDIDGYGIHPALFDAALHPLLALTQPPTNDTDDTNTADTGDQVRLPYAFT
GISLHATHATRLRVRLTRTGADAITVHTSDTTGAPVAIIDSLITRPLTTATGSAPATTAA
GLLHLSWPPHPDTTTDTDTDTDALRYQVIAEPTQQLPRYLHDLHTSTDLHTSTTEADVVV
WPVPVPSNEELQAHQASDTAVSSRIHTLTRQTLTVVQDWLTHPDTTGTRLVIVTRHGVST
SAHDPVPDLAHAAVWGLIRSAQNEHPGRFTLLDTDDNTNSDTLTTALTLPTRENQLAIRR
DTIHIPRLTRTAVLTPPDSGPWRLDTTGKGDLANLALLPTAHTALASGQIRIDVRAAGLN
FHDVVVALGLIPDDGFGGEAAGVISEIGPDVYGFAVGDAVTGMTVSGAFAPSTVADHRMV
MTIPARWSFPQAASIPVVFLTAYIALAEISGLSRGQRVLIHAGTGGVGMAAIQLAHHLGA
EVFATASAAKWSTLEALGVPRDHIASSRTLDFSNAFLDATNGAGVDVVLNCLSGEFVEAS
LALLPRGGHFVEIGKTDIRDTEVIAATHPGVIYRALDLLSVSPDHIQRTLAQLSPLFATD
TLKPLPTTNYSIYQAISALRDMSQARHTGKIVLTAPVVVDPEGTVLITGGTGTLGALFAE
HLVSAHGVRHLLLTSRRGPQAHGATDLQQRLTDLGAHVTITACDISDPEALAALVNSVPT
QHRLTAVVHTAAVLADTPVTELTGDQLDQVLAPKIDAAWQLHQLTYEHNLSAFIMFSSMA
GMIGSPGQGNYAAANTALDALADYRHRLGLPATSLAWGYWQTRTGVTAHLTDVDLARMTR
LGLMPIATSHGLALFDAALATGQPVSIPAPINTHTLARHARDNTLTPILSALITTPRRRA
ASAATDLAARLNGLSPQQQQQTLATLVAAATATVLGHHTPESISPATAFKDLGIDSLTAL
ELRNTLTHNTGLDLPPTLIFDHPTPHALTQHLHTRLTQSHTPVGPIASLLSHAIDEGKFR
AGADLLMAASNLNQSFSNMAELNQLPAVTDIADASPDGLLTLICISTSENEYARLAAANI
HSLTFAEIAAPGFYDAQLPNSIETSAEALATAITGAYANTSIVLVAHSIVCELAQATMTR
LQDADIDLVGLVLLDPLEGTNSTEDYVETVLTRIEHINAPRVGVDGYLAALGRYLQFHED
RRIPIPETRHMTLHSDTKIDRAQTPMNLLQDEAALTALKIGNWMNDTGSIAVTLRDGPVF
LGRARSVNMR

