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Herb_00300 : CDS information

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Organism
StrainAM 3672
Entry nameHerbimycin A
Contig
Start / Stop / Direction85,764 / 82,921 / - [in whole cluster]
85,764 / 82,921 / - [in contig]
Locationcomplement(82921..85764) [in whole cluster]
complement(82921..85764) [in contig]
TypeCDS
Length2,844 bp (947 aa)
Click on the icon to see Genetic map.

close this sectionAnnotation

Category4.1 transcriptional regulator
Productputative LuxR family transcriptional regulator
Product (GenBank)HbmRI
Gene
Gene (GenBank)hbmRI
EC number
Keyword
Note
Note (GenBank)
  • putative transcriptional regulator; LuxR-type
Reference
ACC
PmId
[16085885] Insights into the biosynthesis of the benzoquinone ansamycins geldanamycin and herbimycin, obtained by gene sequencing and disruption. (Appl Environ Microbiol. , 2005)
comment
herbimycin生合成系gene clusterのクローニングを行い、同じbenzoquinone ansamycin系のgeldanamycin のgene clusterと比較し、一部の遺伝子欠損株を作成してその生合成における関与を調べた文献。

HbmRI(2,844bp):LuxR-type transcriptional regulator
hbmRI自体の機能実験は無し。
Related Reference
ACC
Q06BL2
NITE
Gelda_00130
PmId
[18214443] The LuxR family members GdmRI and GdmRII are positive regulators of geldanamycin biosynthesis in Streptomyces hygroscopicus 17997. (Arch Microbiol. , 2008)
comment
<gdmRI, Streptomyces hygroscopicus, BLAST 3; id=83%>

gdmRI, gdmRIIのいずれか一方の欠損株ではgeldanamycinの生産が完全に消失し、欠損した遺伝子をプラスミドで相補すると geldanamycin生産が回復すること、二つの遺伝子の転写は独立に行われ互いを制御していないこと、二つの遺伝子の転写はpolyketide生合成に関与する遺伝子と協調し、post-PKS modification 遺伝子である gdmNとは協調していないことが示されており、gdmRI と gdmRIIはgeldanamycin 生合成経路におけるpolyketide 生合成遺伝子特異的なpositive regulatorsであると結論付けている。

