Fren_00060 : CDS information

close this sectionLocation

Organism
StrainAK24158
Entry nameFrenolicin
Contig
Start / Stop / Direction8,271 / 9,824 / + [in whole cluster]
8,271 / 9,824 / + [in contig]
Location8271..9824 [in whole cluster]
8271..9824 [in contig]
TypeCDS
Length1,554 bp (517 aa)
Click on the icon to see Genetic map.

close this sectionAnnotation

Category4.3 transport
Productputative drug resistance transporter
Product (GenBank)putative antibiotic antiporter
Gene
Gene (GenBank)frnF
EC number
Keyword
Note
Note (GenBank)
  • FrnF; actVA-ORF1 homolog
Reference
ACC
comment
"Analysis of a 27 kb region of Streptomyces roseofulvus containing genes for frenolicin biosynthesis."

論文として報告があるのは10.2kbp領域のみ[PMID:8181754]。
このORFはその範囲外でGenBank登録AF058302に由来する。
Related Reference
ACC
Q9WVV3
PmId
[10198016] Mitomycin resistance in Streptomyces lavendulae includes a novel drug-binding-protein-dependent export system. (J Bacteriol. , 1999)
comment
Blast 8th, id47%, 1e-89
Streptomyces lavendulae_mct
Mct(Putative mitomycin C translocase)

mctの挿入不活化mutantではmitomycin Cの感受性がかなり強くなる。
E.coliでmctを発現するとmitomycin C抵抗性が5倍に増え、細胞内の薬剤蓄積が減る。
mctとmrdを一緒にE.coliで発現すると、抵抗性は150倍になる。

close this sectionSequence

selected fasta
>putative drug resistance transporter [putative antibiotic antiporter]
MSSSPPAPATPGVAPHSPPAPRLGLVLLVCCLAQFLVTLSVAIVNVALPDIQRGLGFSAE
SLQWVVNAYTVTFAGFLLLGGRIADLFGRRRIFLAGVALFALASLAGGLSQNAGTLVAAR
AVQGLAAAVIAPTTLAVLGTSFKDPHQRHRAFGAWGAVSGAGGAFGALAGGALTDAFSWR
WVLFVNLPIGVLLLAGIAWGISELRHAGEDRRIDVAGALTVTLGLLALVLGIVQSGPHGW
GSAATLVPLLGGLALLGAFVLVEGRFAPQPLIPLGIFRSRSVVAANVVAMTSGAALFSMF
YFLTLFLNQVRDYSPLRTGFAYLPLALAIMVAAQFSAALVRVLGPRTTLLVSMALTAAGL
LWLSRLTEDSGFAGGLLGPTLVVGIGQGISMSASAIAGVAGVRPQQAGLASGLLNATRQL
GGALGLAVVAAVATSRADGLLDGVARPTAELARHAQASGHPLSIAVAAALSAVGLLASLA
APGRSPAPTGTRTGGDSAAPAPAAAPAATGTTGPGEI
selected fasta
>putative drug resistance transporter [putative antibiotic antiporter]
ATGTCCTCCTCCCCGCCCGCCCCCGCCACCCCGGGCGTTGCCCCGCACTCGCCGCCCGCT
CCGCGCCTCGGCCTCGTGCTCCTCGTGTGCTGCCTGGCGCAGTTCCTCGTGACGCTCAGC
GTCGCCATCGTCAACGTGGCGCTCCCCGACATCCAGCGCGGGCTCGGCTTCAGCGCCGAG
AGCCTCCAGTGGGTCGTCAACGCCTACACCGTCACCTTCGCGGGCTTCCTGCTCCTCGGC
GGACGGATCGCCGACCTCTTCGGGCGGCGCCGCATCTTCCTCGCGGGTGTCGCGCTCTTC
GCCCTCGCGAGCCTCGCCGGGGGCCTAAGCCAGAACGCGGGGACCCTCGTCGCCGCGCGC
GCCGTGCAGGGCCTCGCCGCCGCCGTCATCGCGCCCACCACCCTCGCCGTGCTCGGCACG
AGCTTCAAGGACCCGCACCAGCGCCACCGCGCCTTCGGCGCCTGGGGCGCGGTCTCCGGT
GCGGGCGGCGCCTTCGGCGCCCTCGCGGGCGGCGCGCTCACGGACGCGTTCTCCTGGCGC
TGGGTGCTCTTCGTCAACCTCCCGATCGGCGTGCTCCTGCTCGCCGGGATCGCCTGGGGC
ATCAGCGAGTTGCGGCACGCGGGCGAGGACCGCCGCATCGACGTCGCGGGCGCCCTCACC
GTGACGCTCGGTCTCCTCGCGCTCGTCCTCGGCATCGTGCAGAGCGGCCCGCACGGCTGG
GGCTCCGCCGCCACCCTCGTCCCGCTCCTCGGCGGCCTCGCCCTGCTCGGTGCCTTCGTT
CTCGTCGAGGGGCGGTTCGCGCCGCAGCCGCTCATACCGCTCGGCATCTTCCGCTCCCGC
TCCGTCGTCGCGGCCAACGTCGTGGCGATGACCAGCGGCGCCGCGCTCTTCAGCATGTTC
TACTTCCTCACCCTCTTCCTCAACCAGGTACGGGACTACAGCCCGCTGCGCACCGGCTTC
GCCTATCTGCCGCTCGCGCTCGCCATCATGGTCGCCGCGCAGTTCTCCGCCGCGCTCGTG
CGCGTCCTCGGCCCCCGTACGACCCTGCTCGTGTCCATGGCTCTCACCGCCGCCGGACTG
CTCTGGCTCTCGCGGCTCACCGAGGACTCCGGGTTCGCGGGCGGACTCCTCGGCCCGACC
CTGGTCGTCGGCATCGGACAGGGCATCTCGATGTCCGCCTCCGCGATCGCGGGGGTCGCC
GGGGTGCGCCCGCAGCAGGCCGGGCTCGCCTCCGGGCTGCTCAACGCGACCCGGCAGCTC
GGCGGCGCCCTCGGCCTCGCGGTCGTCGCCGCCGTCGCCACCTCGCGCGCCGACGGACTC
CTCGACGGGGTCGCGCGGCCCACGGCGGAACTCGCCCGGCACGCCCAGGCGTCCGGGCAC
CCGCTCTCCATCGCCGTGGCCGCGGCGCTGTCCGCCGTCGGCCTGCTCGCCTCGCTCGCC
GCCCCGGGCCGCTCTCCGGCCCCCACCGGCACCCGCACGGGCGGCGACTCCGCCGCACCG
GCTCCCGCGGCGGCCCCCGCCGCCACCGGGACCACCGGCCCCGGCGAGATCTGA