>polyketide synthase [Type I modular polyketide synthase]
GTGGTGTCAACTGAAGAAAACCTACGCGTTTACTTAAAACAGGTCATCACAGACCTCCAC
CAAATGCAGGCACGTCTGCGGAAGATCGAAAAGCAGAGATCAGAGCGGGTGGCGGTGGTG
GGGATGGCGTGTCGTTTCCCCGGTGGTGTCGCATCAGCGGATCAGTTGTGGGACTTGGTG
ATCGCTGGCCGTGATGTGGTGGGTAATTTTCCGGCCGATCGGGGTTGGGATGTGGAGGGA
CTGTTTGATCCCGATCCGGACGCGGTCGGCAAAACCTACACCCGTTACGGCGCGTTCCTT
GACGATGCGGCAGGTTTTGATGCCGGGTTCTTTGGGATCTCTCCACGGGAGGCACGCGCG
ATGGACCCCCAGCAGCGGCTGCTGCTGGAGGTGTGCTGGGAAGCGCTAGAAACCGCGGGT
ATTCCCGCGCACACCTTGGCCGGCACCTCCACCGGGGTATTCGTCGGAGCCTGGGCCCAG
TCCTACGGCGCCACCAACTCCGATGGCGCTGAGGGGTATGCGATGACCGGCGGCTCGACT
AGCGTCATGTCCGGCCGTATCGCCTACACCTTGGGCCTAGAAGGTCCAGCGATCACCGTT
GACACCGCCTGCTCGTCATCGCTGGTGGCAATTCACCTGGCCTGCCAATCCTTACGCAAC
AACGAATCCCAGCTAGCACTGGCCGGCGGCGTCACCGTGATGAGCACACCTGCGGTTTTC
ACCGAGTTCTCCCGCCAACGCGGCCTGGCCCCAGATGGACGCTGCAAAGCCTTCGCCGCT
ACCGCCGATGGCACCGGCTGGGGTGAAGGCGCCGCGGTCTTGGTCCTTGAACGGCTCTCC
GAGGCCCGCCGCAACAACCACCCGGTCCTTGCGATCGTCGCTGGATCGGCGATCAACCAA
GACGGCGCATCCAACGGACTGACCGCACCCCACGGCCCGTCACAACAACGCGTCATCAAC
CAAGCACTAGCCAACGCCGGCCTCACCCACGACCAGGTCGACGCCGTCGAAGCCCACGGC
ACCGGCACCACACTGGGTGACCCCATCGAAGCCAGCGCCCTACACGCCACCTACGGCCAC
CACCACACGCCCGATCAACCGCTTTGGCTGGGATCCATCAAATCCAACATCGGCCACACC
CAAGCCGCCGCCGGCGCCGCCGGTGTGGTCAAGATGATCCAAGCCATCACCCACGCCACC
TTGCCCGCCACCTTGCACGTCGACCAACCCAGCCCCCACATCGACTGGTCCAGCGGCACA
GTCCGACTCCTAACCGAGCCCATCCAATGGCCCAACACCGACCACCCCCGCACCGCGGCG
GTGTCCTCATTCGGCATCAGCGGCACCAACGCCCACCTCATCCTCCAACAACCCCCCACC
CCCGACACCACACAAACCCCCAACACCACAACAGGTTCTGATCCCGCAGTGGGTTCTGAT
TCCGCAGTGGGTTCTGATCCCGCAGTGGGTGTACTGGTGTGGCCGTTGTCAGCGCGTTCA
GCGCCGGGGTTAAGCGCACAAGCGGCCCGTCTGTACCAGCATCTCAGCGCCCACCCCGAT
CTGGATCCGATCGATGTAGCCCACAGCCTGGCTACCACACGCAGCCACCACCCCCACCGC
GCCACCATCACCACCAGCATTGAGCACCACAGCGAAAACAACCACGACACAACCGATGCG
CTGGCCGCACTGCACGCCCTGGCCAACAACGGCACACACCCCCTGCTGAGCAGAGGCCTG
CTGACCCCACAGGGCCCCGGCAAAACAGTGTTCGTGTTCCCCGGACAGGGCAGTCAATAC
CCCGGCATGGGCGCAGATCTCTACCGCCAATTCCCCGTGTTCGCCCACGCCCTCGACGAG
GTCGCTGCGGCGCTGAACCCGCATCTCGATGTTGCGTTGCTTGAGGTGATGTTCAGCCAA
CAAGACACTGCCATGGCGCAACTGCTGGACCAGACCTTCTATGCACAACCGGCGTTGTTC
GCGCTGGGAACCGCTCTACATCGATTGTTCACCCACGCCGGTATCCACCCGGACTACCTG
CTAGGCCACTCCATCGGAGAACTCACCGCGGCATACGCCGCCGGTGTGCTGTCACTGCAA
GACGCAGCCACCTTGGTCACAAGCCGAGGACGACTGATGCAATCCTGCACGCCCGGCGGG
ACGATGCTCGCACTACAAGCCAGCGAAGCAGAAGTACAACCGCTGCTTGAAGGCCTAGAC
CACGCCGTGTCCATCGCCGCGATCAACGGAGCAACGTCGATCGTACTGTCAGGAGATCAC
GACAGCCTCGAACAAATCGGCGAGCACTTCATTACCCAAGATCGACGTACCACCCGACTG
CAGGTCAGTCACGCTTTCCACTCTCCACATATGGACCCCATCCTCGAACAATTCCGCCAG
