Strply_00360 Strply_00360   Strply_00380 Strply_00380

Strply_00370 : CDS information

close this sectionLocation

Organism
StrainNRRL 2433 (=NBRC 13058)
Entry nameStreptolydigin
Contig
Start / Stop / Direction79,840 / 80,457 / + [in whole cluster]
79,840 / 80,457 / + [in contig]
Location79840..80457 [in whole cluster]
79840..80457 [in contig]
TypeCDS
Length618 bp (205 aa)
Click on the icon to see Genetic map.

close this sectionAnnotation

Category5.1 general function
Productputative TetR family transcriptional regulator
Product (GenBank)putative TetR-family transcriptional regulator
Gene
Gene (GenBank)
EC number
Keyword
Note
  • It is supposed that this ORF is not involved in streptolydigin biosynthesis.
Note (GenBank)
  • ORF8
Reference
ACC
PmId
[19875077] Deciphering biosynthesis of the RNA polymerase inhibitor streptolydigin and generation of glycosylated derivatives. (Chem Biol. , 2009)
comment
streptolydigin生合成gene clusterの報告。

ORF7,8,9に関しては、streptolydigin生合成に関与すると思われるタンパク質とのヒットは見られなかった。

ORF8は、Q1EQV0(S. kanamyceticus) Putative TetR-family transcriptional regulatorと相同性を示す。

本ORFは機能解析実験はされていない。
Family/Domain
FD
IPR001647
comment
[IPR001647] Transcription regulator, TetR-like, DNA-binding, bacterial/archaeal (Domain)

close this sectionSequence

selected fasta
>putative TetR family transcriptional regulator [putative TetR-family transcriptional regulator]
MVRVGLTTERLVRAGAELADEVGFDQVTVSALARRFEVKVASLYSHVKNSQDLKTKIALL
ALEELADRGAAALAGRAGKDALTALANVYRDYAREHPGRYAAAQLRLTPAEAAASAGGRH
AQMTRAILRGYELSEPDQTHAVRLLGSVFHGYVSLELGGGFSHSAPDSQETWERILDGLD
ALLRNWPAQAAPSPGPADSGHRTTR
selected fasta
>putative TetR family transcriptional regulator [putative TetR-family transcriptional regulator]
ATGGTGCGCGTGGGGCTGACCACGGAGCGTCTGGTCCGGGCGGGAGCGGAACTGGCCGAT
GAGGTCGGCTTCGACCAGGTGACCGTCTCGGCGCTCGCCAGGCGGTTCGAGGTCAAGGTC
GCGAGTCTGTACTCGCACGTGAAGAACTCCCAGGACCTCAAGACCAAGATCGCGCTGCTG
GCCCTGGAGGAGCTCGCCGACCGGGGCGCCGCCGCGCTGGCCGGCCGGGCCGGCAAGGAC
GCCCTGACCGCCTTGGCGAACGTCTACCGCGACTACGCCCGCGAGCACCCCGGCCGCTAC
GCCGCGGCCCAGCTGCGGCTCACCCCGGCAGAGGCCGCCGCCAGCGCCGGCGGCAGGCAC
GCACAGATGACGCGGGCGATCCTGCGCGGCTACGAGCTGTCGGAGCCGGACCAGACGCAT
GCGGTCCGGCTGCTGGGCAGCGTCTTCCACGGCTACGTCAGCCTGGAGCTGGGAGGGGGG
TTCAGCCACAGTGCCCCCGACTCGCAGGAGACCTGGGAACGGATCCTGGACGGCCTCGAC
GCACTGCTGCGGAACTGGCCCGCGCAGGCCGCCCCGTCACCCGGCCCCGCAGACTCCGGA
CACCGAACGACACGTTGA

close this sectionFeature

BLASTP
Database:UniProtKB:2011_09 		show BLAST table
InterPro
Database:interpro:38.0
IPR001647 DNA-binding HTH domain, TetR-type (Domain)
[5-65] PS50977
PS50977   HTH_TETR_2
[11-53] 8.00000000000001e-07 PF00440
PF00440   TetR_N
IPR009057 Homeodomain-like (Domain)
[4-75] 8.19999506482837e-12 SSF46689
SSF46689   Homeodomain_like
IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal (Domain)
[76-184] 3.60000433965927e-24 SSF48498
SSF48498   TetR_like_C
IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal (Domain)
[5-179] 4.2e-25 G3DSA:1.10.357.10
G3DSA:1.10.357.10   TetR_C
IPR025996 WHG domain (Domain)
[84-159] 1.8e-06 PF13305
PF13305   WHG
SignalP No significant hit
TMHMM No significant hit
Strply_00360 Strply_00360   Strply_00380 Strply_00380
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