Chalc_00360 : CDS information

Location

Organism	Streptomyces bikiniensis
Strain	NRRL 2737
Entry name	Chalcomycin
Contig	AY509120
Start / Stop / Direction	76,537 / 78,375 / + [in whole cluster] 76,537 / 78,375 / + [in contig]
Location	76537..78375 [in whole cluster] 76537..78375 [in contig]
Type	CDS
Length	1,839 bp (612 aa)

Annotation

Category	5.1 general function
Product	putative xanthine permease
Product (GenBank)	putative permease
Gene
Gene (GenBank)	ORF11
EC number
Keyword
Note	It is supposed that this ORF is not involved in chalcomycin biosynthesis.
Note (GenBank)	similar to Streptomyces coelicolor SC6214 and SC6212, Streptomyces avermitilis SAV2016 and SAV1508 xanthine/uracil permease homology family member
Reference	ACC Q5SFC9 PmId [15561847] Chalcomycin biosynthesis gene cluster from Streptomyces bikiniensis: novel features of an unusual ketolide produced through expression of the chm polyketide synthase in Streptomyces fradiae. (Antimicrob Agents Chemother. , 2004) comment Chalcomycin biosynthesis gene clusterに関する文献。 ORF11(612a.a.): Permease
Related Reference	ACC P42086 PmId [9098051] Xanthine metabolism in Bacillus subtilis: characterization of the xpt-pbuX operon and evidence for purine- and nitrogen-controlled expression of genes involved in xanthine salvage and catabolism. (J Bacteriol. , 1997) comment 279th(P42086) 38%, 3e-73 B.subtilis_pbuX Xanthine permease Bacillus subtilisのXanthine metabolismについて。 Uptake rate of [14C]xanthineも見ている。pbuXの欠損株では取り込みが起こらなくなる。

Sequence

>putative xanthine permease [putative permease]
MSQGPALLPRATDHASPTPPHPVDEILPARRMLPAALQHVASMYAGLTAPPLIISSALGL
TPAQLSALLAAALLIAGLGTIAQTLGVYGVGAGLPLVNGVSFAVVSPALATAATQGRDGA
LPAIFGATLVAGLLCLLLAPVFCRLVRFFPPVVSGCVITLVGISLLPVAGTWARGGDAEA
AGFGSPADLALAATTLVITLTVHRMLSGRFLGRVAILIGMLAGTLIAIPLGKVDLDPLAQ
APLFALPTPFGFGTPQFVPTVIATAAVVMIVSMMESTAALLALGAVAERPVRDRTIAGSL
RALGLATVLGGVLGSFTSTSYAQNVGLVSLSRIRSRYVVTLCGAVLVLMGFVPVLGSFVA
LVPLPVLGGAGVVFFGSVAVTGIRTLAKAALGTGHNAVIVSVTLAFGLFPVLDPDFYARL
PAPVATVLGSGITAGCLVAVLLNYLLNHLGRGTEADPDAISAEQVTALDTADTVLGPKRS
SDWTPFQPSGSPSGTPDHGRHTRGTARPAPAWPYVTGPVDPTDTGRHHRPHEVPAPPHRP
DEVPPPLHPSAAHEGEPPPAVTENAVFPGPLHPLHPLHPRPTGRPDRPRQRHSAEADPWQ
HPQTPSASGDSQ

