Phosl_00020 : CDS information

Location

Organism	Streptomyces sp.
Strain	HK803
Entry name	Phoslactomycin
Contig	AY354515
Start / Stop / Direction	2,994 / 5,918 / + [in whole cluster] 2,994 / 5,918 / + [in contig]
Location	2994..5918 [in whole cluster] 2994..5918 [in contig]
Type	CDS
Length	2,925 bp (974 aa)

Annotation

Category	4.1 transcriptional regulator
Product	putative LuxR family transcriptional regulator
Product (GenBank)	PlmR4
Gene
Gene (GenBank)	plmR4
EC number
Keyword
Note	The N-terminal position was modified from original INSDC entry.
Note (GenBank)	transcriptional regulator
Reference	ACC Q6V1P4 PmId [12819191] Enhancement and selective production of phoslactomycin B, a protein phosphatase IIa inhibitor, through identification and engineering of the corresponding biosynthetic gene cluster. (J Biol Chem. , 2003) comment Phoslactomycins生合成gene clusterのクローニング、配列解析報告。 fig2: regulatory geneはplmR1-5 本文に詳細記載なし。
Family/Domain	FD IPR000792 comment [IPR000792] Transcription regulator LuxR, C-terminal (Domain)

Sequence

>putative LuxR family transcriptional regulator [PlmR4]
MDSGRGADTGVVRGATATWTDGASWQLVGREQELAELERCLDDPDGPGLVLVHGERGAGR
SAFAHAAAERLAARDHVVLPLVCVRGDQDRPLLLALRVVTAVREHRSVTGRQPAAGRANP
EAEVLAAAERGDRAALADALLFALTHAAPVAVVVDDAQYADAASLGVLGAVAARCPPEVR
LVITSVRHTGGTGDAASGRRQDQAVGLPAEAGTARTIALPRLTRPQLADMVARRSQAAPD
PALVARVLGLTRGIPAAADALLTEWSRRDAVRIADGHAFLAASAPVPVLPDEDRFMRALH
ELGEPCRTTAAALSVLWPLGRTAVALVAGSTGLSDQEVGDGVRRLIAAGLLDELPGEDGG
GPRGWVFRSPLMEHATRERLGPLERARMSAAAVEALWAARDDTAAATSPRRPAVLLEEAD
TVTYLPERMADAGVLIDRERAAAELTAAAEALHPDPEDRGMLRWFRAALRLIEEPAAREL
ALLRCVKAAWVVGDHPAAGQAAETILRDPSDVVSGPDLHELAALQVVAVTSVKDWPHLSR
MGAAEWWDRLPLPPEAALPARALALCMSGRWPEGLDLFSRTEPVWRPDPHIRLIPELAQA
VGNLVQGRTDMLARALETPPDPGLPPEALYSIAAGYTLQLLGNADLCGAMDLLKDRGMPP
EALPPTSHFLLLHLQGRWDDALALARGMVAKDQAFIAPPQHHLFAAGTAAILLARGKPTG
AARLIAGERGTHEGHVEIFLDVAEAAVLRTMGRPDAADRILRRGLREADARGYVYGTDEL
AAALAMLRAEDGRADAAAGCLRRLEELAGRTGSGRTRLLHLLASARVRRQGSGAARELLH
EAVELARSRCQPYETAVTLVAAAGDAGPPELLHEAYELYGETGSLLSRFHTRAAMREAGL
TVPGRRQAAAENEQLLATLVTEGLANRQIATVLRLSQDAVANRLSRLFARTGLRSRTEIV
SAMLTGNPLTAPDL

