Cosmo_00130 Cosmo_00130   last last

Cosmo_00140 : CDS information

close this sectionLocation

Organism
StrainDAUFPE 5622
Entry nameCosmomycin
Contig
Start / Stop / Direction13,087 / 14,076 / + [in whole cluster]
13,087 / 14,076 / + [in contig]
Location13087..14076 [in whole cluster]
13087..14076 [in contig]
TypeCDS
Length990 bp (329 aa)
Click on the icon to see Genetic map.

close this sectionAnnotation

Category4.3 transport
Productputative drug resistance ABC transporter ATP-binding protein
Product (GenBank)CosI
Gene
Gene (GenBank)cosI
EC number
Keyword
Note
Note (GenBank)
  • putative ABC transporter (ATP binding subunit)
Reference
ACC
PmId
[16810496] Insights in the glycosylation steps during biosynthesis of the antitumor anthracycline cosmomycin: characterization of two glycosyltransferase genes. (Appl Microbiol Biotechnol. , 2006)
comment
cosmomycinsを含むanthracycline複合体retamycinの産生株Streptomyces olindensisの染色体14kb領域から、cosmomycin生合成に関連した13genesを同定。

cosI: ABC transporter (ATP-binding subunit)

cosI については配列解析のみ。
CosI はcosmomycinの排出と抵抗性に関連するABC transporterのATP-binding subunitであるとされている。
Related Reference
ACC
Q9F5K4
NITE
Avil_00350
PmId
[11181344] An ATP-binding cassette transporter and two rRNA methyltransferases are involved in resistance to avilamycin in the producer organism Streptomyces viridochromogenes Tu57. (Antimicrob Agents Chemother. , 2001)
comment
Blast 23th, id59%, 4e-93
Streptomyces viridochromogenes_aviABC1
Putative ATP binding protein

S. lividans TK66にてaviABC1, aviABC2, aviRa, aviRb発現。
--> avilamycin resistance
(avilamycin A inhibited poly(U)-directed polyphenylalanine synthesis)

close this sectionSequence

selected fasta
>putative drug resistance ABC transporter ATP-binding protein [CosI]
MGGADLAIQTEALKKKYGDKEALAGLDLEVPRGVVYGLLGPNGAGKTTAVRILSTLLKYD
EGTARVAGYDVATQSAQVRYSIGLLGQHAAVDEDLSGRQNLVMFGRLYHIGKRNAQARAD
ELLERFGLTEAAGKPAKQYSGGMRRRLDLAASLILAPSVLFLDEPTTGLDPRGRNDVWES
VRGLIAEGRTVLLTTQYLEEADQLADRIALIDNGRVVESGTPDQLKNKIGGDRIDVVLRR
AHDLERATHTIGTLLRSEPETDADNRRISVVVDNRVAALTAVARELDDAGIEAEDIALRR
PTLDEVFLNLTGNGAATSAEQSLKEVAQS
selected fasta
>putative drug resistance ABC transporter ATP-binding protein [CosI]
ATGGGCGGCGCCGACCTGGCGATCCAGACCGAAGCTCTGAAGAAGAAATACGGCGACAAG
GAGGCCCTCGCGGGACTCGACCTGGAGGTACCCCGAGGCGTCGTCTACGGGCTCCTCGGC
CCGAACGGCGCCGGAAAGACCACCGCGGTCCGCATCCTCTCCACCCTGCTGAAGTACGAC
GAGGGAACAGCCCGGGTCGCCGGCTACGACGTCGCCACCCAGTCGGCCCAGGTCCGCTAC
AGCATCGGACTCCTCGGCCAGCACGCCGCAGTGGACGAGGACCTGAGCGGCCGTCAGAAC
CTCGTGATGTTCGGGCGCTTATACCACATCGGTAAACGCAACGCCCAGGCCCGGGCCGAC
GAACTGCTGGAGCGCTTCGGCCTCACCGAGGCCGCCGGCAAGCCGGCCAAGCAGTACTCC
GGCGGTATGCGCCGGCGGCTCGACCTCGCCGCCAGCCTCATCCTGGCCCCGTCCGTGCTG
TTCCTCGACGAGCCCACCACCGGGCTCGACCCGCGGGGCCGCAACGACGTCTGGGAGTCC
GTCCGAGGCCTGATCGCCGAGGGCCGCACGGTCCTGCTGACCACCCAGTACCTGGAGGAG
GCCGACCAGCTCGCCGACCGCATCGCCCTGATCGACAACGGCAGGGTCGTCGAGTCCGGC
ACCCCGGACCAGCTCAAGAACAAGATCGGCGGGGACCGGATCGACGTCGTCCTCCGCCGC
GCCCACGACCTCGAACGCGCCACCCACACGATCGGCACCCTGCTGCGCTCCGAGCCCGAG
ACGGACGCCGACAACCGGCGCATCAGCGTCGTCGTCGACAACCGGGTCGCCGCCCTCACC
GCCGTCGCCCGCGAACTCGACGACGCCGGCATCGAGGCCGAGGACATCGCCCTGCGCAGG
CCCACTCTCGACGAGGTGTTCCTGAACCTGACCGGCAACGGGGCGGCCACGTCCGCCGAG
CAGAGCCTCAAGGAGGTCGCCCAGTCATGA

close this sectionFeature

BLASTP
Database:UniProtKB:2011_09 		show BLAST table
InterPro
Database:interpro:38.0
IPR003439 ABC transporter-like (Domain)
[8-238] PS50893
PS50893   ABC_TRANSPORTER_2
[47-167] 1.2e-18 PF00005
PF00005   ABC_tran
IPR003593 AAA+ ATPase domain (Domain)
[32-215] 1.39999892049878e-12 SM00382
SM00382   AAA
IPR005894 Daunorubicin resistance ABC transporter ATP-binding subunit (Family)
[15-312] 3.99999999999998e-107 TIGR01188
TIGR01188   DrrA
IPR017871 ABC transporter, conserved site (Conserved_site)
[139-153] PS00211
PS00211   ABC_TRANSPORTER_1
SignalP No significant hit
TMHMM No significant hit
Cosmo_00130 Cosmo_00130   last last
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