>putative xanthine permease [putative permease]
GTGTCTCAAGGACCTGCCTTGCTGCCCCGCGCCACTGACCACGCATCGCCGACCCCACCC
CATCCGGTCGACGAGATCCTTCCCGCCCGCCGCATGCTGCCCGCCGCCCTCCAACACGTG
GCGAGCATGTACGCCGGCCTGACCGCACCACCGCTGATCATCAGCAGCGCCCTGGGGCTG
ACCCCGGCCCAGCTCTCCGCCCTCCTGGCCGCCGCGCTGCTGATCGCCGGGCTCGGCACG
ATCGCCCAGACCCTCGGCGTCTACGGCGTCGGCGCCGGGTTGCCCCTCGTCAACGGCGTC
TCGTTCGCCGTCGTGTCACCGGCGCTCGCCACCGCCGCCACCCAGGGGCGCGACGGCGCC
CTCCCGGCGATCTTCGGGGCCACCCTCGTGGCGGGACTCCTCTGCCTGCTCCTCGCTCCC
GTCTTCTGCCGACTGGTCAGGTTCTTCCCACCGGTCGTCAGCGGCTGCGTCATCACCCTG
GTCGGCATCTCCCTCCTGCCGGTCGCCGGCACCTGGGCCCGGGGCGGAGACGCCGAAGCC
GCCGGCTTCGGCTCCCCCGCCGACCTGGCCCTGGCGGCGACGACCCTCGTCATCACCCTG
ACCGTGCACCGCATGCTCTCGGGCCGCTTCCTCGGGCGGGTCGCCATCCTCATCGGCATG
CTCGCGGGCACCCTGATCGCGATCCCGCTGGGCAAGGTCGACCTCGACCCCCTCGCCCAG
GCGCCCCTCTTCGCCCTGCCCACGCCCTTCGGCTTCGGCACCCCGCAGTTCGTCCCCACC
GTGATCGCCACCGCCGCGGTCGTGATGATCGTGTCCATGATGGAGTCCACCGCCGCGCTG
CTGGCGCTGGGCGCGGTCGCCGAACGGCCGGTCCGGGACCGGACCATCGCCGGAAGCCTC
CGCGCCCTCGGCCTCGCCACGGTCCTCGGCGGCGTCCTCGGCTCGTTCACCAGCACGTCG
TACGCGCAGAACGTCGGCCTGGTCTCCCTCAGCCGGATCCGCAGCCGCTATGTGGTCACG
CTCTGCGGCGCCGTCCTCGTCCTGATGGGCTTCGTGCCCGTCCTGGGCTCGTTCGTCGCC
CTCGTCCCTCTGCCCGTCCTCGGCGGTGCGGGGGTGGTCTTCTTCGGCTCCGTCGCCGTC
ACGGGCATCCGTACGCTGGCCAAGGCCGCCCTCGGCACCGGACACAACGCTGTGATCGTC
TCCGTCACCCTCGCCTTCGGTCTCTTCCCCGTCCTGGACCCGGACTTCTACGCCCGTCTT
CCCGCCCCGGTGGCGACCGTGCTCGGCTCGGGGATCACCGCCGGCTGCCTGGTCGCGGTC
CTCCTCAACTACCTCCTGAACCACCTGGGCCGCGGCACCGAGGCCGACCCCGACGCGATC
TCCGCGGAACAGGTCACCGCCCTCGACACCGCGGACACCGTCCTCGGGCCGAAGCGTTCC
TCCGACTGGACGCCCTTCCAGCCCTCCGGCAGCCCCTCCGGCACCCCTGACCACGGCCGT
CACACCAGGGGCACGGCACGGCCCGCTCCCGCCTGGCCCTACGTGACCGGCCCCGTGGAC
CCCACCGACACCGGGCGGCACCACCGGCCGCACGAGGTTCCGGCGCCGCCCCACCGACCA
GACGAGGTGCCCCCGCCGCTCCACCCCTCTGCCGCTCACGAAGGCGAACCCCCGCCCGCC
GTCACCGAGAACGCGGTCTTTCCCGGACCGCTCCACCCGCTCCACCCGCTCCACCCCCGG
CCCACCGGTCGTCCCGACCGTCCCCGGCAACGGCACAGTGCGGAGGCCGACCCCTGGCAG
CATCCGCAGACCCCCTCCGCATCCGGCGACAGCCAGTAG

Feature

BLASTP Database:UniProtKB:2011_09	show BLAST table
InterPro Database:interpro:38.0	IPR006042 Xanthine/uracil permease (Family) TIGR00801 Ncs2 IPR006043 Xanthine/uracil/vitamin C permease (Family) PF00860 Xan_ur_permease IPR017588 Xanthine permease (Family) TIGR03173 PbuX
SignalP	No significant hit
TMHMM	Transmembrane 11

Chalc_00350 Chalc_00370