>putative LuxR family transcriptional regulator [PlmR4]
GTGGACAGTGGCCGGGGGGCGGATACCGGGGTGGTGCGCGGTGCCACGGCGACGTGGACG
GATGGCGCGAGCTGGCAACTGGTGGGTCGCGAGCAGGAGTTGGCAGAGTTGGAACGCTGC
CTGGACGACCCGGACGGTCCCGGCCTGGTGCTCGTCCACGGAGAACGGGGAGCGGGGCGC
AGCGCGTTCGCGCATGCGGCCGCCGAACGGCTGGCTGCGCGGGATCATGTGGTGCTGCCG
TTGGTCTGCGTGCGCGGGGACCAGGACCGTCCGCTCCTGCTGGCGCTGCGGGTGGTCACC
GCCGTGCGGGAGCACCGGTCGGTCACCGGGAGGCAGCCCGCGGCCGGCCGGGCGAACCCG
GAGGCCGAGGTGCTGGCCGCCGCGGAGAGGGGCGATCGGGCGGCGCTCGCCGACGCACTG
CTGTTCGCGCTGACGCATGCGGCGCCCGTGGCCGTGGTGGTGGACGACGCGCAGTACGCC
GACGCGGCATCCCTCGGCGTACTGGGAGCCGTCGCCGCCCGGTGCCCCCCGGAGGTCCGG
CTGGTGATCACGTCGGTACGGCACACCGGCGGGACCGGTGACGCCGCGTCCGGCCGCCGG
CAGGACCAGGCCGTCGGACTGCCGGCGGAAGCGGGCACGGCGCGGACGATCGCCCTGCCG
CGCCTGACCCGGCCGCAGCTCGCCGACATGGTGGCGCGGCGGTCGCAGGCGGCGCCCGAC
CCGGCCCTGGTGGCGCGCGTCCTCGGGCTGACCCGCGGGATTCCCGCAGCCGCCGACGCG
CTGCTCACCGAGTGGTCGCGGCGGGACGCGGTGCGCATCGCCGACGGGCACGCCTTCCTC
GCCGCGAGCGCGCCGGTGCCGGTACTGCCCGATGAGGACCGGTTCATGAGGGCGCTGCAC
GAGCTCGGCGAACCATGCCGGACGACGGCGGCGGCACTGAGCGTCCTGTGGCCGCTCGGC
CGGACGGCGGTGGCGCTGGTGGCCGGGTCCACCGGTCTGTCCGACCAGGAGGTCGGCGAC
GGCGTGCGCCGCCTGATCGCCGCGGGCCTCCTCGACGAACTGCCCGGCGAGGACGGCGGC
GGCCCCCGGGGCTGGGTGTTCCGGTCACCGCTGATGGAGCACGCCACCCGGGAACGGCTC
GGGCCCCTGGAACGCGCCAGGATGTCCGCCGCCGCGGTGGAGGCTCTCTGGGCGGCTCGG
GACGACACGGCCGCAGCGACGTCCCCGCGGCGTCCGGCCGTGCTCCTTGAGGAGGCGGAC
ACCGTGACGTACCTGCCCGAGCGGATGGCCGACGCGGGCGTGCTGATCGACCGCGAGCGC
GCGGCGGCGGAACTCACCGCCGCCGCCGAGGCGTTGCACCCCGACCCCGAGGACCGCGGC
ATGCTGCGGTGGTTCCGGGCGGCGCTGCGCCTGATCGAGGAACCGGCGGCCCGCGAACTG
GCGTTGCTGCGGTGTGTGAAGGCCGCCTGGGTCGTGGGCGACCACCCGGCGGCGGGCCAG
GCGGCGGAGACGATTCTGCGCGACCCCTCCGACGTCGTCAGCGGCCCGGATCTCCACGAG
CTCGCCGCCCTCCAGGTCGTCGCGGTCACCTCCGTGAAGGACTGGCCGCACTTGTCCCGG
ATGGGGGCGGCCGAGTGGTGGGACCGTCTGCCGCTGCCCCCGGAGGCCGCATTGCCGGCG
CGGGCCCTGGCGTTGTGCATGAGCGGGCGGTGGCCGGAGGGTCTGGACCTGTTCTCGCGG
ACGGAGCCGGTGTGGCGCCCGGACCCGCACATCCGGCTGATACCCGAGCTGGCGCAGGCC
GTCGGGAACCTGGTGCAGGGCCGGACCGACATGCTCGCCCGGGCCCTGGAGACACCGCCG
GACCCCGGCCTCCCCCCGGAGGCGCTGTACTCGATAGCAGCCGGGTACACCCTCCAGTTG
CTCGGCAACGCGGACCTGTGCGGCGCCATGGACCTGTTGAAGGACCGCGGGATGCCGCCC
GAGGCGCTTCCCCCCACCAGCCACTTCCTCCTGCTCCACCTCCAGGGCCGGTGGGACGAC
GCGCTGGCGCTGGCGCGCGGCATGGTCGCGAAGGATCAGGCGTTCATCGCGCCGCCCCAG
CACCATCTGTTCGCCGCGGGGACGGCCGCCATCCTGCTGGCCAGGGGCAAGCCGACCGGC
GCCGCCCGTCTGATCGCCGGTGAGCGCGGGACCCACGAGGGTCATGTGGAGATCTTCCTG
GACGTCGCCGAGGCCGCGGTGCTGCGGACCATGGGCCGTCCCGACGCGGCCGACCGCATC
TTGCGGCGCGGGCTGCGGGAGGCCGACGCGCGCGGCTATGTCTACGGAACCGACGAGCTG
GCCGCTGCCCTCGCCATGCTCCGGGCGGAGGACGGCCGGGCCGATGCGGCGGCGGGCTGT
CTGCGGCGCCTGGAGGAACTCGCCGGGCGTACCGGCAGCGGACGCACCCGGCTGCTGCAC
CTGCTGGCATCGGCGCGGGTGCGCCGGCAGGGCTCCGGCGCCGCGCGCGAGCTGCTGCAC
GAGGCGGTGGAGCTGGCCCGCTCGCGGTGCCAGCCGTACGAGACCGCGGTCACGCTGGTG
GCGGCGGCCGGGGACGCGGGCCCCCCGGAGCTGCTGCACGAGGCGTACGAACTGTACGGG
GAGACGGGCTCGTTGCTGAGCCGCTTCCACACCCGGGCCGCGATGCGCGAGGCCGGGCTG
ACCGTCCCCGGCCGCAGACAGGCCGCCGCCGAGAACGAGCAGCTGCTGGCCACCCTGGTT
ACCGAGGGGCTCGCGAACCGCCAGATCGCCACCGTGCTGCGGCTCAGCCAGGACGCCGTC
GCCAATCGCCTGTCACGGCTGTTCGCACGCACCGGTCTTCGGTCTCGTACCGAGATCGTT
TCGGCCATGCTCACCGGCAACCCCCTGACCGCTCCGGACCTCTGA

Feature

BLASTP Database:UniProtKB:2011_09	show BLAST table
InterPro Database:interpro:38.0	IPR000792 Transcription regulator LuxR, C-terminal (Domain) PF00196 GerE SM00421 helix_turn_helix, Lux Regulon IPR011990 Tetratricopeptide-like helical (Domain) G3DSA:1.25.40.10 no description IPR011991 Winged helix-turn-helix transcription repressor DNA-binding (Domain) G3DSA:1.10.10.10 no description IPR016032 Signal transduction response regulator, C-terminal effector (Domain) SSF46894 C-terminal effector domain of the bipartite response regulators
SignalP	No significant hit
TMHMM	No significant hit

Phosl_00010 Phosl_00030