ATCGCGGCCCAACTCACCTTCAGCGCACCCACCCTGCCCATCTTGTCCAACCTCACCGGG
CAGATCGCCCGCCACGACCAACTCGCCTCACCTGACTATTGGACCCAACAGCTACGTAAC
ACTGTCCGGTTCCATGACACTGTCGCTGCCCTGCTCGGGGCGGGTGAGCAGGTTTTCCTG
GAACTTTCACCTCACCCGGTGTTGACACAAGCGATCACCGACACCGTCGAACAAGCCGGC
GGCGGCGGCGCAGCAGTGCCAGCTCTACGCAAGGATCGCCCTGATGCTGTCGCGTTCGCT
GCAGCACTCGGCCAGCTGCACTGCCATGGCATCAGCCCATCCTGGAATGTTCTTTACTGC
CAGGCCCGCCCCCTCACACTGCCCACCTACGCTTTCCAGCATCAGCGTTACTGGCTGCTG
CCCACCGCTGGTGATTTCAGCGGGGCCAATACCCACGCCATGCATCCGCTGCTAGACACC
GCCACCGAACTGGCCGAAAACCGCGGATGGGTGTTCACCGGCCGGATCAGCCCACGCACC
CAACCATGGCTAAACGAACACGCCGTCGAATCAGCCGTGCTGTTCCCAGGCACCGGATTT
GTCGAGCTAGCGCTGCATGTCGCTGACCGTGCCGGATATTCCTCGGTCAACGAACTGATC
GTGCACACCCCCCTGCTACTCGCTGGCCACGACACCGCGGATCTACAGATCACCGTCACC
GACACCGATGACATGGGCCGGCAGTCTCTTAACATCCACTCGCACCCACATATCGGCCAT
GACAACACCACCACCGGCGATGAACAACCCGAGTGGGTCCTGCATGCCAGCGCAGTCCTG
ACCGCACAAACCACCGACCACAACCACCTCCCCCTAACGCCTGTGCCGTGGCCTCCACCC
GGCACAGCCGCGATCGAGGTGGATGACTTCTACGACGACCTGGCTGCACAGGGCTACAAC
TACGGCCCGACATTCCAAGGTGTGCAACGGATATGGCGTGACCACGCCACACCCGATGTC
ATCTACGCCGAAGTTGAACTACCCGAAGACACCGACATCGACGGCTACGGCATCCACCCC
GCCCTATTCGACGCCGCTTTACACCCCCTACTCGCCCTGACCCAACCCCCCACCAACGAC
ACCGATGACACCAACACCGCAGACACCGGTGACCAGGTGCGGCTGCCCTACGCCTTTACC
GGCATCAGTTTGCACGCCACCCACGCCACCCGATTGCGGGTACGGCTGACCCGTACCGGC
GCCGATGCCATCACCGTGCACACCAGTGACACCACCGGAGCCCCGGTGGCGATCATCGAC
TCATTGATCACCCGCCCCCTCACCACCGCCACAGGGTCTGCTCCGGCAACCACAGCAGCT
GGCCTACTACACCTGAGCTGGCCACCACACCCTGACACCACGACCGACACCGACACCGAC
ACCGATGCCCTGCGGTATCAGGTGATCGCCGAACCCACTCAACAACTGCCCCGCTACCTG
CACGACCTACACACCAGCACCGACCTGCACACCAGCACCACCGAAGCAGACGTGGTTGTG
TGGCCGGTACCGGTGCCCAGCAACGAAGAGCTCCAGGCACACCAAGCATCCGACACCGCG
GTGTCTTCTCGGATACACACCCTGACCCGCCAAACACTTACCGTGGTGCAGGACTGGCTC
ACTCACCCCGACACCACCGGCACCCGACTGGTCATCGTGACCCGCCACGGCGTCAGCACC
AGTGCCCACGACCCGGTCCCCGACCTAGCCCACGCCGCAGTGTGGGGCCTGATCCGCAGC
GCCCAAAACGAACACCCCGGACGCTTCACACTGCTCGACACCGACGACAACACCAACAGC
GACACCCTCACCACCGCCCTAACCCTGCCAACCCGCGAAAACCAACTGGCCATACGCCGC
GACACCATCCACATCCCCCGCCTGACCCGCACCGCTGTCCTGACACCACCGGACAGCGGC
CCCTGGCGCCTTGACACCACCGGCAAGGGTGATCTGGCCAACCTCGCCCTGCTACCGACC
GCCCACACTGCCCTGGCCTCTGGACAAATCCGTATCGATGTCCGGGCCGCTGGTTTGAAT
TTTCACGACGTGGTCGTCGCGTTGGGGCTAATCCCCGACGACGGATTCGGCGGAGAAGCC
GCCGGGGTGATCAGCGAGATCGGTCCCGACGTCTACGGATTCGCCGTGGGTGATGCCGTG
ACCGGCATGACCGTCTCTGGTGCGTTTGCCCCCAGCACTGTCGCTGATCACCGCATGGTG
ATGACGATCCCGGCCCGGTGGTCCTTCCCCCAAGCCGCATCCATACCGGTGGTATTCCTG
ACCGCCTACATCGCTTTGGCCGAGATCTCGGGCCTAAGCCGAGGGCAACGAGTGCTGATC