close this sectionSequence

selected fasta
>putative LuxR family transcriptional regulator [HbmRI]
MSMGLTDYQSELRGVLDMAARGNGGLLKVTGGPGVGKTSLLGSLKEQAAESGAVCLMASG
FADDTAIPFNIVEQLIWSSAFTDELDVVARWRTAGERYSEAEPGILRSLVREISDVLHRI
AGGKQLIIAVDDAEHADYPSLMCLLHIARHASGTRTLVVMTCGQSHQLCVGTHGFHELYK
IKIDTLPESGVGHLLERHGDADLADRIRASCHAVSGGNPRLVKALLRDHLQAAPGGSETD
VTVGAEFQETYRGCLLSHPALLQVAQALAVLDRYGGPGRVASLLACGRERATRAITVMNS
AGLLEDGRFRHPAARYITLETLSAEDRARLSAKAAELLYADGADPIAVAELLVTADRTPD
QKDVTVLWHAAQKNLDHGRTEEAIAGLRLAARADLGRREHMDILMALVGALWSSNPATAE
PELDRLMAAIREEFPADIPEQYLCFLLFMVLWFGRFSDGEEAFKWLSGGGDTDNASSMAA
LRVTRQWATFLKPALIHDFPDQASSAGEVDGLWAANLEHGLQLSVDELGMEIGHFQDPRQ
VADFSPDTMHLLSPSNHFWFAYAYACRMVWALAARGEAETADRLCGALFTAAGNLNMKTP
GAVALAMRAYIRCRHGDFTSAIDLAGTALKSIPPRGWGVAIGLPLSVLVAAHTAIGRLDE
AQRYLHYWVPKEMFDSVVGLEYLRARGQYCLATNRPYAALNDFMVSGMLMDQWPVDFGDL
APWRIDAAEAYLRVQEPAEAKRLALEELKLSPDRPLSTRGRALRVLAMAEDPDKRRLLLY
QSAKCLREHGDRFELARTLAELSQDFLSTGETQQARGTWHEAQKLMDECGISAQHESRRD
LVVDGAESPADARLPEPAGDTGEPEESDPAASAEGAEQPVLSEAEWRVATLAASGMSNRQ
IAKSLYITVSTVEQHLTRIYRKLSVGNRQELSRRLWQLIGATGSSSC
selected fasta
>putative LuxR family transcriptional regulator [HbmRI]
ATGAGTATGGGACTGACAGATTATCAATCAGAGCTTCGCGGCGTCCTCGACATGGCAGCA
CGAGGAAACGGCGGGCTTCTCAAAGTGACCGGGGGACCCGGTGTCGGAAAGACCTCCTTA
TTGGGCAGTCTGAAGGAGCAGGCGGCCGAATCGGGTGCGGTCTGTCTTATGGCGTCCGGA
TTCGCGGACGACACCGCGATCCCGTTCAATATAGTGGAACAGCTCATCTGGTCGTCCGCG
TTCACGGATGAATTGGACGTCGTGGCGCGCTGGAGGACCGCCGGAGAGCGGTATTCGGAA
GCCGAACCCGGCATACTGAGAAGCCTGGTCCGAGAGATATCCGATGTGCTGCACCGCATC
GCGGGCGGCAAGCAACTGATCATCGCGGTTGACGATGCCGAGCATGCCGACTACCCCTCC
CTCATGTGCCTGCTGCATATCGCCAGGCATGCCTCCGGCACCCGTACGCTCGTCGTGATG
ACCTGCGGGCAGAGTCATCAGTTGTGTGTCGGCACTCACGGCTTCCATGAGCTCTACAAG
ATCAAGATCGATACACTCCCGGAATCCGGGGTCGGACACCTGCTGGAGCGGCACGGCGAC
GCCGACCTGGCCGACCGGATCCGCGCCTCCTGCCACGCCGTCAGCGGTGGCAACCCACGG
CTGGTCAAGGCCCTGCTGCGGGACCATCTCCAGGCCGCTCCGGGCGGGTCGGAGACGGAT
GTCACCGTCGGCGCGGAGTTCCAGGAGACCTATCGCGGGTGCCTGTTGTCCCATCCGGCG
TTGCTCCAGGTGGCACAGGCCCTCGCGGTGCTGGACCGGTACGGCGGCCCGGGGCGGGTG
GCCAGTCTGCTCGCCTGCGGCCGGGAACGCGCGACCCGGGCCATCACCGTCATGAACTCC
GCCGGACTGCTGGAGGACGGACGGTTCCGGCACCCCGCGGCGCGATACATCACGCTGGAG
ACGCTGTCGGCGGAGGACCGGGCCCGGCTCAGCGCGAAAGCGGCCGAACTTCTGTATGCC
GACGGGGCCGATCCGATCGCGGTGGCGGAACTCCTGGTCACCGCCGACAGAACGCCCGAC
CAAAAAGACGTCACCGTGCTCTGGCACGCGGCCCAGAAGAATCTCGACCACGGCCGTACG
GAGGAAGCGATCGCGGGCCTGCGGCTCGCCGCCCGCGCGGACCTCGGCCGGCGCGAGCAC
ATGGACATTCTCATGGCGCTGGTCGGCGCGTTATGGTCCAGCAATCCGGCGACCGCCGAA
CCCGAACTGGACCGCCTGATGGCCGCGATACGGGAGGAATTCCCCGCGGACATCCCGGAA
CAGTATCTGTGCTTCCTGCTCTTCATGGTGCTCTGGTTCGGCCGGTTCAGCGATGGGGAA
GAAGCCTTCAAGTGGCTTTCGGGCGGTGGTGACACCGATAACGCCTCCAGCATGGCCGCT
CTGCGGGTGACCCGGCAGTGGGCCACCTTCCTCAAACCGGCCCTGATCCATGACTTCCCC
GACCAGGCTTCCTCGGCCGGGGAAGTCGACGGACTGTGGGCGGCCAACCTGGAGCACGGT
CTTCAGCTCTCCGTCGACGAACTGGGCATGGAGATCGGGCATTTCCAGGATCCCCGGCAG
GTGGCGGACTTCTCTCCCGACACCATGCATCTGTTGTCGCCCTCCAACCACTTCTGGTTC
GCCTACGCATACGCCTGCCGGATGGTCTGGGCATTGGCCGCGAGAGGCGAAGCGGAAACG
GCGGACCGGCTGTGCGGCGCGCTTTTCACCGCGGCCGGCAACTTGAACATGAAGACGCCC
GGCGCCGTCGCCCTGGCCATGCGCGCCTACATCAGATGCCGCCATGGGGACTTCACCTCG
GCCATCGATCTCGCCGGCACCGCGCTGAAGTCCATCCCCCCGCGCGGCTGGGGCGTCGCC
ATCGGATTGCCGCTCTCCGTTCTGGTGGCGGCCCACACCGCCATCGGCAGACTCGATGAG
GCCCAGCGATATCTGCATTACTGGGTGCCGAAGGAAATGTTCGACAGCGTTGTCGGGTTG
GAGTACCTCCGGGCCCGTGGACAGTACTGCCTGGCCACCAACCGCCCCTACGCAGCGCTG
AACGACTTCATGGTGAGCGGGATGCTGATGGACCAGTGGCCCGTGGACTTCGGCGACCTG
GCGCCCTGGCGTATCGACGCCGCCGAGGCGTATCTGCGTGTCCAGGAGCCGGCGGAGGCC
AAAAGACTCGCCCTGGAGGAACTCAAGCTGTCGCCCGACCGCCCCTTGAGCACCCGCGGC
CGGGCGCTGCGCGTTCTGGCCATGGCCGAAGACCCGGACAAGCGCAGGCTGCTCCTGTAT
CAGTCCGCCAAGTGTCTGCGCGAGCACGGCGACCGTTTCGAACTCGCCCGTACGCTCGCC
GAGCTCAGCCAGGACTTCCTCAGCACCGGGGAAACCCAGCAGGCCCGCGGCACCTGGCAT
GAGGCGCAGAAGCTGATGGACGAGTGCGGGATCAGCGCCCAGCACGAGAGCCGCAGGGAC
CTCGTCGTGGATGGCGCCGAGAGCCCCGCGGACGCGCGACTGCCGGAACCCGCCGGGGAT
ACCGGGGAGCCCGAGGAGTCGGACCCCGCCGCCTCGGCCGAAGGCGCGGAGCAGCCCGTT
CTCTCGGAGGCCGAGTGGCGCGTGGCGACCCTGGCCGCGTCGGGGATGTCCAACCGGCAG
ATCGCCAAGAGCCTCTACATCACGGTCAGCACCGTGGAGCAGCATCTGACCCGCATCTAC
CGAAAGCTCTCGGTCGGAAATCGGCAGGAGCTGTCGCGTCGGCTGTGGCAGCTCATCGGA
GCCACCGGATCGTCCTCCTGCTGA

