Myxothiazol : Cluster information
Compound
| Entry name | Myxothiazol |
|---|---|
| PKS Type | PKS-NRPS hybrid |
| Starter Unit | 3-methylbutyryl-CoA |
| Chain Length | 6 |
| Sugar Unit | none |
| Classification | Peptide-Polyketide Hybrid |
| Activity | Antifungal |
| Composition | A: C25H33N3O3S2 |
Original source
| Organism | Stigmatella aurantiaca |
|---|---|
| Strain | DW4/3-1 |
| Contig | AF188287 |
PKS/NRPS Module
| Myxo_00020 mtaB | 0 |  | |
| 1 |  | malonyl-CoA not conserved HAFHS(H->Y) | |
| 2 |  | methylmalonyl-CoA | |
| Myxo_00030 mtaC | 3 |  | |
| Myxo_00040 mtaD | 4 | | |
| 5 | | malonyl-CoA | |
| Myxo_00050 mtaE | 6 |  | methylmalonyl-CoA not conserved YASHS(Y->V) |
| Myxo_00060 mtaF | 7 |  | malonyl-CoA |
| Myxo_00070 mtaG | 8 |  |
Reference
- New lessons for combinatorial biosynthesis from myxobacteria. The myxothiazol biosynthetic gene cluster of Stigmatella aurantiaca DW4/3-1.
- Silakowski B, Schairer HU, Ehret H, Kunze B, Weinig S, Nordsiek G, Brandt P, Blocker H, Hofle G, Beyer S, Muller R[PMID: 10601310]J Biol Chem. 274 (1999) 37391-9
- The mtaA gene of the myxothiazol biosynthetic gene cluster from Stigmatella aurantiaca DW4/3-1 encodes a phosphopantetheinyl transferase that activates polyketide synthases and polypeptide synthetases.
- Gaitatzis N, Hans A, Muller R, Beyer S[PMID: 11134965]J Biochem. 129 (2001) 119-24
- Melithiazol biosynthesis: further insights into myxobacterial PKS/NRPS systems and evidence for a new subclass of methyl transferases.
- Weinig S, Hecht HJ, Mahmud T, Muller R[PMID: 14583260]Chem Biol. 10 (2003) 939-52
- A unique mechanism for methyl ester formation via an amide intermediate found in myxobacteria.
- Muller I, Weinig S, Steinmetz H, Kunze B, Veluthoor S, Mahmud T, Muller R[PMID: 16807964]Chembiochem. 7 (2006) 1197-205
Data download
| Compound name | Genomic nucleotide sequence |
Nucleotide sequences of the coding regions | Translation of the coding sequences | List of genes/ORFs | GBK | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
 Myxothiazol |
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History
- 2012-03-28[Release]