close this sectionFeature

BLASTP
Database:UniProtKB:2011_09
show BLAST table
InterPro
Database:interpro:38.0
IPR001411 Tetracycline resistance protein TetB/drug resistance transporter (Family)
 [29-53]  7.89999609889417e-08 PR01036 [89-111]  7.89999609889417e-08 PR01036 [151-175]  7.89999609889417e-08 PR01036 [416-435]  7.89999609889417e-08 PR01036
PR01036   TCRTETB
IPR005829 Sugar transporter, conserved site (Conserved_site)
 [80-96]  PS00216
PS00216   SUGAR_TRANSPORT_1
IPR011701 Major facilitator superfamily (Family)
 [31-425]  9e-51 PF07690
PF07690   MFS_1
IPR016196 Major facilitator superfamily domain, general substrate transporter (Domain)
 [1-481]  1.79999754022378e-71 SSF103473
SSF103473   MFS_gen_substrate_transporter
IPR020846 Major facilitator superfamily domain (Domain)
 [26-486]  PS50850
PS50850   MFS
SignalP
 [1-41]  0.478 Signal
Bacteria, Gram-positive   
 [1-42]  0.885 Signal
Eukaryota   
TMHMM
 [25-47]  Transmembrane (i-o) [62-84]  Transmembrane (o-i) [91-113]  Transmembrane (i-o) [117-139]  Transmembrane (o-i) [152-174]  Transmembrane (i-o) [179-201]  Transmembrane (o-i) [213-235]  Transmembrane (i-o) [240-262]  Transmembrane (o-i) [283-305]  Transmembrane (i-o) [320-342]  Transmembrane (o-i) [349-366]  Transmembrane (i-o) [376-398]  Transmembrane (o-i) [411-433]  Transmembrane (i-o) [461-483]  Transmembrane (o-i)
Transmembrane 14   
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