CATGCCGGCACTGGCGGTGTGGGTATGGCTGCGATTCAATTGGCACACCATTTGGGTGCC
GAAGTATTCGCCACCGCCAGCGCCGCGAAATGGAGCACCCTTGAGGCACTGGGGGTACCG
CGCGACCATATCGCTTCCTCGCGTACTCTGGACTTTTCCAACGCATTCCTCGATGCCACC
AACGGCGCCGGTGTTGATGTCGTATTGAACTGCCTCAGTGGTGAATTCGTCGAAGCATCC
CTAGCCCTGCTGCCCCGCGGTGGCCATTTCGTCGAAATCGGCAAAACCGACATCCGTGAT
ACCGAGGTCATCGCCGCAACCCATCCCGGCGTCATTTACCGCGCCCTCGATCTGCTCAGC
GTCTCCCCCGATCACATCCAGCGCACACTGGCCCAACTGTCCCCACTGTTTGCCACCGAC
ACCCTAAAACCCCTACCGACCACTAATTACAGCATCTACCAAGCCATCTCGGCCTTACGT
GACATGAGTCAAGCCCGTCACACAGGCAAGATCGTGCTCACTGCGCCGGTGGTGGTAGAT
CCTGAGGGCACGGTGTTGATCACCGGGGGGACCGGGACGCTGGGTGCCTTGTTCGCCGAG
CATCTGGTTTCTGCCCATGGTGTCCGGCATCTGTTGTTGACCTCGCGGCGCGGACCTCAG
GCCCACGGTGCCACCGATCTGCAGCAGCGGCTCACCGATCTAGGTGCTCATGTCACCATC
ACGGCCTGCGATATCAGCGACCCCGAAGCACTGGCCGCCCTGGTCAATTCAGTGCCCACA
CAACACCGTTTAACCGCGGTAGTGCACACCGCCGCGGTATTGGCCGACACCCCGGTCACC
GAGTTGACCGGCGATCAACTCGACCAGGTGCTGGCCCCCAAAATCGACGCGGCATGGCAG
CTGCACCAACTCACCTACGAACACAACCTGTCTGCATTCATCATGTTCTCGTCCATGGCC
GGAATGATAGGCAGTCCCGGTCAGGGTAACTACGCGGCAGCCAACACCGCGTTAGATGCT
CTCGCCGACTACCGCCACCGCCTGGGCTTGCCCGCGACCAGCCTGGCCTGGGGCTACTGG
CAGACCCGCACCGGTGTCACCGCGCATCTAACCGATGTAGATCTAGCCCGCATGACCCGC
CTGGGTTTGATGCCCATCGCCACCAGCCACGGACTGGCCCTGTTCGATGCCGCCCTCGCC
ACCGGACAGCCCGTTTCGATACCCGCCCCGATCAACACCCACACCCTGGCCCGACACGCC
CGCGACAACACCCTGACCCCGATCCTGTCTGCGCTGATCACCACACCACGGCGCCGGGCG
GCCTCTGCCGCAACCGATCTCGCTGCCCGCCTCAACGGACTTAGCCCCCAACAGCAACAA
CAAACACTGGCCACCCTCGTGGCCGCGGCCACCGCCACCGTGCTGGGCCACCACACCCCC
GAAAGCATCAGCCCAGCCACCGCGTTCAAAGACCTCGGAATCGATTCGCTGACCGCCCTT
GAACTGCGCAACACCCTCACCCACAACACCGGCCTGGATCTGCCCCCCACCCTCATCTTC
GATCACCCCACACCCCATGCGCTAACCCAACACCTGCACACCCGACTCACCCAAAGCCAT
ACCCCGGTCGGACCAATTGCGTCCCTGCTAAGCCACGCGATCGATGAGGGCAAATTCCGT
GCCGGCGCTGACCTATTGATGGCCGCATCCAATTTGAACCAAAGTTTCAGCAATATGGCT
GAACTCAACCAGCTCCCGGCCGTGACGGACATAGCTGACGCGTCTCCTGATGGGCTACTC
ACCCTGATCTGCATCTCTACCTCAGAGAATGAGTACGCTCGCCTCGCTGCTGCGAACATT
CATTCACTGACCTTCGCTGAAATTGCGGCGCCCGGCTTTTACGACGCGCAGCTGCCAAAT
TCGATAGAGACGTCGGCAGAGGCGCTGGCAACTGCCATCACAGGCGCCTACGCAAATACG
TCCATTGTTCTGGTAGCGCACTCCATTGTCTGCGAGCTAGCTCAGGCAACGATGACACGT
CTACAAGACGCTGACATCGATCTTGTGGGTCTGGTTCTGTTGGATCCACTCGAAGGGACT
AACAGCACTGAAGATTATGTGGAGACAGTCTTGACTCGAATCGAGCATATCAATGCACCG
AGGGTCGGAGTAGACGGTTACCTTGCCGCCCTGGGCCGCTATCTCCAATTCCACGAAGAC
CGCCGAATACCAATACCGGAAACGCGGCACATGACACTGCACTCGGACACGAAAATTGAC
CGTGCCCAAACACCAATGAACTTATTACAAGATGAGGCAGCGTTGACCGCCCTCAAAATA
GGAAACTGGATGAACGACACAGGGAGTATCGCAGTAACACTGAGAGATGGACCCGTATTC
TTGGGCAGGGCCCGCTCTGTCAACATGAGGTGA

