Rapam_00050 Rapam_00050   Rapam_00070 Rapam_00070

Rapam_00060 : CDS information

close this sectionLocation

Organism
StrainNRRL 5491
Entry nameRapamycin
Contig
Start / Stop / Direction6,497 / 5,184 / - [in whole cluster]
6,497 / 5,184 / - [in contig]
Locationcomplement(5184..6497) [in whole cluster]
complement(5184..6497) [in contig]
TypeCDS
Length1,314 bp (437 aa)
Click on the icon to see Genetic map.

close this sectionAnnotation

Category5.4 hypothetical protein
Producthypothetical protein
Product (GenBank)membrane transport protein
Gene
Gene (GenBank)orfV
EC number
Keyword
Note
Note (GenBank)
Reference
ACC
PmId
[7644502] The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin. (Proc Natl Acad Sci U S A. , 1995)
[8635730] Organisation of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of genes flanking the polyketide synthase. (Gene. , 1996)
comment
[PMID: 7644502](1995)
rapamycin生合成gene clusterの報告。配列解析。
ORF V: membrane transport protein?

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[PMID: 8635730](1996)
PKS flanking genesの配列解析。
orfV, W, Xはoperonを形成しているようで、その遺伝子産物は排出で機能するかもしれない。
OrfV and OrfWは相互に相同であり(id37%)、4つのTMSsを持つ。

close this sectionSequence

selected fasta
>hypothetical protein [membrane transport protein]
MNFVKRAGMSLGARKSKSAALLAIFVVICTLLLGGFLLQAAAARQEAGAQRTIGVDVTVR
KKGLTAVLADRLGASDLVYRYNPELPVRAGARGFTPLTSDAPKPGDAGAGAGAGPGAGAG
KKEQGPLAVNGVRDSGMLLPFSYGSTKITAGRGITPEDAGRNAAVIEQRLADRNHLKVGD
TIHVRSVDDKETVPLQVVGVFQNPTQDPARWTAPHKLPGNALYVPMGTAQRLGPGNVAVS
EAVYKIGSPEQAERLHTEAERLLGGDGFDFRVNDRAYKDQVRPIQRVGAFAGLIVWVIAL
AGTLILGLIVALQIRERRAELGVLLAMGEKRWKLIGQHAVEVAAVALPAIALAALAGSLA
GQPAGDTLLGRQDGKPAAAAAAAGVPDAEIAPPTVRVEPATVGKVAGIGLGISLVATVIP
GIGILRLHPRSILTDTE
selected fasta
>hypothetical protein [membrane transport protein]
ATGAACTTCGTCAAGCGCGCCGGGATGAGCCTGGGGGCCAGAAAGTCCAAGAGCGCCGCG
TTGCTGGCGATCTTCGTCGTCATCTGCACCCTGCTTCTCGGCGGCTTTCTGCTGCAGGCC
GCCGCGGCCCGCCAGGAAGCCGGCGCGCAGCGCACCATCGGCGTCGACGTCACCGTCAGG
AAGAAGGGCCTTACCGCGGTCCTCGCGGACCGGCTCGGTGCCTCGGATCTGGTGTACCGC
TACAACCCGGAGCTTCCGGTGCGGGCCGGGGCGCGTGGCTTCACGCCGCTGACGTCGGAC
GCGCCGAAGCCGGGCGATGCGGGTGCGGGTGCGGGTGCCGGTCCAGGTGCCGGTGCCGGG
AAGAAGGAGCAGGGCCCGCTGGCCGTGAACGGCGTCCGTGACTCGGGCATGCTGCTGCCC
TTCTCGTACGGCTCGACGAAGATCACGGCAGGGCGCGGCATCACCCCCGAGGACGCGGGC
CGCAACGCCGCGGTGATCGAGCAGCGGCTGGCCGACAGGAATCACCTCAAGGTGGGCGAC
ACGATCCATGTGCGGTCGGTGGACGACAAGGAAACCGTTCCGCTGCAGGTGGTCGGCGTC
TTCCAGAACCCCACGCAGGATCCGGCGCGCTGGACGGCACCGCACAAACTGCCCGGCAAC
GCGCTGTACGTGCCGATGGGCACGGCGCAGCGGCTCGGTCCCGGCAACGTGGCGGTCAGC
GAGGCGGTGTACAAGATCGGCTCGCCGGAGCAGGCCGAGCGGCTGCACACCGAGGCCGAG
CGTCTCCTGGGCGGGGACGGCTTCGACTTCCGCGTCAACGACAGGGCGTACAAGGACCAG
GTCCGCCCGATCCAGCGGGTCGGCGCGTTCGCGGGACTGATCGTCTGGGTGATCGCGCTG
GCCGGGACGCTGATCCTCGGCTTGATCGTGGCGCTGCAGATCCGCGAGCGGCGCGCCGAG
CTCGGGGTGCTCCTCGCGATGGGCGAGAAGAGGTGGAAGCTCATCGGCCAGCACGCCGTG
GAGGTGGCGGCCGTGGCCCTGCCCGCCATCGCGCTCGCCGCGCTGGCCGGTTCACTCGCC
GGACAGCCCGCGGGTGACACCCTCCTCGGGCGGCAGGACGGCAAGCCGGCCGCGGCGGCC
GCGGCGGCCGGTGTGCCCGATGCCGAGATCGCGCCGCCGACCGTACGAGTCGAGCCCGCC
ACCGTCGGCAAGGTCGCCGGCATCGGGCTCGGCATCTCCCTGGTCGCCACCGTCATCCCG
GGCATCGGGATCCTGCGCCTGCATCCCCGCTCCATCCTCACCGACACCGAATAG

close this sectionFeature

BLASTP
Database:UniProtKB:2011_09 		show BLAST table
InterPro
Database:interpro:38.0
IPR003838 Permease FtsX-like (Domain)
[293-429] 4.10000000000001e-22 PF02687
PF02687   FtsX
IPR025857 MacB-like periplasmic core domain (Domain)
[113-261] 3.90000000000001e-18 PF12704
PF12704   MacB_PCD
SignalP
[1-40] 1 Signal
Bacteria, Gram-negative   
[1-42] 0.745 Signal
Eukaryota   
[1-43] 1 Signal
Bacteria, Gram-positive   
TMHMM
[21-43] Transmembrane (i-o) [290-312] Transmembrane (o-i) [339-361] Transmembrane (i-o) [405-427] Transmembrane (o-i)
Transmembrane 4   
Rapam_00050 Rapam_00050   Rapam_00070 Rapam_00070
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