close this sectionFeature

BLASTP
Database:UniProtKB:2011_09
show BLAST table
InterPro
Database:interpro:38.0
IPR000792 Transcription regulator LuxR, C-terminal (Domain)
 [895-922]  PS00622
PS00622   HTH_LUXR_1
 [878-935]  2.30000440726534e-21 SM00421
SM00421   HTH_LUXR
 [881-895]  1.49999977583352e-08 PR00038 [895-911]  1.49999977583352e-08 PR00038 [911-923]  1.49999977583352e-08 PR00038
PR00038   HTHLUXR
 [874-939]  PS50043
PS50043   HTH_LUXR_2
 [879-932]  8.60000000000001e-14 PF00196
PF00196   GerE
IPR011990 Tetratricopeptide-like helical (Domain)
 [572-840]  1.7e-14 G3DSA:1.25.40.10
G3DSA:1.25.40.10   TPR-like_helical
IPR011991 Winged helix-turn-helix transcription repressor DNA-binding (Domain)
 [877-937]  2.90000000000001e-19 G3DSA:1.10.10.10
G3DSA:1.10.10.10   Wing_hlx_DNA_bd
IPR016032 Signal transduction response regulator, C-terminal effector (Domain)
 [859-938]  1.89999859865864e-16 SSF46894
SSF46894   Bipartite_resp_reg_C-effector
SignalP No significant hit
TMHMM No significant hit
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