[9] KS	35..408

[9] AT	590..912

[9] malonyl-CoA	784..788

[9] DH	955..1128

[9] ER	1470..1773

[9] KR	1783..1963

[9] ACP	2063..2133

[9] KS	103..1224

[9] AT	1768..2736

[9] malonyl-CoA	2350..2364

[9] DH	2863..3384

[9] ER	4408..5319

[9] KR	5347..5889

[9] ACP	6187..6399

Feature

BLASTP Database:UniProtKB:2011_09	show BLAST table
InterPro Database:interpro:38.0	IPR001227 Acyl transferase domain (Domain) G3DSA:3.40.366.10 Ac_transferase_reg IPR006162 Phosphopantetheine attachment site (PTM) PS00012 PHOSPHOPANTETHEINE IPR009081 Acyl carrier protein-like (Domain) PF00550 PP-binding PS50075 ACP_DOMAIN SSF47336 ACP_like G3DSA:1.10.1200.10 ACP_like IPR011032 GroES-like (Domain) SSF50129 GroES_like IPR013149 Alcohol dehydrogenase, C-terminal (Domain) PF00107 ADH_zinc_N IPR013154 Alcohol dehydrogenase GroES-like (Domain) PF08240 ADH_N IPR013968 Polyketide synthase, KR (Domain) PF08659 KR IPR014030 Beta-ketoacyl synthase, N-terminal (Domain) PF00109 ketoacyl-synt IPR014031 Beta-ketoacyl synthase, C-terminal (Domain) PF02801 Ketoacyl-synt_C IPR014043 Acyl transferase (Domain) PF00698 Acyl_transf_1 IPR015083 Polyketide synthase, docking (Domain) SSF101173 Polyketide_synth_docking PF08990 Docking IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase (Domain) SSF52151 Acyl_Trfase/lysoPlipase IPR016036 Malonyl-CoA ACP transacylase, ACP-binding (Domain) SSF55048 Malonyl_transacylase_ACP-bd IPR016038 Thiolase-like, subgroup (Domain) G3DSA:3.40.47.10 Thiolase-like_subgr IPR016039 Thiolase-like (Domain) SSF53901 Thiolase-like IPR016040 NAD(P)-binding domain (Domain) G3DSA:3.40.50.720 NAD(P)-bd IPR018201 Beta-ketoacyl synthase, active site (Active_site) PS00606 B_KETOACYL_SYNTHASE IPR020801 Polyketide synthase, acyl transferase domain (Domain) SM00827 PKS_AT IPR020806 Polyketide synthase, phosphopantetheine-binding domain (Domain) SM00823 PKS_PP IPR020807 Polyketide synthase, dehydratase domain (Domain) SM00826 PKS_DH IPR020841 Polyketide synthase, beta-ketoacyl synthase domain (Domain) SM00825 PKS_KS IPR020842 Polyketide synthase/Fatty acid synthase, KR (Domain) SM00822 PKS_KR IPR020843 Polyketide synthase, enoylreductase (Domain) SM00829 PKS_ER
SignalP	No significant hit
TMHMM	No significant hit

MUP_00380 MUP_00400